CN105796749B - 一种缓解视疲劳的中药组合物 - Google Patents
一种缓解视疲劳的中药组合物 Download PDFInfo
- Publication number
- CN105796749B CN105796749B CN201610119085.4A CN201610119085A CN105796749B CN 105796749 B CN105796749 B CN 105796749B CN 201610119085 A CN201610119085 A CN 201610119085A CN 105796749 B CN105796749 B CN 105796749B
- Authority
- CN
- China
- Prior art keywords
- chinese medicine
- medicine composition
- traditional chinese
- visual fatigue
- relieving
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 208000003464 asthenopia Diseases 0.000 title claims abstract description 46
- 239000003814 drug Substances 0.000 title claims abstract description 31
- 239000000203 mixture Substances 0.000 title claims abstract description 20
- 235000007516 Chrysanthemum Nutrition 0.000 claims abstract description 17
- 244000037364 Cinnamomum aromaticum Species 0.000 claims abstract description 14
- 235000014489 Cinnamomum aromaticum Nutrition 0.000 claims abstract description 14
- 235000008708 Morus alba Nutrition 0.000 claims abstract description 10
- 244000197580 Poria cocos Species 0.000 claims abstract description 10
- 235000008599 Poria cocos Nutrition 0.000 claims abstract description 10
- 240000005250 Chrysanthemum indicum Species 0.000 claims abstract description 9
- 240000000249 Morus alba Species 0.000 claims abstract description 9
- 235000015468 Lycium chinense Nutrition 0.000 claims abstract description 8
- 235000013399 edible fruits Nutrition 0.000 claims abstract description 5
- 244000241838 Lycium barbarum Species 0.000 claims description 12
- 235000015459 Lycium barbarum Nutrition 0.000 claims description 12
- 241000675108 Citrus tangerina Species 0.000 claims description 8
- 238000002360 preparation method Methods 0.000 claims description 8
- 239000002994 raw material Substances 0.000 claims description 8
- 235000017784 Mespilus germanica Nutrition 0.000 claims description 4
- 235000000560 Mimusops elengi Nutrition 0.000 claims description 4
- 235000007837 Vangueria infausta Nutrition 0.000 claims description 4
- 241000092665 Atractylodes macrocephala Species 0.000 claims description 2
- 244000182216 Mimusops elengi Species 0.000 claims 1
- 241000218231 Moraceae Species 0.000 claims 1
- 239000010227 chenpi Substances 0.000 claims 1
- 210000000582 semen Anatomy 0.000 claims 1
- 230000000694 effects Effects 0.000 abstract description 16
- 235000006200 Glycyrrhiza glabra Nutrition 0.000 abstract description 7
- 201000010099 disease Diseases 0.000 abstract description 5
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract description 5
- 244000303040 Glycyrrhiza glabra Species 0.000 abstract 1
- 235000017443 Hedysarum boreale Nutrition 0.000 abstract 1
- 235000007858 Hedysarum occidentale Nutrition 0.000 abstract 1
- 244000241872 Lycium chinense Species 0.000 abstract 1
- 239000001947 glycyrrhiza glabra rhizome/root Substances 0.000 abstract 1
- 210000000952 spleen Anatomy 0.000 description 21
- 210000004185 liver Anatomy 0.000 description 18
- 210000003734 kidney Anatomy 0.000 description 12
- 238000000034 method Methods 0.000 description 12
- 208000024891 symptom Diseases 0.000 description 12
- 230000004438 eyesight Effects 0.000 description 10
- 210000002784 stomach Anatomy 0.000 description 9
- 244000189548 Chrysanthemum x morifolium Species 0.000 description 8
- 239000008280 blood Substances 0.000 description 8
- 210000004369 blood Anatomy 0.000 description 8
- 241000202807 Glycyrrhiza Species 0.000 description 7
- 230000001914 calming effect Effects 0.000 description 7
- 235000009508 confectionery Nutrition 0.000 description 7
- 210000004072 lung Anatomy 0.000 description 7
