CN1835910B - 2-氨基苯甲酰基衍生物 - Google Patents

2-氨基苯甲酰基衍生物 Download PDF

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Publication number
CN1835910B
CN1835910B CN200480017943XA CN200480017943A CN1835910B CN 1835910 B CN1835910 B CN 1835910B CN 200480017943X A CN200480017943X A CN 200480017943XA CN 200480017943 A CN200480017943 A CN 200480017943A CN 1835910 B CN1835910 B CN 1835910B
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CN
China
Prior art keywords
compound
hydrogen
disorder
aminobenzoyl
qualification
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Expired - Fee Related
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CN200480017943XA
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Chinese (zh)
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CN1835910A (zh
Inventor
纳瓦·奇撒贝尔
姆士·劳丹
迪佛拉·戴立
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Neurim Pharmaceuticals 1991 Ltd
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Neurim Pharmaceuticals 1991 Ltd
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Publication of CN1835910A publication Critical patent/CN1835910A/zh
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C225/00—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones
    • C07C225/22—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones having amino groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/132—Amines having two or more amino groups, e.g. spermidine, putrescine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/136—Amines having aromatic rings, e.g. ketamine, nortriptyline having the amino group directly attached to the aromatic ring, e.g. benzeneamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/10—Drugs for disorders of the urinary system of the bladder
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/18—Feminine contraceptives
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
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    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
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    • A—HUMAN NECESSITIES
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    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
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    • A61P9/00—Drugs for disorders of the cardiovascular system
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    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C225/00—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones
    • C07C225/02—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones having amino groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C225/14—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones having amino groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being unsaturated
    • C07C225/16—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones having amino groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being unsaturated and containing six-membered aromatic rings

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Reproductive Health (AREA)
  • Pain & Pain Management (AREA)
  • Cardiology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Urology & Nephrology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Psychiatry (AREA)
  • Addiction (AREA)
  • Epidemiology (AREA)
  • Obesity (AREA)
  • Vascular Medicine (AREA)
  • Child & Adolescent Psychology (AREA)
  • Immunology (AREA)
  • Pregnancy & Childbirth (AREA)
  • Emergency Medicine (AREA)
  • Dermatology (AREA)
  • Anesthesiology (AREA)
  • Rheumatology (AREA)
CN200480017943XA 2003-06-26 2004-06-24 2-氨基苯甲酰基衍生物 Expired - Fee Related CN1835910B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IL156669 2003-06-26
IL15666903A IL156669A0 (en) 2003-06-26 2003-06-26 2-aminobenzoyl derivatives
PCT/IL2004/000567 WO2004112690A2 (en) 2003-06-26 2004-06-24 2-aminobenzoyl derivatives

Publications (2)

Publication Number Publication Date
CN1835910A CN1835910A (zh) 2006-09-20
CN1835910B true CN1835910B (zh) 2010-09-29

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ID=32587677

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CN200480017943XA Expired - Fee Related CN1835910B (zh) 2003-06-26 2004-06-24 2-氨基苯甲酰基衍生物

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US (1) US8309767B2 (enExample)
EP (1) EP1644316B1 (enExample)
JP (1) JP4646907B2 (enExample)
KR (1) KR101115196B1 (enExample)
CN (1) CN1835910B (enExample)
AR (1) AR044786A1 (enExample)
AT (1) ATE460391T1 (enExample)
AU (1) AU2004249012B2 (enExample)
BR (1) BRPI0411382A (enExample)
CA (1) CA2527112C (enExample)
CY (1) CY1110043T1 (enExample)
DE (1) DE602004025937D1 (enExample)
DK (1) DK1644316T3 (enExample)
EA (1) EA011255B1 (enExample)
ES (1) ES2341958T3 (enExample)
HN (1) HN2004000224A (enExample)
IL (1) IL156669A0 (enExample)
IS (1) IS8235A (enExample)
MX (1) MXPA06000022A (enExample)
NO (1) NO20060420L (enExample)
NZ (1) NZ544908A (enExample)
PA (1) PA8605401A1 (enExample)
PE (1) PE20050230A1 (enExample)
PL (1) PL1644316T3 (enExample)
PT (1) PT1644316E (enExample)
SI (1) SI1644316T1 (enExample)
TW (1) TWI342210B (enExample)
UA (1) UA85187C2 (enExample)
UY (1) UY28382A1 (enExample)
WO (1) WO2004112690A2 (enExample)
ZA (1) ZA200600640B (enExample)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1869002A (zh) * 2005-05-27 2006-11-29 中国科学院上海药物研究所 一类非甾体雄激素受体调节剂、其制备方法和用途
US7622495B2 (en) 2006-10-03 2009-11-24 Neurim Pharmaceuticals (1991) Ltd. Substituted aryl-indole compounds and their kynurenine/kynuramine-like metabolites as therapeutic agents
KR20150087400A (ko) 2012-11-20 2015-07-29 버텍스 파마슈티칼스 인코포레이티드 인돌아민 2,3-디옥시게나제의 억제제로서 유용한 화합물
WO2016027757A1 (ja) * 2014-08-18 2016-02-25 国立大学法人大阪大学 新規２－アミノベンゾイル誘導体
JP6836044B2 (ja) * 2015-03-05 2021-02-24 国立大学法人 東京医科歯科大学 長期記憶誘導剤
US11712425B2 (en) 2018-03-14 2023-08-01 Albert Einstein College Of Medicine Immunoregulatory role of 3-OH-kynurenamine and uses thereof
US11911376B2 (en) 2020-03-30 2024-02-27 The Regents Of The University Of Colorado Methods for preventing and treating retinal damage

