CN1617736A - 治疗运动神经元疾病的疫苗和方法 - Google Patents

治疗运动神经元疾病的疫苗和方法 Download PDF

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Publication number
CN1617736A
CN1617736A CNA028277015A CN02827701A CN1617736A CN 1617736 A CN1617736 A CN 1617736A CN A028277015 A CNA028277015 A CN A028277015A CN 02827701 A CN02827701 A CN 02827701A CN 1617736 A CN1617736 A CN 1617736A
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CN
China
Prior art keywords
vaccine
active agent
cop1
cop
mice
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CNA028277015A
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English (en)
Chinese (zh)
Inventor
M·埃森巴赫·施瓦茨
E·约勒斯
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Yeda Research and Development Co Ltd
Original Assignee
Yeda Research and Development Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yeda Research and Development Co Ltd filed Critical Yeda Research and Development Co Ltd
Priority to CN201110056639.8A priority Critical patent/CN102151330B/zh
Publication of CN1617736A publication Critical patent/CN1617736A/zh
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A61K39/0008—Antigens related to auto-immune diseases; Preparations to induce self-tolerance
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A61K39/0007—Nervous system antigens; Prions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Rheumatology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
CNA028277015A 2001-12-06 2002-12-05 治疗运动神经元疾病的疫苗和方法 Pending CN1617736A (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201110056639.8A CN102151330B (zh) 2001-12-06 2002-12-05 治疗运动神经元疾病的疫苗和方法

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US33613901P 2001-12-06 2001-12-06
US60/336,139 2001-12-06

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CN201110056639.8A Division CN102151330B (zh) 2001-12-06 2002-12-05 治疗运动神经元疾病的疫苗和方法

Publications (1)

Publication Number Publication Date
CN1617736A true CN1617736A (zh) 2005-05-18

Family

ID=23314742

Family Applications (2)

Application Number Title Priority Date Filing Date
CNA028277015A Pending CN1617736A (zh) 2001-12-06 2002-12-05 治疗运动神经元疾病的疫苗和方法
CN201110056639.8A Expired - Fee Related CN102151330B (zh) 2001-12-06 2002-12-05 治疗运动神经元疾病的疫苗和方法

Family Applications After (1)

Application Number Title Priority Date Filing Date
CN201110056639.8A Expired - Fee Related CN102151330B (zh) 2001-12-06 2002-12-05 治疗运动神经元疾病的疫苗和方法

Country Status (23)

Country Link
US (1) US7351686B2 (enExample)
EP (1) EP1429800B1 (enExample)
JP (1) JP4542339B2 (enExample)
KR (1) KR20040081431A (enExample)
CN (2) CN1617736A (enExample)
AT (1) ATE422362T1 (enExample)
AU (1) AU2002353486B2 (enExample)
CA (1) CA2469092C (enExample)
CY (1) CY1109044T1 (enExample)
DE (1) DE60231131D1 (enExample)
DK (1) DK1429800T3 (enExample)
ES (1) ES2322566T3 (enExample)
HU (1) HU228207B1 (enExample)
IL (1) IL160105A0 (enExample)
IS (1) IS2670B (enExample)
MX (1) MXPA04005537A (enExample)
NO (1) NO336231B1 (enExample)
NZ (1) NZ533356A (enExample)
PL (1) PL205469B1 (enExample)
PT (1) PT1429800E (enExample)
RU (1) RU2303996C2 (enExample)
SI (1) SI1429800T1 (enExample)
WO (1) WO2003047500A2 (enExample)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN100448481C (zh) * 2006-06-22 2009-01-07 中国科学院遗传与发育生物学研究所 xCT蛋白及其编码基因的新用途
CN104471394A (zh) * 2012-03-26 2015-03-25 耶达研究及发展有限公司 用于诊断阿尔茨海默氏病和用于阿尔茨海默氏病进展的细胞标志物

