CN1778802A - 培美曲塞二钠的一种新晶型及其制备方法 - Google Patents
培美曲塞二钠的一种新晶型及其制备方法 Download PDFInfo
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- CN1778802A CN1778802A CN 200410097283 CN200410097283A CN1778802A CN 1778802 A CN1778802 A CN 1778802A CN 200410097283 CN200410097283 CN 200410097283 CN 200410097283 A CN200410097283 A CN 200410097283A CN 1778802 A CN1778802 A CN 1778802A
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- disodium
- hydrate
- pemetrexed disodium
- cancer
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- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Description
d-间距() | I/I0 | d-间距() | I/I0 | d-间距() | I/I0 |
33.0019.1811.579.518.627.876.305.995.74 | 112122392411252660 | 5.154.964.824.654.283.903.743.453.31 | 2862473818100803929 | 3.243.143.112.972.582.602.29 | 18334923111617 |
培美曲塞二钠水合物 | d-间距() | I/I0 |
2.5水合物七水合物三水合物 | 18.66±0.047.78±0.043.90或3.74±0.04 | 100100100 |
培美曲塞二钠水合物 | 含水量(%) | ||||
0小时 | 0.5小时 | 1.0小时 | 1.5小时 | 2.0小时 | |
2.5水合物七水合物三水合物 | 8.821.210.1 | 9.521.010.0 | 10.120.410.3 | 10.720.010.5 | 11.219.310.9 |
培美曲塞二钠水合物 | 含水量(%) | ||||
0月 | 1月 | 2月 | 3月 | 6月 | |
2.5水合物七水合物三水合物 | 8.921.310.4 | 8.919.010.2 | 8.717.110.6 | 9.015.810.3 | 8.712.910.0 |
Claims (10)
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CNB2004100972832A CN100364994C (zh) | 2004-11-25 | 2004-11-25 | 培美曲塞二钠的一种新晶型及其制备方法 |
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CNB2004100972832A CN100364994C (zh) | 2004-11-25 | 2004-11-25 | 培美曲塞二钠的一种新晶型及其制备方法 |
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CN1778802A true CN1778802A (zh) | 2006-05-31 |
CN100364994C CN100364994C (zh) | 2008-01-30 |
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Cited By (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2009056029A1 (fr) | 2007-10-24 | 2009-05-07 | Chongqing Pharmaceutical Research Institute Co., Ltd. | Procédé de purification de sels, sels sodiques et sels dissodiques de pemetrexed |
CN101092417B (zh) * | 2006-06-19 | 2011-04-27 | 上海金色医药科技发展有限公司 | 一种叶酸类似物及用于医疗的叶酸类似物的盐 |
CN102050825A (zh) * | 2009-11-05 | 2011-05-11 | 上海希迪制药有限公司 | 制备培美曲塞二钠2.5水结晶的方法 |
WO2011064256A1 (en) | 2009-11-24 | 2011-06-03 | Azad Pharmaceutical Ingredients Ag | A new crystalline form of pemetrexed disodium |
CN102086204A (zh) * | 2010-12-27 | 2011-06-08 | 江苏奥赛康药业有限公司 | 一种高纯度培美曲塞二钠的工业化生产方法 |
CN102106833A (zh) * | 2011-02-12 | 2011-06-29 | 海南锦瑞制药股份有限公司 | 一种培美曲塞二钠冻干粉针剂及其制备方法 |
EP2334685A4 (en) * | 2008-09-08 | 2011-10-26 | Reddys Lab Ltd Dr | AMORPHOUS PEMETREXED DISODIUM |
CN102977107A (zh) * | 2012-12-25 | 2013-03-20 | 山西普德药业股份有限公司 | 一种培美曲塞二钠化合物及其组合物 |
CN103459392A (zh) * | 2011-03-25 | 2013-12-18 | 台湾神隆股份有限公司 | 一种制备培美曲塞盐的方法 |
CN104119345A (zh) * | 2014-06-18 | 2014-10-29 | 威海昊同医药科技有限公司 | 一种注射级培美曲塞二钠的纯化方法 |
WO2015008221A1 (en) | 2013-07-16 | 2015-01-22 | Dr. Reddy’S Laboratories Limited | Novel crystalline forms of pemetrexed tromethamine salts |
CN105985326A (zh) * | 2015-02-16 | 2016-10-05 | 上海宣创生物科技有限公司 | 嘧啶衍生物晶型ⅲ及其制备方法和用途 |
CN115252564A (zh) * | 2022-08-30 | 2022-11-01 | 海南锦瑞制药有限公司 | 一种注射用培美曲塞二钠的制备方法 |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
PT1259513E (pt) * | 2000-02-25 | 2004-02-27 | Lilly Co Eli | Nova forma cristalina de acido n-¬4- ¬2-amino-4,7-dihidro -4-oxo-3h-pirrolo¬2,3-d|pirimidin-5-il)etil| - benzoil|-l-glutamico e processo para a sua obtencao |
-
2004
