CN1729288A - 新型腈水合酶 - Google Patents

新型腈水合酶 Download PDF

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Publication number
CN1729288A
CN1729288A CNA2003801069930A CN200380106993A CN1729288A CN 1729288 A CN1729288 A CN 1729288A CN A2003801069930 A CNA2003801069930 A CN A2003801069930A CN 200380106993 A CN200380106993 A CN 200380106993A CN 1729288 A CN1729288 A CN 1729288A
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CN
China
Prior art keywords
amino acid
sequence
nitrile hydratase
acid sequence
subunit
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CNA2003801069930A
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English (en)
Chinese (zh)
Inventor
八卷俊文
番场伸一
的石香
伊藤洁
小林英树
田中英司
及川利洋
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Mitsui Chemicals Inc
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Mitsui Chemicals Inc
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Filing date
Publication date
Application filed by Mitsui Chemicals Inc filed Critical Mitsui Chemicals Inc
Publication of CN1729288A publication Critical patent/CN1729288A/zh
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/88—Lyases (4.)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y402/00—Carbon-oxygen lyases (4.2)
    • C12Y402/01—Hydro-lyases (4.2.1)
    • C12Y402/01084—Nitrile hydratase (4.2.1.84)

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
CNA2003801069930A 2002-12-19 2003-12-15 新型腈水合酶 Pending CN1729288A (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP2002368360A JP2004194588A (ja) 2002-12-19 2002-12-19 新規なニトリルヒドラターゼ
JP368360/2002 2002-12-19
JP379280/2003 2003-11-10
JP2003379280 2003-11-10

Related Child Applications (3)

Application Number Title Priority Date Filing Date
CN2012105742761A Division CN103103175A (zh) 2002-12-19 2003-12-15 新型腈水合酶
CN2012105742117A Division CN103215242A (zh) 2002-12-19 2003-12-15 新型腈水合酶
CN2010101672031A Division CN101892211A (zh) 2002-12-19 2003-12-15 新型腈水合酶

Publications (1)

Publication Number Publication Date
CN1729288A true CN1729288A (zh) 2006-02-01

Family

ID=32684188

Family Applications (4)

Application Number Title Priority Date Filing Date
CNA2003801069930A Pending CN1729288A (zh) 2002-12-19 2003-12-15 新型腈水合酶
CN2010101672031A Pending CN101892211A (zh) 2002-12-19 2003-12-15 新型腈水合酶
CN2012105742117A Pending CN103215242A (zh) 2002-12-19 2003-12-15 新型腈水合酶
CN2012105742761A Pending CN103103175A (zh) 2002-12-19 2003-12-15 新型腈水合酶

Family Applications After (3)

Application Number Title Priority Date Filing Date
CN2010101672031A Pending CN101892211A (zh) 2002-12-19 2003-12-15 新型腈水合酶
CN2012105742117A Pending CN103215242A (zh) 2002-12-19 2003-12-15 新型腈水合酶
CN2012105742761A Pending CN103103175A (zh) 2002-12-19 2003-12-15 新型腈水合酶

Country Status (7)

Country Link
US (1) US7595184B2 (enExample)
EP (1) EP1586637B1 (enExample)
JP (1) JP2004194588A (enExample)
KR (5) KR100825147B1 (enExample)
CN (4) CN1729288A (enExample)
AU (2) AU2003289338A1 (enExample)
WO (1) WO2004056990A1 (enExample)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102517271A (zh) * 2011-12-13 2012-06-27 清华大学 一种突变腈水合酶
CN104531654A (zh) * 2011-06-07 2015-04-22 三菱丽阳株式会社 改良型腈水合酶
CN104725476A (zh) * 2015-03-31 2015-06-24 清华大学 一种钩状结构寡肽及其应用
CN102216455B (zh) * 2008-11-14 2016-05-04 三井化学株式会社 腈水合酶突变体
CN112522245A (zh) * 2020-12-09 2021-03-19 江南大学 一种腈水合酶氨基酸基序的改造及其应用

