CN104306636A - 洋参苁蓉温肾养肾复方制剂 - Google Patents

洋参苁蓉温肾养肾复方制剂 Download PDF

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CN104306636A
CN104306636A CN201410568654.4A CN201410568654A CN104306636A CN 104306636 A CN104306636 A CN 104306636A CN 201410568654 A CN201410568654 A CN 201410568654A CN 104306636 A CN104306636 A CN 104306636A
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刘郁
刘连新
刘春杰
董立珉
燕传勇
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Xinjiang life nuclear force high-tech limited company
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Abstract

本发明公开了一种洋参苁蓉温肾养肾复方制剂,属中成药的配方及制备方法。本处方由西洋参、肉苁蓉、熟地黄、枸杞、牛膝、淫羊藿、鹿茸、狗脊、山药、肉桂、附子、牡丹皮、泽泻组成。具有温肾、养肾的作用。西洋参、肉苁蓉具有补肾阳、益精血以及强筋骨的作用,以上二味为君。熟地黄、枸杞、牛膝滋补肾阴,及对腰膝酸痛具有缓解作用,助君补肾,以其为臣。淫羊藿、鹿茸、狗脊、山药、肉桂、附子补火助阳,引火归元,散寒止痛,温通经脉,以其为佐。牡丹皮、泽泻以上二味回阳救逆,补火助阳,散寒止痛,利水渗湿,以其为使。本发明对于肾阳不足,精血亏虚,阳痿不孕,腰膝酸软,筋骨无力,手足冰冷有明显的改善作用。

Description

洋参苁蓉温肾养肾复方制剂
技术领域
本发明涉及一种洋参苁蓉温肾养肾复方制剂,属于中成药的配方及制备方法。主要用于肾阳不足,精血亏虚,阳痿不孕,腰膝酸软,筋骨无力,手足冰冷体征的人,有明显的改善效果。
背景技术
中医理论中,肾是一个非常特殊的脏器。古代医家认为:父母两精交媾,先成胚芽,然后便发育为“肾”,禀受于父母的先天之精(可近似地理解为今人所说的“遗传基因”)即藏之于肾,故有“肾为行天之本”的说法。也许从五行学说中推导而出(肾属水、主冬、水下行而静;冬则蛰藏),或受启于它因,古医家认为肾有司封藏的功能特点。这具体表现在将“精”(包括先在之精,也包括后天之精)密固于“肾”中而为“肾精”,使这类维系生命的重要物质不致于无谓的耗损或流失,能发挥其促进生长、发育与生殖的功能,故有“肾主藏精,所藏之精主生长、发育与生殖”之说。封藏也表现在肾能协助肺的呼吸,使之不过于浅有,吸入之气可纳入肾中,这称作“肾主纳气”。此外,与现代认识相一致,中医理论强调“肾主小便”,小便是由肾中阳气蒸腾体内津液,留下清的,滤出浊的,并将其暂贮于膀胱,阶段性地排出体外来完成的。再加上脾肺等脏也参与了体内津液的输布,但肺脾等脏的这一功能有赖于肾中阳气的推动,故中医理论中,肾调节并决定着体内津液代谢的平衡,而有“肾主水”之说。
除上述功能外,中医理论认为“腰为肾之府”,肾的位置在于腰部,腰部的慢性伤损、疼痛常与肾有关。肾位于五脏最低位置,生殖器和肛门的病变常也与肾有关,踝膝关节等的某些症状也反映了肾脏的状态。此外,全身的骨、髓、脊髓、头发、齿等都与肾所藏之精密切相关,因为是肾中所藏之精化生成髓,髓灌注在骨腔中以充养骨;充养和滋润脊髓;并上注于脑而为脑髓;充养头发;齿为骨之余;齿亦与肾精息息相关。再者,耳朵与肾有着众多特别紧密的联系,遂有“肾开窍于耳”之说。
中医认为肾阳虚:腰背酸痛,遗精阳痿,多尿或不禁,面色苍白,畏寒肢冷,下利清谷或五更泄泻,舌质淡胖有齿痕,苔白,脉沉迟。
本发明对于肾阳不足,精血亏虚,阳痿不孕,腰膝酸软,筋骨无力,手足冰冷有明显的改善作用。
发明内容
本发明的目的是提供一种洋参苁蓉温肾养肾复方制剂,对于肾阳不足,精血亏虚,阳痿不孕,腰膝酸软,筋骨无力,手足冰冷有明显的改善作用。
本发明是以如下技术方案实现的:一种洋参苁蓉温肾养肾复方制剂,其特征是:由下述重量份的原料制成:
西洋参8-12份、肉苁蓉8-12份、熟地黄8-12份、枸杞8-12份、
牛膝8-12份、淫羊藿8-12份、鹿茸3-5份、狗脊3-5份、
山药8-12份、肉桂5-7份、附子3-5份、牡丹皮5-7份、
泽泻5-7份。
上述洋参苁蓉温肾养肾复方制剂的制备方法,
(a)按处方称取原料:肉苁蓉、熟地黄、牛膝、淫羊藿、狗脊、附子、牡丹皮和泽泻;
(b)将上述各味药材合并用体积浓度不低于75%的乙醇溶剂浸泡30分钟,然后进行煮沸回流提取2-3次;3次溶剂的用量即乙醇溶剂与药材体积之比分别为10,8,8;煮沸回流的时间从沸腾开始计时,每次回流1个小时;
(c)合并上述提取液,用真空旋转蒸发仪减压浓缩,回收溶剂乙醇,浓缩到密度为1.20-1.25g/ml,得膏状物;
(d)按照处方量,称取西洋参、枸杞、鹿茸、山药和肉桂,干燥,粉碎,过100目筛子,备用;
(e)将步骤(c)的膏状物与步骤(d)药材细粉,以及辅料包括蔗糖、糊精、微晶纤维素和80%的乙醇,16目筛造粒,在电热恒温干燥箱中进行烘干即可,最后整粒;备用;
(f)按照剂型的要求,加入硬脂酸镁制备成片剂、胶囊、颗粒剂。
本发明还可以采用中药制剂学常规工艺制成胶囊剂;采用中药制剂学常规工艺制成片剂、散剂或颗粒剂、口服液
方解:
西洋参 归心、肺、肾经。补气养阴,清热生津。用于气虚阴亏,虚热烦倦,咳喘痰血,内热消渴,口燥咽干。肉苁蓉 归肾、大肠经。补肾阳,益精血,润肠通便。用于肾阳不足,精血亏虚,阳痿不孕,腰膝酸软,筋骨无力,肠燥便秘。肉苁蓉也叫沙漠人参,主治肾阳不足、温补精血、保肝润燥,有很重要的食疗功效和作用。熟地黄 归肝、肾经。补血滋阴,益精填髓。用于肝肾阴虚,腰膝酸软,骨蒸潮热,盗汗遗精,内热消渴,眩晕。枸杞 归肝、肾经。滋补肝肾,益精明目。用于虚劳精亏,腰膝酸痛,眩晕耳鸣,阳萎遗精,内热消渴,血虚萎黄,目昏不明。枸杞子味甘,性平,归肝肾经,能滋补肾阴,“枸杞味重而纯,擅长补阴,阴中有阳,故能补气,所以滋阴而不致阴衰,助阳能使阳旺。牛膝 苦、甘、酸,平。归肝、肾经。逐瘀通经,补肝肾,强筋骨,利尿通淋,引血下行。用于经闭,痛经,腰膝酸痛,筋骨无力,淋证,水肿,头痛,眩晕,牙痛,口疮,吐血,衄血。淫羊藿 其味辛甘,其气温,归肝、肾经。其性温而不燥,补而不峻,助阳而不伤阴,为平补肾阳之要药。鹿茸 归肾、肝经。壮肾阳,益精血,强筋骨。