CN1733286A - 一种防治酒精性肠道损伤和肝损伤的中药复方制剂 - Google Patents
一种防治酒精性肠道损伤和肝损伤的中药复方制剂 Download PDFInfo
- Publication number
- CN1733286A CN1733286A CN 200510028975 CN200510028975A CN1733286A CN 1733286 A CN1733286 A CN 1733286A CN 200510028975 CN200510028975 CN 200510028975 CN 200510028975 A CN200510028975 A CN 200510028975A CN 1733286 A CN1733286 A CN 1733286A
- Authority
- CN
- China
- Prior art keywords
- rhizoma
- radix
- ethanol
- extract
- group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001875 compounds Chemical class 0.000 title claims abstract description 25
- 238000002360 preparation method Methods 0.000 title claims abstract description 25
- 230000006378 damage Effects 0.000 title claims abstract description 22
- 231100000753 hepatic injury Toxicity 0.000 title claims abstract description 20
- 230000001476 alcoholic effect Effects 0.000 title claims abstract description 18
- 210000001035 gastrointestinal tract Anatomy 0.000 title claims description 11
- 239000003814 drug Substances 0.000 claims abstract description 50
- 239000000284 extract Substances 0.000 claims abstract description 47
- 239000008187 granular material Substances 0.000 claims abstract description 28
- VYQNWZOUAUKGHI-UHFFFAOYSA-N monobenzone Chemical compound C1=CC(O)=CC=C1OCC1=CC=CC=C1 VYQNWZOUAUKGHI-UHFFFAOYSA-N 0.000 claims abstract description 24
- 239000000203 mixture Substances 0.000 claims abstract description 13
- 239000007787 solid Substances 0.000 claims abstract description 9
- 239000002552 dosage form Substances 0.000 claims abstract description 8
- 239000003826 tablet Substances 0.000 claims abstract description 8
- 239000000546 pharmaceutical excipient Substances 0.000 claims abstract description 4
- 239000000126 substance Substances 0.000 claims abstract description 4
- 239000002775 capsule Substances 0.000 claims abstract description 3
- 239000007938 effervescent tablet Substances 0.000 claims abstract description 3
- 238000009472 formulation Methods 0.000 claims abstract description 3
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 claims description 24
- 229940079593 drug Drugs 0.000 claims description 22
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims description 21
- 229920002472 Starch Polymers 0.000 claims description 19
- 239000008107 starch Substances 0.000 claims description 19
- 235000019698 starch Nutrition 0.000 claims description 19
- 238000002481 ethanol extraction Methods 0.000 claims description 18
- 239000000796 flavoring agent Substances 0.000 claims description 16
- 235000019634 flavors Nutrition 0.000 claims description 16
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims description 12
- 235000019359 magnesium stearate Nutrition 0.000 claims description 12
- 239000000741 silica gel Substances 0.000 claims description 12
- 229910002027 silica gel Inorganic materials 0.000 claims description 12
- 238000002156 mixing Methods 0.000 claims description 11
- 238000000746 purification Methods 0.000 claims description 11
- 238000000034 method Methods 0.000 claims description 10
- 239000002671 adjuvant Substances 0.000 claims description 8
- 229920001353 Dextrin Polymers 0.000 claims description 7
- 239000004375 Dextrin Substances 0.000 claims description 7
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 claims description 7
- UIIMBOGNXHQVGW-DEQYMQKBSA-M Sodium bicarbonate-14C Chemical compound [Na+].O[14C]([O-])=O UIIMBOGNXHQVGW-DEQYMQKBSA-M 0.000 claims description 7
- 235000019425 dextrin Nutrition 0.000 claims description 7
- 239000008101 lactose Substances 0.000 claims description 7
