CN1839150A - 脂肽抗菌衍生物组合物及其应用方法 - Google Patents

脂肽抗菌衍生物组合物及其应用方法 Download PDF

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Publication number
CN1839150A
CN1839150A CNA200480020655XA CN200480020655A CN1839150A CN 1839150 A CN1839150 A CN 1839150A CN A200480020655X A CNA200480020655X A CN A200480020655XA CN 200480020655 A CN200480020655 A CN 200480020655A CN 1839150 A CN1839150 A CN 1839150A
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CN
China
Prior art keywords
compound
acid
amino acid
alkyl
aryl
Prior art date
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Pending
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CNA200480020655XA
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English (en)
Chinese (zh)
Inventor
戴尔·R·卡梅伦
文森特·A·博伊德
理查德·A·利斯
威廉·V·柯伦
唐纳德·B·博德斯
保罗·W·M·斯加尔比
雪莉·A·瓦克维希·斯加尔比
马修·诺德维尔
陈玉琛
贾琦
多米尼克·迪古尔
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Biowest Therapeutics Inc
Original Assignee
Migenix Inc
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Publication date
Application filed by Migenix Inc filed Critical Migenix Inc
Publication of CN1839150A publication Critical patent/CN1839150A/zh
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/50—Cyclic peptides containing at least one abnormal peptide link
    • C07K7/54—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring
    • C07K7/56—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring the cyclisation not occurring through 2,4-diamino-butanoic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Urology & Nephrology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CNA200480020655XA 2003-07-17 2004-06-28 脂肽抗菌衍生物组合物及其应用方法 Pending CN1839150A (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US48833103P 2003-07-17 2003-07-17
US60/488,331 2003-07-17
US56491204P 2004-04-23 2004-04-23
US60/564,912 2004-04-23

Publications (1)

Publication Number Publication Date
CN1839150A true CN1839150A (zh) 2006-09-27

Family

ID=36203969

Family Applications (1)

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CNA200480020655XA Pending CN1839150A (zh) 2003-07-17 2004-06-28 脂肽抗菌衍生物组合物及其应用方法

Country Status (11)

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US (1) US7868135B2 (enExample)
EP (2) EP2147925A1 (enExample)
JP (1) JP2007536200A (enExample)
CN (1) CN1839150A (enExample)
AU (1) AU2004252174A1 (enExample)
CA (1) CA2530063A1 (enExample)
EA (1) EA010294B1 (enExample)
IL (1) IL172647A0 (enExample)
NZ (1) NZ544750A (enExample)
WO (1) WO2005000878A2 (enExample)
ZA (1) ZA200600008B (enExample)

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102939301A (zh) * 2010-03-10 2013-02-20 巴塞罗那大学 作为抗菌剂使用的肽化合物
CN104557743A (zh) * 2014-12-02 2015-04-29 南京邮电大学 一类包含不饱和脂肪酸结构的抗白色念珠菌药物及其制备方法
CN104817619A (zh) * 2015-04-23 2015-08-05 浙江大学 抗菌化合物及其应用
CN107108698A (zh) * 2014-11-14 2017-08-29 百时美施贵宝公司 用作免疫调节剂的大环肽
CN109593808A (zh) * 2017-09-30 2019-04-09 上海医药工业研究院 达托霉素发酵培养基及其制备方法
CN111434775A (zh) * 2019-01-11 2020-07-21 上海医药工业研究院 一种发酵制备达托霉素的方法
CN112625106A (zh) * 2021-01-13 2021-04-09 兰州大学 一种抗菌多肽化合物、合成方法及其应用
US12209106B2 (en) 2018-07-20 2025-01-28 Fujimoto Chemicals Co., Ltd. Alkoxyphenyl derivatives, protected nucleosides and protected nucleotides, method for producing oligonucleotides, and method for removing substituents