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1334884A (en) * 1970-12-18 1973-10-24 Sumitomo Chemical Co Aminoalcohols and their conversion to aminoketones

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT305987B (de) 1969-12-18 1973-03-26 Degussa Verfahren zur Herstellung von neuen Aminoketonen
JPS5336455B2 (enExample) * 1973-02-03 1978-10-03
US4018823A (en) 1976-04-20 1977-04-19 Morton-Norwich Products, Inc. 4',5'-Dimethoxy-2',3-diaminopropiophenone dihydrochloride
FR2569185B1 (fr) * 1984-08-20 1986-09-05 Lafon Labor Derives de 1-(aminophenyl)-2-amino-ethanone, procede de preparation et utilisation en therapeutique

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1334884A (en) * 1970-12-18 1973-10-24 Sumitomo Chemical Co Aminoalcohols and their conversion to aminoketones

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
back, w.synthesis of o-acylamino-b-aminopropiophenones. 4. synthesisof primary mannich bases.pharmazeutischen gesellschatf305 6.1972,305(6),448-455.
back, w.synthesis of o-acylamino-b-aminopropiophenones. 4. synthesisof primary mannich bases.pharmazeutischen gesellschatf305 6.1972,305(6),448-455. *

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US20060270733A1 (en) 2006-11-30
SI1644316T1 (sl) 2010-06-30
ZA200600640B (en) 2007-05-30
US8309767B2 (en) 2012-11-13
JP2007518673A (ja) 2007-07-12
EP1644316B1 (en) 2010-03-10
NO20060420L (no) 2006-01-25
AU2004249012A1 (en) 2004-12-29
CA2527112C (en) 2012-08-21
CN1835910A (zh) 2006-09-20
WO2004112690A2 (en) 2004-12-29
CA2527112A1 (en) 2004-12-29
AU2004249012B2 (en) 2010-04-01
UY28382A1 (es) 2004-11-08
ES2341958T3 (es) 2010-06-30
PL1644316T3 (pl) 2010-08-31
IL156669A0 (en) 2004-01-04
EA200600115A1 (ru) 2008-06-30
PE20050230A1 (es) 2005-04-22
JP4646907B2 (ja) 2011-03-09
HN2004000224A (es) 2007-12-21
CY1110043T1 (el) 2015-01-14
BRPI0411382A (pt) 2006-09-19
TWI342210B (en) 2011-05-21
NZ544908A (en) 2009-11-27
ATE460391T1 (de) 2010-03-15
DK1644316T3 (da) 2010-07-19
PT1644316E (pt) 2010-06-02
MXPA06000022A (es) 2006-07-06
WO2004112690B1 (en) 2005-05-19
EP1644316A2 (en) 2006-04-12
WO2004112690A3 (en) 2005-03-17
IS8235A (is) 2006-01-16
UA85187C2 (en) 2009-01-12
EA011255B1 (ru) 2009-02-27
AR044786A1 (es) 2005-10-05
DE602004025937D1 (de) 2010-04-22
HK1094795A1 (en) 2007-04-13
TW200503672A (en) 2005-02-01
EP1644316A4 (en) 2006-10-25
KR101115196B1 (ko) 2012-02-24
PA8605401A1 (es) 2006-03-24
KR20060023581A (ko) 2006-03-14

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