CA2527112C - 2-aminobenzoyl derivatives as nmda receptor antagonists - Google Patents

2-aminobenzoyl derivatives as nmda receptor antagonists Download PDF

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Publication number
CA2527112C
CA2527112C CA2527112A CA2527112A CA2527112C CA 2527112 C CA2527112 C CA 2527112C CA 2527112 A CA2527112 A CA 2527112A CA 2527112 A CA2527112 A CA 2527112A CA 2527112 C CA2527112 C CA 2527112C
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Prior art keywords
disorders
alkyl
hydrogen
pharmaceutically acceptable
compound
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Expired - Fee Related
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CA2527112A
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English (en)
French (fr)
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CA2527112A1 (en
Inventor
Nava Zisapel
Moshe Laudon
Dvorah Daily
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Neurim Pharmaceuticals 1991 Ltd
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Neurim Pharmaceuticals 1991 Ltd
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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C225/00Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones
    • C07C225/22Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones having amino groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/13Amines
    • A61K31/132Amines having two or more amino groups, e.g. spermidine, putrescine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/13Amines
    • A61K31/135Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/136Amines having aromatic rings, e.g. ketamine, nortriptyline having the amino group directly attached to the aromatic ring, e.g. benzeneamine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/08Drugs for disorders of the urinary system of the prostate
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/10Drugs for disorders of the urinary system of the bladder
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • A61P15/18Feminine contraceptives
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    • A61P23/00Anaesthetics
    • AHUMAN NECESSITIES
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    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
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    • A61P25/04Centrally acting analgesics, e.g. opioids
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    • A61P25/26Psychostimulants, e.g. nicotine, cocaine
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    • A61P25/30Drugs for disorders of the nervous system for treating abuse or dependence
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    • A61P5/00Drugs for disorders of the endocrine system
    • A61P5/02Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin
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    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/12Antihypertensives
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C225/00Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones
    • C07C225/02Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones having amino groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C225/14Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones having amino groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being unsaturated
    • C07C225/16Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones having amino groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being unsaturated and containing six-membered aromatic rings

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Pain & Pain Management (AREA)
  • Reproductive Health (AREA)
  • Ophthalmology & Optometry (AREA)
  • Psychiatry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Urology & Nephrology (AREA)
  • Obesity (AREA)
  • Addiction (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Rheumatology (AREA)
  • Vascular Medicine (AREA)
  • Emergency Medicine (AREA)
  • Anesthesiology (AREA)
  • Dermatology (AREA)
  • Pregnancy & Childbirth (AREA)
  • Child & Adolescent Psychology (AREA)
CA2527112A 2003-06-26 2004-06-24 2-aminobenzoyl derivatives as nmda receptor antagonists Expired - Fee Related CA2527112C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IL156669 2003-06-26
IL15666903A IL156669A0 (en) 2003-06-26 2003-06-26 2-aminobenzoyl derivatives
PCT/IL2004/000567 WO2004112690A2 (en) 2003-06-26 2004-06-24 2-aminobenzoyl derivatives

Publications (2)

Publication Number Publication Date
CA2527112A1 CA2527112A1 (en) 2004-12-29
CA2527112C true CA2527112C (en) 2012-08-21

Family

ID=32587677

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2527112A Expired - Fee Related CA2527112C (en) 2003-06-26 2004-06-24 2-aminobenzoyl derivatives as nmda receptor antagonists

