CN1684961A - 生产羟烷基莨菪烷酯的方法 - Google Patents

生产羟烷基莨菪烷酯的方法 Download PDF

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Publication number
CN1684961A
CN1684961A CNA038233215A CN03823321A CN1684961A CN 1684961 A CN1684961 A CN 1684961A CN A038233215 A CNA038233215 A CN A038233215A CN 03823321 A CN03823321 A CN 03823321A CN 1684961 A CN1684961 A CN 1684961A
Authority
CN
China
Prior art keywords
tropane
ester
reaction
alkane glycol
hydroxypropyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CNA038233215A
Other languages
English (en)
Chinese (zh)
Inventor
A·H·卢因
J·P·海斯
钟德松
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Entropin Inc
Original Assignee
Entropin Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Entropin Inc filed Critical Entropin Inc
Publication of CN1684961A publication Critical patent/CN1684961A/zh
Pending legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
    • C07D451/06—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
    • C07D451/06—Oxygen atoms
    • C07D451/10—Oxygen atoms acylated by aliphatic or araliphatic carboxylic acids, e.g. atropine, scopolamine

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
CNA038233215A 2002-08-21 2003-08-21 生产羟烷基莨菪烷酯的方法 Pending CN1684961A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US40543302P 2002-08-21 2002-08-21
US60/405,433 2002-08-21

Publications (1)

Publication Number Publication Date
CN1684961A true CN1684961A (zh) 2005-10-19

Family

ID=31946871

Family Applications (1)

Application Number Title Priority Date Filing Date
CNA038233215A Pending CN1684961A (zh) 2002-08-21 2003-08-21 生产羟烷基莨菪烷酯的方法

Country Status (10)

Country Link
US (1) US20040171834A1 (es)
EP (1) EP1532143A1 (es)
JP (1) JP2005537311A (es)
CN (1) CN1684961A (es)
AU (1) AU2003265626A1 (es)
BR (1) BR0313652A (es)
CA (1) CA2495988A1 (es)
MX (1) MXPA05002012A (es)
TW (1) TW200410966A (es)
WO (1) WO2004018464A1 (es)

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2893996A (en) * 1957-10-14 1959-07-07 Grace W R & Co N-amino derivatives of tropine alkaloids
US2948730A (en) * 1959-02-04 1960-08-09 Grace W R & Co 8-aminotropanium compounds
US4469700A (en) * 1981-06-19 1984-09-04 Lowell M. Somers Benzoylecgonine or benzoylnorecgonine as active agents for the treatment of rheumatoid arthritis
US4512996A (en) * 1982-12-13 1985-04-23 Lowell Somers Benzoylecgonine or benzoylnorecgonine as active agents for the treatment of rheumatoid arthritis
US4556663A (en) * 1982-12-13 1985-12-03 Somers Lowell M Benzoylecgonine, benzoylnorecgonine and ecgonine as active agents for the treatment of rheumatoid arthritis and osteoarthritis
US5376667A (en) * 1992-12-31 1994-12-27 Entropin, Inc. Derivatives of benzoylecgonine, ecgonine and their multiple pharmacological properties

Also Published As

Publication number Publication date
US20040171834A1 (en) 2004-09-02
AU2003265626A1 (en) 2004-03-11
BR0313652A (pt) 2005-06-21
JP2005537311A (ja) 2005-12-08
EP1532143A1 (en) 2005-05-25
TW200410966A (en) 2004-07-01
MXPA05002012A (es) 2005-08-29
CA2495988A1 (en) 2004-03-04
WO2004018464A1 (en) 2004-03-04

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C06 Publication
PB01 Publication
C02 Deemed withdrawal of patent application after publication (patent law 2001)
WD01 Invention patent application deemed withdrawn after publication