ATE476419T1 - Isochinolinon-kaliumkanalinhibitoren - Google Patents
Isochinolinon-kaliumkanalinhibitorenInfo
- Publication number
- ATE476419T1 ATE476419T1 AT04784368T AT04784368T ATE476419T1 AT E476419 T1 ATE476419 T1 AT E476419T1 AT 04784368 T AT04784368 T AT 04784368T AT 04784368 T AT04784368 T AT 04784368T AT E476419 T1 ATE476419 T1 AT E476419T1
- Authority
- AT
- Austria
- Prior art keywords
- potassium channel
- channel inhibitors
- isoquinolinone
- isoquinolinone potassium
- inhibitors
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
- C07D217/24—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US50521503P | 2003-09-23 | 2003-09-23 | |
| PCT/US2004/030484 WO2005030726A1 (en) | 2003-09-23 | 2004-09-17 | Isoquinolinone potassium channel inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE476419T1 true ATE476419T1 (de) | 2010-08-15 |
Family
ID=34392991
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT04784368T ATE476419T1 (de) | 2003-09-23 | 2004-09-17 | Isochinolinon-kaliumkanalinhibitoren |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US7741322B2 (enExample) |
| EP (1) | EP1667976B1 (enExample) |
| JP (1) | JP4717815B2 (enExample) |
| CN (1) | CN1856472A (enExample) |
| AT (1) | ATE476419T1 (enExample) |
| AU (1) | AU2004276238B2 (enExample) |
| CA (1) | CA2539729C (enExample) |
| DE (1) | DE602004028493D1 (enExample) |
| WO (1) | WO2005030726A1 (enExample) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4719151B2 (ja) * | 2003-09-23 | 2011-07-06 | メルク・シャープ・エンド・ドーム・コーポレイション | イソキノリノンカリウムチャネル阻害剤 |
| CN1856473A (zh) * | 2003-09-23 | 2006-11-01 | 默克公司 | 异喹啉酮钾通道抑制剂 |
| JP4718467B2 (ja) * | 2003-09-23 | 2011-07-06 | メルク・シャープ・エンド・ドーム・コーポレイション | イソキノリノンカリウムチャネル阻害剤 |
| US7763614B2 (en) * | 2003-09-23 | 2010-07-27 | Merck Sharp & Dohme Corp. | Isoquinoline potassium channel inhibitors |
| US7569589B2 (en) | 2004-07-29 | 2009-08-04 | Merck & Co., Inc. | Potassium channel inhibitors |
| CA2575003C (en) | 2004-07-29 | 2010-02-16 | Merck & Co., Inc. | Potassium channel inhibitors |
| CN101277939A (zh) | 2005-09-09 | 2008-10-01 | 布里斯托尔-迈尔斯斯奎布公司 | 无环ikur抑制剂 |
| US20070219193A1 (en) * | 2006-03-17 | 2007-09-20 | Kalypsys, Inc | Alkylamine-substituted bicyclic aryl compounds useful as modulators of ppar |
| DE102006019589A1 (de) * | 2006-04-27 | 2007-10-31 | Sanofi-Aventis Deutschland Gmbh | Inhibitoren des TASK-1 und Task-3 Ionenkanals |
| US9604931B2 (en) | 2007-01-22 | 2017-03-28 | Gtx, Inc. | Nuclear receptor binding agents |
| US9623021B2 (en) * | 2007-01-22 | 2017-04-18 | Gtx, Inc. | Nuclear receptor binding agents |
| WO2008091555A2 (en) | 2007-01-22 | 2008-07-31 | Gtx, Inc. | Nuclear receptor binding agents |
| EP3668841A1 (en) * | 2017-08-14 | 2020-06-24 | Acesion Pharma ApS | Substituted benzimidazoles as potassium channel inhibitors |
| CN110670090B (zh) * | 2019-11-13 | 2021-06-29 | 广西师范大学 | 一种基于电化学合成异喹啉酮类化合物的方法 |
| IL314895A (en) * | 2022-02-16 | 2024-10-01 | Duke Street Bio Ltd | Pharmaceutical compound |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3594380A (en) * | 1969-02-18 | 1971-07-20 | American Home Prod | Isoquinolin-1(2h)-ones |
| ATE161530T1 (de) | 1992-09-04 | 1998-01-15 | Takeda Chemical Industries Ltd | Kondensierte heterozyklische verbindungen, deren herstellung und verwendung |
| EP0634402A1 (en) * | 1993-07-14 | 1995-01-18 | Takeda Chemical Industries, Ltd. | Isochinolinone derivatives, their production and use |
| US5387685A (en) | 1993-07-16 | 1995-02-07 | American Cyanamid Co | MDR reversal agents |
| JP4854909B2 (ja) | 2000-09-20 | 2012-01-18 | メルク・シャープ・エンド・ドーム・コーポレイション | イソキノリノン系カリウムチャンネル阻害剤 |
