CN1660048A - 一种具有美容养颜作用的霜剂 - Google Patents
一种具有美容养颜作用的霜剂 Download PDFInfo
- Publication number
- CN1660048A CN1660048A CN 200410104437 CN200410104437A CN1660048A CN 1660048 A CN1660048 A CN 1660048A CN 200410104437 CN200410104437 CN 200410104437 CN 200410104437 A CN200410104437 A CN 200410104437A CN 1660048 A CN1660048 A CN 1660048A
- Authority
- CN
- China
- Prior art keywords
- radix
- cream
- mannatide
- beautification
- fructus
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000843 powder Substances 0.000 title claims abstract description 30
- 230000000694 effects Effects 0.000 title claims description 37
- 239000006071 cream Substances 0.000 claims abstract description 51
- 239000003814 drug Substances 0.000 claims abstract description 43
- 239000000203 mixture Substances 0.000 claims abstract description 20
- 150000008442 polyphenolic compounds Chemical class 0.000 claims abstract description 20
- 235000013824 polyphenols Nutrition 0.000 claims abstract description 20
- YWIVKILSMZOHHF-QJZPQSOGSA-N sodium;(2s,3s,4s,5r,6r)-6-[(2s,3r,4r,5s,6r)-3-acetamido-2-[(2s,3s,4r,5r,6r)-6-[(2r,3r,4r,5s,6r)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2- Chemical compound [Na+].CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 YWIVKILSMZOHHF-QJZPQSOGSA-N 0.000 claims abstract description 20
- 239000000463 material Substances 0.000 claims abstract description 15
- 239000002537 cosmetic Substances 0.000 claims abstract description 11
- 244000269722 Thea sinensis Species 0.000 claims description 28
- 244000293323 Cosmos caudatus Species 0.000 claims description 24
- 235000005956 Cosmos caudatus Nutrition 0.000 claims description 24
- 210000000582 semen Anatomy 0.000 claims description 22
- 235000013616 tea Nutrition 0.000 claims description 19
- 241000190633 Cordyceps Species 0.000 claims description 11
- 241000218628 Ginkgo Species 0.000 claims description 11
- 235000011201 Ginkgo Nutrition 0.000 claims description 11
- 235000008100 Ginkgo biloba Nutrition 0.000 claims description 11
- 235000009569 green tea Nutrition 0.000 claims description 11
- 230000005855 radiation Effects 0.000 claims description 11
- 241000208340 Araliaceae Species 0.000 claims description 9
- 235000005035 Panax pseudoginseng ssp. pseudoginseng Nutrition 0.000 claims description 9
- 235000003140 Panax quinquefolius Nutrition 0.000 claims description 9
- 235000008434 ginseng Nutrition 0.000 claims description 9
- 230000003647 oxidation Effects 0.000 claims description 9
- 238000007254 oxidation reaction Methods 0.000 claims description 9
- 241000222336 Ganoderma Species 0.000 claims description 8
- 241000180649 Panax notoginseng Species 0.000 claims description 8
- 235000003143 Panax notoginseng Nutrition 0.000 claims description 8
- 241001448530 Rohdea japonica Species 0.000 claims description 8
- 235000010603 pastilles Nutrition 0.000 claims description 8
- 230000003110 anti-inflammatory effect Effects 0.000 claims description 6
- 239000009636 Huang Qi Substances 0.000 claims description 5
- 241000237636 Pheretima Species 0.000 claims description 5
- 239000010135 fructus aurantii immaturus Substances 0.000 claims description 5
- 239000004615 ingredient Substances 0.000 claims description 5
- 210000002826 placenta Anatomy 0.000 claims description 5
- 230000002804 anti-anaphylactic effect Effects 0.000 claims description 4
- 238000000034 method Methods 0.000 abstract description 16
- 238000002360 preparation method Methods 0.000 abstract description 16
- 230000009759 skin aging Effects 0.000 abstract description 11
- 108090000765 processed proteins & peptides Proteins 0.000 abstract description 10
- 229920000057 Mannan Polymers 0.000 abstract description 6
- 230000008569 process Effects 0.000 abstract description 5
- 230000007246 mechanism Effects 0.000 abstract description 3
- 102000004196 processed proteins & peptides Human genes 0.000 abstract description 3
- 229920002385 Sodium hyaluronate Polymers 0.000 abstract 1
- 241001122767 Theaceae Species 0.000 abstract 1
- 229940010747 sodium hyaluronate Drugs 0.000 abstract 1
- 210000003491 skin Anatomy 0.000 description 47
- 239000000243 solution Substances 0.000 description 34
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 21
- 241001494479 Pecora Species 0.000 description 19