- 230000009885 systemic effect Effects 0.000 description 7
- 241000132012 Atractylodes Species 0.000 description 6
- 235000001453 Glycyrrhiza echinata Nutrition 0.000 description 6
- 235000017382 Glycyrrhiza lepidota Nutrition 0.000 description 6
- 206010062717 Increased upper airway secretion Diseases 0.000 description 6
- 230000007812 deficiency Effects 0.000 description 6
- 208000002173 dizziness Diseases 0.000 description 6
- 206010016256 fatigue Diseases 0.000 description 6
- 229940010454 licorice Drugs 0.000 description 6
- 208000026435 phlegm Diseases 0.000 description 6
- 206010011224 Cough Diseases 0.000 description 5
- 206010012735 Diarrhoea Diseases 0.000 description 5
- 208000011580 syndromic disease Diseases 0.000 description 5
- 244000061520 Angelica archangelica Species 0.000 description 4
- 235000001287 Guettarda speciosa Nutrition 0.000 description 4
- 208000004880 Polyuria Diseases 0.000 description 4
- 230000035619 diuresis Effects 0.000 description 4
- 238000001035 drying Methods 0.000 description 4
- 239000000796 flavoring agent Substances 0.000 description 4
- 235000019634 flavors Nutrition 0.000 description 4
- 230000006870 function Effects 0.000 description 4
- 241000205585 Aquilegia canadensis Species 0.000 description 3
- 244000025254 Cannabis sativa Species 0.000 description 3
- 240000002624 Mespilus germanica Species 0.000 description 3
- 206010059013 Nocturnal emission Diseases 0.000 description 3
- 241000405911 Rehmannia glutinosa Species 0.000 description 3
- 208000032023 Signs and Symptoms Diseases 0.000 description 3
- 208000009205 Tinnitus Diseases 0.000 description 3
- 206010047700 Vomiting Diseases 0.000 description 3
- 229940079593 drug Drugs 0.000 description 3
- 210000003811 finger Anatomy 0.000 description 3
- 235000013402 health food Nutrition 0.000 description 3
- 210000002216 heart Anatomy 0.000 description 3
- 210000003127 knee Anatomy 0.000 description 3
- 230000003340 mental effect Effects 0.000 description 3
- 210000001747 pupil Anatomy 0.000 description 3
- 230000001105 regulatory effect Effects 0.000 description 3
- 210000003813 thumb Anatomy 0.000 description 3
- 231100000886 tinnitus Toxicity 0.000 description 3
- 230000008673 vomiting Effects 0.000 description 3
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 description 2
- 208000000044 Amnesia Diseases 0.000 description 2
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 2
- 240000007371 Cuscuta campestris Species 0.000 description 2
- 241001523681 Dendrobium Species 0.000 description 2
- 240000005717 Dioscorea alata Species 0.000 description 2
- 235000002723 Dioscorea alata Nutrition 0.000 description 2
- 235000005362 Dioscorea floribunda Nutrition 0.000 description 2
- 235000004868 Dioscorea macrostachya Nutrition 0.000 description 2
- 235000005361 Dioscorea nummularia Nutrition 0.000 description 2
- 235000005360 Dioscorea spiculiflora Nutrition 0.000 description 2
- 206010013774 Dry eye Diseases 0.000 description 2
- 239000009429 Ginkgo biloba extract Substances 0.000 description 2
- 206010019233 Headaches Diseases 0.000 description 2
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 2
- 235000006679 Mentha X verticillata Nutrition 0.000 description 2
- 235000002899 Mentha suaveolens Nutrition 0.000 description 2
- 235000001636 Mentha x rotundifolia Nutrition 0.000 description 2
- 206010028813 Nausea Diseases 0.000 description 2
- 206010030113 Oedema Diseases 0.000 description 2
- 208000002193 Pain Diseases 0.000 description 2
- 206010033557 Palpitations Diseases 0.000 description 2
- 208000013738 Sleep Initiation and Maintenance disease Diseases 0.000 description 2