| EP1396488A1 (en) * | 2001-05-23 | 2004-03-10 | Mitsubishi Pharma Corporation | Fused heterocyclic compound and medicinal use thereof |
| WO2003068750A1 (en) * | 2002-02-13 | 2003-08-21 | Takeda Chemical Industries, Ltd. | Jnk inhibitor |
| JP4719151B2 (ja) * | 2003-09-23 | 2011-07-06 | メルク・シャープ・エンド・ドーム・コーポレイション | イソキノリノンカリウムチャネル阻害剤 |
| US7763614B2 (en) * | 2003-09-23 | 2010-07-27 | Merck Sharp & Dohme Corp. | Isoquinoline potassium channel inhibitors |
| JP4718467B2 (ja) * | 2003-09-23 | 2011-07-06 | メルク・シャープ・エンド・ドーム・コーポレイション | イソキノリノンカリウムチャネル阻害剤 |
| CN1856473A (zh) * | 2003-09-23 | 2006-11-01 | 默克公司 | 异喹啉酮钾通道抑制剂 |
-
2004
- 2004-09-17 AT AT04784368T patent/ATE476419T1/de not_active IP Right Cessation
- 2004-09-17 WO PCT/US2004/030484 patent/WO2005030726A1/en not_active Ceased
- 2004-09-17 DE DE602004028493T patent/DE602004028493D1/de not_active Expired - Lifetime
- 2004-09-17 EP EP04784368A patent/EP1667976B1/en not_active Expired - Lifetime
- 2004-09-17 JP JP2006527053A patent/JP4717815B2/ja not_active Expired - Fee Related
- 2004-09-17 CN CNA2004800273770A patent/CN1856472A/zh active Pending
- 2004-09-17 US US10/571,858 patent/US7741322B2/en not_active Expired - Fee Related
- 2004-09-17 AU AU2004276238A patent/AU2004276238B2/en not_active Ceased
- 2004-09-17 CA CA2539729A patent/CA2539729C/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| JP4717815B2 (ja) | 2011-07-06 |
| DE602004028493D1 (de) | 2010-09-16 |
| EP1667976B1 (en) | 2010-08-04 |
| US7741322B2 (en) | 2010-06-22 |
| AU2004276238A1 (en) | 2005-04-07 |
| EP1667976A1 (en) | 2006-06-14 |
| JP2007506679A (ja) | 2007-03-22 |
| US20060281743A1 (en) | 2006-12-14 |
| AU2004276238B2 (en) | 2010-10-28 |
| CA2539729C (en) | 2010-09-07 |
| EP1667976A4 (en) | 2008-02-13 |
| CA2539729A1 (en) | 2005-04-07 |
| WO2005030726A1 (en) | 2005-04-07 |
| CN1856472A (zh) | 2006-11-01 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| WO2005030791A3 (en) | Isoquinolinone potassium channel inhibitors | |
| NO20082298L (no) | Kaliumkanalinhibitorer | |
| WO2005046578A3 (en) | Isoquinolinone potassium channel inhibitors | |
| WO2005030129A3 (en) | Quinoline potassium channel inhibitors | |
| WO2005030130A3 (en) | Isoquinoline potassium channel inhibitors | |
| WO2006015159A3 (en) | Potassium channel inhibitors | |
| IS7721A (is) | Píperidín-pýrídasón og þalasón sem PDE4 hemlar | |
| DE69940480D1 (de) | Carbocyclische kaliumkanalhemmer | |
| ATE290382T1 (de) | Heterozyklische kalium-kanal inhibitoren | |
| BRPI0411897A (pt) | pirroldihidroisoquinolinas como inibidores de pde10 | |
| BRPI0414599A (pt) | pirrol-indóis substituìdos | |
| EA200701396A1 (ru) | Триазолофталазины в качестве ингибиторов pde-2 | |
| ATE549024T1 (de) | Chinazolin-kaliumkanalhemmer | |
| DE602004028493D1 (de) | Isochinolinon-kaliumkanalinhibitoren | |
| DK1318992T3 (da) | Imidazolderivater som Raf-kinaseinhibitorer | |
| HRP20080057T3 (en) | 9,10-alpha,alpha-oh-taxane analogs and methods for production thereof | |
| WO2005030792A3 (en) | Quinoline potassium channel inhibitors | |
| DE60329326D1 (de) | Tace inhibitoren | |
| WO2007050348A3 (en) | Potassium channel inhibitors | |
| EA201270630A1 (ru) | Гетероциклические сетр ингибиторы | |
| ATE372330T1 (de) | N-sulfonylurea-apoptosis-förderer | |
| ATE542796T1 (de) | N-sulfonylcarboximidamidverbindungen als apoptosepromotoren | |
| WO2006014877A3 (en) | Potassium channel inhibitors | |
| WO2007089743A3 (en) | Potassium channel inhibitors | |
| TW200815363A (en) | KV1.5 potassium channel inhibitors |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |