AR044786A1 - Derivados de 2- aminobenzoilo - Google Patents
Derivados de 2- aminobenzoiloInfo
- Publication number
- AR044786A1 AR044786A1 ARP040102095A ARP040102095A AR044786A1 AR 044786 A1 AR044786 A1 AR 044786A1 AR P040102095 A ARP040102095 A AR P040102095A AR P040102095 A ARP040102095 A AR P040102095A AR 044786 A1 AR044786 A1 AR 044786A1
- Authority
- AR
- Argentina
- Prior art keywords
- arylalkyl
- alkyl
- group
- haloalkyl
- alkoxy
- Prior art date
Links
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 8
- -1 nitro, amino, cyano, cyanamido, guanidino, amidino Chemical group 0.000 abstract 7
- 150000001875 compounds Chemical class 0.000 abstract 5
- 125000001188 haloalkyl group Chemical group 0.000 abstract 4
- 229910052739 hydrogen Inorganic materials 0.000 abstract 4
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 4
- 125000004423 acyloxy group Chemical group 0.000 abstract 3
- 125000003342 alkenyl group Chemical group 0.000 abstract 3
- 125000003545 alkoxy group Chemical group 0.000 abstract 3
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- 125000000304 alkynyl group Chemical group 0.000 abstract 3
- 125000003118 aryl group Chemical group 0.000 abstract 3
- 125000000852 azido group Chemical group *N=[N+]=[N-] 0.000 abstract 3
- 125000001475 halogen functional group Chemical group 0.000 abstract 3
- 125000001072 heteroaryl group Chemical group 0.000 abstract 3
- 125000000623 heterocyclic group Chemical group 0.000 abstract 3
- 239000001257 hydrogen Substances 0.000 abstract 3
- 125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 3
- 125000002768 hydroxyalkyl group Chemical group 0.000 abstract 3
- 150000003573 thiols Chemical class 0.000 abstract 3
- 125000003161 (C1-C6) alkylene group Chemical group 0.000 abstract 2
- 125000000033 alkoxyamino group Chemical group 0.000 abstract 2
- 150000001356 alkyl thiols Chemical class 0.000 abstract 2
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 abstract 1
- 208000024172 Cardiovascular disease Diseases 0.000 abstract 1
- 125000004442 acylamino group Chemical group 0.000 abstract 1
- 125000005018 aryl alkenyl group Chemical group 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 125000000816 ethylene group Chemical group [H]C([H])([*:1])C([H])([H])[*:2] 0.000 abstract 1
- 125000002485 formyl group Chemical group [H]C(*)=O 0.000 abstract 1
- 208000014674 injury Diseases 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 230000001613 neoplastic effect Effects 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 230000004962 physiological condition Effects 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000005504 styryl group Chemical group 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
- 230000008733 trauma Effects 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C225/00—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones
- C07C225/22—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones having amino groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/132—Amines having two or more amino groups, e.g. spermidine, putrescine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A61K31/136—Amines having aromatic rings, e.g. ketamine, nortriptyline having the amino group directly attached to the aromatic ring, e.g. benzeneamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/10—Drugs for disorders of the urinary system of the bladder
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/18—Feminine contraceptives
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P23/00—Anaesthetics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/36—Opioid-abuse
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/02—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C225/00—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones
- C07C225/02—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones having amino groups bound to acyclic carbon atoms of the carbon skeleton
- C07C225/14—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones having amino groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being unsaturated