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4922757B2 (ja) * 2004-05-26 2012-04-25 三菱レイヨン株式会社 改良型ニトリルヒドラターゼ
EP1842907A1 (en) 2006-04-07 2007-10-10 B.R.A.I.N. Ag A group of novel enantioselective microbial nitrile hydratases with broad substrate specificity
JP5069032B2 (ja) * 2007-04-04 2012-11-07 ダイヤニトリックス株式会社 改良型ニトリルヒドラターゼ
JP5532618B2 (ja) * 2009-01-30 2014-06-25 三菱レイヨン株式会社 改良型ニトリルヒドラターゼ及びその製造方法
KR20120058452A (ko) 2009-04-30 2012-06-07 미쓰이 가가쿠 가부시키가이샤 3-메르캅토프로피온산 또는 그 염을 제조하는 방법
AU2012264058B2 (en) 2011-05-31 2015-10-22 Mitsubishi Chemical Corporation Improved nitrile hydratase
CN116536293A (zh) 2014-06-06 2023-08-04 三菱化学株式会社 改良型腈水合酶
RU2736086C1 (ru) * 2016-12-28 2020-11-11 Мицуи Кемикалс, Инк. Мутантная нитрилгидратаза, нуклеиновая кислота, кодирующая указанную мутантную нитрилгидратазу, вектор экспрессии и трансформант, содержащие указанную нуклеиновую кислоту, способ получения указанной мутантной нитрилгидратазы и способ получения амидного соединения
KR20190049109A (ko) 2017-11-01 2019-05-09 (주)대화정공 풀리 제조방법
KR102146408B1 (ko) 2019-04-08 2020-08-21 (주)대화정공 단류선 개선을 위해 압연롤러를 이용한 자동차 댐퍼풀리 제조방법
KR102068615B1 (ko) 2019-04-08 2020-01-21 (주)대화정공 자동차 댐퍼풀리 제조방법
CN111690675B (zh) * 2019-08-01 2022-07-19 安徽瑞邦生物科技有限公司 一种表达腈水合酶突变体的重组菌及其制备方法和应用
CN112322606B (zh) * 2020-11-20 2022-05-10 江南大学 一种腈水合酶突变体及其应用
CN113151234B (zh) * 2021-04-13 2022-08-12 浙江工业大学 腈水合酶赖氨酸突变体hba-k2h2r、编码基因及应用
CN113444714B (zh) * 2021-07-29 2022-06-21 浙江大学杭州国际科创中心 一种β亚基突变的腈水合酶突变体及其应用
CN114317507B (zh) * 2021-11-30 2024-07-02 清华大学 腈水合酶突变体及其应用
CN119343452A (zh) * 2022-06-30 2025-01-21 三井化学株式会社 突变型腈水合酶、编码该突变型腈水合酶的核酸、含有该核酸的载体及转化体、该突变型腈水合酶的制造方法、及酰胺化合物的制造方法
CN115772514B (zh) * 2022-11-03 2025-03-04 无锡新晨宇生物工程有限公司 一种腈水合酶底物通道氨基酸基序的改造用于肉桂酰胺的制备
EP4600368A1 (en) * 2024-02-09 2025-08-13 Adisseo France S.A.S. A method for enzymatic production of an amide compound

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DD274631A5 (de) 1987-09-18 1989-12-27 Kk Verfahren zur biologischen herstellung von amiden
AU627648B2 (en) 1990-02-28 1992-08-27 Teruhiko Beppu Dna fragment encoding a polypeptide having nitrile hydratase activity, a transformant containing the gene and a process for the production of amides using the transformant
JPH0856684A (ja) 1994-08-16 1996-03-05 Mitsui Toatsu Chem Inc 微生物によるアミド化合物の製造法
DE69739026D1 (de) 1996-02-14 2008-11-20 Mitsui Chemicals Inc Nitril-Hydratase, ihre Derivate und Verfahren zur Herstellung von Verbindungen
JP3380133B2 (ja) 1996-02-14 2003-02-24 三井化学株式会社 新規なニトリルヒドラターゼ
JP3408737B2 (ja) 1998-03-16 2003-05-19 三井化学株式会社 ニトリルヒドラターゼの活性化に関与するタンパク質及びそれをコードする遺伝子

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102216455B (zh) * 2008-11-14 2016-05-04 三井化学株式会社 腈水合酶突变体
CN105624139A (zh) * 2008-11-14 2016-06-01 三井化学株式会社 腈水合酶突变体
CN104531654A (zh) * 2011-06-07 2015-04-22 三菱丽阳株式会社 改良型腈水合酶
CN102517271A (zh) * 2011-12-13 2012-06-27 清华大学 一种突变腈水合酶
CN102517271B (zh) * 2011-12-13 2013-04-03 清华大学 一种突变腈水合酶
CN104725476A (zh) * 2015-03-31 2015-06-24 清华大学 一种钩状结构寡肽及其应用
CN104725476B (zh) * 2015-03-31 2018-10-16 清华大学 一种钩状结构寡肽及其应用
CN112522245A (zh) * 2020-12-09 2021-03-19 江南大学 一种腈水合酶氨基酸基序的改造及其应用

Also Published As

Publication number Publication date
KR100785549B1 (ko) 2007-12-12
KR20070110146A (ko) 2007-11-15
AU2003289338A1 (en) 2004-07-14
KR100819228B1 (ko) 2008-04-03
EP1586637B1 (en) 2014-02-26
AU2010202683A1 (en) 2010-07-15
CN101892211A (zh) 2010-11-24
KR100785548B1 (ko) 2007-12-12
JP2004194588A (ja) 2004-07-15
KR20070087054A (ko) 2007-08-27
CN103215242A (zh) 2013-07-24
KR100825147B1 (ko) 2008-04-24
KR20070007393A (ko) 2007-01-15
EP1586637A1 (en) 2005-10-19
EP1586637A4 (en) 2008-03-19
KR20050089972A (ko) 2005-09-09
AU2010202683B2 (en) 2012-01-19
KR100794001B1 (ko) 2008-01-10
WO2004056990A1 (ja) 2004-07-08
US7595184B2 (en) 2009-09-29
CN103103175A (zh) 2013-05-15
KR20070011620A (ko) 2007-01-24
US20070009985A1 (en) 2007-01-11

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Application publication date: 20060201