- 239000000047 product Substances 0.000 description 19
- 238000012360 testing method Methods 0.000 description 19
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 17
- 210000003743 erythrocyte Anatomy 0.000 description 17
- 238000000855 fermentation Methods 0.000 description 16
- 230000004151 fermentation Effects 0.000 description 15
- 108010010998 polyactin A Proteins 0.000 description 15
- 230000001580 bacterial effect Effects 0.000 description 14
- 239000008363 phosphate buffer Substances 0.000 description 14
- 239000013558 reference substance Substances 0.000 description 14
- 238000004519 manufacturing process Methods 0.000 description 13
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 12
- 230000000295 complement effect Effects 0.000 description 12
- 150000003254 radicals Chemical class 0.000 description 12
- 239000000725 suspension Substances 0.000 description 10
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 9
- 206010018910 Haemolysis Diseases 0.000 description 9
- 230000008588 hemolysis Effects 0.000 description 9
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 8
- 239000000427 antigen Substances 0.000 description 8
- 108091007433 antigens Proteins 0.000 description 8
- 102000036639 antigens Human genes 0.000 description 8
- 108090000623 proteins and genes Proteins 0.000 description 8
- 235000001014 amino acid Nutrition 0.000 description 7
- 150000001413 amino acids Chemical class 0.000 description 7
- 239000007788 liquid Substances 0.000 description 7
- 235000016709 nutrition Nutrition 0.000 description 7
- 230000035764 nutrition Effects 0.000 description 7
- 102000004169 proteins and genes Human genes 0.000 description 7
- 206010070834 Sensitisation Diseases 0.000 description 6
- 239000003153 chemical reaction reagent Substances 0.000 description 6
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 6
- 238000010790 dilution Methods 0.000 description 6
- 239000012895 dilution Substances 0.000 description 6
- 230000005847 immunogenicity Effects 0.000 description 6
- 239000007924 injection Substances 0.000 description 6
- 238000002347 injection Methods 0.000 description 6
- 230000008313 sensitization Effects 0.000 description 6
- 239000011780 sodium chloride Substances 0.000 description 6
- 238000003756 stirring Methods 0.000 description 6
- 239000006228 supernatant Substances 0.000 description 6
- PMMYEEVYMWASQN-DMTCNVIQSA-N Hydroxyproline Chemical compound O[C@H]1CN[C@H](C(O)=O)C1 PMMYEEVYMWASQN-DMTCNVIQSA-N 0.000 description 5
- 208000003351 Melanosis Diseases 0.000 description 5
- 241000699666 Mus <mouse, genus> Species 0.000 description 5
- 210000004027 cell Anatomy 0.000 description 5
- 238000005660 chlorination reaction Methods 0.000 description 5
- 230000009849 deactivation Effects 0.000 description 5
- PMMYEEVYMWASQN-UHFFFAOYSA-N dl-hydroxyproline Natural products OC1C[NH2+]C(C([O-])=O)C1 PMMYEEVYMWASQN-UHFFFAOYSA-N 0.000 description 5
- 229940079593 drug Drugs 0.000 description 5
- 229960004756 ethanol Drugs 0.000 description 5
- 230000006870 function Effects 0.000 description 5
- 239000001963 growth medium Substances 0.000 description 5
- 229960002591 hydroxyproline Drugs 0.000 description 5
- 244000005700 microbiome Species 0.000 description 5
- 239000002245 particle Substances 0.000 description 5
- 238000011218 seed culture Methods 0.000 description 5
- 239000000126 substance Substances 0.000 description 5
- FGMPLJWBKKVCDB-UHFFFAOYSA-N trans-L-hydroxy-proline Natural products ON1CCCC1C(O)=O FGMPLJWBKKVCDB-UHFFFAOYSA-N 0.000 description 5
- 230000037303 wrinkles Effects 0.000 description 5
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 4
- 241000894006 Bacteria Species 0.000 description 4
- 206010008570 Chloasma Diseases 0.000 description 4
- 102000008186 Collagen Human genes 0.000 description 4
- 108010035532 Collagen Proteins 0.000 description 4
- WQZGKKKJIJFFOK-QTVWNMPRSA-N D-mannopyranose Chemical compound OC[C@H]1OC(O)[C@@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-QTVWNMPRSA-N 0.000 description 4
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 4
- 108010006464 Hemolysin Proteins Proteins 0.000 description 4
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 4
- 241001465754 Metazoa Species 0.000 description 4
