ATE476419T1 - Isochinolinon-kaliumkanalinhibitoren - Google Patents
Isochinolinon-kaliumkanalinhibitorenInfo
- Publication number
- ATE476419T1 ATE476419T1 AT04784368T AT04784368T ATE476419T1 AT E476419 T1 ATE476419 T1 AT E476419T1 AT 04784368 T AT04784368 T AT 04784368T AT 04784368 T AT04784368 T AT 04784368T AT E476419 T1 ATE476419 T1 AT E476419T1
- Authority
- AT
- Austria
- Prior art keywords
- potassium channel
- channel inhibitors
- isoquinolinone
- isoquinolinone potassium
- inhibitors
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
- C07D217/24—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hospice & Palliative Care (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US50521503P | 2003-09-23 | 2003-09-23 | |
| PCT/US2004/030484 WO2005030726A1 (en) | 2003-09-23 | 2004-09-17 | Isoquinolinone potassium channel inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE476419T1 true ATE476419T1 (de) | 2010-08-15 |
Family
ID=34392991
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT04784368T ATE476419T1 (de) | 2003-09-23 | 2004-09-17 | Isochinolinon-kaliumkanalinhibitoren |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US7741322B2 (enExample) |
| EP (1) | EP1667976B1 (enExample) |
| JP (1) | JP4717815B2 (enExample) |
| CN (1) | CN1856472A (enExample) |
| AT (1) | ATE476419T1 (enExample) |
| AU (1) | AU2004276238B2 (enExample) |
| CA (1) | CA2539729C (enExample) |
| DE (1) | DE602004028493D1 (enExample) |
| WO (1) | WO2005030726A1 (enExample) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2004276236B2 (en) * | 2003-09-23 | 2008-01-24 | Merck Sharp & Dohme Corp. | Isoquinolinone potassium channel inhibitors |
| EP1667978B1 (en) * | 2003-09-23 | 2013-09-04 | Merck Sharp & Dohme Corp. | Isoquinolinone potassium channel inhibitors |
| US7763614B2 (en) * | 2003-09-23 | 2010-07-27 | Merck Sharp & Dohme Corp. | Isoquinoline potassium channel inhibitors |
| WO2005030727A1 (en) * | 2003-09-23 | 2005-04-07 | Merck & Co., Inc. | Isoquinolinone potassium channel inhibitors |
| US7569589B2 (en) | 2004-07-29 | 2009-08-04 | Merck & Co., Inc. | Potassium channel inhibitors |
| AU2005267884B2 (en) | 2004-07-29 | 2011-04-21 | Merck Sharp & Dohme Corp. | Potassium channel inhibitors |
| EP1922311A2 (en) | 2005-09-09 | 2008-05-21 | Brystol-Myers Squibb Company | Acyclic ikur inhibitors |
| EP1996198A1 (en) * | 2006-03-17 | 2008-12-03 | Kalypsys, Inc. | Alkylamine-substituted bicyclic aryl compounds useful as modulators of ppar |
| DE102006019589A1 (de) * | 2006-04-27 | 2007-10-31 | Sanofi-Aventis Deutschland Gmbh | Inhibitoren des TASK-1 und Task-3 Ionenkanals |
| BRPI0806371A2 (pt) | 2007-01-22 | 2011-09-13 | Gtx Inc | agentes ligação de receptor nuclear |
| US9604931B2 (en) | 2007-01-22 | 2017-03-28 | Gtx, Inc. | Nuclear receptor binding agents |
| US9623021B2 (en) * | 2007-01-22 | 2017-04-18 | Gtx, Inc. | Nuclear receptor binding agents |
| CA3072648A1 (en) * | 2017-08-14 | 2019-02-21 | Acesion Pharma Aps | Substituted benzimidazoles as potassium channel inhibitors |
| CN110670090B (zh) * | 2019-11-13 | 2021-06-29 | 广西师范大学 | 一种基于电化学合成异喹啉酮类化合物的方法 |
| EP4444305A2 (en) * | 2022-02-16 | 2024-10-16 | Duke Street Bio Limited | Pharmaceutical compound |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3594380A (en) * | 1969-02-18 | 1971-07-20 | American Home Prod | Isoquinolin-1(2h)-ones |
| NO179904C (no) | 1992-09-04 | 1997-01-08 | Takeda Chemical Industries Ltd | Kondenserte heterocykliske forbindelser og deres anvendelse |
| EP0634402A1 (en) * | 1993-07-14 | 1995-01-18 | Takeda Chemical Industries, Ltd. | Isochinolinone derivatives, their production and use |
| US5387685A (en) | 1993-07-16 | 1995-02-07 | American Cyanamid Co | MDR reversal agents |
| AU2002212969B2 (en) | 2000-09-20 | 2006-07-06 | Merck Sharp & Dohme Corp. | Isoquinolinone potassium channel inhibitors |
| WO2002094790A1 (en) * | 2001-05-23 | 2002-11-28 | Mitsubishi Pharma Corporation | Fused heterocyclic compound and medicinal use thereof |
| US7402595B2 (en) * | 2002-02-13 | 2008-07-22 | Takeda Pharmaceutical Company Limited | JNK inhibitor |
| AU2004276236B2 (en) * | 2003-09-23 | 2008-01-24 | Merck Sharp & Dohme Corp. | Isoquinolinone potassium channel inhibitors |
| WO2005030727A1 (en) * | 2003-09-23 | 2005-04-07 | Merck & Co., Inc. | Isoquinolinone potassium channel inhibitors |
| US7763614B2 (en) * | 2003-09-23 | 2010-07-27 | Merck Sharp & Dohme Corp. | Isoquinoline potassium channel inhibitors |
| EP1667978B1 (en) * | 2003-09-23 | 2013-09-04 | Merck Sharp & Dohme Corp. | Isoquinolinone potassium channel inhibitors |
-
2004
- 2004-09-17 WO PCT/US2004/030484 patent/WO2005030726A1/en not_active Ceased
- 2004-09-17 US US10/571,858 patent/US7741322B2/en not_active Expired - Fee Related
- 2004-09-17 EP EP04784368A patent/EP1667976B1/en not_active Expired - Lifetime
- 2004-09-17 AT AT04784368T patent/ATE476419T1/de not_active IP Right Cessation
- 2004-09-17 JP JP2006527053A patent/JP4717815B2/ja not_active Expired - Fee Related
- 2004-09-17 AU AU2004276238A patent/AU2004276238B2/en not_active Ceased
- 2004-09-17 CA CA2539729A patent/CA2539729C/en not_active Expired - Fee Related
- 2004-09-17 DE DE602004028493T patent/DE602004028493D1/de not_active Expired - Lifetime
- 2004-09-17 CN CNA2004800273770A patent/CN1856472A/zh active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| AU2004276238B2 (en) | 2010-10-28 |
| CN1856472A (zh) | 2006-11-01 |
| AU2004276238A1 (en) | 2005-04-07 |
| US20060281743A1 (en) | 2006-12-14 |
| EP1667976A4 (en) | 2008-02-13 |
| DE602004028493D1 (de) | 2010-09-16 |
| CA2539729C (en) | 2010-09-07 |
| JP2007506679A (ja) | 2007-03-22 |
| CA2539729A1 (en) | 2005-04-07 |
| US7741322B2 (en) | 2010-06-22 |
| JP4717815B2 (ja) | 2011-07-06 |
| WO2005030726A1 (en) | 2005-04-07 |
| EP1667976B1 (en) | 2010-08-04 |
| EP1667976A1 (en) | 2006-06-14 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |