CN1449283A - 用于改善注意力缺乏多动性障碍的组合物 - Google Patents
用于改善注意力缺乏多动性障碍的组合物 Download PDFInfo
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- CN1449283A CN1449283A CN01814820A CN01814820A CN1449283A CN 1449283 A CN1449283 A CN 1449283A CN 01814820 A CN01814820 A CN 01814820A CN 01814820 A CN01814820 A CN 01814820A CN 1449283 A CN1449283 A CN 1449283A
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Abstract
本发明提供以含有茶氨酸为特征的用于改善注意力缺乏多动性障碍的组合物以及通过个体服用茶氨酸来改善注意力缺乏多动性障碍的方法。
Description
技术领域
本发明涉及用于改善注意力缺乏多动性障碍的组合物以及改善注意力缺乏多动性障碍的方法。
背景技术
注意力缺乏多动性障碍(attention-deficit hyperactivitydisorder：ADHD)是指自己不能控制集中力、注意力、冲动性、多动性的脑神经学上的障碍。主要是小孩产生的一种病症障碍，但近年来，精神医学家已经搞清楚，它不仅是幼年时代的障碍，即使成人以后仍会继续。这种障碍的特征在于伴随有注意力障碍、活动性障碍和冲动性异常3种症状，已经把它与自闭性等广泛性发育障碍和狂郁症、焦虑障碍区分开来了。还有，注意力缺乏多动性障碍中，没有较多地看到多动性(活动过多)时，称之为注意力缺乏障碍(attention-deficitdisorder：ADD)，而没有较多地看到注意力缺乏(注意力低下)时则称为多动性障碍。
对于注意力缺乏多动性障碍的原因，已经提出可能是受外伤、疾病以及胎儿期的酒精与烟、发育初期的高浓度铅的影响等使脑损伤和发育异常；遗传、神经递质的分泌和再吸收、分解异常；脑的特定区域的功能钝化等，不过，正确的原因还不清楚。
过去，此障碍的治疗主要是采用康复疗法？药物疗法。作为康复疗法，是对患者进行精神疗法、行动疗法、感觉综合疗法等，进行训练使其会适当的社会生活。然而，不能立即见效，而且还必须有家庭、学校的合作，治疗中需要很多的时间和专门的教育。另一方面，药物有产生很多副作用的倾向，必须要高度注意管理和剂量测定。例如，使用的托模新定(特表平10-512262号公报)、2-(4-甲氨基丁氧基)二苯甲烷(特开平8-81366号公报)等都是药物，剂量必须测定。还有，已经报道pycnogenol(法国海岸松树皮提取物)也有改善ADHD的效果，不过非常贵，难以使用。
本发明的目的在于，提供没有副作用而且便宜的、可以日常使用的用于改善注意力缺乏多动性障碍的组合物、以及有效改善注意力缺乏多动性障碍的方法。
发明的公开
为了解决上述课题，本发明人等进行了刻意的研究，结果发现，在茶中所含有的茶氨酸具有所期望的效果，至此完成了本发明。
也就是说，本发明涉及：
(1)一种用于改善注意力缺乏多动性障碍的组合物，其特征为，含有茶氨酸；
(2)上述(1)所述的组合物，其中，它是食品组合物或医药组合物；
(3)一种给个体服用茶氨酸来改善注意力缺乏多动性障碍的方法；以及
(4)用于制造改善注意力缺乏多动性障碍用的药物的茶氨酸的用途。
实施发明的最佳形态
本发明的用于改善注意力缺乏多动性障碍的组合物(以下称为组合物)是以含有茶氨酸为特征的物质。使用此组合物就可以有效改善注意力缺乏多动性障碍。还有，由于没有副作用的担忧，而且便宜，所以可日常使用。本发明组合物表现出预期的效果是基于最初看到的所述组合物中含有的茶氨酸对注意力缺乏多动性障碍的缓和与减轻作用。
再者，本说明书中，作为本发明的组合物的适应症的“注意力缺乏多动性障碍”，它是指由DSM-IV精神障碍的诊断？统计手册(1996年医学书院出版)所定义的、基于ADHD的诊断方法所判定的症状。具体说，是指与以下诊断基准相符合的症状。
[诊断基准]
显示出下述的“不注意”症状中的6个以上或“多动性和冲动性”症状中的6个以上时，被判定为注意力缺乏多动性障碍。但是，作出该判定的条件必须是，这些症状频繁地出现，而且至少在6个月中连续出现与患者的发育水平不一致的不合的表现。此外，这些症状中有些在7岁以前引起问题，而且现在在2个以上场所(例如，学校和家庭)也发生问题也是诊断的条件。还有，作出该判定限于在社会生活、学业、工作上有明显的障碍、且其症状均不是由任何其它病因所造成的。
(不注意的症状)
●对事物不能集中注意，在学习、工作和其它活动中由于注意力不集中而出错；
●对安排的工作和游戏的注意力持续感到困难；
●直接对话却看上去没有听；
●不能按照指令去做，在学习、日常杂事、工作场所不能逐一执行任务；