用于肾阳不足,精血亏虚,阳痿滑精。狗脊 苦、甘,温。归肝、肾经。祛风湿,补肝肾,强腰膝。用于风湿痹痛,腰膝酸软,下肢无力。山药 归脾、肺、肾经。补脾养胃,生津益肺,补肾涩精。肉桂 归肾、脾、心、肝经。补火助阳,引火归元,散寒止痛,温通经脉。用于阳痿宫冷,腰膝冷痛,肾虚作喘,虚阳上浮,眩晕目赤等症状。附子 归心、肾、脾经。回阳救逆,补火助阳,散寒止痛。用于亡阳虚脱,肾阳虚衰,阳痿宫冷,阴寒水肿,阳虚外感,寒湿痹痛。健脾益胃,培元滋肾,主治虚劳损伤,肌体消瘦,腰酸膝软,目暗耳鸣,饮食无味。牡丹皮 归心、肾、脾经。回阳救逆,补火助阳,散寒止痛。用于亡阳虚脱,肢冷脉微,心阳不足,胸痹心痛,虚寒吐泻,脘腹冷痛,肾阳虚衰,阳痿宫冷,阴寒水肿,阳虚外感,寒湿痹痛。清热凉血,活血化瘀。用于热入营血,温毒发斑等。泽泻 归肾、膀胱经。利水渗湿,泄热,化浊降脂。用于小便不利,水肿胀满,泄泻尿少,痰饮眩晕,热淋涩痛,高脂血症。
西洋参、肉苁蓉具有补肾阳、益精血以及强筋骨的作用,以上二味为君。熟地黄、枸杞、牛膝滋补肾阴,及对腰膝酸痛具有缓解作用,助君补肾,以其为臣。淫羊藿、鹿茸、狗脊、山药、肉桂、附子补火助阳,引火归元,散寒止痛,温通经脉,以其为佐。牡丹皮、泽泻以上二味回阳救逆,补火助阳,散寒止痛,利水渗湿,以其为使。本处方对于肾阳不足,精血亏虚,阳痿不孕,腰膝酸软,筋骨无力,手足冰冷有明显的改善作用。
具体实施方式
下面结合实施例对本发明作进一步说明;
实施例1
组方:
西洋参200g,肉苁蓉200g、熟地黄200g、枸杞200g、牛膝200g、淫羊藿200g、鹿茸80g、狗脊80g、山药200g、肉桂120g、附子80g、牡丹皮120g、泽泻120g。
制备方法
按照处方量,将苁蓉、熟地黄、牛膝、淫羊藿、狗脊、附子、牡丹皮和泽泻各味药材用75%(V/V)的乙醇溶剂,浸泡30分钟,然后进行煮沸,从沸腾开始计时1个小时;如此共提取3次;3次的溶剂用量分别为药材体积的10,8,8倍;合并上述3次提取液;
按照处方量,将西洋参、枸杞、鹿茸、山药和肉桂,干燥,粉碎,过100目筛子得药材细粉,备用。
将合并后的提取液用真空旋转蒸发仪减压浓缩,回收溶剂乙醇,浓缩到密度为1.25g/ml,将浓缩得到的膏状物与上述药材细粉,以及辅料(蔗糖、糊精、微晶纤维素等)和(V/V)80%的乙醇,16目筛造粒,在电热恒温干燥箱中进行烘干即可,最后整粒,即为有效成分,备用。
按照剂型的要求,加入处方量的硬脂酸镁制备成片剂。
实施例2
组方:
西洋参200g,肉苁蓉200g、熟地黄200g、枸杞200g、牛膝200g、淫羊藿200g、鹿茸80g、狗脊80g、山药200g、肉桂120g、附子80g、牡丹皮120g、泽泻120g。
制备方法
按照处方量,将苁蓉、熟地黄、牛膝、淫羊藿、狗脊、附子、牡丹皮和泽泻各味药材用75%(V/V)的乙醇溶剂,浸泡30分钟,然后进行煮沸,从沸腾开始计时1个小时;如此共提取2次;2次的溶剂用量分别为药材体积的10,8倍;合并上述2次提取液;
按照处方量,将西洋参、枸杞、鹿茸、山药和肉桂,干燥,粉碎,过100目筛子得药材细粉,备用。
将合并后的提取液用真空旋转蒸发仪减压浓缩,回收溶剂乙醇,浓缩到密度为1.20g/ml,将浓缩得到的膏状物与上述药材细粉,以及辅料(蔗糖、糊精、微晶纤维素等)和(V/V)80%的乙醇,16目筛造粒,在电热恒温干燥箱中进行烘干即可,最后整粒,即为有效成分,备用。
按照剂型的要求,灌装制备成胶囊剂。
疗效分析
治疗效果
治疗组98例,显效78例(79.6%),有效53例(54.1%),无效7例(7.1%)。总有效率为133.7%。对照组85例,显效58例(68.2%),有效32例(37.6%),无效16例(18.8%)。总有效率为105.8%。两组总有效率比较,差异显著。
典型案例:
(1)某女:44岁,糖尿病患者,腰膝酸软、乏力倦怠、记忆减退、眩晕、畏寒肢冷、脸色苍白、潮热、多尿等。服每日5-8g,口服。服用6个月后,身体感觉比较轻松,腰膝酸软、乏力倦怠、眩晕、畏寒肢冷、脸色苍白、颧红、潮热、多尿等现象有所改善。现在一直在服用,效果较好。
(2)某男,43岁,工作压力大,经常伴有头痛,睡眠不好,血压偏高,腰膝酸软、乏力倦怠、记忆减退、眩晕、畏寒肢冷、多尿等服用了按照该方制备的胶囊剂,2个月以后,睡眠、腰膝酸软、乏力倦怠、眩晕、畏寒肢冷、多尿状况改善。现在一直在服用,效果明显。
(3)某女:68岁,经常感觉头晕、健忘、神疲乏力、精神不振、活力低下、易疲劳、畏寒怕冷、四肢发凉、身体发沉、腰膝酸痛、腰背冷痛、筋骨萎软等。服用了按照该方制备的胶囊剂,3个月后,精神饱满,睡眠质量,神疲乏力,腰膝酸痛,腰背冷痛,畏寒怕冷、四肢发凉缓解。现在一直在服用,效果很好。