- 239000011734 sodium Substances 0.000 claims description 7
- 229910052708 sodium Inorganic materials 0.000 claims description 7
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 7
- 229920001661 Chitosan Polymers 0.000 claims description 6
- 239000006286 aqueous extract Substances 0.000 claims description 6
- 238000012869 ethanol precipitation Methods 0.000 claims description 6
- 239000006186 oral dosage form Substances 0.000 claims description 6
- 230000008569 process Effects 0.000 claims description 6
- 238000012545 processing Methods 0.000 claims description 6
- 229930192961 schisandrol Natural products 0.000 claims description 6
- 238000003809 water extraction Methods 0.000 claims description 6
- 238000001035 drying Methods 0.000 claims description 2
- 239000012567 medical material Substances 0.000 claims description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract description 87
- 239000002158 endotoxin Substances 0.000 abstract description 50
- 230000002440 hepatic effect Effects 0.000 abstract description 25
- 230000000694 effects Effects 0.000 abstract description 24
- 108060008682 Tumor Necrosis Factor Proteins 0.000 abstract description 14
- 102000000852 Tumor Necrosis Factor-alpha Human genes 0.000 abstract description 14
- 230000000968 intestinal effect Effects 0.000 abstract description 13
- UFTFJSFQGQCHQW-UHFFFAOYSA-N triformin Chemical compound O=COCC(OC=O)COC=O UFTFJSFQGQCHQW-UHFFFAOYSA-N 0.000 abstract description 13
- 210000002966 serum Anatomy 0.000 abstract description 9
- MZOFCQQQCNRIBI-VMXHOPILSA-N (3s)-4-[[(2s)-1-[[(2s)-1-[[(1s)-1-carboxy-2-hydroxyethyl]amino]-4-methyl-1-oxopentan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-3-[[2-[[(2s)-2,6-diaminohexanoyl]amino]acetyl]amino]-4-oxobutanoic acid Chemical compound OC[C@@H](C(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(O)=O)NC(=O)CNC(=O)[C@@H](N)CCCCN MZOFCQQQCNRIBI-VMXHOPILSA-N 0.000 abstract description 8
- 230000007863 steatosis Effects 0.000 abstract description 7
- 231100000240 steatosis hepatitis Toxicity 0.000 abstract description 7
- 208000037817 intestinal injury Diseases 0.000 abstract description 5
- 230000003870 intestinal permeability Effects 0.000 abstract description 5
- 230000036285 pathological change Effects 0.000 abstract description 5
- 231100000915 pathological change Toxicity 0.000 abstract description 5
- 230000003035 anti-peroxidant effect Effects 0.000 abstract description 3
- 230000002757 inflammatory effect Effects 0.000 abstract description 3
- 238000010171 animal model Methods 0.000 abstract description 2
- 230000008485 antagonism Effects 0.000 abstract description 2
- 229940126678 chinese medicines Drugs 0.000 abstract description 2
- 150000002632 lipids Chemical class 0.000 abstract description 2
- 238000012360 testing method Methods 0.000 abstract description 2
- 239000007788 liquid Substances 0.000 description 41
- 229920006008 lipopolysaccharide Polymers 0.000 description 30
- 210000001519 tissue Anatomy 0.000 description 23
- 239000000843 powder Substances 0.000 description 15
- 210000002381 plasma Anatomy 0.000 description 12
- 241000700159 Rattus Species 0.000 description 10
- 210000004185 liver Anatomy 0.000 description 8
- 208000022309 Alcoholic Liver disease Diseases 0.000 description 7
- 238000002474 experimental method Methods 0.000 description 7
- GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 description 5
- 239000003795 chemical substances by application Substances 0.000 description 5
- 238000007908 dry granulation Methods 0.000 description 5
