CN1548107A - 活血止痛丸及制备方法 - Google Patents
活血止痛丸及制备方法 Download PDFInfo
- Publication number
- CN1548107A CN1548107A CNA031244483A CN03124448A CN1548107A CN 1548107 A CN1548107 A CN 1548107A CN A031244483 A CNA031244483 A CN A031244483A CN 03124448 A CN03124448 A CN 03124448A CN 1548107 A CN1548107 A CN 1548107A
- Authority
- CN
- China
- Prior art keywords
- angelicae sinensis
- radix angelicae
- volatile oil
- standby
- borneolum syntheticum
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 230000017531 blood circulation Effects 0.000 title abstract description 7
- 230000001737 promoting effect Effects 0.000 title abstract description 7
- 239000000843 powder Substances 0.000 claims abstract description 47
- 238000002360 preparation method Methods 0.000 claims abstract description 21
- 239000003814 drug Substances 0.000 claims abstract description 18
- 239000000341 volatile oil Substances 0.000 claims description 38
- DTGKSKDOIYIVQL-WEDXCCLWSA-N (+)-borneol Chemical compound C1C[C@@]2(C)[C@@H](O)C[C@@H]1C2(C)C DTGKSKDOIYIVQL-WEDXCCLWSA-N 0.000 claims description 35
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 28
- 238000002156 mixing Methods 0.000 claims description 27
- 238000001035 drying Methods 0.000 claims description 25
- 229920000858 Cyclodextrin Polymers 0.000 claims description 22
- HFHDHCJBZVLPGP-UHFFFAOYSA-N schardinger α-dextrin Chemical compound O1C(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(O)C2O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC2C(O)C(O)C1OC2CO HFHDHCJBZVLPGP-UHFFFAOYSA-N 0.000 claims description 22
- 239000000463 material Substances 0.000 claims description 20
- 239000006187 pill Substances 0.000 claims description 18
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 15
- 239000006071 cream Substances 0.000 claims description 14
- 239000000284 extract Substances 0.000 claims description 11
- 241001489978 Eupolyphaga Species 0.000 claims description 10
- 241000717739 Boswellia sacra Species 0.000 claims description 9
- 239000004863 Frankincense Substances 0.000 claims description 9
- 235000003143 Panax notoginseng Nutrition 0.000 claims description 9
- 241000180649 Panax notoginseng Species 0.000 claims description 9
- 238000001914 filtration Methods 0.000 claims description 9
- 239000012535 impurity Substances 0.000 claims description 9
- 230000002879 macerating effect Effects 0.000 claims description 8
- 239000000047 product Substances 0.000 claims description 7
- 238000001694 spray drying Methods 0.000 claims description 7
- 239000000706 filtrate Substances 0.000 claims description 6
- 239000007921 spray Substances 0.000 claims description 6
- 238000001291 vacuum drying Methods 0.000 claims description 6
- 238000005242 forging Methods 0.000 claims description 5
- 238000000034 method Methods 0.000 claims description 5
- 229920002153 Hydroxypropyl cellulose Polymers 0.000 claims description 4
- 239000012141 concentrate Substances 0.000 claims description 4
- -1 hydroxypropyl Chemical group 0.000 claims description 4
- 239000001863 hydroxypropyl cellulose Substances 0.000 claims description 4
- 235000010977 hydroxypropyl cellulose Nutrition 0.000 claims description 4
- 239000012567 medical material Substances 0.000 claims description 4
- 235000013599 spices Nutrition 0.000 claims description 4
- 238000000108 ultra-filtration Methods 0.000 claims description 4
- 239000002671 adjuvant Substances 0.000 claims description 3
- 229940126678 chinese medicines Drugs 0.000 claims description 3
- 239000011248 coating agent Substances 0.000 claims description 3
- 238000000576 coating method Methods 0.000 claims description 3
- 238000000605 extraction Methods 0.000 claims description 3
- 238000010298 pulverizing process Methods 0.000 claims description 3
- 238000003908 quality control method Methods 0.000 claims description 3
- KSEBMYQBYZTDHS-HWKANZROSA-M (E)-Ferulic acid Natural products COC1=CC(\C=C\C([O-])=O)=CC=C1O KSEBMYQBYZTDHS-HWKANZROSA-M 0.000 claims description 2
- GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 claims description 2
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims description 2
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 claims description 2
- 229920000168 Microcrystalline cellulose Polymers 0.000 claims description 2
- 239000004372 Polyvinyl alcohol Substances 0.000 claims description 2
- 229920003081 Povidone K 30 Polymers 0.000 claims description 2
