CN1472183A - 高纯度番茄红素的制备方法 - Google Patents
高纯度番茄红素的制备方法 Download PDFInfo
- Publication number
- CN1472183A CN1472183A CNA031293824A CN03129382A CN1472183A CN 1472183 A CN1472183 A CN 1472183A CN A031293824 A CNA031293824 A CN A031293824A CN 03129382 A CN03129382 A CN 03129382A CN 1472183 A CN1472183 A CN 1472183A
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- CN
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- Prior art keywords
- lycopene
- purity
- oleoresin
- temperature
- crystals
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- JEVVKJMRZMXFBT-XWDZUXABSA-N Lycophyll Natural products OC/C(=C/CC/C(=C\C=C\C(=C/C=C/C(=C\C=C\C=C(/C=C/C=C(\C=C\C=C(/CC/C=C(/CO)\C)\C)/C)\C)/C)\C)/C)/C JEVVKJMRZMXFBT-XWDZUXABSA-N 0.000 title claims description 51
- 235000012661 lycopene Nutrition 0.000 title claims description 51
- OAIJSZIZWZSQBC-GYZMGTAESA-N lycopene Chemical compound CC(C)=CCC\C(C)=C\C=C\C(\C)=C\C=C\C(\C)=C\C=C\C=C(/C)\C=C\C=C(/C)\C=C\C=C(/C)CCC=C(C)C OAIJSZIZWZSQBC-GYZMGTAESA-N 0.000 title claims description 51
- 239000001751 lycopene Substances 0.000 title claims description 51
- 229960004999 lycopene Drugs 0.000 title claims description 51
- ZCIHMQAPACOQHT-ZGMPDRQDSA-N trans-isorenieratene Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/c1c(C)ccc(C)c1C)C=CC=C(/C)C=Cc2c(C)ccc(C)c2C ZCIHMQAPACOQHT-ZGMPDRQDSA-N 0.000 title claims description 51
- 238000002360 preparation method Methods 0.000 title claims description 3
- 238000001816 cooling Methods 0.000 claims abstract description 10
- 239000012047 saturated solution Substances 0.000 claims abstract description 8
- 239000004215 Carbon black (E152) Substances 0.000 claims abstract description 6
- 229930195733 hydrocarbon Natural products 0.000 claims abstract description 6
- 150000002430 hydrocarbons Chemical class 0.000 claims abstract description 6
- 238000000034 method Methods 0.000 claims description 16
- VLKZOEOYAKHREP-UHFFFAOYSA-N n-Hexane Chemical compound CCCCCC VLKZOEOYAKHREP-UHFFFAOYSA-N 0.000 claims description 13
- 239000008601 oleoresin Substances 0.000 claims description 13
- 239000013078 crystal Substances 0.000 claims description 12
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 10
- 238000002425 crystallisation Methods 0.000 claims description 10
- 239000003960 organic solvent Substances 0.000 claims description 10
- 230000008025 crystallization Effects 0.000 claims description 8
- 239000000706 filtrate Substances 0.000 claims description 8
- 239000011261 inert gas Substances 0.000 claims description 5
- 229910052757 nitrogen Inorganic materials 0.000 claims description 5
- 239000012535 impurity Substances 0.000 claims description 4
- 239000000243 solution Substances 0.000 claims description 3
- 238000007796 conventional method Methods 0.000 claims description 2
- 239000012452 mother liquor Substances 0.000 claims description 2
- 239000007787 solid Substances 0.000 claims description 2
- 238000004090 dissolution Methods 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 abstract description 6
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- UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 description 6
- 239000000047 product Substances 0.000 description 5
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 3
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 description 3
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 3
- 241000227653 Lycopersicon Species 0.000 description 3
- 235000007688 Lycopersicon esculentum Nutrition 0.000 description 3
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- 235000015113 tomato pastes and purées Nutrition 0.000 description 2
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- 208000024172 Cardiovascular disease Diseases 0.000 description 1
- 244000241235 Citrullus lanatus Species 0.000 description 1
- 235000012828 Citrullus lanatus var citroides Nutrition 0.000 description 1
- XDTMQSROBMDMFD-UHFFFAOYSA-N Cyclohexane Chemical compound C1CCCCC1 XDTMQSROBMDMFD-UHFFFAOYSA-N 0.000 description 1
- MYMOFIZGZYHOMD-UHFFFAOYSA-N Dioxygen Chemical compound O=O MYMOFIZGZYHOMD-UHFFFAOYSA-N 0.000 description 1
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- OENHQHLEOONYIE-UKMVMLAPSA-N all-trans beta-carotene Natural products CC=1CCCC(C)(C)C=1/C=C/C(/C)=C/C=C/C(/C)=C/C=C/C=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C OENHQHLEOONYIE-UKMVMLAPSA-N 0.000 description 1
- 239000003963 antioxidant agent Substances 0.000 description 1