- C07C225/16—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones having amino groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being unsaturated and containing six-membered aromatic rings
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Pain & Pain Management (AREA)
- Hematology (AREA)
- Reproductive Health (AREA)
- Ophthalmology & Optometry (AREA)
- Psychiatry (AREA)
- Urology & Nephrology (AREA)
- Cardiology (AREA)
- Gynecology & Obstetrics (AREA)
- Heart & Thoracic Surgery (AREA)
- Epidemiology (AREA)
- Addiction (AREA)
- Obesity (AREA)
- Anesthesiology (AREA)
- Child & Adolescent Psychology (AREA)
- Immunology (AREA)
- Emergency Medicine (AREA)
- Rheumatology (AREA)
- Pregnancy & Childbirth (AREA)
- Dermatology (AREA)
- Vascular Medicine (AREA)
Abstract
Compuestos que tienen la fórmula (1), y composiciones farmacéuticas que los contienen, donde los símbolos tienen valores especificados. Estos compuestos son útiles para tratar o prevenir varias condiciones. Condición fisiológica seleccionado entre trauma del CNS, trastornos cardiovasculares, enfermedades neoplásticos. Reivindicación 1: Un compuesto, caracterizado por la fórmula (1), y estereoisómeros y sales farmacéuticamente aceptables del mismo, donde: A es alquileno C1-6; R, R1 y R2 son independientemente hidrógeno, halo, haloalquilo, arilo, un grupo heterocíclico, un grupo heteroarilo, alquilo, alquenilo, alquinilo, arilalquilo, arilalquenilo, arilalquinilo, hidroxialquilo, nitro, amino, ciano, cianamido, guanidino, amidino, acilamido, hidroxi, tiol, aciloxi, azido, alcoxi, carboxi, carbonilamino, S-alquilo o alquiltiol; X es >alquileno C1-6, >C=O ó >C=S ó una ligadura simple; e Y es hidrógeno, halo, haloalquilo, arilo, un grupo heterociclico, un grupo heteroarilo, alquilo, alquenilo, alquinilo, arilalquilo, arilalquenilo, arilalquinilo, hidroxialquilo, nitro, amino, ciano, cianamido, guanidino, amidino, acilamido, hidroxi, tiol, aciloxi, azido, alcoxi, carboxi, carbonilamidoestirilo que puede estar sustituido en el anillo por hasta cuatro sustituyentes seleccionados independientemente entre hidrógeno, halo, haloalquilo, arilo, un grupo heterociclilo, un grupo heteroarilo, alquilo, alquenilo, alquinilo, arilalquilo, arilalquenilo, arilalquinilo, hidroxialquilo, nitro, amino, ciano, cianamido, guanidino, amidino, acilamino, hidroxi, tiol, aciloxi, azido, alcoxi, S-alquilo, alquiltiol ó -COQ, donde Q es hidroxi, alcoxi C1-6, amino, mono-alquilamino (C1-6), di-alquilamino (C1-6), hidroxilamino, alcoxiamino C1-4 ó aril-alcoxiamino (C1-4), pero excluyendo: a) los compuestos donde simultáneamente X es >C=O, Y es metilo, A es CH2CH2, R es 5-metoxi, R1 es H ó formilo y R2 es H, y b) los compuestos donde el grupo -A(R2)-NH-X-Y es -CH2CH(COQ)-NH2 ó -CH(haloalquilo)-CH(COQ)-NH2.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IL15666903A IL156669A0 (en) | 2003-06-26 | 2003-06-26 | 2-aminobenzoyl derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR044786A1 true AR044786A1 (es) | 2005-10-05 |
Family
ID=32587677
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP040102095A AR044786A1 (es) | 2003-06-26 | 2004-06-16 | Derivados de 2- aminobenzoilo |
Country Status (32)
| Country | Link |
|---|---|
| US (1) | US8309767B2 (es) |
| EP (1) | EP1644316B1 (es) |
| JP (1) | JP4646907B2 (es) |
| KR (1) | KR101115196B1 (es) |
| CN (1) | CN1835910B (es) |
| AR (1) | AR044786A1 (es) |
| AT (1) | ATE460391T1 (es) |
| AU (1) | AU2004249012B2 (es) |
| BR (1) | BRPI0411382A (es) |
| CA (1) | CA2527112C (es) |
| CY (1) | CY1110043T1 (es) |
| DE (1) | DE602004025937D1 (es) |
| DK (1) | DK1644316T3 (es) |
| EA (1) | EA011255B1 (es) |
| ES (1) | ES2341958T3 (es) |
| HK (1) | HK1094795A1 (es) |
| HN (1) | HN2004000224A (es) |
| IL (1) | IL156669A0 (es) |
| IS (1) | IS8235A (es) |
| MX (1) | MXPA06000022A (es) |
| NO (1) | NO20060420L (es) |
| NZ (1) | NZ544908A (es) |
| PA (1) | PA8605401A1 (es) |
| PE (1) | PE20050230A1 (es) |
| PL (1) | PL1644316T3 (es) |
| PT (1) | PT1644316E (es) |
| SI (1) | SI1644316T1 (es) |
| TW (1) | TWI342210B (es) |
