CN1679657A - 东紫苏提取物以及在制药中的应用 - Google Patents
东紫苏提取物以及在制药中的应用 Download PDFInfo
- Publication number
- CN1679657A CN1679657A CN 200410030595 CN200410030595A CN1679657A CN 1679657 A CN1679657 A CN 1679657A CN 200410030595 CN200410030595 CN 200410030595 CN 200410030595 A CN200410030595 A CN 200410030595A CN 1679657 A CN1679657 A CN 1679657A
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- CN
- China
- Prior art keywords
- extract
- medicine
- preparation
- solvent
- application
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000284 extract Substances 0.000 title claims abstract description 36
- 239000003814 drug Substances 0.000 title claims abstract description 16
- 238000002360 preparation method Methods 0.000 title claims description 11
- 235000004347 Perilla Nutrition 0.000 title abstract 3
- 244000124853 Perilla frutescens Species 0.000 title 1
- 239000002904 solvent Substances 0.000 claims abstract description 13
- 208000006454 hepatitis Diseases 0.000 claims abstract description 5
- 238000001035 drying Methods 0.000 claims abstract description 4
- 238000010992 reflux Methods 0.000 claims abstract description 4
- 238000007670 refining Methods 0.000 claims abstract description 3
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 claims description 10
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 9
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims description 8
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 claims description 6
- 241000712461 unidentified influenza virus Species 0.000 claims description 6
- 239000012141 concentrate Substances 0.000 claims description 5
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 claims description 4
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 claims description 4
- 239000000706 filtrate Substances 0.000 claims description 4
- 241000119909 Elsholtzia bodinieri Species 0.000 claims description 3
- 230000000202 analgesic effect Effects 0.000 claims description 3
- 230000000954 anitussive effect Effects 0.000 claims description 3
- 229940124584 antitussives Drugs 0.000 claims description 3
- ZZVUWRFHKOJYTH-UHFFFAOYSA-N diphenhydramine Chemical compound C=1C=CC=CC=1C(OCCN(C)C)C1=CC=CC=C1 ZZVUWRFHKOJYTH-UHFFFAOYSA-N 0.000 claims description 3
- 238000002791 soaking Methods 0.000 claims description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 3
- 239000002260 anti-inflammatory agent Substances 0.000 claims description 2
- 230000001741 anti-phlogistic effect Effects 0.000 claims description 2
- 235000008216 herbs Nutrition 0.000 claims description 2
- 239000003208 petroleum Substances 0.000 claims description 2
- 238000000926 separation method Methods 0.000 claims description 2
- 206010011224 Cough Diseases 0.000 abstract description 3
- 206010022000 influenza Diseases 0.000 abstract description 3
- 231100000283 hepatitis Toxicity 0.000 abstract description 2
- 241000229722 Perilla <angiosperm> Species 0.000 abstract 2
- 206010061218 Inflammation Diseases 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 238000001914 filtration Methods 0.000 abstract 1
- 230000004054 inflammatory process Effects 0.000 abstract 1
- 238000012360 testing method Methods 0.000 description 12
- 241000196324 Embryophyta Species 0.000 description 4
- 241000699670 Mus sp. Species 0.000 description 4
- CTQNGGLPUBDAKN-UHFFFAOYSA-N O-Xylene Chemical compound CC1=CC=CC=C1C CTQNGGLPUBDAKN-UHFFFAOYSA-N 0.000 description 4
- 238000005516 engineering process Methods 0.000 description 4
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 3
- 241000699666 Mus <mouse, genus> Species 0.000 description 3
- 235000019439 ethyl acetate Nutrition 0.000 description 3
- 239000000546 pharmaceutical excipient Substances 0.000 description 3
- -1 Dichlorodiphenyl Acetate Chemical compound 0.000 description 2
- 208000005141 Otitis Diseases 0.000 description 2
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 2
- RAHZWNYVWXNFOC-UHFFFAOYSA-N Sulphur dioxide Chemical compound O=S=O RAHZWNYVWXNFOC-UHFFFAOYSA-N 0.000 description 2
- 239000002775 capsule Substances 0.000 description 2
- 239000008187 granular material Substances 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 230000000144 pharmacologic effect Effects 0.000 description 2
- 230000002265 prevention Effects 0.000 description 2
- 239000000741 silica gel Substances 0.000 description 2
- 229910002027 silica gel Inorganic materials 0.000 description 2
- VZGDMQKNWNREIO-UHFFFAOYSA-N tetrachloromethane Chemical compound ClC(Cl)(Cl)Cl VZGDMQKNWNREIO-UHFFFAOYSA-N 0.000 description 2
- 241000287828 Gallus gallus Species 0.000 description 1
- 239000009636 Huang Qi Substances 0.000 description 1
- 229920000168 Microcrystalline cellulose Polymers 0.000 description 1
- 240000000249 Morus alba Species 0.000 description 1
- 235000008708 Morus alba Nutrition 0.000 description 1
- 244000061458 Solanum melongena Species 0.000 description 1
- 229910000831 Steel Inorganic materials 0.000 description 1
- 241000194017 Streptococcus Species 0.000 description 1
- 241000193998 Streptococcus pneumoniae Species 0.000 description 1