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7399740B2 (en) 2001-06-28 2008-07-15 Yeda Research And Development Co. Ltd. Poly-Glu,Tyr for neuroprotective therapy
WO2004060265A2 (en) * 2003-01-07 2004-07-22 Yeda Research And Development Co. Ltd. Eye-drop vaccine containing copolymer 1 for therapeutic immunization
CA2546077C (en) 2003-11-12 2016-07-05 Yeda Research And Development Co. Ltd. Vaccine and method for treatment of neurodegenerative diseases
DK1701730T3 (da) 2003-12-09 2013-11-25 Yeda Res & Dev Fremgangsmåde og vaccine omfattende copolymer 1 til behandling af psykiatriske forstyrrelser
EP1778286A4 (en) * 2004-03-03 2009-04-08 Teva Pharma COMBINATION THERAPY WITH ACETATE OF GLATIRAMER AND RILUZOLE
US7655221B2 (en) 2004-05-07 2010-02-02 Peptimmune, Inc. Methods of treating disease with random copolymers
CA2565819A1 (en) * 2004-05-07 2005-12-01 Peptimmune, Inc. Methods of treating disease with random copolymers
JP5241012B2 (ja) * 2005-07-15 2013-07-17 ノバルティス アーゲー Ｐａｍｐｓ、病原体関連分子パターン
WO2009040814A1 (en) 2007-09-24 2009-04-02 Hadasit Medical Research Services & Development Ltd Use of copolymer 1 for treatment of muscular dystrophy
USRE49251E1 (en) 2010-01-04 2022-10-18 Mapi Pharma Ltd. Depot systems comprising glatiramer or pharmacologically acceptable salt thereof
US8759302B2 (en) * 2010-03-16 2014-06-24 Teva Pharmaceutical Industries, Ltd. Methods of treating a subject afflicted with an autoimmune disease using predictive biomarkers of clinical response to glatiramer acetate therapy in multiple sclerosis
EA025780B1 (ru) 2010-10-11 2017-01-30 Тева Фармасьютикал Индастриз Лтд. Цитокиновые биомаркеры в качестве биомаркеров, прогнозирующих клинический ответ на глатирамер ацетат
ES2601892T3 (es) 2011-04-21 2017-02-16 Mapi Pharma Limited Pentapolímero aleatorio para el tratamiento de enfermedades autoinmunes
MX2014004309A (es) 2011-10-10 2015-07-06 Teva Pharma Polimorfismos de nucleotidos individuales utiles para predecir una respuesta clinica para el acetato de glatiramer.
US9861686B2 (en) * 2011-12-05 2018-01-09 Ben-Gurion University Of The Negev Research & Development Authority Diagnostic and therapeutic methods and their application in amyotrophic lateral sclerosis (ALS)
EP2892353A4 (en) 2012-09-10 2016-10-26 Yeda Res & Dev INDIVIDUALIZED IMMUNOMODULATION THERAPY FOR NEURODEGENERATIVE ILLNESSES, CNS LESIONS AND AGGREGATIVE DEMENTIA
US12097292B2 (en) 2016-08-28 2024-09-24 Mapi Pharma Ltd. Process for preparing microparticles containing glatiramer acetate
AU2017319728B2 (en) 2016-08-31 2024-09-05 Mapi Pharma Ltd Depot systems comprising glatiramer acetate
IL316573A (en) 2017-03-26 2024-12-01 Mapi Pharma Ltd Storage systems containing glatiramer acetate for the treatment of multiple sclerosis