- 208000005392 Spasm Diseases 0.000 description 2
- 206010047513 Vision blurred Diseases 0.000 description 2
- 229930003451 Vitamin B1 Natural products 0.000 description 2
- 230000004308 accommodation Effects 0.000 description 2
- 238000001467 acupuncture Methods 0.000 description 2
- OENHQHLEOONYIE-UKMVMLAPSA-N all-trans beta-carotene Natural products CC=1CCCC(C)(C)C=1/C=C/C(/C)=C/C=C/C(/C)=C/C=C/C=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C OENHQHLEOONYIE-UKMVMLAPSA-N 0.000 description 2
- 208000006673 asthma Diseases 0.000 description 2
- 235000013734 beta-carotene Nutrition 0.000 description 2
- 239000011648 beta-carotene Substances 0.000 description 2
- TUPZEYHYWIEDIH-WAIFQNFQSA-N beta-carotene Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1=C(C)CCCC1(C)C)C=CC=C(/C)C=CC2=CCCCC2(C)C TUPZEYHYWIEDIH-WAIFQNFQSA-N 0.000 description 2
- 229960002747 betacarotene Drugs 0.000 description 2
- 229940102480 bilberry extract Drugs 0.000 description 2
- 235000019209 bilberry extract Nutrition 0.000 description 2
- 244000309466 calf Species 0.000 description 2
- 238000003745 diagnosis Methods 0.000 description 2
- 235000004879 dioscorea Nutrition 0.000 description 2
- SZGZILRQIYNODJ-UHFFFAOYSA-L disodium;7,12-dihydroquinoxalino[3,2-b]phenazine-2,9-disulfonate Chemical compound [Na+].[Na+].[O-]S(=O)(=O)C1=CC=C2N=C(C=C3C(NC4=CC=C(C=C4N3)S(=O)(=O)[O-])=C3)C3=NC2=C1 SZGZILRQIYNODJ-UHFFFAOYSA-L 0.000 description 2
- 208000030533 eye disease Diseases 0.000 description 2
- 239000003889 eye drop Substances 0.000 description 2
- 210000004247 hand Anatomy 0.000 description 2
- 210000003128 head Anatomy 0.000 description 2
- 231100000869 headache Toxicity 0.000 description 2
- 235000015092 herbal tea Nutrition 0.000 description 2
- 239000004615 ingredient Substances 0.000 description 2
- 206010022437 insomnia Diseases 0.000 description 2
- 210000003205 muscle Anatomy 0.000 description 2
- 230000008693 nausea Effects 0.000 description 2
- 210000005036 nerve Anatomy 0.000 description 2
- 210000003516 pericardium Anatomy 0.000 description 2
- 239000000825 pharmaceutical preparation Substances 0.000 description 2
- 230000008961 swelling Effects 0.000 description 2
- XOAAWQZATWQOTB-UHFFFAOYSA-N taurine Chemical compound NCCS(O)(=O)=O XOAAWQZATWQOTB-UHFFFAOYSA-N 0.000 description 2
- 229960003495 thiamine Drugs 0.000 description 2
- DPJRMOMPQZCRJU-UHFFFAOYSA-M thiamine hydrochloride Chemical compound Cl.[Cl-].CC1=C(CCO)SC=[N+]1CC1=CN=C(C)N=C1N DPJRMOMPQZCRJU-UHFFFAOYSA-M 0.000 description 2
- 230000035922 thirst Effects 0.000 description 2
- 210000002303 tibia Anatomy 0.000 description 2
- 231100000331 toxic Toxicity 0.000 description 2
- 230000002588 toxic effect Effects 0.000 description 2
- 230000000007 visual effect Effects 0.000 description 2
- 235000010374 vitamin B1 Nutrition 0.000 description 2
- 239000011691 vitamin B1 Substances 0.000 description 2
- OENHQHLEOONYIE-JLTXGRSLSA-N β-Carotene Chemical compound CC=1CCCC(C)(C)C=1\C=C\C(\C)=C\C=C\C(\C)=C\C=C\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C OENHQHLEOONYIE-JLTXGRSLSA-N 0.000 description 2
- 206010000060 Abdominal distension Diseases 0.000 description 1
- 241000748223 Alisma Species 0.000 description 1
- 208000031091 Amnestic disease Diseases 0.000 description 1
- 241000208340 Araliaceae Species 0.000 description 1
- 241000883964 Ariocarpus retusus Species 0.000 description 1
- 235000017166 Bambusa arundinacea Nutrition 0.000 description 1
- 235000017491 Bambusa tulda Nutrition 0.000 description 1
- 206010006002 Bone pain Diseases 0.000 description 1