- 241000283973 Oryctolagus cuniculus Species 0.000 description 4
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N Phenol Chemical compound OC1=CC=CC=C1 ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 description 4
- 241000194017 Streptococcus Species 0.000 description 4
- 238000010241 blood sampling Methods 0.000 description 4
- 238000006243 chemical reaction Methods 0.000 description 4
- 239000003085 diluting agent Substances 0.000 description 4
- 238000001035 drying Methods 0.000 description 4
- 238000005516 engineering process Methods 0.000 description 4
- 230000003203 everyday effect Effects 0.000 description 4
- 239000008103 glucose Substances 0.000 description 4
- 239000003228 hemolysin Substances 0.000 description 4
- 238000009413 insulation Methods 0.000 description 4
- 235000013372 meat Nutrition 0.000 description 4
- 238000004321 preservation Methods 0.000 description 4
- 235000018102 proteins Nutrition 0.000 description 4
- 238000012216 screening Methods 0.000 description 4
- 210000002966 serum Anatomy 0.000 description 4
- 229910052708 sodium Inorganic materials 0.000 description 4
- 239000011734 sodium Substances 0.000 description 4
- 239000008354 sodium chloride injection Substances 0.000 description 4
- 235000014347 soups Nutrition 0.000 description 4
- 230000001954 sterilising effect Effects 0.000 description 4
- WVDDGKGOMKODPV-UHFFFAOYSA-N Benzyl alcohol Chemical compound OCC1=CC=CC=C1 WVDDGKGOMKODPV-UHFFFAOYSA-N 0.000 description 3
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 3
- 239000001888 Peptone Substances 0.000 description 3
- 108010080698 Peptones Proteins 0.000 description 3
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 3
- 230000032683 aging Effects 0.000 description 3
- 230000001476 alcoholic effect Effects 0.000 description 3
- 238000004458 analytical method Methods 0.000 description 3
- 210000004204 blood vessel Anatomy 0.000 description 3
- 238000009395 breeding Methods 0.000 description 3
- 229940041514 candida albicans extract Drugs 0.000 description 3
- 230000008859 change Effects 0.000 description 3
- 239000012153 distilled water Substances 0.000 description 3
- 239000002054 inoculum Substances 0.000 description 3
- 239000006166 lysate Substances 0.000 description 3
- 238000002156 mixing Methods 0.000 description 3
- 238000002703 mutagenesis Methods 0.000 description 3
- 231100000350 mutagenesis Toxicity 0.000 description 3
- 238000012856 packing Methods 0.000 description 3
- 235000019319 peptone Nutrition 0.000 description 3
- NLKNQRATVPKPDG-UHFFFAOYSA-M potassium iodide Chemical compound [K+].[I-] NLKNQRATVPKPDG-UHFFFAOYSA-M 0.000 description 3
- 239000002244 precipitate Substances 0.000 description 3
- 210000004927 skin cell Anatomy 0.000 description 3
- 239000001117 sulphuric acid Substances 0.000 description 3
- 235000011149 sulphuric acid Nutrition 0.000 description 3
- 238000005303 weighing Methods 0.000 description 3
- 239000012138 yeast extract Substances 0.000 description 3
- 241000700199 Cavia porcellus Species 0.000 description 2
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 description 2
- 206010015150 Erythema Diseases 0.000 description 2
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 description 2
- 238000012449 Kunming mouse Methods 0.000 description 2
- ONIBWKKTOPOVIA-BYPYZUCNSA-N L-Proline Chemical compound OC(=O)[C@@H]1CCCN1 ONIBWKKTOPOVIA-BYPYZUCNSA-N 0.000 description 2
- ONIBWKKTOPOVIA-UHFFFAOYSA-N Proline Natural products OC(=O)C1CCCN1 ONIBWKKTOPOVIA-UHFFFAOYSA-N 0.000 description 2
- 244000061458 Solanum melongena Species 0.000 description 2
- 239000002671 adjuvant Substances 0.000 description 2
- 230000003266 anti-allergic effect Effects 0.000 description 2
- 238000003556 assay Methods 0.000 description 2
- 238000005842 biochemical reaction Methods 0.000 description 2
- 230000033228 biological regulation Effects 0.000 description 2
- 210000004369 blood Anatomy 0.000 description 2
- 239000008280 blood Substances 0.000 description 2
- 230000037396 body weight Effects 0.000 description 2
- 230000001488 breeding effect Effects 0.000 description 2
- JJWKPURADFRFRB-UHFFFAOYSA-N carbonyl sulfide Chemical compound O=C=S JJWKPURADFRFRB-UHFFFAOYSA-N 0.000 description 2
- 230000019522 cellular metabolic process Effects 0.000 description 2