- 244000269722 Thea sinensis Species 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
- 230000003110 anti-inflammatory effect Effects 0.000 description 1
- 229940088710 antibiotic agent Drugs 0.000 description 1
- 239000010692 aromatic oil Substances 0.000 description 1
- 230000003385 bacteriostatic effect Effects 0.000 description 1
- 210000003837 chick embryo Anatomy 0.000 description 1
- 230000006837 decompression Effects 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 239000002552 dosage form Substances 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 210000004907 gland Anatomy 0.000 description 1
- 230000035931 haemagglutination Effects 0.000 description 1
- 230000002949 hemolytic effect Effects 0.000 description 1
- 231100000753 hepatic injury Toxicity 0.000 description 1
- 238000011534 incubation Methods 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 210000001161 mammalian embryo Anatomy 0.000 description 1
- 239000012567 medical material Substances 0.000 description 1
- 235000019813 microcrystalline cellulose Nutrition 0.000 description 1
- 239000008108 microcrystalline cellulose Substances 0.000 description 1
- 229940016286 microcrystalline cellulose Drugs 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 229940100691 oral capsule Drugs 0.000 description 1
- 239000000419 plant extract Substances 0.000 description 1
- 239000010773 plant oil Substances 0.000 description 1
- 230000001681 protective effect Effects 0.000 description 1
- 238000004064 recycling Methods 0.000 description 1
- 239000011347 resin Substances 0.000 description 1
- 229920005989 resin Polymers 0.000 description 1
- 210000002345 respiratory system Anatomy 0.000 description 1
- 239000007901 soft capsule Substances 0.000 description 1
- 239000010959 steel Substances 0.000 description 1
- 239000003826 tablet Substances 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 231100000820 toxicity test Toxicity 0.000 description 1
- 239000003643 water by type Substances 0.000 description 1
- 239000008096 xylene Substances 0.000 description 1
Landscapes
- Medicines Containing Plant Substances (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Description
Claims (10)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CNB2004100305951A CN100389788C (zh) | 2004-04-10 | 2004-04-10 | 东紫苏提取物以及在制药中的应用 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CNB2004100305951A CN100389788C (zh) | 2004-04-10 | 2004-04-10 | 东紫苏提取物以及在制药中的应用 |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CNA2007101806886A Division CN101156889A (zh) | 2004-04-10 | 2004-04-10 | 东紫苏提取物在制药中的应用 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN1679657A true CN1679657A (zh) | 2005-10-12 |
CN100389788C CN100389788C (zh) | 2008-05-28 |
Family
ID=35066663
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CNB2004100305951A Expired - Lifetime CN100389788C (zh) | 2004-04-10 | 2004-04-10 | 东紫苏提取物以及在制药中的应用 |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN100389788C (zh) |
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2010184915A (ja) * | 2009-02-13 | 2010-08-26 | Maruzen Pharmaceut Co Ltd | 化粧料及び飲食品 |
CN102204952A (zh) * | 2011-05-20 | 2011-10-05 | 山东大学齐鲁医院 | 一种紫苏提取物口含片 |
CN104171211A (zh) * | 2014-09-11 | 2014-12-03 | 勐海茶业有限责任公司 | 一种凉茶及其制备方法 |
CN108095030A (zh) * | 2017-12-14 | 2018-06-01 | 成都新柯力化工科技有限公司 | 一种从紫苏叶中提取天然食品口感调节剂的方法 |
CN116392518A (zh) * | 2023-04-19 | 2023-07-07 | 昆明理工大学 | 东紫苏及其提取物在制备慢性压力脑区病变药物中的应用 |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1060019C (zh) * | 1996-09-28 | 2001-01-03 | 李金穗 | 凤尾茶的制备方法 |
-
2004
- 2004-04-10 CN CNB2004100305951A patent/CN100389788C/zh not_active Expired - Lifetime
Cited By (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2010184915A (ja) * | 2009-02-13 | 2010-08-26 | Maruzen Pharmaceut Co Ltd | 化粧料及び飲食品 |
CN102204952A (zh) * | 2011-05-20 | 2011-10-05 | 山东大学齐鲁医院 | 一种紫苏提取物口含片 |
CN104171211A (zh) * | 2014-09-11 | 2014-12-03 | 勐海茶业有限责任公司 | 一种凉茶及其制备方法 |
CN108095030A (zh) * | 2017-12-14 | 2018-06-01 | 成都新柯力化工科技有限公司 | 一种从紫苏叶中提取天然食品口感调节剂的方法 |
CN116392518A (zh) * | 2023-04-19 | 2023-07-07 | 昆明理工大学 | 东紫苏及其提取物在制备慢性压力脑区病变药物中的应用 |
CN116392518B (zh) * | 2023-04-19 | 2024-03-15 | 昆明理工大学 | 东紫苏及其提取物在制备慢性压力脑区病变药物中的应用 |
Also Published As
Publication number | Publication date |
---|---|
CN100389788C (zh) | 2008-05-28 |
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C06 | Publication | ||
PB01 | Publication | ||
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SE01 | Entry into force of request for substantive examination | ||
C14 | Grant of patent or utility model | ||
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Application publication date: 20051012 Assignee: Yunnan Baiyao Group Co.,Ltd. Assignor: YUNNAN INSTITUTE OF MATERIA MEDICA Contract record no.: X2022530000005 Denomination of invention: Perilla frutescens extract and its application in pharmaceutical industry Granted publication date: 20080528 License type: Common License Record date: 20220624 |
|
CX01 | Expiry of patent term | ||
CX01 | Expiry of patent term |
Granted publication date: 20080528 |