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- 235000006708 antioxidants Nutrition 0.000 description 1
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- TUPZEYHYWIEDIH-WAIFQNFQSA-N beta-carotene Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1=C(C)CCCC1(C)C)C=CC=C(/C)C=CC2=CCCCC2(C)C TUPZEYHYWIEDIH-WAIFQNFQSA-N 0.000 description 1
- 229960002747 betacarotene Drugs 0.000 description 1
- 235000021466 carotenoid Nutrition 0.000 description 1
- 150000001747 carotenoids Chemical class 0.000 description 1
- 235000014113 dietary fatty acids Nutrition 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 235000013399 edible fruits Nutrition 0.000 description 1
- 239000000839 emulsion Substances 0.000 description 1
- 150000002148 esters Chemical class 0.000 description 1
- RTZKZFJDLAIYFH-UHFFFAOYSA-N ether Substances CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 1
- 125000001033 ether group Chemical group 0.000 description 1
- 239000000284 extract Substances 0.000 description 1
- 229930195729 fatty acid Natural products 0.000 description 1
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- 235000021588 free fatty acids Nutrition 0.000 description 1
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 description 1
- 235000011187 glycerol Nutrition 0.000 description 1
- 235000013402 health food Nutrition 0.000 description 1
- 210000002865 immune cell Anatomy 0.000 description 1
- 238000009776 industrial production Methods 0.000 description 1
- 230000035992 intercellular communication Effects 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 201000005202 lung cancer Diseases 0.000 description 1
- 208000020816 lung neoplasm Diseases 0.000 description 1
- 238000011112 process operation Methods 0.000 description 1
- 238000010298 pulverizing process Methods 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 238000004366 reverse phase liquid chromatography Methods 0.000 description 1
- 230000002000 scavenging effect Effects 0.000 description 1
- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 description 1
- 235000019165 vitamin E Nutrition 0.000 description 1
- 229940046009 vitamin E Drugs 0.000 description 1
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- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
- OENHQHLEOONYIE-JLTXGRSLSA-N β-Carotene Chemical compound CC=1CCCC(C)(C)C=1\C=C\C(\C)=C\C=C\C(\C)=C\C=C\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C OENHQHLEOONYIE-JLTXGRSLSA-N 0.000 description 1
Landscapes
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA031293824A CN1472183A (zh) | 2003-06-19 | 2003-06-19 | 高纯度番茄红素的制备方法 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA031293824A CN1472183A (zh) | 2003-06-19 | 2003-06-19 | 高纯度番茄红素的制备方法 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1472183A true CN1472183A (zh) | 2004-02-04 |
Family
ID=34153505
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNA031293824A Pending CN1472183A (zh) | 2003-06-19 | 2003-06-19 | 高纯度番茄红素的制备方法 |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1472183A (zh:) |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1326836C (zh) * | 2006-02-23 | 2007-07-18 | 上海交通大学 | 番茄红素的提纯制备方法 |
| CN100341950C (zh) * | 2005-11-10 | 2007-10-10 | 南京工业大学 | 一种制取番茄红素油树脂和番茄红素的方法 |
| CN101006854B (zh) * | 2006-05-27 | 2011-08-17 | 新疆屯河投资股份有限公司 | 番茄红素粉的制备方法 |
| CN103664462A (zh) * | 2013-11-19 | 2014-03-26 | 新疆红帆生物科技有限公司 | 番茄油中番茄红素的二次回收方法 |
| CN105693583A (zh) * | 2015-12-30 | 2016-06-22 | 晨光生物科技集团股份有限公司 | 一种去除类胡萝卜素中危害成分的方法 |
-
2003
- 2003-06-19 CN CNA031293824A patent/CN1472183A/zh active Pending
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100341950C (zh) * | 2005-11-10 | 2007-10-10 | 南京工业大学 | 一种制取番茄红素油树脂和番茄红素的方法 |
| CN1326836C (zh) * | 2006-02-23 | 2007-07-18 | 上海交通大学 | 番茄红素的提纯制备方法 |
| CN101006854B (zh) * | 2006-05-27 | 2011-08-17 | 新疆屯河投资股份有限公司 | 番茄红素粉的制备方法 |
| CN103664462A (zh) * | 2013-11-19 | 2014-03-26 | 新疆红帆生物科技有限公司 | 番茄油中番茄红素的二次回收方法 |
| CN105693583A (zh) * | 2015-12-30 | 2016-06-22 | 晨光生物科技集团股份有限公司 | 一种去除类胡萝卜素中危害成分的方法 |
| CN105693583B (zh) * | 2015-12-30 | 2018-02-09 | 晨光生物科技集团股份有限公司 | 一种去除类胡萝卜素中危害成分的方法 |
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| PB01 | Publication | ||
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| SE01 | Entry into force of request for substantive examination | ||
| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
| WD01 | Invention patent application deemed withdrawn after publication |