- 229920002472 Starch Polymers 0.000 claims description 2
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 claims description 2
- 229930006000 Sucrose Natural products 0.000 claims description 2
- 239000003795 chemical substances by application Substances 0.000 claims description 2
- 238000004090 dissolution Methods 0.000 claims description 2
- 238000004821 distillation Methods 0.000 claims description 2
- KSEBMYQBYZTDHS-HWKANZROSA-N ferulic acid Chemical compound COC1=CC(\C=C\C(O)=O)=CC=C1O KSEBMYQBYZTDHS-HWKANZROSA-N 0.000 claims description 2
- 229940114124 ferulic acid Drugs 0.000 claims description 2
- KSEBMYQBYZTDHS-UHFFFAOYSA-N ferulic acid Natural products COC1=CC(C=CC(O)=O)=CC=C1O KSEBMYQBYZTDHS-UHFFFAOYSA-N 0.000 claims description 2
- 235000001785 ferulic acid Nutrition 0.000 claims description 2
- 239000000796 flavoring agent Substances 0.000 claims description 2
- 235000019634 flavors Nutrition 0.000 claims description 2
- 239000012530 fluid Substances 0.000 claims description 2
- 238000004108 freeze drying Methods 0.000 claims description 2
- 238000007654 immersion Methods 0.000 claims description 2
- 150000002505 iron Chemical class 0.000 claims description 2
- 239000008101 lactose Substances 0.000 claims description 2
- YLGXILFCIXHCMC-JHGZEJCSSA-N methyl cellulose Chemical compound COC1C(OC)C(OC)C(COC)O[C@H]1O[C@H]1C(OC)C(OC)C(OC)OC1COC YLGXILFCIXHCMC-JHGZEJCSSA-N 0.000 claims description 2
- 239000008108 microcrystalline cellulose Substances 0.000 claims description 2
- 235000019813 microcrystalline cellulose Nutrition 0.000 claims description 2
- 229940016286 microcrystalline cellulose Drugs 0.000 claims description 2
- 229920002451 polyvinyl alcohol Polymers 0.000 claims description 2
- 239000001253 polyvinylpolypyrrolidone Substances 0.000 claims description 2
- 229920000523 polyvinylpolypyrrolidone Polymers 0.000 claims description 2
- 235000013809 polyvinylpolypyrrolidone Nutrition 0.000 claims description 2
- 229920000036 polyvinylpyrrolidone Polymers 0.000 claims description 2
- 239000001267 polyvinylpyrrolidone Substances 0.000 claims description 2
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims description 2
- 229910052708 sodium Inorganic materials 0.000 claims description 2
- 239000011734 sodium Substances 0.000 claims description 2
- 239000008107 starch Substances 0.000 claims description 2
- 235000019698 starch Nutrition 0.000 claims description 2
- 210000002784 stomach Anatomy 0.000 claims description 2
- 239000005720 sucrose Substances 0.000 claims description 2
- QURCVMIEKCOAJU-UHFFFAOYSA-N trans-isoferulic acid Natural products COC1=CC=C(C=CC(O)=O)C=C1O QURCVMIEKCOAJU-UHFFFAOYSA-N 0.000 claims description 2
- 230000008901 benefit Effects 0.000 abstract description 5
- 239000002775 capsule Substances 0.000 abstract description 5
- 230000000694 effects Effects 0.000 abstract description 4
- 230000008961 swelling Effects 0.000 abstract 2
- 208000007536 Thrombosis Diseases 0.000 abstract 1
- 239000008280 blood Substances 0.000 abstract 1
- 210000004369 blood Anatomy 0.000 abstract 1
- 208000014674 injury Diseases 0.000 abstract 1
- 230000007794 irritation Effects 0.000 abstract 1
- 230000008736 traumatic injury Effects 0.000 abstract 1
- 238000005516 engineering process Methods 0.000 description 28
- 239000002552 dosage form Substances 0.000 description 5
- 239000013558 reference substance Substances 0.000 description 4
- 229940079593 drug Drugs 0.000 description 3
- 238000012545 processing Methods 0.000 description 3
- 230000000857 drug effect Effects 0.000 description 2
- 229930182494 ginsenoside Natural products 0.000 description 2
- 229940089161 ginsenoside Drugs 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 238000012856 packing Methods 0.000 description 2
- 238000003556 assay Methods 0.000 description 1
- 230000002950 deficient Effects 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 238000007689 inspection Methods 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 238000012544 monitoring process Methods 0.000 description 1
- 239000002547 new drug Substances 0.000 description 1
- 239000008188 pellet Substances 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 239000001397 quillaja saponaria molina bark Substances 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 229930182490 saponin Natural products 0.000 description 1
- 150000007949 saponins Chemical class 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 239000010409 thin film Substances 0.000 description 1
