BR0313652A - Processos para a produção de ésteres de hidroxialquil tropano - Google Patents
Processos para a produção de ésteres de hidroxialquil tropanoInfo
- Publication number
- BR0313652A BR0313652A BR0313652-3A BR0313652A BR0313652A BR 0313652 A BR0313652 A BR 0313652A BR 0313652 A BR0313652 A BR 0313652A BR 0313652 A BR0313652 A BR 0313652A
- Authority
- BR
- Brazil
- Prior art keywords
- tropane
- hydroxyalkyl
- ester
- processes
- production
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
- C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
- C07D451/06—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
- C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
- C07D451/06—Oxygen atoms
- C07D451/10—Oxygen atoms acylated by aliphatic or araliphatic carboxylic acids, e.g. atropine, scopolamine
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
"PROCESSOS PARA A PRODUçãO DE éSTERES DE HIDROXIALQUIL TROPANO". A presente invenção refere-se a proporciona um processo para a preparação de éster de hidroxialquil tropano, compreendendo: (a) contatar um tropano com 1,1<39>-carbonildiimidazol para produzir um éster ativado de tropano; (b) contatar o éster ativado de tropano com um excesso de um alcanodiol para formar uma mistura de reação; e (c) manter a mistura de reação a uma temperatura e por um tempo suficiente para que o éster ativado de tropano reaja com o alcanodiol para formar o correspondente éster de hidroxialquil tropano. Esse processo pode ser utilizado para produzir derivados de hidroxialquil tropanos, tais como, benzoilecgonina, ecgonina e ecgonidina.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US40543302P | 2002-08-21 | 2002-08-21 | |
PCT/US2003/026433 WO2004018464A1 (en) | 2002-08-21 | 2003-08-21 | Methods for producing hydroxyalkyl tropane esters |
Publications (1)
Publication Number | Publication Date |
---|---|
BR0313652A true BR0313652A (pt) | 2005-06-21 |
Family
ID=31946871
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR0313652-3A BR0313652A (pt) | 2002-08-21 | 2003-08-21 | Processos para a produção de ésteres de hidroxialquil tropano |
Country Status (10)
Country | Link |
---|---|
US (1) | US20040171834A1 (pt) |
EP (1) | EP1532143A1 (pt) |
JP (1) | JP2005537311A (pt) |
CN (1) | CN1684961A (pt) |
AU (1) | AU2003265626A1 (pt) |
BR (1) | BR0313652A (pt) |
CA (1) | CA2495988A1 (pt) |
MX (1) | MXPA05002012A (pt) |
TW (1) | TW200410966A (pt) |
WO (1) | WO2004018464A1 (pt) |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2893996A (en) * | 1957-10-14 | 1959-07-07 | Grace W R & Co | N-amino derivatives of tropine alkaloids |
US2948730A (en) * | 1959-02-04 | 1960-08-09 | Grace W R & Co | 8-aminotropanium compounds |
US4469700A (en) * | 1981-06-19 | 1984-09-04 | Lowell M. Somers | Benzoylecgonine or benzoylnorecgonine as active agents for the treatment of rheumatoid arthritis |
US4512996A (en) * | 1982-12-13 | 1985-04-23 | Lowell Somers | Benzoylecgonine or benzoylnorecgonine as active agents for the treatment of rheumatoid arthritis |
US4556663A (en) * | 1982-12-13 | 1985-12-03 | Somers Lowell M | Benzoylecgonine, benzoylnorecgonine and ecgonine as active agents for the treatment of rheumatoid arthritis and osteoarthritis |
US5376667A (en) * | 1992-12-31 | 1994-12-27 | Entropin, Inc. | Derivatives of benzoylecgonine, ecgonine and their multiple pharmacological properties |
-
2003
- 2003-08-21 WO PCT/US2003/026433 patent/WO2004018464A1/en not_active Application Discontinuation
- 2003-08-21 US US10/646,284 patent/US20040171834A1/en not_active Abandoned
- 2003-08-21 JP JP2004529903A patent/JP2005537311A/ja not_active Withdrawn
- 2003-08-21 AU AU2003265626A patent/AU2003265626A1/en not_active Abandoned
- 2003-08-21 TW TW092123031A patent/TW200410966A/zh unknown
- 2003-08-21 CN CNA038233215A patent/CN1684961A/zh active Pending
- 2003-08-21 MX MXPA05002012A patent/MXPA05002012A/es active IP Right Grant
- 2003-08-21 BR BR0313652-3A patent/BR0313652A/pt not_active Application Discontinuation
- 2003-08-21 EP EP03793331A patent/EP1532143A1/en not_active Withdrawn
- 2003-08-21 CA CA002495988A patent/CA2495988A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
JP2005537311A (ja) | 2005-12-08 |
US20040171834A1 (en) | 2004-09-02 |
AU2003265626A1 (en) | 2004-03-11 |
EP1532143A1 (en) | 2005-05-25 |
TW200410966A (en) | 2004-07-01 |
CA2495988A1 (en) | 2004-03-04 |
MXPA05002012A (es) | 2005-08-29 |
CN1684961A (zh) | 2005-10-19 |
WO2004018464A1 (en) | 2004-03-04 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
B11A | Dismissal acc. art.33 of ipl - examination not requested within 36 months of filing | ||
B11Y | Definitive dismissal - extension of time limit for request of examination expired [chapter 11.1.1 patent gazette] |