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 1
- 208000002177 Cataract Diseases 0.000 description 1
- 241000007126 Codonopsis pilosula Species 0.000 description 1
- 206010051625 Conjunctival hyperaemia Diseases 0.000 description 1
- 206010010726 Conjunctival oedema Diseases 0.000 description 1
- 206010010774 Constipation Diseases 0.000 description 1
- 235000002991 Coptis groenlandica Nutrition 0.000 description 1
- 244000247747 Coptis groenlandica Species 0.000 description 1
- ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 description 1
- 235000001602 Digitaria X umfolozi Nutrition 0.000 description 1
- 240000003176 Digitaria ciliaris Species 0.000 description 1
- 235000017898 Digitaria ciliaris Nutrition 0.000 description 1
- 235000005476 Digitaria cruciata Nutrition 0.000 description 1
- 235000006830 Digitaria didactyla Nutrition 0.000 description 1
- 235000005804 Digitaria eriantha ssp. eriantha Nutrition 0.000 description 1
- 235000010823 Digitaria sanguinalis Nutrition 0.000 description 1
- 235000002722 Dioscorea batatas Nutrition 0.000 description 1
- 235000007056 Dioscorea composita Nutrition 0.000 description 1
- 235000009723 Dioscorea convolvulacea Nutrition 0.000 description 1
- 235000006536 Dioscorea esculenta Nutrition 0.000 description 1
- 240000001811 Dioscorea oppositifolia Species 0.000 description 1
- 235000003416 Dioscorea oppositifolia Nutrition 0.000 description 1
- 235000007877 Diospyros australis Nutrition 0.000 description 1
- 208000003556 Dry Eye Syndromes Diseases 0.000 description 1
- 208000000059 Dyspnea Diseases 0.000 description 1
- 206010013975 Dyspnoeas Diseases 0.000 description 1
- 235000014716 Eleusine indica Nutrition 0.000 description 1
- 208000005189 Embolism Diseases 0.000 description 1
- 206010015958 Eye pain Diseases 0.000 description 1
- 241001289529 Fallopia multiflora Species 0.000 description 1
- 235000011201 Ginkgo Nutrition 0.000 description 1
- 235000008100 Ginkgo biloba Nutrition 0.000 description 1
- 244000194101 Ginkgo biloba Species 0.000 description 1
- 206010018612 Gonorrhoea Diseases 0.000 description 1
- 241000096284 Gynochthodes officinalis Species 0.000 description 1
- 235000006350 Ipomoea batatas var. batatas Nutrition 0.000 description 1
- 206010024264 Lethargy Diseases 0.000 description 1
- 206010024642 Listless Diseases 0.000 description 1
- 208000026139 Memory disease Diseases 0.000 description 1
- 244000179970 Monarda didyma Species 0.000 description 1
- 235000010672 Monarda didyma Nutrition 0.000 description 1
- 206010049816 Muscle tightness Diseases 0.000 description 1
- 206010028391 Musculoskeletal Pain Diseases 0.000 description 1
- 241000475481 Nebula Species 0.000 description 1
- 241000180649 Panax notoginseng Species 0.000 description 1
- 235000003143 Panax notoginseng Nutrition 0.000 description 1
- 244000082204 Phyllostachys viridis Species 0.000 description 1
- 235000015334 Phyllostachys viridis Nutrition 0.000 description 1
- 241000208966 Polygala Species 0.000 description 1
- 240000002577 Prunus nigra Species 0.000 description 1
- 235000010875 Prunus nigra Nutrition 0.000 description 1
- 235000010575 Pueraria lobata Nutrition 0.000 description 1
- 244000046146 Pueraria lobata Species 0.000 description 1
- 208000007613 Shoulder Pain Diseases 0.000 description 1
- 244000228451 Stevia rebaudiana Species 0.000 description 1
- 208000001871 Tachycardia Diseases 0.000 description 1
- 240000001949 Taraxacum officinale Species 0.000 description 1
- 235000005187 Taraxacum officinale ssp. officinale Nutrition 0.000 description 1
- 208000012886 Vertigo Diseases 0.000 description 1