- 210000002808 connective tissue Anatomy 0.000 description 2
- 238000001816 cooling Methods 0.000 description 2
- 239000012531 culture fluid Substances 0.000 description 2
- 230000006378 damage Effects 0.000 description 2
- 231100000321 erythema Toxicity 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 210000002744 extracellular matrix Anatomy 0.000 description 2
- 238000001914 filtration Methods 0.000 description 2
- 238000011010 flushing procedure Methods 0.000 description 2
- 230000012010 growth Effects 0.000 description 2
- 229910001385 heavy metal Inorganic materials 0.000 description 2
- 206010021198 ichthyosis Diseases 0.000 description 2
- 238000007654 immersion Methods 0.000 description 2
- 230000005764 inhibitory process Effects 0.000 description 2
- 238000007689 inspection Methods 0.000 description 2
- 238000010253 intravenous injection Methods 0.000 description 2
- 150000002632 lipids Chemical class 0.000 description 2
- 239000002609 medium Substances 0.000 description 2
- 239000002207 metabolite Substances 0.000 description 2
- 230000005486 microgravity Effects 0.000 description 2
- 230000000877 morphologic effect Effects 0.000 description 2
- 230000035772 mutation Effects 0.000 description 2
- 229910052757 nitrogen Inorganic materials 0.000 description 2
- WWZKQHOCKIZLMA-UHFFFAOYSA-N octanoic acid Chemical compound CCCCCCCC(O)=O WWZKQHOCKIZLMA-UHFFFAOYSA-N 0.000 description 2
- 230000003287 optical effect Effects 0.000 description 2
- 238000011020 pilot scale process Methods 0.000 description 2
- 239000011148 porous material Substances 0.000 description 2
- 238000003906 pulsed field gel electrophoresis Methods 0.000 description 2
- 238000007894 restriction fragment length polymorphism technique Methods 0.000 description 2
- 238000000926 separation method Methods 0.000 description 2
- 239000001509 sodium citrate Substances 0.000 description 2
- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 2
- HRZFUMHJMZEROT-UHFFFAOYSA-L sodium disulfite Chemical compound [Na+].[Na+].[O-]S(=O)S([O-])(=O)=O HRZFUMHJMZEROT-UHFFFAOYSA-L 0.000 description 2
- 235000010262 sodium metabisulphite Nutrition 0.000 description 2
- 210000004243 sweat Anatomy 0.000 description 2
- 239000012085 test solution Substances 0.000 description 2
- 210000001519 tissue Anatomy 0.000 description 2
- DQJCDTNMLBYVAY-ZXXIYAEKSA-N (2S,5R,10R,13R)-16-{[(2R,3S,4R,5R)-3-{[(2S,3R,4R,5S,6R)-3-acetamido-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}-5-(ethylamino)-6-hydroxy-2-(hydroxymethyl)oxan-4-yl]oxy}-5-(4-aminobutyl)-10-carbamoyl-2,13-dimethyl-4,7,12,15-tetraoxo-3,6,11,14-tetraazaheptadecan-1-oic acid Chemical compound NCCCC[C@H](C(=O)N[C@@H](C)C(O)=O)NC(=O)CC[C@H](C(N)=O)NC(=O)[C@@H](C)NC(=O)C(C)O[C@@H]1[C@@H](NCC)C(O)O[C@H](CO)[C@H]1O[C@H]1[C@H](NC(C)=O)[C@@H](O)[C@H](O)[C@@H](CO)O1 DQJCDTNMLBYVAY-ZXXIYAEKSA-N 0.000 description 1
- FPIPGXGPPPQFEQ-UHFFFAOYSA-N 13-cis retinol Natural products OCC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-UHFFFAOYSA-N 0.000 description 1
- QCKMEYKASJTMKI-ILCMOUOISA-N 2-aminoacetic acid;(2s)-2-aminopentanedioic acid;(2s)-pyrrolidine-2-carboxylic acid Chemical compound NCC(O)=O.OC(=O)[C@@H]1CCCN1.OC(=O)[C@@H](N)CCC(O)=O QCKMEYKASJTMKI-ILCMOUOISA-N 0.000 description 1
- 229920001817 Agar Polymers 0.000 description 1
- 206010003694 Atrophy Diseases 0.000 description 1
- 108700016947 Bos taurus structural-GP Proteins 0.000 description 1
- 239000005635 Caprylic acid (CAS 124-07-2) Substances 0.000 description 1
- 206010009900 Colitis ulcerative Diseases 0.000 description 1
- 201000004624 Dermatitis Diseases 0.000 description 1
- 101100117236 Drosophila melanogaster speck gene Proteins 0.000 description 1
- 206010013786 Dry skin Diseases 0.000 description 1
- 102000016942 Elastin Human genes 0.000 description 1
- 108010014258 Elastin Proteins 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 102000010834 Extracellular Matrix Proteins Human genes 0.000 description 1
- 108010037362 Extracellular Matrix Proteins Proteins 0.000 description 1
- 244000182067 Fraxinus ornus Species 0.000 description 1
- 235000002917 Fraxinus ornus Nutrition 0.000 description 1
- 241000233866 Fungi Species 0.000 description 1