- 238000000605 extraction Methods 0.000 description 5
- 238000001694 spray drying Methods 0.000 description 5
- 210000002784 stomach Anatomy 0.000 description 5
- 210000003240 portal vein Anatomy 0.000 description 4
- 241000196324 Embryophyta Species 0.000 description 3
- 206010067125 Liver injury Diseases 0.000 description 3
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 3
- 230000008859 change Effects 0.000 description 3
- 238000004043 dyeing Methods 0.000 description 3
- 235000013399 edible fruits Nutrition 0.000 description 3
- 210000005228 liver tissue Anatomy 0.000 description 3
- 230000007246 mechanism Effects 0.000 description 3
- 238000011160 research Methods 0.000 description 3
- 244000183685 Citrus aurantium Species 0.000 description 2
- 235000007716 Citrus aurantium Nutrition 0.000 description 2
- 101710173228 Glutathione hydrolase proenzyme Proteins 0.000 description 2
- 101001009581 Molluscum contagiosum virus subtype 1 Glutathione peroxidase Proteins 0.000 description 2
- 240000006079 Schisandra chinensis Species 0.000 description 2
- 235000008422 Schisandra chinensis Nutrition 0.000 description 2
- 208000027418 Wounds and injury Diseases 0.000 description 2
- 210000004369 blood Anatomy 0.000 description 2
- 239000008280 blood Substances 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- WGXUDTHMEITUBO-YFKPBYRVSA-N glutaurine Chemical compound OC(=O)[C@@H](N)CCC(=O)NCCS(O)(=O)=O WGXUDTHMEITUBO-YFKPBYRVSA-N 0.000 description 2
- 208000014674 injury Diseases 0.000 description 2
- 230000010354 integration Effects 0.000 description 2
- 208000019423 liver disease Diseases 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 210000000110 microvilli Anatomy 0.000 description 2
- 230000007170 pathology Effects 0.000 description 2
- 210000000813 small intestine Anatomy 0.000 description 2
- 238000001262 western blot Methods 0.000 description 2
- 241000049624 Alisma plantago-aquatica subsp. orientale Species 0.000 description 1
- 241000345998 Calamus manan Species 0.000 description 1
- 241000189115 Catananche Species 0.000 description 1
- 239000003390 Chinese drug Substances 0.000 description 1
- 235000000228 Citrus myrtifolia Nutrition 0.000 description 1
- 235000016646 Citrus taiwanica Nutrition 0.000 description 1
- 102000004127 Cytokines Human genes 0.000 description 1
- 108090000695 Cytokines Proteins 0.000 description 1
- 208000004930 Fatty Liver Diseases 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- 241000207923 Lamiaceae Species 0.000 description 1
- 241000218377 Magnoliaceae Species 0.000 description 1
- NPGIHFRTRXVWOY-UHFFFAOYSA-N Oil red O Chemical compound Cc1ccc(C)c(c1)N=Nc1cc(C)c(cc1C)N=Nc1c(O)ccc2ccccc12 NPGIHFRTRXVWOY-UHFFFAOYSA-N 0.000 description 1
- 241000736199 Paeonia Species 0.000 description 1
- 244000046146 Pueraria lobata Species 0.000 description 1
- 241000731396 Pueraria montana var. thomsonii Species 0.000 description 1
- 241000218201 Ranunculaceae Species 0.000 description 1
- 241000304195 Salvia miltiorrhiza Species 0.000 description 1
- 235000011135 Salvia miltiorrhiza Nutrition 0.000 description 1
- 241000736078 Schisandra sphenanthera Species 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 230000004913 activation Effects 0.000 description 1
- 239000003963 antioxidant agent Substances 0.000 description 1
- 230000003078 antioxidant effect Effects 0.000 description 1
- 238000013459 approach Methods 0.000 description 1
- 125000000837 carbohydrate group Chemical group 0.000 description 1
- 235000014633 carbohydrates Nutrition 0.000 description 1