- 229930003268 Vitamin C Natural products 0.000 description 1
- 229930003427 Vitamin E Natural products 0.000 description 1
- 235000018288 Vitex doniana Nutrition 0.000 description 1
- 206010052428 Wound Diseases 0.000 description 1
- 208000027418 Wounds and injury Diseases 0.000 description 1
- WHMDKBIGKVEYHS-IYEMJOQQSA-L Zinc gluconate Chemical compound [Zn+2].OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O.OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O WHMDKBIGKVEYHS-IYEMJOQQSA-L 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- 230000006986 amnesia Effects 0.000 description 1
- 230000001093 anti-cancer Effects 0.000 description 1
- 230000001437 anti-cataract Effects 0.000 description 1
- 230000001166 anti-perspirative effect Effects 0.000 description 1
- 230000003471 anti-radiation Effects 0.000 description 1
- 239000003213 antiperspirant Substances 0.000 description 1
- 230000036528 appetite Effects 0.000 description 1
- 235000019789 appetite Nutrition 0.000 description 1
- 230000001174 ascending effect Effects 0.000 description 1
- 239000011425 bamboo Substances 0.000 description 1
- 238000005452 bending Methods 0.000 description 1
- 230000036772 blood pressure Effects 0.000 description 1
- 210000001124 body fluid Anatomy 0.000 description 1
- 239000010839 body fluid Substances 0.000 description 1
- 210000000988 bone and bone Anatomy 0.000 description 1
- 239000011575 calcium Substances 0.000 description 1
- 229910052791 calcium Inorganic materials 0.000 description 1
- 235000001465 calcium Nutrition 0.000 description 1
- 230000000052 comparative effect Effects 0.000 description 1
- 239000002934 diuretic Substances 0.000 description 1
- 230000001882 diuretic effect Effects 0.000 description 1
- 206010013990 dysuria Diseases 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- 229940012356 eye drops Drugs 0.000 description 1
- 208000027993 eye symptom Diseases 0.000 description 1
- 210000004709 eyebrow Anatomy 0.000 description 1
- 230000001605 fetal effect Effects 0.000 description 1
- 210000003754 fetus Anatomy 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 210000000245 forearm Anatomy 0.000 description 1
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 description 1
- 235000020686 ginkgo biloba extract Nutrition 0.000 description 1
- 229940068052 ginkgo biloba extract Drugs 0.000 description 1
- 208000001786 gonorrhea Diseases 0.000 description 1
- 210000004209 hair Anatomy 0.000 description 1
- 239000007902 hard capsule Substances 0.000 description 1
- 208000006278 hypochromic anemia Diseases 0.000 description 1
- 210000000936 intestine Anatomy 0.000 description 1
- LTINPJMVDKPJJI-UHFFFAOYSA-N iodinated glycerol Chemical compound CC(I)C1OCC(CO)O1 LTINPJMVDKPJJI-UHFFFAOYSA-N 0.000 description 1
- 229910052742 iron Inorganic materials 0.000 description 1
- 210000002429 large intestine Anatomy 0.000 description 1
- 239000008141 laxative Substances 0.000 description 1
- 230000002475 laxative effect Effects 0.000 description 1
- 208000017971 listlessness Diseases 0.000 description 1
- 230000014759 maintenance of location Effects 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 235000012054 meals Nutrition 0.000 description 1
- 230000006984 memory degeneration Effects 0.000 description 1
- 230000006386 memory function Effects 0.000 description 1
- 208000023060 memory loss Diseases 0.000 description 1
- 230000036630 mental development Effects 0.000 description 1
- 230000027939 micturition Effects 0.000 description 1
- 210000004237 neck muscle Anatomy 0.000 description 1
- 206010029410 night sweats Diseases 0.000 description 1