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US (1) US8309767B2 (enExample)
EP (1) EP1644316B1 (enExample)
JP (1) JP4646907B2 (enExample)
KR (1) KR101115196B1 (enExample)
CN (1) CN1835910B (enExample)
AR (1) AR044786A1 (enExample)
AT (1) ATE460391T1 (enExample)
AU (1) AU2004249012B2 (enExample)
BR (1) BRPI0411382A (enExample)
CA (1) CA2527112C (enExample)
CY (1) CY1110043T1 (enExample)
DE (1) DE602004025937D1 (enExample)
DK (1) DK1644316T3 (enExample)
EA (1) EA011255B1 (enExample)
ES (1) ES2341958T3 (enExample)
HN (1) HN2004000224A (enExample)
IL (1) IL156669A0 (enExample)
IS (1) IS8235A (enExample)
MX (1) MXPA06000022A (enExample)
NO (1) NO20060420L (enExample)
NZ (1) NZ544908A (enExample)
PA (1) PA8605401A1 (enExample)
PE (1) PE20050230A1 (enExample)
PL (1) PL1644316T3 (enExample)
PT (1) PT1644316E (enExample)
SI (1) SI1644316T1 (enExample)
TW (1) TWI342210B (enExample)
UA (1) UA85187C2 (enExample)
UY (1) UY28382A1 (enExample)
WO (1) WO2004112690A2 (enExample)
ZA (1) ZA200600640B (enExample)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1869002A (zh) * 2005-05-27 2006-11-29 中国科学院上海药物研究所 一类非甾体雄激素受体调节剂、其制备方法和用途
US7622495B2 (en) 2006-10-03 2009-11-24 Neurim Pharmaceuticals (1991) Ltd. Substituted aryl-indole compounds and their kynurenine/kynuramine-like metabolites as therapeutic agents
HK1215256A1 (zh) 2012-11-20 2016-08-19 Vertex Pharmaceuticals Incorporated 用作吲哚胺2,3-二氧化酶的抑制劑的化合物
WO2016027757A1 (ja) * 2014-08-18 2016-02-25 国立大学法人大阪大学 新規2-アミノベンゾイル誘導体
JP6836044B2 (ja) * 2015-03-05 2021-02-24 国立大学法人 東京医科歯科大学 長期記憶誘導剤
US11712425B2 (en) 2018-03-14 2023-08-01 Albert Einstein College Of Medicine Immunoregulatory role of 3-OH-kynurenamine and uses thereof
US11911376B2 (en) 2020-03-30 2024-02-27 The Regents Of The University Of Colorado Methods for preventing and treating retinal damage

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT305987B (de) 1969-12-18 1973-03-26 Degussa Verfahren zur Herstellung von neuen Aminoketonen
GB1334884A (en) * 1970-12-18 1973-10-24 Sumitomo Chemical Co Aminoalcohols and their conversion to aminoketones
JPS5336455B2 (enExample) * 1973-02-03 1978-10-03
US4018823A (en) 1976-04-20 1977-04-19 Morton-Norwich Products, Inc. 4',5'-Dimethoxy-2',3-diaminopropiophenone dihydrochloride
FR2569185B1 (fr) * 1984-08-20 1986-09-05 Lafon Labor Derives de 1-(aminophenyl)-2-amino-ethanone, procede de preparation et utilisation en therapeutique

Also Published As

Publication number Publication date
AU2004249012B2 (en) 2010-04-01
ATE460391T1 (de) 2010-03-15
ES2341958T3 (es) 2010-06-30
AR044786A1 (es) 2005-10-05
WO2004112690A3 (en) 2005-03-17
CN1835910B (zh) 2010-09-29
UY28382A1 (es) 2004-11-08
IS8235A (is) 2006-01-16
KR101115196B1 (ko) 2012-02-24
IL156669A0 (en) 2004-01-04
PA8605401A1 (es) 2006-03-24
DK1644316T3 (da) 2010-07-19
EA011255B1 (ru) 2009-02-27
JP2007518673A (ja) 2007-07-12
EA200600115A1 (ru) 2008-06-30
TWI342210B (en) 2011-05-21
US20060270733A1 (en) 2006-11-30
UA85187C2 (en) 2009-01-12
ZA200600640B (en) 2007-05-30
TW200503672A (en) 2005-02-01
PT1644316E (pt) 2010-06-02
HN2004000224A (es) 2007-12-21
MXPA06000022A (es) 2006-07-06
PE20050230A1 (es) 2005-04-22
KR20060023581A (ko) 2006-03-14
CA2527112A1 (en) 2004-12-29
US8309767B2 (en) 2012-11-13
EP1644316B1 (en) 2010-03-10
BRPI0411382A (pt) 2006-09-19
EP1644316A2 (en) 2006-04-12
WO2004112690A2 (en) 2004-12-29
CY1110043T1 (el) 2015-01-14
NO20060420L (no) 2006-01-25
CN1835910A (zh) 2006-09-20
WO2004112690B1 (en) 2005-05-19
NZ544908A (en) 2009-11-27
DE602004025937D1 (de) 2010-04-22
SI1644316T1 (sl) 2010-06-30
HK1094795A1 (en) 2007-04-13
JP4646907B2 (ja) 2011-03-09
EP1644316A4 (en) 2006-10-25
AU2004249012A1 (en) 2004-12-29
PL1644316T3 (pl) 2010-08-31

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