Claims (6)

1.一种洋参苁蓉温肾养肾复方制剂,其特征是:由下述重量份的原料制成: 
西洋参8-12份、肉苁蓉8-12份、熟地黄8-12份、枸杞8-12份、 
牛膝8-12份、淫羊藿8-12份、鹿茸3-5份、狗脊3-5份、 
山药8-12份、肉桂5-7份、附子3-5份、牡丹皮5-7份、 
泽泻5-7份。 
2.一种权利要求1所述的洋参苁蓉温肾养肾复方制剂的制备方法,其特征是: 
(a)按处方称取原料:肉苁蓉、熟地黄、牛膝、淫羊藿、狗脊、附子、牡丹皮和泽泻; 
(b)将上述各味药材合并用体积浓度不低于75%的乙醇溶剂浸泡30分钟,然后进行煮沸回流提取2-3次;3次溶剂的用量即乙醇溶剂与药材体积之比分别为10,8,8;煮沸回流的时间从沸腾开始计时,每次回流1个小时; 
(c)合并上述提取液,用真空旋转蒸发仪减压浓缩,回收溶剂乙醇,浓缩到密度为1.20-1.25g/ml,得膏状物; 
(d)按照处方量,称取西洋参、枸杞、鹿茸、山药和肉桂,干燥,粉碎,过100目筛子,备用; 
(e)将步骤(c)的膏状物与步骤(d)药材细粉,以及辅料包括蔗糖、糊精、微晶纤维素和80%的乙醇,16目筛造粒,在电热恒温干燥箱中进行烘干即可,最后整粒;备用; 
(f)按照剂型的要求,制备成片剂、胶囊、颗粒剂。 
3.如权利要求1所述的洋参苁蓉温肾养肾复方制剂,其特征是:采用中药制剂学常规工艺制成胶囊剂。 
4.如权利要求1所述的洋参苁蓉温肾养肾复方制剂,其特征在于采用中药制剂学常规工艺制成片剂。 
5.如权利要求1所述的洋参苁蓉温肾养肾复方制剂,其特征在于采用中药制剂学常规工艺制成散剂或颗粒剂。 
6.如权利要求1所述的洋参苁蓉温肾养肾复方制剂,其特征在于采用中药制剂学常规工艺制成口服液。 
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Cited By (3)

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Publication number Priority date Publication date Assignee Title
CN108785482A (zh) * 2017-05-05 2018-11-13 洛阳士雄聚元医疗集团股份有限公司 一种治疗女性相对不孕的中药
CN108936598A (zh) * 2018-05-22 2018-12-07 河南中立生物科技有限公司 一种五行养肾分解粥及其制备方法
CN110856732A (zh) * 2018-08-06 2020-03-03 严育斌 一种起痿胶囊

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101628071A (zh) * 2009-08-25 2010-01-20 红桃开集团股份有限公司 一种用于健肾壮阳的药物组合物

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101628071A (zh) * 2009-08-25 2010-01-20 红桃开集团股份有限公司 一种用于健肾壮阳的药物组合物

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108785482A (zh) * 2017-05-05 2018-11-13 洛阳士雄聚元医疗集团股份有限公司 一种治疗女性相对不孕的中药
CN108936598A (zh) * 2018-05-22 2018-12-07 河南中立生物科技有限公司 一种五行养肾分解粥及其制备方法
CN110856732A (zh) * 2018-08-06 2020-03-03 严育斌 一种起痿胶囊

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