Landscapes
- Medicinal Preparation (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
Description
Claims (9)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CNB031244483A CN100482214C (zh) | 2003-05-24 | 2003-05-24 | 活血止痛丸及制备方法 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CNB031244483A CN100482214C (zh) | 2003-05-24 | 2003-05-24 | 活血止痛丸及制备方法 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN1548107A true CN1548107A (zh) | 2004-11-24 |
CN100482214C CN100482214C (zh) | 2009-04-29 |
Family
ID=34321703
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CNB031244483A Expired - Lifetime CN100482214C (zh) | 2003-05-24 | 2003-05-24 | 活血止痛丸及制备方法 |
Country Status (1)
Country | Link |
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CN (1) | CN100482214C (zh) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1311849C (zh) * | 2005-07-07 | 2007-04-25 | 云南省药物研究所 | 治疗肿痛的药物组合物 |
CN102755365A (zh) * | 2012-08-02 | 2012-10-31 | 珠海安生凤凰制药有限公司 | 一种具有活血散瘀、消肿止痛作用的活血止痛滴丸及其制备方法 |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1366888A (zh) * | 2001-01-22 | 2002-09-04 | 杨孟君 | 纳米活血止痛制剂药物及其制备方法 |
-
2003
- 2003-05-24 CN CNB031244483A patent/CN100482214C/zh not_active Expired - Lifetime
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1311849C (zh) * | 2005-07-07 | 2007-04-25 | 云南省药物研究所 | 治疗肿痛的药物组合物 |
CN102755365A (zh) * | 2012-08-02 | 2012-10-31 | 珠海安生凤凰制药有限公司 | 一种具有活血散瘀、消肿止痛作用的活血止痛滴丸及其制备方法 |
Also Published As
Publication number | Publication date |
---|---|
CN100482214C (zh) | 2009-04-29 |
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Date | Code | Title | Description |
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C06 | Publication | ||
PB01 | Publication | ||
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
C14 | Grant of patent or utility model | ||
GR01 | Patent grant | ||
EE01 | Entry into force of recordation of patent licensing contract |
Assignee: Jiangxi Changnuo Pharmaceutical Co.,Ltd. Assignor: Mao Youchang Contract fulfillment period: 2009.4.22 to 2019.4.21 Contract record no.: 2009360000035 Denomination of invention: Blood circulation promoting and pain relieving bolus and its prepn Granted publication date: 20090429 License type: Exclusive license Record date: 20090707 |
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LIC | Patent licence contract for exploitation submitted for record |
Free format text: EXCLUSIVE LICENSE; TIME LIMIT OF IMPLEMENTING CONTACT: 2009.4.22 TO 2019.4.21; CHANGE OF CONTRACT Name of requester: JIANGXI CHANGNUO MEDICINE CO., LTD. Effective date: 20090707 |
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ASS | Succession or assignment of patent right |
Owner name: JIANGXI CHANGNUO PHARMACEUTICAL CO.,LTD. Free format text: FORMER OWNER: MAO YOUCHANG Effective date: 20100408 |
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C41 | Transfer of patent application or patent right or utility model | ||
COR | Change of bibliographic data |
Free format text: CORRECT: ADDRESS; FROM: 330002 ROOM 301, UNIT 3, BUILDING 34, XIANSHIHU RESIDENTIAL AREA, XIANSHI 1ST ROAD, NANCHANG CITY, JIANGXI PROVINCE TO: 344700 JINSHANKOU INDUSTRY DISTRICT, NANCHENG COUNTY, FUZHOU CITY, JIANGXI PROVINCE |
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TR01 | Transfer of patent right |
Effective date of registration: 20100408 Address after: 344700 Jinshan Industrial Zone, Nancheng County, Jiangxi, Fuzhou Patentee after: Jiangxi Changnuo Pharmaceutical Co.,Ltd. Address before: 330002 Jiangxi city in Nanchang Province, a residential area of Lake Magi Magi building 3 unit 34 Room 301 Patentee before: Mao Youchang |
|
C56 | Change in the name or address of the patentee |
Owner name: JIANGXI BAISHEN CHANGNUO PHARMACEUTICAL CO., LTD. Free format text: FORMER NAME: JIANGXI CHANGNUO MEDICINE CO., LTD. |
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CP01 | Change in the name or title of a patent holder |
Address after: 344700 Jinshan Industrial Zone, Nancheng County, Jiangxi, Fuzhou Patentee after: JIANGXI BAISHEN CHANGNUO PHARMACEUTICAL Co.,Ltd. Address before: 344700 Jinshan Industrial Zone, Nancheng County, Jiangxi, Fuzhou Patentee before: Jiangxi Changnuo Pharmaceutical Co.,Ltd. |
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CX01 | Expiry of patent term |
Granted publication date: 20090429 |
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CX01 | Expiry of patent term |