- WHUUTDBJXJRKMK-UHFFFAOYSA-N Glutamic acid Natural products OC(=O)C(N)CCC(O)=O WHUUTDBJXJRKMK-UHFFFAOYSA-N 0.000 description 1
- 108010068370 Glutens Proteins 0.000 description 1
- 239000004471 Glycine Substances 0.000 description 1
- 108010015899 Glycopeptides Proteins 0.000 description 1
- 102000002068 Glycopeptides Human genes 0.000 description 1
- 229920002683 Glycosaminoglycan Polymers 0.000 description 1
- 101000911390 Homo sapiens Coagulation factor VIII Proteins 0.000 description 1
- 206010020741 Hyperpyrexia Diseases 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 description 1
- 208000019255 Menstrual disease Diseases 0.000 description 1
- 208000036626 Mental retardation Diseases 0.000 description 1
- 241000699670 Mus sp. Species 0.000 description 1
- 240000007594 Oryza sativa Species 0.000 description 1
- 235000007164 Oryza sativa Nutrition 0.000 description 1
- 241000283898 Ovis Species 0.000 description 1
- 102000035195 Peptidases Human genes 0.000 description 1
- 108091005804 Peptidases Proteins 0.000 description 1
- 208000012641 Pigmentation disease Diseases 0.000 description 1
- 241001619461 Poria <basidiomycete fungus> Species 0.000 description 1
- 206010039792 Seborrhoea Diseases 0.000 description 1
- 206010040799 Skin atrophy Diseases 0.000 description 1
- 206010040880 Skin irritation Diseases 0.000 description 1
- VMHLLURERBWHNL-UHFFFAOYSA-M Sodium acetate Chemical compound [Na+].CC([O-])=O VMHLLURERBWHNL-UHFFFAOYSA-M 0.000 description 1
- 102000003425 Tyrosinase Human genes 0.000 description 1
- 108060008724 Tyrosinase Proteins 0.000 description 1
- 201000006704 Ulcerative Colitis Diseases 0.000 description 1
- 240000003864 Ulex europaeus Species 0.000 description 1
- 241000700647 Variola virus Species 0.000 description 1
- 241000700605 Viruses Species 0.000 description 1
- FPIPGXGPPPQFEQ-BOOMUCAASA-N Vitamin A Natural products OC/C=C(/C)\C=C\C=C(\C)/C=C/C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-BOOMUCAASA-N 0.000 description 1
- 238000005903 acid hydrolysis reaction Methods 0.000 description 1
- 239000000853 adhesive Substances 0.000 description 1
- 230000001070 adhesive effect Effects 0.000 description 1
- 239000008272 agar Substances 0.000 description 1
- 229930013930 alkaloid Natural products 0.000 description 1
- 150000003797 alkaloid derivatives Chemical class 0.000 description 1
- FPIPGXGPPPQFEQ-OVSJKPMPSA-N all-trans-retinol Chemical compound OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-OVSJKPMPSA-N 0.000 description 1
- 125000000539 amino acid group Chemical group 0.000 description 1
- 230000008485 antagonism Effects 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
- 230000037444 atrophy Effects 0.000 description 1
- 244000052616 bacterial pathogen Species 0.000 description 1
- 230000004888 barrier function Effects 0.000 description 1
- 235000019445 benzyl alcohol Nutrition 0.000 description 1
- 230000008512 biological response Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 239000012490 blank solution Substances 0.000 description 1
- 239000000872 buffer Substances 0.000 description 1
- 238000004364 calculation method Methods 0.000 description 1
- 230000004663 cell proliferation Effects 0.000 description 1
- 239000006285 cell suspension Substances 0.000 description 1
- 230000001413 cellular effect Effects 0.000 description 1
- 235000013339 cereals Nutrition 0.000 description 1
- 239000011248 coating agent Substances 0.000 description 1
- 238000000576 coating method Methods 0.000 description 1
- 229920001436 collagen Polymers 0.000 description 1
- 235000009508 confectionery Nutrition 0.000 description 1
- 239000012043 crude product Substances 0.000 description 1
- 238000012258 culturing Methods 0.000 description 1
- 238000005520 cutting process Methods 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- 230000007850 degeneration Effects 0.000 description 1
- 229960000935 dehydrated alcohol Drugs 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 230000001627 detrimental effect Effects 0.000 description 1
- 230000008034 disappearance Effects 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- BNIILDVGGAEEIG-UHFFFAOYSA-L disodium hydrogen phosphate Chemical compound [Na+].[Na+].OP([O-])([O-])=O BNIILDVGGAEEIG-UHFFFAOYSA-L 0.000 description 1
