CN1856472A - 异喹啉酮钾通道抑制剂 - Google Patents

异喹啉酮钾通道抑制剂 Download PDF

Info

Publication number
CN1856472A
CN1856472A CNA2004800273770A CN200480027377A CN1856472A CN 1856472 A CN1856472 A CN 1856472A CN A2004800273770 A CNA2004800273770 A CN A2004800273770A CN 200480027377 A CN200480027377 A CN 200480027377A CN 1856472 A CN1856472 A CN 1856472A
Authority
CN
China
Prior art keywords
phenyl
methyl
methoxyl group
compound
ethyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CNA2004800273770A
Other languages
English (en)
Chinese (zh)
Inventor
C·J·丁斯莫尔
J·M·伯格曼
C·J·麦金太尔
R·伊萨克斯
D·A·克莱尔蒙
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of CN1856472A publication Critical patent/CN1856472A/zh
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
    • C07D217/24—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
CNA2004800273770A 2003-09-23 2004-09-17 异喹啉酮钾通道抑制剂 Pending CN1856472A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US50521503P 2003-09-23 2003-09-23
US60/505,215 2003-09-23

Publications (1)

Publication Number Publication Date
CN1856472A true CN1856472A (zh) 2006-11-01

Family

ID=34392991

Family Applications (1)

Application Number Title Priority Date Filing Date
CNA2004800273770A Pending CN1856472A (zh) 2003-09-23 2004-09-17 异喹啉酮钾通道抑制剂

Country Status (9)

Country Link
US (1) US7741322B2 (enExample)
EP (1) EP1667976B1 (enExample)
JP (1) JP4717815B2 (enExample)
CN (1) CN1856472A (enExample)
AT (1) ATE476419T1 (enExample)
AU (1) AU2004276238B2 (enExample)
CA (1) CA2539729C (enExample)
DE (1) DE602004028493D1 (enExample)
WO (1) WO2005030726A1 (enExample)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110670090A (zh) * 2019-11-13 2020-01-10 广西师范大学 一种基于电化学合成异喹啉酮类化合物的方法
CN111344281A (zh) * 2017-08-14 2020-06-26 阿塞西翁制药公司 取代苯并咪唑类的钾通道抑制剂

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7723352B2 (en) * 2003-09-23 2010-05-25 Merck Sharp & Dohme Isoquinolinone potassium channel inhibitors
US7781457B2 (en) * 2003-09-23 2010-08-24 Merck Sharp & Dohme Corp. Isoquinolinone potassium channel inhibitors
US7709476B2 (en) * 2003-09-23 2010-05-04 Merck Sharp & Dohme Corp. Isoquinolinone potassium channel inhibitors
CN1856477A (zh) * 2003-09-23 2006-11-01 默克公司 异喹啉钾通道抑制剂
EP1781635B1 (en) 2004-07-29 2012-06-13 Merck Sharp & Dohme Corp. Potassium channel inhibitors
US7569589B2 (en) 2004-07-29 2009-08-04 Merck & Co., Inc. Potassium channel inhibitors
US7915410B2 (en) 2005-09-09 2011-03-29 Bristol-Myers Squibb Company Acyclic IKur inhibitors
WO2007109577A1 (en) * 2006-03-17 2007-09-27 Kalypsys, Inc. Alkylamine-substituted bicyclic aryl compounds useful as modulators of ppar
DE102006019589A1 (de) * 2006-04-27 2007-10-31 Sanofi-Aventis Deutschland Gmbh Inhibitoren des TASK-1 und Task-3 Ionenkanals
US9604931B2 (en) 2007-01-22 2017-03-28 Gtx, Inc. Nuclear receptor binding agents
KR101638035B1 (ko) 2007-01-22 2016-07-11 지티엑스, 인코포레이티드 핵 수용체에 결합하는 물질
US9623021B2 (en) * 2007-01-22 2017-04-18 Gtx, Inc. Nuclear receptor binding agents
JP2025508714A (ja) * 2022-02-16 2025-04-10 デューク ストリート バイオ リミテッド 医薬化合物