- 210000000170 cell membrane Anatomy 0.000 description 1
- 230000001684 chronic effect Effects 0.000 description 1
- 238000010219 correlation analysis Methods 0.000 description 1
- 230000007850 degeneration Effects 0.000 description 1
- 239000012153 distilled water Substances 0.000 description 1
- 238000007877 drug screening Methods 0.000 description 1
- 231100000284 endotoxic Toxicity 0.000 description 1
- 230000002346 endotoxic effect Effects 0.000 description 1
- 210000002919 epithelial cell Anatomy 0.000 description 1
- 230000006870 function Effects 0.000 description 1
- 230000002496 gastric effect Effects 0.000 description 1
- 208000006454 hepatitis Diseases 0.000 description 1
- 210000003494 hepatocyte Anatomy 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 238000001802 infusion Methods 0.000 description 1
- 210000004347 intestinal mucosa Anatomy 0.000 description 1
- 210000000936 intestine Anatomy 0.000 description 1
- 230000001788 irregular Effects 0.000 description 1
- 210000001865 kupffer cell Anatomy 0.000 description 1
- 235000021374 legumes Nutrition 0.000 description 1
- 230000003859 lipid peroxidation Effects 0.000 description 1
- 210000005229 liver cell Anatomy 0.000 description 1
- 230000003908 liver function Effects 0.000 description 1
- 208000018191 liver inflammation Diseases 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 238000012423 maintenance Methods 0.000 description 1
- 206010025482 malaise Diseases 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 230000004898 mitochondrial function Effects 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 230000008506 pathogenesis Effects 0.000 description 1
- 150000002978 peroxides Chemical class 0.000 description 1
- 230000037452 priming Effects 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 238000011552 rat model Methods 0.000 description 1
- 235000012950 rattan cane Nutrition 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- YEFOAORQXAOVJQ-RZFZLAGVSA-N schisandrol a Chemical compound C1[C@H](C)[C@@](C)(O)CC2=CC(OC)=C(OC)C(OC)=C2C2=C1C=C(OC)C(OC)=C2OC YEFOAORQXAOVJQ-RZFZLAGVSA-N 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- 230000001235 sensitizing effect Effects 0.000 description 1
- 238000007493 shaping process Methods 0.000 description 1
- 230000008961 swelling Effects 0.000 description 1
- 231100000167 toxic agent Toxicity 0.000 description 1
- 239000003440 toxic substance Substances 0.000 description 1
Images
Landscapes
- Medicinal Preparation (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
Description
Claims (8)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CNB2005100289756A CN100355448C (zh) | 2005-08-19 | 2005-08-19 | 一种防治酒精性肠道损伤和肝损伤的中药复方制剂 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CNB2005100289756A CN100355448C (zh) | 2005-08-19 | 2005-08-19 | 一种防治酒精性肠道损伤和肝损伤的中药复方制剂 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN1733286A true CN1733286A (zh) | 2006-02-15 |
CN100355448C CN100355448C (zh) | 2007-12-19 |
Family
ID=36076042
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CNB2005100289756A Active CN100355448C (zh) | 2005-08-19 | 2005-08-19 | 一种防治酒精性肠道损伤和肝损伤的中药复方制剂 |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN100355448C (zh) |
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102548567A (zh) * | 2009-09-24 | 2012-07-04 | 好侍食品株式会社 | 含有姜黄提取物和莪术提取物的组合物 |
CN102961522A (zh) * | 2011-09-01 | 2013-03-13 | 上海中医药大学附属曙光医院 | 一种防治酒精性肠病的中药复方制剂 |
CN105999212A (zh) * | 2016-05-13 | 2016-10-12 | 无限极(中国)有限公司 | 一种具有解酒作用的组合物及其制备方法与用途 |
CN110787272A (zh) * | 2019-11-13 | 2020-02-14 | 上海现代中医药股份有限公司 | 一种中药复方在制备治疗非酒精性脂肪性肝炎的药物中的应用 |