- 230000036565 night sweats Effects 0.000 description 1
- 231100000957 no side effect Toxicity 0.000 description 1
- 231100000862 numbness Toxicity 0.000 description 1
- 230000008506 pathogenesis Effects 0.000 description 1
- 239000008194 pharmaceutical composition Substances 0.000 description 1
- 230000002028 premature Effects 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 238000010926 purge Methods 0.000 description 1
- 238000010791 quenching Methods 0.000 description 1
- 230000000171 quenching effect Effects 0.000 description 1
- HELXLJCILKEWJH-NCGAPWICSA-N rebaudioside A Chemical compound O([C@H]1[C@H](O)[C@@H](CO)O[C@H]([C@@H]1O[C@H]1[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O1)O)O[C@]12C(=C)C[C@@]3(C1)CC[C@@H]1[C@@](C)(CCC[C@]1([C@@H]3CC2)C)C(=O)O[C@H]1[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O1)O)[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O HELXLJCILKEWJH-NCGAPWICSA-N 0.000 description 1
- 230000036299 sexual function Effects 0.000 description 1
- 208000013220 shortness of breath Diseases 0.000 description 1
- 230000002269 spontaneous effect Effects 0.000 description 1
- 238000005728 strengthening Methods 0.000 description 1
- 230000035900 sweating Effects 0.000 description 1
- 230000006794 tachycardia Effects 0.000 description 1
- 229960003080 taurine Drugs 0.000 description 1
- 230000002123 temporal effect Effects 0.000 description 1
- 210000002435 tendon Anatomy 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 210000000115 thoracic cavity Anatomy 0.000 description 1
- 231100000889 vertigo Toxicity 0.000 description 1
- 230000004382 visual function Effects 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 235000019154 vitamin C Nutrition 0.000 description 1
- 239000011718 vitamin C Substances 0.000 description 1
- 235000019165 vitamin E Nutrition 0.000 description 1
- 239000011709 vitamin E Substances 0.000 description 1
- 229940046009 vitamin E Drugs 0.000 description 1
- 210000000707 wrist Anatomy 0.000 description 1
- 229960000306 zinc gluconate Drugs 0.000 description 1
- 235000011478 zinc gluconate Nutrition 0.000 description 1
- 239000011670 zinc gluconate Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/81—Solanaceae (Potato family), e.g. tobacco, nightshade, tomato, belladonna, capsicum or jimsonweed
- A61K36/815—Lycium (desert-thorn)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/06—Fungi, e.g. yeasts
- A61K36/07—Basidiomycota, e.g. Cryptococcus
- A61K36/076—Poria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/284—Atractylodes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/287—Chrysanthemum, e.g. daisy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/482—Cassia, e.g. golden shower tree
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/484—Glycyrrhiza (licorice)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/60—Moraceae (Mulberry family), e.g. breadfruit or fig
- A61K36/605—Morus (mulberry)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
- A61K36/752—Citrus, e.g. lime, orange or lemon
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Chemical & Material Sciences (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Medical Informatics (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Alternative & Traditional Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines Containing Plant Substances (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
一种缓解视疲劳的穴位按摩及中药组合物。本发明涉及一种缓解视疲劳的中药组合物。其包含：枸杞子；桑椹子；决明子；菊花；陈皮：茯苓；炒白术；炙甘草。该中药组合物配合自我穴位按摩，可以达到对视疲劳标本兼治的效果。
Description
技术领域
本发明涉及一种缓解视疲劳的中药组合物。更涉及一种缓解视疲劳的穴位按摩及中药组合物。
背景技术
