CN1706847B - 制备10α-[4'-(S,S-二氧代硫代吗啉-1'-基)]-10-脱氧-10-二氢青蒿素的方法 - Google Patents
制备10α-[4'-(S,S-二氧代硫代吗啉-1'-基)]-10-脱氧-10-二氢青蒿素的方法 Download PDFInfo
- Publication number
- CN1706847B CN1706847B CN2005100792783A CN200510079278A CN1706847B CN 1706847 B CN1706847 B CN 1706847B CN 2005100792783 A CN2005100792783 A CN 2005100792783A CN 200510079278 A CN200510079278 A CN 200510079278A CN 1706847 B CN1706847 B CN 1706847B
- Authority
- CN
- China
- Prior art keywords
- formula
- compound
- reaction
- thiomorpholine
- dihydroartemisinin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 0 C[C@]1[C@@](CC2)[C@]34OOC2(C)O[C@]3*C(*)[C@@](C)[C@@]4CC1 Chemical compound C[C@]1[C@@](CC2)[C@]34OOC2(C)O[C@]3*C(*)[C@@](C)[C@@]4CC1 0.000 description 2
- HZXPDQRNVWNKOY-UHFFFAOYSA-N CC(CC1)CCS1(=O)=O Chemical compound CC(CC1)CCS1(=O)=O HZXPDQRNVWNKOY-UHFFFAOYSA-N 0.000 description 1
- BUGOPWGPQGYYGR-UHFFFAOYSA-N O=S1(CCCCC1)=O Chemical compound O=S1(CCCCC1)=O BUGOPWGPQGYYGR-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/12—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains three hetero rings
- C07D493/18—Bridged systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
- A61P33/06—Antimalarials
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Tropical Medicine & Parasitology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Abstract
Description
Claims (15)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE102004027871.7 | 2004-06-08 | ||
DE102004027871A DE102004027871B3 (de) | 2004-06-08 | 2004-06-08 | Verfahren zur Herstellung von 10α-[4'-(S,S-Dioxothiomorpholin-1'-yl)]-10-desoxo-10-dihydroartemisinin |
Publications (2)
Publication Number | Publication Date |
---|---|
CN1706847A CN1706847A (zh) | 2005-12-14 |
CN1706847B true CN1706847B (zh) | 2011-11-23 |
Family
ID=34981617
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN2005100792783A Expired - Fee Related CN1706847B (zh) | 2004-06-08 | 2005-06-08 | 制备10α-[4'-(S,S-二氧代硫代吗啉-1'-基)]-10-脱氧-10-二氢青蒿素的方法 |
Country Status (6)
Country | Link |
---|---|
US (1) | US7241888B2 (zh) |
EP (1) | EP1604992B1 (zh) |
JP (1) | JP4790317B2 (zh) |
CN (1) | CN1706847B (zh) |
AT (1) | ATE438648T1 (zh) |
DE (2) | DE102004027871B3 (zh) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2009033494A1 (en) * | 2007-09-10 | 2009-03-19 | Dafra Pharma N.V. | 1- or 2-substituted artemisinin derivatives for increasing the in vivo biological activity of biologically active compounds |
JP6335877B2 (ja) | 2012-04-18 | 2018-05-30 | ザ ホン コン ユニバーシティ オブ サイエンス アンド テクノロジイ | ウイルス感染を治療する方法および組成物 |
CN107793427A (zh) * | 2016-08-30 | 2018-03-13 | 天津太平洋制药有限公司 | 一种青蒿琥酯的制备方法 |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6649647B1 (en) * | 1998-07-14 | 2003-11-18 | Richard Haynes | Trioxane derivatives |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IE46285B1 (en) * | 1977-01-17 | 1983-04-20 | Warner Lambert Co | 6,7-dimethoxy-2-(4-thiomorpholinyl)-4-quinazolinamine,its oxides and salts |
EP0004904B1 (de) * | 1978-04-14 | 1981-07-29 | Bayer Ag | 2-Amino-3a,4,5,6-tetrahydro-perimidin-Derivate, diese enthaltende Arzneimittel und Verfahren zu ihrer Herstellung |
US4572910A (en) * | 1983-03-03 | 1986-02-25 | Riker Laboratories, Inc. | Triazolo[1,5-c]pyrimidines substituted by nitrogen-containing heterocyclic rings |
YU2101A (sh) * | 1998-07-14 | 2005-06-10 | Bayer Aktiengesellschaft | Antiparazitski derivati artemisinina (endoperoksidi) |
US20020137755A1 (en) * | 2000-12-04 | 2002-09-26 | Bilodeau Mark T. | Tyrosine kinase inhibitors |
DE60222931T2 (de) * | 2001-12-13 | 2008-07-10 | Asubio Pharma Co., Ltd. | Pyrazolopyrimidinonderivate mit pde7-hemmender wirkung |
NZ535084A (en) * | 2002-03-08 | 2006-05-26 | Bayer Business Services Gmbh | C-10 substituted artemisinin derivatives for the treatment of diseases caused by infection with a parasite |
-
2004
- 2004-06-08 DE DE102004027871A patent/DE102004027871B3/de not_active Expired - Fee Related
-
2005
- 2005-05-21 DE DE502005007827T patent/DE502005007827D1/de active Active
- 2005-05-21 EP EP05011046A patent/EP1604992B1/de not_active Not-in-force
- 2005-05-21 AT AT05011046T patent/ATE438648T1/de active
- 2005-06-01 JP JP2005161774A patent/JP4790317B2/ja not_active Expired - Fee Related
- 2005-06-06 US US11/145,840 patent/US7241888B2/en not_active Expired - Fee Related
- 2005-06-08 CN CN2005100792783A patent/CN1706847B/zh not_active Expired - Fee Related
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6649647B1 (en) * | 1998-07-14 | 2003-11-18 | Richard Haynes | Trioxane derivatives |
Also Published As
Publication number | Publication date |
---|---|
JP2005350461A (ja) | 2005-12-22 |
DE502005007827D1 (de) | 2009-09-17 |
US20050282804A1 (en) | 2005-12-22 |
DE102004027871B3 (de) | 2006-03-16 |
CN1706847A (zh) | 2005-12-14 |
US7241888B2 (en) | 2007-07-10 |
EP1604992B1 (de) | 2009-08-05 |
EP1604992A1 (de) | 2005-12-14 |
JP4790317B2 (ja) | 2011-10-12 |
ATE438648T1 (de) | 2009-08-15 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
C06 | Publication | ||
PB01 | Publication | ||
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
ASS | Succession or assignment of patent right |
Owner name: SALTIGO GMBH Free format text: FORMER OWNER: LANXESS DEUTSCHLAND GMBH Effective date: 20081024 |
|
C41 | Transfer of patent application or patent right or utility model | ||
TA01 | Transfer of patent application right |
Effective date of registration: 20081024 Address after: Germany Lang root saierde Applicant after: Saltigo GmbH Address before: Germany Leverkusen Applicant before: Lanxess Deutschland GmbH |
|
C14 | Grant of patent or utility model | ||
GR01 | Patent grant | ||
CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20111123 Termination date: 20150608 |
|
EXPY | Termination of patent right or utility model |