- 2004-11-25 CN CNB2004100972832A patent/CN100364994C/zh active Active
Cited By (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101092417B (zh) * | 2006-06-19 | 2011-04-27 | 上海金色医药科技发展有限公司 | 一种叶酸类似物及用于医疗的叶酸类似物的盐 |
US8686140B2 (en) | 2007-10-24 | 2014-04-01 | Chongqing Pharmaceutical Research Institute Co., Ltd. | Method of purifying a salt, sodium salt and disodium salt of pemetrexed |
CN101417998B (zh) * | 2007-10-24 | 2012-10-24 | 重庆医药工业研究院有限责任公司 | 一种培美曲塞盐的纯化方法 |
WO2009056029A1 (fr) | 2007-10-24 | 2009-05-07 | Chongqing Pharmaceutical Research Institute Co., Ltd. | Procédé de purification de sels, sels sodiques et sels dissodiques de pemetrexed |
EP2334685A4 (en) * | 2008-09-08 | 2011-10-26 | Reddys Lab Ltd Dr | AMORPHOUS PEMETREXED DISODIUM |
CN102050825A (zh) * | 2009-11-05 | 2011-05-11 | 上海希迪制药有限公司 | 制备培美曲塞二钠2.5水结晶的方法 |
CN102050825B (zh) * | 2009-11-05 | 2014-12-17 | 上海创诺制药有限公司 | 制备培美曲塞二钠2.5水结晶的方法 |
WO2011064256A1 (en) | 2009-11-24 | 2011-06-03 | Azad Pharmaceutical Ingredients Ag | A new crystalline form of pemetrexed disodium |
CN102086204A (zh) * | 2010-12-27 | 2011-06-08 | 江苏奥赛康药业有限公司 | 一种高纯度培美曲塞二钠的工业化生产方法 |
CN102086204B (zh) * | 2010-12-27 | 2012-08-29 | 江苏奥赛康药业股份有限公司 | 一种高纯度培美曲塞二钠的工业化生产方法 |
CN102106833A (zh) * | 2011-02-12 | 2011-06-29 | 海南锦瑞制药股份有限公司 | 一种培美曲塞二钠冻干粉针剂及其制备方法 |
CN103459392A (zh) * | 2011-03-25 | 2013-12-18 | 台湾神隆股份有限公司 | 一种制备培美曲塞盐的方法 |
CN102977107A (zh) * | 2012-12-25 | 2013-03-20 | 山西普德药业股份有限公司 | 一种培美曲塞二钠化合物及其组合物 |
CN102977107B (zh) * | 2012-12-25 | 2015-04-22 | 山西普德药业股份有限公司 | 一种培美曲塞二钠化合物及其组合物 |
WO2015008221A1 (en) | 2013-07-16 | 2015-01-22 | Dr. Reddy’S Laboratories Limited | Novel crystalline forms of pemetrexed tromethamine salts |
US9688682B2 (en) | 2013-07-16 | 2017-06-27 | Dr. Reddy's Laboratories Limited | Crystalline forms of pemetrexed tromethamine salts |
CN104119345A (zh) * | 2014-06-18 | 2014-10-29 | 威海昊同医药科技有限公司 | 一种注射级培美曲塞二钠的纯化方法 |
CN105985326A (zh) * | 2015-02-16 | 2016-10-05 | 上海宣创生物科技有限公司 | 嘧啶衍生物晶型ⅲ及其制备方法和用途 |
CN105985326B (zh) * | 2015-02-16 | 2020-04-14 | 上海宣创生物科技有限公司 | 嘧啶衍生物晶型ⅲ及其制备方法和用途 |
CN115252564A (zh) * | 2022-08-30 | 2022-11-01 | 海南锦瑞制药有限公司 | 一种注射用培美曲塞二钠的制备方法 |
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Effective date of registration: 20090515 Address after: 565 zip code of Tu Shan Road, Nanan District, Chongqing: 400061 Co-patentee after: Shanghai Chemo Wanbang Biopharma Co., Ltd. Patentee after: Chongqing pharmaceutical industry research institute limited liability company Address before: 565 zip code of Tu Shan Road, Nanan District, Chongqing: 400061 Co-patentee before: Shanghai Clonbiotech Co., Ltd. Patentee before: Chongqing pharmaceutical industry research institute limited liability company |
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Effective date of registration: 20200416 Address after: 401221, No. 3, No. 1 South Road, Changshou chemical industry park, Chongqing Co-patentee after: CHONGQING PHARMACEUTICAL RESEARCH INSTITUTE Co.,Ltd. Patentee after: CHONGQING CARELIFE PHARMACEUTICAL Co.,Ltd. Co-patentee after: SHANGHAI CHEMO WANBANG BIOPHARMA Co.,Ltd. Address before: 401221 No. 2 Yanjiahua South Third Branch Road, Changshou District, Chongqing Co-patentee before: CHONGQING PHARMACEUTICAL RESEARCH INSTITUTE Co.,Ltd. Patentee before: Chongqing Medical Institute Pharmaceutical Co., Ltd. Co-patentee before: SHANGHAI CHEMO WANBANG BIOPHARMA Co.,Ltd. |