目前，计算机、电视机、手机等视屏显示终端已渗透到我们日常生活的每个部分，随之而来的是视疲劳患者越来越多，视疲劳成为眼科的常见病之一。视疲劳又称眼疲劳，在临床上较为常见，但其并非独立的眼病，而是以病人眼的自觉症状为基础，眼或全身器质性因素与精神因素相互交织的综合征，又称眼疲劳综合征。视疲劳是一种以眼部自觉症状为主要流程表现的综合征，一般出现在过度注视后，主要表现为：眼球和眼眶周围的不适或疼痛感，鼻根部或颞部的酸胀感，视物模糊、眼睛干涩、流泪等症状，严重时出现恶心、呕吐、眩晕、盗汗、面色苍白、心动过速，颈部肌肉紧张、肩部酸痛等全身症状，并常伴有精神萎靡、嗜睡、记忆力减退、失眠等精神症状。其发生原因多种多样的，常见的有调节性视疲劳、屈光参差性视疲劳、眼肌性视疲劳、调节和集合性视疲劳、眼病所致的症状性视疲劳、全身性疾病所致的视疲劳、环境引起的视疲劳、VDT(visual/video display terminal，VDT)综合症和心理因素等。目前认为，视疲劳的发生可能与眼、全身器质性因素、精神心理因素及环境因素等有关，但其具体相关因素和发病机制尚不清楚。视疲劳不仅不同程度地影响人体的视觉功能和生活质量，也影响其健康的身心发育。
在临床工作中已经用局部点眼药水等方法治疗视疲劳，但是收效有限。中医认为：视疲劳肝、脾、肾亏损是气血运行不畅所致，肝开窍于目，肝肾同源，肝肾阴亏，精血虚衰、不荣目窍，故视物不清、眼干涩脾胃升降失和，津液上承不足等。治疗视疲劳总的原则：减轻疲劳、滋补肾、肝、脾。
目前公开报道的中医缓解和/或治疗视疲劳的方法主要有中药成分的保健食品和中药制剂。CN101040893A公开了一种具有缓解视疲劳作用的保健食品，其原料组成以越橘提取物和维生素为主；CN1943693A公开了一种以中药为原料的具有缓解视疲劳作用的重要制剂，其原料组成为山药、茯苓、熟地黄、泽泻、枸杞子、菊花和当归等；CN1334097A报道了一种以越橘提取物和银杏叶提取物为原料的硬胶囊；CN1334097A公开了一种具有改善视力、缓解视疲劳、抗辐射和预防白内障作用的保健食品，其原料组成为枸杞、菊花、银杏叶提取物、牛磺酸、β-胡萝卜素和葡萄糖酸锌等。CN102824548公开一种新的中药组合物。由枸杞子、菊花、熟地黄、山药、川穹(川芎)、当归、石斛、黄连、石决明、谷精草、陈皮、甘草组成。该组合物具有养肝明目的作用，用于治疗视疲劳，以及因用眼过度、肝肾气血亏损、髓海不足引起的双目酸困、视物模糊等症。CN103520548公开了一种改善视疲劳药物组合物，包括枸杞、决明子、巴戟天、甘草、三七、葛根、淡竹叶、佛手；治疗效果好、毒副作用小，价格低廉、制备方法简便，适于临床应用。CN103893549涉及一种缓解疲劳的中药组合物及其制备方法和用途，该中药组合物包括以下重量配比的原料：枸杞子、黄精、山药、菊花、甘草、乌梅和陈皮。具有缓解体力疲劳和视疲劳、以及有助于改善记忆和性功能的作用，功效明确，安全无毒副作用。CN104474321涉及一种缓解眼疲劳的中药滴眼液及其制备方法，按照重量份数计，包括以下药物成分：石斛、马唐、枸杞、决明子、银杏、甘草、金银花、薄荷、生地、苍术、甘菊、川芎、维生素B1和维生素E。具有清热泻火，解痉去翳，养肝明目的作用。CN104920736公开一种既具有传统凉茶作用，又具有缓解视疲劳、预防视觉危害保健功效的中草药保健凉茶。包括：枸杞、金银花、决明子、菊花、菟丝子、桑叶、生地、甜叶菊、当归、云香草、蒲公英、薄荷、甘草、川芎、远志、七星草、何首乌。CN105031071提供了一种治疗视疲劳的药物制剂，它由如下原料制备得到：空桶参、秃疮花、铁角凤尾草、犁头草、决明子、金银花、菊花、地黄、当归、党参、菟丝子、枸杞子、刺五加、夜交藤、枸杞子、酸枣仁、甘草。
发明内容
本发明提供一种采用中药组合物，其配合自我穴位按摩，可以达到对视疲劳标本兼治的效果。
一种缓解视疲劳的中药组合物。其包含：枸杞子5-15；桑椹子10-12；决明子10-15；菊花10-15；陈皮10-12：茯苓9-15；炒白术10-12；炙甘草10-12(以重量份数计)。
进一步，其特征在于：枸杞子10；桑椹子12；决明子15；菊花10；陈皮12：茯苓9；炒白术10；炙甘草12。
一种上述的中药组合物缓解视疲劳的中药组合物的使用方法。上述的中药组合物在缓解和/或治疗视疲劳中的用途。
枸杞子；甘，平。归肝、肾经。滋补肝肾，益精明目。用于虚劳精亏，腰膝酸痛，眩晕耳鸣，内热消渴，血虚萎黄，目昏不明。肾阴亏虚，肝血不足，引起腰膝酸软、头昏、耳鸣、遗精等症。
桑椹子；甘、酸，寒。归心、肝、肾经。补血滋阴，生津润燥。用于眩晕耳鸣，心悸失眠，须发早白，津伤口渴，内热消渴，血虚便秘。
决明子；味苦、甘、咸，性微寒，入肝、肾、大肠经；清热平肝、降脂降压、润肠通便、明目益睛。
菊花：甘、苦，微寒。归肺、肝经。散风清热，平肝明目。用于风热感冒，头痛眩晕，目赤肿痛，眼目昏花。
陈皮：性味苦、辛，温。归肺、脾经。具有理气健脾，燥湿化痰的功效。可治疗胸脘胀满，食少吐泻，咳嗽痰多等。
茯苓；性味甘、淡，平，入心、肺、脾经，具有渗湿利水，健脾和胃，宁心安神的功效，可治小便不利，水肿胀满，痰饮咳逆，呕逆，恶阻，泄泻，遗精，淋浊，惊悸，健忘等症。
炒白术；性味苦、甘、温。归脾、胃经。具有补脾益气、燥湿利尿、和中安胎、固表止汗，抗癌的功效。可治疗脾虚食少、腹胀泄泻、痰饮眩悸、水肿、自汗、胎动不安、哮喘、痰嗽、白带、白浊、遗精、淋病、小便频数等。
炙甘草：性味甘平，归心肺脾胃经。补脾益气，润肺止咳，缓急止痛，止咳平喘，用于脾胃虚弱，中气不足，气短乏力，食少便溏。
在使用本发明的中药时，配合自我按摩，该按摩方法如下：
一、眼局部穴：
1、睛明穴(足太阳膀胱经)位置：在面部，内眦角稍上方凹陷处。方法：一手食指、拇指同时按压左右睛明穴，轻轻按摩5-10分钟，每日3-4次。
2、太阳穴(奇穴)位置：太阳穴位于头部侧面，眉梢和外眼角之间向后一横指凹陷处。(在颞部，当眉梢与外眦之间，向后一横指凹陷处)。手法：双手拇指分别按压同侧太阳穴，轻轻按摩，顺时针7圈，逆时针7圈，每日3-4次。
3、四白穴(足阴明胃经)位置：四白穴位于面部，瞳孔直下，当眶下孔凹陷处(目下一寸当眶下孔部位，直对瞳孔)。手法：双手食指按摩穴位，轻轻按摩，5-10分钟，每日3-4次。
二、循经取穴：
1、内关穴(手厥阴心包经)位置：内关穴位于前臂掌侧，稍微握拳用力时手腕有两个大筋，从腕横纹向上2寸的中央便是此穴。
2、三阴交(足太阴脾经)位置：在小腿内侧，当足内踝尖上3寸，胫骨内侧缘后方；正位屈膝成直角取穴。手法：拇指按摩穴位，有酸麻胀感为度，双侧各10分钟，每日3-4次。
三、健脾益气，调和气血药物。枸杞子含有丰富的β胡萝卜素、维生素B1、维生素C、钙、铁具有补肝、益肾、明目的作用；桑椹子能补肝肾、肝肾同源；决明子有清热明目、补脑髓、镇肝气、益筋骨的作用；菊花有疏风、清热、平肝明目的作用；陈皮：归脾、胃、肺经，具有理气降逆、调中开胃，燥湿化痰之功；茯苓能够入心、脾、肺、肾四经，有利水渗湿、健脾止泻、宁心安神等作用；炒白术有健脾益气、燥湿利水的作用；炙甘草养脾胃补中气，益气血生化之源。视疲劳者如能较好坚持服用，既能消除视疲劳症状，又能增强体质。
采用中药配合自我穴位按摩及中药可到达标本兼治，收到明显的效果。已经治疗视疲劳50余例。
具体实施方式
实施例1
枸杞子10；桑椹子12；决明子15；菊花10；陈皮12：茯苓9；炒白术10；炙甘草12。
实施例2
枸杞子5；桑椹子11；决明子10；菊花15；陈皮10：茯苓15；炒白术12；炙甘草10。
实施例3
枸杞子15；桑椹子10；决明子12；菊花13；陈皮11：茯苓13；炒白术11；炙甘草12。
以上实施例用量均以重量份数计。
实施例4
一种缓解视疲劳的穴位按摩的方法，其特征在于：该按摩方法如下：一、眼局部穴：1、睛明穴(足太阳膀胱经)位置：在面部，内眦角稍上方凹陷处；2、太阳穴(奇穴)位置：太阳穴位于头部侧面，眉梢和外眼角之间向后一横指凹陷处；3、四白穴(足阴明胃经)位置：四白穴位于面部，瞳孔直下，当眶下孔凹陷处；二、循经取穴：1、内关穴(手厥阴心包经)位置：2、三阴交(足太阴脾经)位置：在小腿内侧，当足内踝尖上3寸，胫骨内侧缘后方；三、配合使用实施例1-3任一项所述的中药组合物。
本发明药物制剂治疗视疲劳临床研究
一般性资料：本药物制剂应用于临床观察视疲劳病例20例，年龄15～48岁。病程最短者3个月，最长者达2年。
诊断标准：主症：不耐久视，干涩灼热。次症：眼胀痛，眉棱骨胀痛，头晕，头痛。具备主症2项，次症2项或以上即可诊断。
试验方法：按上述制备方法制备临床样品，五天为一疗程，一天三付，分早、中、晚三次饭前半小时服用，配合本发明记载的方法按摩。服药期间忌食生冷、辛辣、刺激及腐烂之物。空白组不服药，仪按本发明记载的方法按摩，五天为一疗程。