- 229910000397 disodium phosphate Inorganic materials 0.000 description 1
- 235000019800 disodium phosphate Nutrition 0.000 description 1
- 238000009826 distribution Methods 0.000 description 1
- 230000005782 double-strand break Effects 0.000 description 1
- 230000037336 dry skin Effects 0.000 description 1
- 229920002549 elastin Polymers 0.000 description 1
- 230000002124 endocrine Effects 0.000 description 1
- 238000003912 environmental pollution Methods 0.000 description 1
- 238000012869 ethanol precipitation Methods 0.000 description 1
- 230000005284 excitation Effects 0.000 description 1
- 238000011049 filling Methods 0.000 description 1
- 235000011389 fruit/vegetable juice Nutrition 0.000 description 1
- 239000000499 gel Substances 0.000 description 1
- 235000013922 glutamic acid Nutrition 0.000 description 1
- 239000004220 glutamic acid Substances 0.000 description 1
- 150000004676 glycans Chemical class 0.000 description 1
- 230000005484 gravity Effects 0.000 description 1
- 230000009605 growth rhythm Effects 0.000 description 1
- 238000005534 hematocrit Methods 0.000 description 1
- 102000057593 human F8 Human genes 0.000 description 1
- 230000036571 hydration Effects 0.000 description 1
- 238000006703 hydration reaction Methods 0.000 description 1
- 230000036737 immune function Effects 0.000 description 1
- 230000003053 immunization Effects 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 239000012535 impurity Substances 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 238000011081 inoculation Methods 0.000 description 1
- 150000002500 ions Chemical class 0.000 description 1
- 210000004731 jugular vein Anatomy 0.000 description 1
- 238000002386 leaching Methods 0.000 description 1
- 235000014666 liquid concentrate Nutrition 0.000 description 1
- 208000019423 liver disease Diseases 0.000 description 1
- 210000002752 melanocyte Anatomy 0.000 description 1
- 230000002503 metabolic effect Effects 0.000 description 1
- 230000007102 metabolic function Effects 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 230000000813 microbial effect Effects 0.000 description 1
- 239000003607 modifier Substances 0.000 description 1
- 230000003020 moisturizing effect Effects 0.000 description 1
- 229910000402 monopotassium phosphate Inorganic materials 0.000 description 1
- 235000019796 monopotassium phosphate Nutrition 0.000 description 1
- 230000007935 neutral effect Effects 0.000 description 1
- 235000015097 nutrients Nutrition 0.000 description 1
- 229960002446 octanoic acid Drugs 0.000 description 1
- 230000009965 odorless effect Effects 0.000 description 1
- 230000037312 oily skin Effects 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- -1 oxygen free radical Chemical class 0.000 description 1
- KHIWWQKSHDUIBK-UHFFFAOYSA-N periodic acid Chemical compound OI(=O)(=O)=O KHIWWQKSHDUIBK-UHFFFAOYSA-N 0.000 description 1
- 230000035699 permeability Effects 0.000 description 1
- 238000005502 peroxidation Methods 0.000 description 1
- 230000003285 pharmacodynamic effect Effects 0.000 description 1
- PJNZPQUBCPKICU-UHFFFAOYSA-N phosphoric acid;potassium Chemical compound [K].OP(O)(O)=O PJNZPQUBCPKICU-UHFFFAOYSA-N 0.000 description 1
- 208000007578 phototoxic dermatitis Diseases 0.000 description 1
- XNGIFLGASWRNHJ-UHFFFAOYSA-L phthalate(2-) Chemical compound [O-]C(=O)C1=CC=CC=C1C([O-])=O XNGIFLGASWRNHJ-UHFFFAOYSA-L 0.000 description 1
- 230000035479 physiological effects, processes and functions Effects 0.000 description 1
- 230000019612 pigmentation Effects 0.000 description 1
- 229920002401 polyacrylamide Polymers 0.000 description 1
- 238000006116 polymerization reaction Methods 0.000 description 1
- 229920001282 polysaccharide Polymers 0.000 description 1
- 239000005017 polysaccharide Substances 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- 230000035935 pregnancy Effects 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 239000002516 radical scavenger Substances 0.000 description 1
- 229940047431 recombinate Drugs 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 230000002787 reinforcement Effects 0.000 description 1
- 230000008521 reorganization Effects 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 235000009566 rice Nutrition 0.000 description 1
- 230000000630 rising effect Effects 0.000 description 1