CN112595698A (zh) * | 2020-11-18 | 2021-04-02 | 上海中医药大学 | 油红o的应用及定量检测组织或细胞内脂质的方法 |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1087625C (zh) * | 1998-01-17 | 2002-07-17 | 吴书西 | 治疗结肠炎的中药制剂 |
CN1218706C (zh) * | 2001-05-20 | 2005-09-14 | 许喜训 | 乙肝转阴丸 |
-
2005
- 2005-08-19 CN CNB2005100289756A patent/CN100355448C/zh active Active
Cited By (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102548567A (zh) * | 2009-09-24 | 2012-07-04 | 好侍食品株式会社 | 含有姜黄提取物和莪术提取物的组合物 |
CN102961522A (zh) * | 2011-09-01 | 2013-03-13 | 上海中医药大学附属曙光医院 | 一种防治酒精性肠病的中药复方制剂 |
CN102961522B (zh) * | 2011-09-01 | 2014-07-30 | 上海中医药大学附属曙光医院 | 一种防治酒精性肠病的中药复方制剂 |
CN105999212A (zh) * | 2016-05-13 | 2016-10-12 | 无限极(中国)有限公司 | 一种具有解酒作用的组合物及其制备方法与用途 |
CN110787272A (zh) * | 2019-11-13 | 2020-02-14 | 上海现代中医药股份有限公司 | 一种中药复方在制备治疗非酒精性脂肪性肝炎的药物中的应用 |
CN112595698A (zh) * | 2020-11-18 | 2021-04-02 | 上海中医药大学 | 油红o的应用及定量检测组织或细胞内脂质的方法 |
Also Published As
Publication number | Publication date |
---|---|
CN100355448C (zh) | 2007-12-19 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN1839996A (zh) | 一种治疗慢性肝病的中药复方制剂及其制备方法 | |
CN100342889C (zh) | 一种治疗痛风的中药制剂及其制备方法和应用 | |
CN1907462A (zh) | 一种治疗肝炎和脂肪肝的中药组合物 | |
CN1853682A (zh) | 用于改善睡眠持续时间和质量的基于植物的食品强化剂 | |
CN1840166A (zh) | 温胆汤现代中药口服制剂及其生产方法 | |
CN1813961A (zh) | 一种用于治疗便秘的药物组合物 | |
CN1457808A (zh) | 一种铁皮石斛复方制剂及制备和应用 | |
CN1824211A (zh) | 清金止嗽化痰制剂及新的制备方法 | |
CN1733286A (zh) | 一种防治酒精性肠道损伤和肝损伤的中药复方制剂 | |
CN1561994A (zh) | 治疗类风湿性关节炎和免疫性疾病的含青蒿提取物药物组合物 | |
CN101066402A (zh) | 一种清热祛湿、利水通淋、消炎止痛、排石的中药制剂、制备方法及应用 | |
CN1557842A (zh) | 玉竹多糖的提取方法、药物制剂制备方法及其用途 | |
CN1879845A (zh) | 一种具有预防或治疗急慢性肝病的药物组合物 | |
CN1283281C (zh) | 一种含酸枣仁、灵芝、人参叶药物组合物及其制备和应用 | |
CN1850255A (zh) | 一种药物组合物及其制备方法 | |
CN1478508A (zh) | 一种治疗脂肪肝的中药组合物及其制备方法 | |
CN1899415A (zh) | 一种治疗慢性肝病的中药复方制剂及其制备方法 | |
CN1319588C (zh) | 治疗高血脂、脂肪肝、肝纤维化的药物和制备方法 | |
CN1539460A (zh) | 一种补肾壮阳延龄长春中药制剂及制备方法 | |
CN1839956A (zh) | 一种含姜黄素的药物组合物及其制剂 | |
CN1053376C (zh) | 一种抗肿瘤的中药制剂及其制备方法 | |
CN1947787A (zh) | 治疗脂肪肝的药物及其制备方法 | |
CN1824079A (zh) | 阑尾消炎制剂及新的制备方法 | |
CN1709381A (zh) | 一种益肾蠲痹药物组合物及其制备方法 | |
CN101053598A (zh) | 一种防治心脑血管疾病及糖尿病的药物组合物 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
C06 | Publication | ||
PB01 | Publication | ||
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
C14 | Grant of patent or utility model | ||
GR01 | Patent grant | ||
ASS | Succession or assignment of patent right |
Owner name: SHANGHAI MODERN TCM CO., LTD. Free format text: FORMER OWNER: SHUGUANG HOSPITAL Effective date: 20120815 |
|
C41 | Transfer of patent application or patent right or utility model | ||
COR | Change of bibliographic data |
Free format text: CORRECT: ADDRESS; FROM: 200021 HUANGPU, SHANGHAI TO: 200050 CHANGNING, SHANGHAI |
|
TR01 | Transfer of patent right |
Effective date of registration: 20120815 Address after: 200050, 33 floor, multimedia Industrial Park, No. 1027, Changning Road, Shanghai Patentee after: Shanghai Sundise Chinese Medicine Technology Development Co.,Ltd. Address before: 200021 Shanghai city Pu Road No. 185 Patentee before: SHUGUANG HOSPITAL AFFILIATED WITH SHANGHAI University OF TRADITIONAL CHINESE MEDICINE |
|
CP03 | Change of name, title or address | ||
CP03 | Change of name, title or address |
Address after: Room 3301-3302, No. 1027, Changning Road, Changning District, Shanghai 200050 Patentee after: Shanghai Baiyang Pharmaceutical Co.,Ltd. Address before: 33rd Floor, Multimedia Industrial Park, No. 1027 Changning Road, Shanghai, 200050 Patentee before: Shanghai Sundise Chinese Medicine Technology Development Co.,Ltd. |