CN1596985A - 用于在放射免疫疗法之前测定血液学毒性的新临床参数 - Google Patents

用于在放射免疫疗法之前测定血液学毒性的新临床参数 Download PDF

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Publication number
CN1596985A
CN1596985A CNA2004100590274A CN200410059027A CN1596985A CN 1596985 A CN1596985 A CN 1596985A CN A2004100590274 A CNA2004100590274 A CN A2004100590274A CN 200410059027 A CN200410059027 A CN 200410059027A CN 1596985 A CN1596985 A CN 1596985A
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CN
China
Prior art keywords
antibody
nhl
bone marrow
radiolabeled
lymphoma
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Pending
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CNA2004100590274A
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English (en)
Chinese (zh)
Inventor
W·拉斯泰特
C·怀特
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Idec Pharmaceuticals Corp
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Idec Pharmaceuticals Corp
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Application filed by Idec Pharmaceuticals Corp filed Critical Idec Pharmaceuticals Corp
Publication of CN1596985A publication Critical patent/CN1596985A/zh
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
    • A61K51/1027—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody against receptors, cell-surface antigens or cell-surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2887—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against CD20
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2896—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5091—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing the pathological state of an organism
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5094—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for blood cell populations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Hematology (AREA)
  • Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Biotechnology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Genetics & Genomics (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Ecology (AREA)
  • Epidemiology (AREA)
  • Optics & Photonics (AREA)
  • Physiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Peptides Or Proteins (AREA)
CNA2004100590274A 1999-08-11 2000-07-31 用于在放射免疫疗法之前测定血液学毒性的新临床参数 Pending CN1596985A (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US14828899P 1999-08-11 1999-08-11
US60/148,288 1999-08-11
US09/625,856 2000-07-26
US09/625,856 US6451284B1 (en) 1999-08-11 2000-07-26 Clinical parameters for determining hematologic toxicity prior to radioimmunotheraphy

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CNB008124426A Division CN100540053C (zh) 1999-08-11 2000-07-31 用于在放射免疫疗法之前测定血液学毒性的新临床参数

Publications (1)

Publication Number Publication Date
CN1596985A true CN1596985A (zh) 2005-03-23

Family

ID=26845721

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CNA2004100590274A Pending CN1596985A (zh) 1999-08-11 2000-07-31 用于在放射免疫疗法之前测定血液学毒性的新临床参数
CNB008124426A Expired - Lifetime CN100540053C (zh) 1999-08-11 2000-07-31 用于在放射免疫疗法之前测定血液学毒性的新临床参数

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CNB008124426A Expired - Lifetime CN100540053C (zh) 1999-08-11 2000-07-31 用于在放射免疫疗法之前测定血液学毒性的新临床参数

Country Status (17)

Country Link
US (3) US6451284B1 (https=)
EP (1) EP1207904B1 (https=)
JP (1) JP4662672B2 (https=)
CN (2) CN1596985A (https=)
AT (1) ATE387915T1 (https=)
AU (2) AU780222B2 (https=)
CA (1) CA2378584C (https=)
CY (1) CY1108118T1 (https=)
DE (1) DE60038239T2 (https=)
DK (1) DK1207904T3 (https=)
ES (1) ES2302698T3 (https=)
MX (1) MXPA02001403A (https=)
MY (1) MY135734A (https=)
NO (1) NO329592B1 (https=)
PT (1) PT1207904E (https=)
TW (1) TWI317284B (https=)
WO (1) WO2001010461A1 (https=)

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Also Published As

Publication number Publication date
CA2378584C (en) 2011-10-11
AU780222B2 (en) 2005-03-10
DK1207904T3 (da) 2008-07-07
TWI317284B (en) 2009-11-21
PT1207904E (pt) 2008-06-17
MXPA02001403A (es) 2002-08-12
AU7052100A (en) 2001-03-05
CA2378584A1 (en) 2001-02-15
US7195750B2 (en) 2007-03-27
CY1108118T1 (el) 2014-02-12
AU2005202560B2 (en) 2008-01-31
EP1207904A1 (en) 2002-05-29
US6451284B1 (en) 2002-09-17
MY135734A (en) 2008-06-30
AU2005202560A1 (en) 2005-07-07
ATE387915T1 (de) 2008-03-15
US20030211038A1 (en) 2003-11-13
NO20020637D0 (no) 2002-02-08
NO20020637L (no) 2002-04-11
EP1207904A4 (en) 2002-10-25
JP4662672B2 (ja) 2011-03-30
ES2302698T3 (es) 2008-08-01
DE60038239T2 (de) 2009-04-30
JP2003506414A (ja) 2003-02-18
CN100540053C (zh) 2009-09-16
EP1207904B1 (en) 2008-03-05
DE60038239D1 (de) 2008-04-17
US20070148714A1 (en) 2007-06-28
CN1450911A (zh) 2003-10-22
WO2001010461A1 (en) 2001-02-15
NO329592B1 (no) 2010-11-22

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