- 239000004576 sand Substances 0.000 description 1
- 210000002374 sebum Anatomy 0.000 description 1
- 230000028327 secretion Effects 0.000 description 1
- 230000035807 sensation Effects 0.000 description 1
- 206010040872 skin infection Diseases 0.000 description 1
- 230000036556 skin irritation Effects 0.000 description 1
- 231100000475 skin irritation Toxicity 0.000 description 1
- 230000036560 skin regeneration Effects 0.000 description 1
- 239000001632 sodium acetate Substances 0.000 description 1
- 235000017281 sodium acetate Nutrition 0.000 description 1
- 229940001584 sodium metabisulfite Drugs 0.000 description 1
- AKHNMLFCWUSKQB-UHFFFAOYSA-L sodium thiosulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=S AKHNMLFCWUSKQB-UHFFFAOYSA-L 0.000 description 1
- 235000019345 sodium thiosulphate Nutrition 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 230000035882 stress Effects 0.000 description 1
- 239000000758 substrate Substances 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 230000009967 tasteless effect Effects 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
- YODZTKMDCQEPHD-UHFFFAOYSA-N thiodiglycol Chemical compound OCCSCCO YODZTKMDCQEPHD-UHFFFAOYSA-N 0.000 description 1
- 229950006389 thiodiglycol Drugs 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 239000011573 trace mineral Substances 0.000 description 1
- 235000013619 trace mineral Nutrition 0.000 description 1
- 238000001291 vacuum drying Methods 0.000 description 1
- 210000003462 vein Anatomy 0.000 description 1
- 238000009423 ventilation Methods 0.000 description 1
- 235000019155 vitamin A Nutrition 0.000 description 1
- 239000011719 vitamin A Substances 0.000 description 1
- 229940045997 vitamin a Drugs 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
- 230000004580 weight loss Effects 0.000 description 1
- 210000004885 white matter Anatomy 0.000 description 1
- 230000002087 whitening effect Effects 0.000 description 1
- 230000037314 wound repair Effects 0.000 description 1
- 230000037373 wrinkle formation Effects 0.000 description 1
Landscapes
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
Description
组别 | 动物数 | 羟脯氨酸含量(g/100g) |
空白对照组本发明所述第一种霜剂组本发明所述第二种霜剂组本发明所述第三种霜剂组本发明所述第四种霜剂组本发明所述第五种霜剂组本发明所述第六种霜剂组α-甘露聚糖肽粉组玉兰油营养菁华霜组 | 101010101010101010 | 1.46±0.142.10±0.26**2.17±0.40**2.23±0.45**2.31±0.4***235±0.57***2.40±0.47***1.55±0.171.67±0.25 |
组别 | 动物数 甘氨酸 谷氨酸 脯氨酸 |
空白对照组本发明所述第一种霜剂组本发明所述第二种霜剂组本发明所述第三种霜剂组本发明所述第四种霜剂组本发明所述第五种霜剂组本发明所述第六种霜剂组α-甘露聚糖肽粉组玉兰油营养菁华霜组 | 10 8.91±1.14 9.99±0.82 3.57±0.4010 10.10±0.6** 11.47±0.97* 4.02±0.16*10 10.17±0.43** 11.51±1.20* 4.11±0.23*10 10.23±0.57** 12.10±0.89** 4.24±0.29**10 10.31±0.88*** 12.21±1.13** 4.30±0.37**10 10.40±0.69*** 12.40±1.42** 4.41±0.39**10 10.47±0.75*** 12.81±1.64** 4.45±0.65**10 8.95±1.21 10.04±0.21 3.60±0.2110 8.93±0.65 10.13±0.64 3.59±0.46 |
Claims (10)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CNB2004101044376A CN100453063C (zh) | 2003-12-31 | 2004-12-19 | 一种具有美容养颜作用的膏霜剂 |
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN200310122256.1 | 2003-12-31 | ||
CN200310122256 | 2003-12-31 | ||
CNB2004101044376A CN100453063C (zh) | 2003-12-31 | 2004-12-19 | 一种具有美容养颜作用的膏霜剂 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN1660048A true CN1660048A (zh) | 2005-08-31 |
CN100453063C CN100453063C (zh) | 2009-01-21 |
Family
ID=35009797
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CNB2004101044376A Expired - Fee Related CN100453063C (zh) | 2003-12-31 | 2004-12-19 | 一种具有美容养颜作用的膏霜剂 |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN100453063C (zh) |
Cited By (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102198073A (zh) * | 2011-06-08 | 2011-09-28 | 浙江欧诗漫集团有限公司 | 一种珍珠美白精华素的制备工艺 |
CN102580018A (zh) * | 2011-01-13 | 2012-07-18 | 赵金中 | 一种美白祛斑的外用保健品及其制备、使用方法 |
CN103315926A (zh) * | 2012-03-20 | 2013-09-25 | 董根荣 | 一种具有祛斑抗皱功效的中药面膜及其制备方法 |
CN103961542A (zh) * | 2014-05-26 | 2014-08-06 | 路明芳 | 一种用于祛皱的中药面膜 |
CN105381012A (zh) * | 2015-12-24 | 2016-03-09 | 兰州古驰生物科技有限公司 | 一种具有祛斑养颜功能的中药保健制剂 |
CN105581946A (zh) * | 2016-02-29 | 2016-05-18 | 苏州婷美母婴健康管理有限公司 | 一种祛除膨胀纹的乳霜 |
CN107385894A (zh) * | 2017-08-15 | 2017-11-24 | 苏州市纤维检验所 | 一种植物基抗紫外织物整理剂及其制备工艺 |
CN108014041A (zh) * | 2017-11-30 | 2018-05-11 | 陈炳坤(天津)生物技术有限公司 | 一种抗紫外线的植物提取物组合物及其制备方法 |