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3594380A (en) * 1969-02-18 1971-07-20 American Home Prod Isoquinolin-1(2h)-ones
DE69315920T2 (de) 1992-09-04 1998-06-10 Takeda Chemical Industries Ltd Kondensierte heterozyklische Verbindungen, deren Herstellung und Verwendung
EP0634402A1 (en) * 1993-07-14 1995-01-18 Takeda Chemical Industries, Ltd. Isochinolinone derivatives, their production and use
US5387685A (en) 1993-07-16 1995-02-07 American Cyanamid Co MDR reversal agents
CA2421819C (en) 2000-09-20 2010-03-09 Merck & Co., Inc. Isoquinolinone potassium channel inhibitors
US20040176361A1 (en) * 2001-05-23 2004-09-09 Masakazu Fujio Fused heterocyclic compound and medicinal use thereof
US7402595B2 (en) * 2002-02-13 2008-07-22 Takeda Pharmaceutical Company Limited JNK inhibitor
US7723352B2 (en) * 2003-09-23 2010-05-25 Merck Sharp & Dohme Isoquinolinone potassium channel inhibitors
CN1856477A (zh) * 2003-09-23 2006-11-01 默克公司 异喹啉钾通道抑制剂
US7709476B2 (en) * 2003-09-23 2010-05-04 Merck Sharp & Dohme Corp. Isoquinolinone potassium channel inhibitors
US7781457B2 (en) * 2003-09-23 2010-08-24 Merck Sharp & Dohme Corp. Isoquinolinone potassium channel inhibitors

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111344281A (zh) * 2017-08-14 2020-06-26 阿塞西翁制药公司 取代苯并咪唑类的钾通道抑制剂
CN111344281B (zh) * 2017-08-14 2023-11-14 阿塞西翁制药公司 取代苯并咪唑类的钾通道抑制剂
CN110670090A (zh) * 2019-11-13 2020-01-10 广西师范大学 一种基于电化学合成异喹啉酮类化合物的方法

Also Published As

Publication number Publication date
ATE476419T1 (de) 2010-08-15
WO2005030726A1 (en) 2005-04-07
JP4717815B2 (ja) 2011-07-06
EP1667976B1 (en) 2010-08-04
DE602004028493D1 (de) 2010-09-16
US20060281743A1 (en) 2006-12-14
JP2007506679A (ja) 2007-03-22
EP1667976A1 (en) 2006-06-14
US7741322B2 (en) 2010-06-22
CA2539729C (en) 2010-09-07
AU2004276238A1 (en) 2005-04-07
EP1667976A4 (en) 2008-02-13
CA2539729A1 (en) 2005-04-07
AU2004276238B2 (en) 2010-10-28

Similar Documents

Publication Publication Date Title
CN1856307A (zh) 喹啉钾通道抑制剂
CN1856474A (zh) 异喹啉钾通道抑制剂
CN1856476A (zh) 异喹啉酮钾通道抑制剂
CN100337626C (zh) 酰化的、杂芳基－稠合的环烯基胺和它们作为药物的用途
CN1856475A (zh) 异喹啉钾通道抑制剂
CN1300114C (zh) 苯基吡啶甲酰哌嗪衍生物
CN1206228C (zh) 作为nos抑制剂的n－杂环衍生物
CN1291988C (zh) 三氮杂螺[5,5]十一烷衍生物及包含其作为活性成分的药物组合物
CN1441783A (zh) 含二氰基吡啶衍生物的药物
CN1585751A (zh) 喹啉化合物
CN1993347A (zh) 钾通道抑制剂
CN1856473A (zh) 异喹啉酮钾通道抑制剂
CN1856477A (zh) 异喹啉钾通道抑制剂
CN1468216A (zh) 含氮五员环化合物
CN1476434A (zh) 新化合物
CN1327444A (zh) 肾上腺素能α1β受体拮抗药
CN1454211A (zh) 作为Xa因子抑制剂的含氮杂双环化合物
CN1102648A (zh) 取代的单-和双-吡啶基甲基吡啶酮类化合物
CN1856310A (zh) 喹唑啉钾通道抑制剂
CN1701068A (zh) 新颖的化合物和它们的用途
CN1684951A (zh) 新的嘧啶胺衍生物及其用途
CN1694879A (zh) 具有激酶抑制活性的异喹啉衍生物和包含异喹啉衍生物的药剂
CN1863795A (zh) P－糖蛋白抑制剂,其制备方法和包括该抑制剂的药物组合物
CN1812986A (zh) 呋咱并苯并咪唑类化合物
CN1856470A (zh) 喹啉钾通道抑制剂

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C02 Deemed withdrawal of patent application after publication (patent law 2001)
WD01 Invention patent application deemed withdrawn after publication