| UA (1) | UA85187C2 (es) |
| UY (1) | UY28382A1 (es) |
| WO (1) | WO2004112690A2 (es) |
| ZA (1) | ZA200600640B (es) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1869002A (zh) | 2005-05-27 | 2006-11-29 | 中国科学院上海药物研究所 | 一类非甾体雄激素受体调节剂、其制备方法和用途 |
| US7622495B2 (en) | 2006-10-03 | 2009-11-24 | Neurim Pharmaceuticals (1991) Ltd. | Substituted aryl-indole compounds and their kynurenine/kynuramine-like metabolites as therapeutic agents |
| RU2015124002A (ru) | 2012-11-20 | 2017-01-10 | Вертекс Фармасьютикалз Инкорпорейтед | Соединения, применяемые в качестве ингибиторов индоламин-2,3-диоксигеназы |
| WO2016027757A1 (ja) * | 2014-08-18 | 2016-02-25 | 国立大学法人大阪大学 | 新規２－アミノベンゾイル誘導体 |
| US11712425B2 (en) | 2018-03-14 | 2023-08-01 | Albert Einstein College Of Medicine | Immunoregulatory role of 3-OH-kynurenamine and uses thereof |
| US11911376B2 (en) | 2020-03-30 | 2024-02-27 | The Regents Of The University Of Colorado | Methods for preventing and treating retinal damage |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AT305987B (de) | 1969-12-18 | 1973-03-26 | Degussa | Verfahren zur Herstellung von neuen Aminoketonen |
| GB1334884A (en) | 1970-12-18 | 1973-10-24 | Sumitomo Chemical Co | Aminoalcohols and their conversion to aminoketones |
| JPS5336455B2 (es) | 1973-02-03 | 1978-10-03 | ||
| US4018823A (en) | 1976-04-20 | 1977-04-19 | Morton-Norwich Products, Inc. | 4',5'-Dimethoxy-2',3-diaminopropiophenone dihydrochloride |
| FR2569185B1 (fr) | 1984-08-20 | 1986-09-05 | Lafon Labor | Derives de 1-(aminophenyl)-2-amino-ethanone, procede de preparation et utilisation en therapeutique |
-
2003
- 2003-06-26 IL IL15666903A patent/IL156669A0/xx not_active IP Right Cessation
-
2004
- 2004-06-16 AR ARP040102095A patent/AR044786A1/es not_active Application Discontinuation
- 2004-06-18 PE PE2004000604A patent/PE20050230A1/es not_active Application Discontinuation
- 2004-06-22 PA PA20048605401A patent/PA8605401A1/es unknown
- 2004-06-23 UY UY28382A patent/UY28382A1/es not_active Application Discontinuation
- 2004-06-24 EP EP04744907A patent/EP1644316B1/en not_active Expired - Lifetime
- 2004-06-24 KR KR1020057025006A patent/KR101115196B1/ko not_active IP Right Cessation
- 2004-06-24 AU AU2004249012A patent/AU2004249012B2/en not_active Ceased
- 2004-06-24 MX MXPA06000022A patent/MXPA06000022A/es active IP Right Grant
- 2004-06-24 AT AT04744907T patent/ATE460391T1/de not_active IP Right Cessation
- 2004-06-24 WO PCT/IL2004/000567 patent/WO2004112690A2/en active Search and Examination
- 2004-06-24 UA UAA200600303A patent/UA85187C2/ru unknown
- 2004-06-24 EA EA200600115A patent/EA011255B1/ru not_active IP Right Cessation
- 2004-06-24 ES ES04744907T patent/ES2341958T3/es not_active Expired - Lifetime
- 2004-06-24 CN CN200480017943XA patent/CN1835910B/zh not_active Expired - Fee Related
- 2004-06-24 PT PT04744907T patent/PT1644316E/pt unknown
- 2004-06-24 HN HN2004000224A patent/HN2004000224A/es unknown
- 2004-06-24 BR BRPI0411382-9A patent/BRPI0411382A/pt not_active IP Right Cessation
- 2004-06-24 PL PL04744907T patent/PL1644316T3/pl unknown
- 2004-06-24 TW TW093118235A patent/TWI342210B/zh not_active IP Right Cessation
- 2004-06-24 DK DK04744907.9T patent/DK1644316T3/da active
- 2004-06-24 DE DE602004025937T patent/DE602004025937D1/de not_active Expired - Lifetime
- 2004-06-24 NZ NZ544908A patent/NZ544908A/en unknown
- 2004-06-24 US US10/562,197 patent/US8309767B2/en not_active Expired - Fee Related
- 2004-06-24 JP JP2006516814A patent/JP4646907B2/ja not_active Expired - Fee Related
- 2004-06-24 ZA ZA200600640A patent/ZA200600640B/en unknown
- 2004-06-24 SI SI200431416T patent/SI1644316T1/sl unknown
- 2004-06-24 CA CA2527112A patent/CA2527112C/en not_active Expired - Fee Related
-
2006
- 2006-01-16 IS IS8235A patent/IS8235A/is unknown
- 2006-01-25 NO NO20060420A patent/NO20060420L/no not_active Application Discontinuation
-
2007
- 2007-02-27 HK HK07102168.5A patent/HK1094795A1/xx not_active IP Right Cessation
-
2010
- 2010-05-25 CY CY20101100463T patent/CY1110043T1/el unknown
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