CN108524352A (zh) * | 2018-04-19 | 2018-09-14 | 绍兴文理学院 | 一种抗辐射制剂及其应用 |
CN108685777A (zh) * | 2018-07-10 | 2018-10-23 | 广州兰寇化妆品有限公司 | 保湿护肤组合物以及保湿护肤眼霜 |
CN110897958A (zh) * | 2019-12-18 | 2020-03-24 | 广州和佳润颜医药有限公司 | 一种抗衰老组合物及其应用 |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1096199A (zh) * | 1994-01-22 | 1994-12-14 | 福州昌江生化技术研究所 | 全溶珍珠粉及其制备方法 |
CN1175899C (zh) * | 2003-03-31 | 2004-11-17 | 成都利尔药业有限公司 | 一种药物组合物及其制备方法和用途 |
-
2004
- 2004-12-19 CN CNB2004101044376A patent/CN100453063C/zh not_active Expired - Fee Related
Cited By (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102580018A (zh) * | 2011-01-13 | 2012-07-18 | 赵金中 | 一种美白祛斑的外用保健品及其制备、使用方法 |
CN102198073A (zh) * | 2011-06-08 | 2011-09-28 | 浙江欧诗漫集团有限公司 | 一种珍珠美白精华素的制备工艺 |
CN103315926A (zh) * | 2012-03-20 | 2013-09-25 | 董根荣 | 一种具有祛斑抗皱功效的中药面膜及其制备方法 |
CN103961542A (zh) * | 2014-05-26 | 2014-08-06 | 路明芳 | 一种用于祛皱的中药面膜 |
CN105381012A (zh) * | 2015-12-24 | 2016-03-09 | 兰州古驰生物科技有限公司 | 一种具有祛斑养颜功能的中药保健制剂 |
CN105581946A (zh) * | 2016-02-29 | 2016-05-18 | 苏州婷美母婴健康管理有限公司 | 一种祛除膨胀纹的乳霜 |
CN107385894A (zh) * | 2017-08-15 | 2017-11-24 | 苏州市纤维检验所 | 一种植物基抗紫外织物整理剂及其制备工艺 |
CN108014041A (zh) * | 2017-11-30 | 2018-05-11 | 陈炳坤(天津)生物技术有限公司 | 一种抗紫外线的植物提取物组合物及其制备方法 |
CN108524352A (zh) * | 2018-04-19 | 2018-09-14 | 绍兴文理学院 | 一种抗辐射制剂及其应用 |
CN108685777A (zh) * | 2018-07-10 | 2018-10-23 | 广州兰寇化妆品有限公司 | 保湿护肤组合物以及保湿护肤眼霜 |
CN110897958A (zh) * | 2019-12-18 | 2020-03-24 | 广州和佳润颜医药有限公司 | 一种抗衰老组合物及其应用 |
Also Published As
Publication number | Publication date |
---|---|
CN100453063C (zh) | 2009-01-21 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN106727147B (zh) | 草本洋参皮肤美容改善药物及化妆品应用和制备 | |
CN100350969C (zh) | 一种具有美容养颜作用的冲剂 | |
KR20080094457A (ko) | 주름개선용 화장료 조성물 | |
CN106389225A (zh) | 一种红酒补水保湿营养面膜及其制备方法 | |
KR102125316B1 (ko) | 신규한 락토바실러스 펜토서스 j2k-185 유산균 균주 및 상기 균주를 포함하는 자극완화 및 피부진정 개선용 화장료 조성물 | |
CN100453063C (zh) | 一种具有美容养颜作用的膏霜剂 | |
CN104667197B (zh) | 一种增强免疫力的组合物及其制备方法和应用 | |
CN104491003B (zh) | 加味玉屏风凝胶剂及其制备方法和用途 | |
CN105726439A (zh) | 金蝉花美白保湿药妆品及其制备方法 | |
CN116492280A (zh) | 白细胞提取物的制备方法及其在化妆品中的应用 | |
CN108066237B (zh) | 一种具有美白、淡斑功效的组合物及其应用、护肤品 | |
CN108434338A (zh) | 以抗癌中草药为原料的扶正补虚中药制剂 | |
KR102101949B1 (ko) | 우장지버섯 자실체 추출물 또는 우장지버섯 균사체 추출물을 함유하는 피부 외용제 또는 화장료 조성물 | |
KR101794419B1 (ko) | 버섯 함유 삼투압 효소 발효물 천연 리포좀, 그 제조방법, 및 이를 포함하는 화장료, 식품 또는 약학 조성물 | |
CN107595687A (zh) | 一种广光谱防护的精华液及其制备方法 | |
CN103494746A (zh) | 檀香的新用途及一种中药复方防晒组合物 | |
CN1663602A (zh) | 一种治疗神经衰弱的药物 | |
CN106389305A (zh) | 凝肌乳 | |
CN1053568C (zh) | 草药健康美容产品 | |
CN1663606A (zh) | 一种治疗放射病的药物 | |
CN107890441B (zh) | 一种提取物及其制备方法与应用 | |
CN1176697C (zh) | 抗衰老药物组合物及其制备方法 | |
CN101711790A (zh) | 一种用于治疗肝癌的野生核桃楸树皮水提取物 | |
CN110302260A (zh) | 一种降血脂的冬虫夏草含片及其制备方法 | |
CN114272195B (zh) | 一种抗紫外线和蓝光损伤的组合物及其制备方法和应用 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
C06 | Publication | ||
PB01 | Publication | ||
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
ASS | Succession or assignment of patent right |
Owner name: XI AN HENGTONG GUANGHUA PHARMACEUTICAL CO., LTD. Free format text: FORMER OWNER: ZHAO HENG Effective date: 20080111 |
|
C41 | Transfer of patent application or patent right or utility model | ||
TA01 | Transfer of patent application right |
Effective date of registration: 20080111 Address after: E, Shenyang International Building, No. 27, 17 hi tech development road, West Shaanxi, Xi'an Province, China: 710075 Applicant after: Xi'an Hengtong Guanghue Pharmaceutical Co.,Ltd Address before: E 17 building, 710075 Yang Road, 27 hi tech Zone, hi tech Zone, Shaanxi, Xi'an, China Applicant before: Zhao Heng |
|
C14 | Grant of patent or utility model | ||
GR01 | Patent grant | ||
PP01 | Preservation of patent right |
Effective date of registration: 20081225 Pledge (preservation): Preservation |
|
PD01 | Discharge of preservation of patent |
Date of cancellation: 20091225 Pledge (preservation): Preservation registration |
|
PP01 | Preservation of patent right |
Effective date of registration: 20100611 Granted publication date: 20090121 |
|
PD01 | Discharge of preservation of patent |
Date of cancellation: 20101211 Granted publication date: 20090121 |
|
C17 | Cessation of patent right | ||
CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20090121 Termination date: 20101219 |