疗效标准：参考《临床疾病诊断依据治愈好转标准》和《中医病证诊断疗效标准》拟定。痊愈：坚持近距离用眼时间延长1倍以上或达到45min以上，眼部及全身症状、体征明显改善，n≥70％；有效：坚持近距离用眼时间延长1/2以上或达到30min以上，眼部及全身症状、体征有改善，30％≤n＜70％；无效：各项指标未达到有效标准，眼部及全身症状、体征无改善，n＜30％。
治疗效果：见表1。
表1两组疗效比较
| 痊愈 | 有效 | 无效 | 总有效率％ | |
| 实施例1 | 5 | 3 | 1 | 88.9 |
| 实施例2 | 4 | 2 | 1 | 85.7 |
| 实施例3 | 4 | 3 | 1 | 87.5 |
| 对照例 | 0 | 4 | 4 | 50 |
可见，本发明的组合物配合按摩可以有效安全治疗视疲劳，且无毒副作用。
Claims (3)
1.一种缓解视疲劳的中药组合物，其特征在于：其由下列重量份的原料组成，枸杞子5-15；桑椹子10-12；决明子10-15；菊花10-15；陈皮10-12：茯苓9-15；炒白术10-12；炙甘草10-12。
2.根据权利要求1所述的中药组合物，其特征在于：枸杞子10；桑椹子12；决明子15；菊花10；陈皮12：茯苓9；炒白术10；炙甘草12。
3.权利要求1或2所述的中药组合物在制备缓解视疲劳的药物中的用途。
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610119085.4A CN105796749B (zh) | 2016-03-03 | 2016-03-03 | 一种缓解视疲劳的中药组合物 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610119085.4A CN105796749B (zh) | 2016-03-03 | 2016-03-03 | 一种缓解视疲劳的中药组合物 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN105796749A CN105796749A (zh) | 2016-07-27 |
| CN105796749B true CN105796749B (zh) | 2018-05-22 |
Family
ID=56466599
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201610119085.4A Expired - Fee Related CN105796749B (zh) | 2016-03-03 | 2016-03-03 | 一种缓解视疲劳的中药组合物 |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN105796749B (zh) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN117771322A (zh) * | 2024-02-26 | 2024-03-29 | 云南红青夫生物科技股份有限公司 | 一种缓解视疲劳的虾青素胶囊 |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1781539A (zh) * | 2005-09-29 | 2006-06-07 | 李广中 | 紫睛健脾丸 |
| CN1943693A (zh) * | 2006-10-17 | 2007-04-11 | 宝鸡市瑞海药业有限责任公司 | 用于眼科保健、缓解视疲劳的中药制剂 |
| CN103893549A (zh) * | 2014-04-21 | 2014-07-02 | 上海创隆生物技术有限公司 | 一种缓解疲劳的中药组合物及其制备方法和用途 |
| CN105311383A (zh) * | 2015-07-06 | 2016-02-10 | 厦门医学高等专科学校 | 一种预防和改善视疲劳的保健中药组合物及其制备方法 |
-
2016
- 2016-03-03 CN CN201610119085.4A patent/CN105796749B/zh not_active Expired - Fee Related
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1781539A (zh) * | 2005-09-29 | 2006-06-07 | 李广中 | 紫睛健脾丸 |
| CN1943693A (zh) * | 2006-10-17 | 2007-04-11 | 宝鸡市瑞海药业有限责任公司 | 用于眼科保健、缓解视疲劳的中药制剂 |
| CN103893549A (zh) * | 2014-04-21 | 2014-07-02 | 上海创隆生物技术有限公司 | 一种缓解疲劳的中药组合物及其制备方法和用途 |
| CN105311383A (zh) * | 2015-07-06 | 2016-02-10 | 厦门医学高等专科学校 | 一种预防和改善视疲劳的保健中药组合物及其制备方法 |
Also Published As
| Publication number | Publication date |
|---|---|
| CN105796749A (zh) | 2016-07-27 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN109966462A (zh) | 一种调理体质的膏方及其制备方法 | |
| CN104069474B (zh) | 一种治疗脂溢性脱发的中药组合物及其制备方法 | |
| CN102698092A (zh) | 一种治疗肝阳上亢型高血压的中药组合物 | |
| CN105664099A (zh) | 一种温补肾阳的中药组合物及其制备方法 | |
| CN101590104A (zh) | 一种治疗阻塞性脉管炎的中药 | |
| CN103316141A (zh) | 一种治疗颈椎病的中药组合物 | |
| CN102908474B (zh) | 一种治疗神经官能症的药酒 | |
| CN104547621A (zh) | 一种护眼中药 | |
| CN105796749B (zh) | 一种缓解视疲劳的中药组合物 | |
| CN102698093A (zh) | 一种治疗肝肾阴虚型高血压的中药组合物及其制备方法 | |
| CN104274630A (zh) | 一种止脱生发的中药配方及其制备方法 | |
| CN104491596A (zh) | 一种治疗肝肾阴虚型中风的中药组合物及应用 | |
| CN104524479B (zh) | 一种治疗经前期综合征的中药组合物及其制备方法 | |
| CN103463467A (zh) | 一种具有滋补肾阴功效的苗方药酒 | |
| CN103751465A (zh) | 一种强筋祛湿的药酒 | |
| CN107714798A (zh) | 一种用于治疗黄褐斑的中药组合物及其制备方法 | |
| CN112451601A (zh) | 一种中老年人慢性病的综合防治药物 | |
| CN104800610A (zh) | 一种治疗帕金森病的中药制剂及其制备方法 | |
| CN104906526A (zh) | 一种用于卵巢早衰的中药制剂及其制备方法 | |
| CN112915148A (zh) | 一种治疗阳痿、早泄及性功能障碍的中药组合物 | |
| CN103933473B (zh) | 一种补气养血祛斑美容的颗粒剂及其制备方法 | |
| CN103223048A (zh) | 一种治疗面部白斑病的中药组合物 | |
| CN107334996A (zh) | 一种抗衰老的回春丸 | |
| CN105727137A (zh) | 一种治疗糖尿病的中药 | |
| CN105535771A (zh) | 一种抗衰老的中药及其制备方法 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20180522 Termination date: 20200303 |
|
| CF01 | Termination of patent right due to non-payment of annual fee |