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL36670A (en) * 1971-04-21 1974-09-10 Sela M Therapeutic basic copolymers of amino acids
US3849650A (en) 1973-03-29 1974-11-19 Picker Corp Automatic x-ray inspection system
IL113812A (en) 1994-05-24 2000-06-29 Yeda Res & Dev Copolymer-1 pharmaceutical compositions containing it and its use
SE505316C2 (sv) * 1995-10-17 1997-08-04 Kenneth G Haglid Användning av proteinet S-100b för framställning av läkemedel för nervceller
RU2211697C2 (ru) * 1996-09-27 2003-09-10 Гилфорд Фармасьютикалз Инк. Способ лечения глутаматных расстройств
JP2002503658A (ja) * 1998-02-13 2002-02-05 オートイミューン インク ＣＯＰ−１及びＴｈ−２促進性サイトカインを使用した、多発性硬化症の治療
US20030108528A1 (en) 1998-05-19 2003-06-12 Michal Eisenbach-Schwartz Activated t-cells, nervous system-specific antigens and their uses
US20020072493A1 (en) 1998-05-19 2002-06-13 Yeda Research And Development Co. Ltd. Activated T cells, nervous system-specific antigens and their uses
WO1999060021A2 (en) 1998-05-19 1999-11-25 Yeda Research And Development Co. Ltd. Use of activated t cells, nervous system-specific antigens for treating disorders of the nevrous system
EP1039929A1 (en) 1998-07-21 2000-10-04 YEDA RESEARCH AND DEVELOPMENT Co. Ltd. Activated t-cells and their uses
JP2003521448A (ja) 1998-07-23 2003-07-15 ザ・プレジデント・アンド・フェローズ・オブ・ハーバード・カレッジ 合成ペプチドおよび自己免疫疾患治療のための使用方法
RU2155063C1 (ru) * 1999-10-20 2000-08-27 Санкт-Петербургская общественная организация "Институт биорегуляции и геронтологии" Тетрапептид, стимулирующий функциональную активность нейронов, фармакологическое средство на его основе и способ его применения
HK1054507B (zh) * 2000-01-20 2008-10-31 耶达研究及发展有限公司 共聚物1和相关肽和多肽及其处理过的t细胞在神经保护性治疗中的用途
DE60116467T2 (de) 2000-06-07 2006-11-02 Yeda Research And Development Co., Ltd. Verwendung des Copolymer-1 Peptids sowie von damit verwandten Peptiden und Polypeptiden und von damit behandelten T-Zellen zur Neuroprotektion gegen die Toxizität von Glutamat
WO2002076503A1 (en) * 2000-06-20 2002-10-03 Mayo Foundation For Medical Education And Research Treatment of central nervous system diseases by antibodies against glatiramer acetate
US6835711B2 (en) * 2001-06-28 2004-12-28 Yeda Research And Development Co. Ltd. Use of poly-Glu,Tyr for neuroprotective therapy
US7399740B2 (en) * 2001-06-28 2008-07-15 Yeda Research And Development Co. Ltd. Poly-Glu,Tyr for neuroprotective therapy

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN100448481C (zh) * 2006-06-22 2009-01-07 中国科学院遗传与发育生物学研究所 xCT蛋白及其编码基因的新用途
CN104471394A (zh) * 2012-03-26 2015-03-25 耶达研究及发展有限公司 用于诊断阿尔茨海默氏病和用于阿尔茨海默氏病进展的细胞标志物
CN104471394B (zh) * 2012-03-26 2017-04-05 耶达研究及发展有限公司 用于诊断阿尔茨海默氏病和用于阿尔茨海默氏病进展的细胞标志物

Also Published As

Publication number Publication date
WO2003047500A2 (en) 2003-06-12
AU2002353486B2 (en) 2009-01-15
EP1429800A2 (en) 2004-06-23
PL370070A1 (en) 2005-05-16
HK1067043A1 (en) 2005-04-01
IS2670B (is) 2010-09-15
CN102151330A (zh) 2011-08-17
IL160105A0 (en) 2004-06-20
DK1429800T3 (da) 2009-04-27
HUP0500039A2 (hu) 2005-03-29
SI1429800T1 (sl) 2009-08-31
ATE422362T1 (de) 2009-02-15
NZ533356A (en) 2006-10-27
JP4542339B2 (ja) 2010-09-15
ES2322566T3 (es) 2009-06-23
HU228207B1 (hu) 2013-01-28
CA2469092A1 (en) 2003-06-12
NO336231B1 (no) 2015-06-22
PT1429800E (pt) 2009-04-27
US7351686B2 (en) 2008-04-01
IS7296A (is) 2004-06-03
KR20040081431A (ko) 2004-09-21
CY1109044T1 (el) 2014-07-02
MXPA04005537A (es) 2004-11-01
NO20042833L (no) 2004-08-12
DE60231131D1 (de) 2009-03-26
CA2469092C (en) 2013-02-19
RU2303996C2 (ru) 2007-08-10
US20050220802A1 (en) 2005-10-06
EP1429800B1 (en) 2009-02-11
EP1429800A4 (en) 2006-03-22
RU2004120536A (ru) 2005-03-27
AU2002353486A1 (en) 2003-06-17
WO2003047500A3 (en) 2004-03-18
CN102151330B (zh) 2017-04-12
HUP0500039A3 (en) 2010-01-28
PL205469B1 (pl) 2010-04-30
JP2005515198A (ja) 2005-05-26

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Open date: 20050518