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US7951232B2 (en) * 2006-02-09 2011-05-31 Elevance Renewable Sciences, Inc. Surface coating compositions and methods
CA2641991A1 (en) * 2006-02-09 2007-08-16 Elevance Renewable Sciences, Inc. Antimicrobial compositions, methods and systems
GB0821540D0 (en) * 2008-11-25 2008-12-31 Merlion Pharmaceuticals Pte Ltd Lipopeptide compounds and their use
RU2532222C2 (ru) 2009-02-16 2014-10-27 Серенис Терапьютикс Холдинг С.А, Миметики аполипопротеина а-i
DE102009060102A1 (de) * 2009-12-21 2011-06-22 Martin-Luther-Universität Halle-Wittenberg, 06108 Derivatisierungsreagenzien zur tandem-massenspektrometrischen Quantifizierung von Proteinen
BR112012021931A2 (pt) * 2010-03-09 2016-05-31 Merck Canada Inc composto, composição farmacêutica, método para tratar uma infecção bacteriana, e, uso de composto
US9428845B1 (en) 2010-12-28 2016-08-30 Warp Drive Bio, Inc. Identifying new therapeutic agents
US10501493B2 (en) 2011-05-27 2019-12-10 Rqx Pharmaceuticals, Inc. Broad spectrum antibiotics
WO2012166665A2 (en) * 2011-05-27 2012-12-06 Rqx Pharmaceuticals, Inc. Broad spectrum antibiotics
EP2703410B1 (en) * 2012-08-28 2015-10-14 Leibniz-Institut für Naturstoff-Forschung und Infektionsbiologie Jagaricin, derivatives, and uses thereof
CA2892027A1 (en) 2012-11-21 2014-05-30 Rqx Pharmaceuticals, Inc. Macrocyclic broad spectrum antibiotics
RU2016146581A (ru) 2014-05-20 2018-06-21 АрКьюЭкс ФАРМАСЪЮТИКЛС, ИНК. Макроциклические антибиотики широкого спектра действия
US10533016B2 (en) 2015-01-09 2020-01-14 Revolution Medicines, Inc. Compounds that participate in cooperative binding and uses thereof
CN105231000B (zh) * 2015-09-25 2020-01-07 广东海洋大学 一种利用水产品下脚料生产抗菌营养复合型饲料添加剂的方法
EP3377474B1 (en) 2015-11-20 2023-08-16 RQX Pharmaceuticals, Inc. Macrocyclic broad spectrum antibiotics
JP2020513036A (ja) * 2017-04-05 2020-04-30 レボリューション メディシンズ インコーポレイテッドＲｅｖｏｌｕｔｉｏｎ Ｍｅｄｉｃｉｎｅｓ，Ｉｎｃ． 協同的結合に関与する化合物及びその使用
JP7296636B2 (ja) * 2018-07-20 2023-06-23 藤本化学製品株式会社 アルコキシフェニル誘導体、ヌクレオシド保護体およびヌクレオチド保護体、オリゴヌクレオチド製造方法、ならびに、置換基除去方法
WO2020031083A1 (en) * 2018-08-06 2020-02-13 KHAN, Khalid Antimicrobial formulations comprising vancomycin or tobramycin
IL295889B2 (en) 2019-05-28 2025-01-01 Hoffmann La Roche Broad-spectrum macrocyclic antibiotic
RU2762182C1 (ru) * 2020-12-08 2021-12-16 Федеральное государственное бюджетное научное учреждение "Научно-исследовательский институт по изысканию новых антибиотиков имени Г.Ф. Гаузе" Гауземицины А и В - гликолипопептидные антибактериальные антибиотики и способ их получения

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DE4411025A1 (de) * 1994-03-30 1995-10-05 Hoechst Ag Lipopeptid-Derivate, Verfahren zu ihrer Herstellung und ihre Verwendung
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DE19807972A1 (de) 1998-02-25 1999-08-26 Hoechst Marion Roussel De Gmbh Lipopeptidantibiotika-Calciumsalze, Verfahren zu ihrer Herstellung und Verwendung
AU7893301A (en) * 2000-07-17 2002-01-30 Intrabiotics Pharmaceuticals Antimicrobial sulfonamide derivatives of lipopeptide antibiotics
US6750199B2 (en) 2000-07-17 2004-06-15 Micrologix Biotech Inc. Antimicrobial sulfonamide derivatives of lipopeptide antibiotics
US6716962B2 (en) 2000-07-17 2004-04-06 Micrologix Biotech Inc. Extractive purification of lipopeptide antibiotics
JP4402463B2 (ja) 2002-01-03 2010-01-20 マイジェニックス インコーポレイテッド リポペプチド抗生物質のＤａｂ９誘導体およびそれを製造および使用する方法

Cited By (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102939301A (zh) * 2010-03-10 2013-02-20 巴塞罗那大学 作为抗菌剂使用的肽化合物
CN107108698A (zh) * 2014-11-14 2017-08-29 百时美施贵宝公司 用作免疫调节剂的大环肽
CN104557743A (zh) * 2014-12-02 2015-04-29 南京邮电大学 一类包含不饱和脂肪酸结构的抗白色念珠菌药物及其制备方法
CN104817619A (zh) * 2015-04-23 2015-08-05 浙江大学 抗菌化合物及其应用
CN104817619B (zh) * 2015-04-23 2018-07-17 浙江大学 抗菌化合物及其应用
CN109593808A (zh) * 2017-09-30 2019-04-09 上海医药工业研究院 达托霉素发酵培养基及其制备方法
CN109593808B (zh) * 2017-09-30 2022-10-04 上海医药工业研究院 达托霉素发酵培养基及其制备方法
US12209106B2 (en) 2018-07-20 2025-01-28 Fujimoto Chemicals Co., Ltd. Alkoxyphenyl derivatives, protected nucleosides and protected nucleotides, method for producing oligonucleotides, and method for removing substituents
CN111434775A (zh) * 2019-01-11 2020-07-21 上海医药工业研究院 一种发酵制备达托霉素的方法
CN111434775B (zh) * 2019-01-11 2022-12-06 上海医药工业研究院 一种发酵制备达托霉素的方法
CN112625106A (zh) * 2021-01-13 2021-04-09 兰州大学 一种抗菌多肽化合物、合成方法及其应用

Also Published As

Publication number Publication date
WO2005000878A3 (en) 2005-06-16
EP2147925A1 (en) 2010-01-27
EP1656390A2 (en) 2006-05-17
NZ544750A (en) 2009-06-26
EA200600280A1 (ru) 2006-10-27
WO2005000878A2 (en) 2005-01-06
WO2005000878A8 (en) 2006-06-08
AU2004252174A1 (en) 2005-01-06
EA010294B1 (ru) 2008-08-29
ZA200600008B (en) 2007-09-26
CA2530063A1 (en) 2005-01-06
US7868135B2 (en) 2011-01-11
IL172647A0 (en) 2006-04-10
JP2007536200A (ja) 2007-12-13
US20050153876A1 (en) 2005-07-14

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