●不能按照顺序来进行所安排的工作和活动；
●避开、讨嫌、勉强进行需要持续脑力活动的工作与学习；
●丢失工作和学习所必要的东西(玩具、学校的课外作业、铅笔、书本、文具等)；
●受其它的刺激就分散注意力；
●忘记日常活动。
(多动性和冲动性的症状)
●手脚乱动，坐卧不安；
●在教室内离开坐位，不得不坐时就站在坐位旁；
●在不适当的情况下来回走动，爬上爬下(成长为青年和成年人时有急躁情绪)；
●在空闲时间也不能安静地玩或度过；
●总在动，就像有马达驱动那样的动；
●喋喋不休，总说；
●在提问还没有完就抢着回答；
●不能按次序等待；
●骚扰他人。
还有，所谓“改善注意力缺乏多动性障碍”是指缓和、减轻注意力缺乏多动性障碍的症状，广义上包括对注意力缺乏多动性障碍的预防和治疗。
用茶氨酸所表现出的缓和、减轻注意力缺乏多动性障碍的作用，可以通过临床试验来评价，即让诊断出符合上述[诊断基准]的患者服用茶氨酸，并与服用茶氨酸之前比较，来观察其对注意力缺乏多动性障碍的改善效果。
本发明所使用的茶氨酸是谷氨酸的衍生物(γ-谷氨酰基乙基酰胺)，是天然地在茶叶中较多地含有的氨基酸成分。本发明所用的茶氨酸的制造方法，例如有，从茶叶中提取的方法、有机合成的方法(Chem.Pharm.Bull.，19(7)1301-1307(1971))、谷氨酰胺和乙胺的混合物与谷氨酰胺酶作用得到茶氨酸的方法(特表平7-55154号公报)、用含乙胺的培养基来培养茶的培养细胞群，一边使培养细胞群中的茶氨酸累积量增加，一边谋求促进培养细胞群的增殖的方法(特开平5-123166号公报)以及在特表平7-55154号公报、特开平5-123166号公报中所述的将乙胺置换成乙胺盐酸盐等乙胺衍生物来得到L-茶氨酸的方法等，这些方法中的任何一种方法都行。再者，前述茶叶列举有绿茶叶、乌龙茶叶、红茶叶等。
茶氨酸无论是L-茶氨酸、D-茶氨酸还是DL-茶氨酸都可以使用，其中的L-体在也已经被确认为食品添加剂，由于其从经济上讲也容易利用，因此本发明以L-体为优选。还有，作为所使用的茶氨酸的形态，无论是精制品、粗制品(crudely purified products)还是提取物等任何形态都行。还有，使用市售品[太阳化学(株)制造的SUNTHEANINE(注册商标)]也行。
对本发明的组合物中的茶氨酸的含量没有特别的限制，以根据要求来适当调整为好。例如，考虑本发明所期望的效果的体现，优选为0.00025～100重量％，更优选为0.001～100重量％，进一步优选为0.001～20重量％。
对本发明的组合物中的茶氨酸的检测方法并没有特别的限制，但优选的是，用前置(pre-column)柱把邻苯二醛衍生化后用ODS柱由高性能液相色谱(HPLC)分离并用荧光检测器检测定量的方法，和用ODS柱由高性能液相色谱(HPLC)分离并在波长210nm下检测定量的方法。
本发明的组合物中，也可进一步含有各种矿物质。由于含有矿物质的组合物可以起到补充体内常常缺乏的必须元素和微量必须元素的进一步的效果，因此是更为优选的。组合物中矿物质的含量，以例如0.0001～99.9重量％为优选，0.01～99.9重量％为更优选。所述矿物质有，铁、镁、铜、锌、硒、钙、钾、锰、铬、碘、钼、镍、钒等维持、调节生命体恒定性所必须的金属类和它们的金属盐类。它们可以单独使用，或者2种以上混合使用。
又，在组合物中还可以共同含有生药(crude medicines)、草药、氨基酸、维生素、其它食品中允许的原材料·原料。它们可以单独使用，或者2种以上混合使用。
对生药没有特别的限制，例如，列举有，森林匙羹藤、藤黄、缬草根、杜仲、当归、芍药、牡丹、高丽人参、灵芝、地黄茎、大枣、刺五加等，以稳定精神状态有效的灵芝、地黄茎、大枣等为优选。对其形态没有特别的限制，提取物、干制品等都行。对草药没有特别的限制，例如，列举的有，阿母拉(Amla)、茴芹、胡萝籽、丁香、芫荽、柏木属(cypress)、肉桂、杜松、生姜、甜橙、松叶、罗勒、广藿香、苦橙、茴香、黑胡椒、月桂、薄荷、佛手(bergamot)、桔、没药、柠檬草、迷迭香、葡萄柚、杉木、香茅、鼠尾草、麝香草、茶树、紫罗兰、香草属、牛膝草、桉叶、酸橙(lime)、柠檬、衣兰、小豆蔻、香紫苏(clary sage)、茉莉、老鹳草、春黄菊、保加利亚玫瑰、蔷薇属、乳香(olibanum)、熏衣草、洋甘菊(白花母菊；chamomile)、天竺葵、檀香木橙花、马鞭草属、橙叶(petigrain)、香根草、牛至、蜂花(密里萨香草；lemon balm)、降香(蔷薇木；rosewood)、金丝桃属(hypericum)、圣约翰斯草(St.John’s wort)、醉椒、西番莲、总状升麻等。其中，以有镇静效果、松弛效果的薄荷、佛手、衣兰、老鹳草、春黄菊、熏衣草、圣约翰斯草、醉椒为优选。其形态列举有，例如，提取物(extracts)、精油、汤药(herb teas)等，并没有特别的限制。对氨基酸也没有特别的限制。例如，列举的L型氨基酸有，丙氨酸、精氨酸、精氨酸乙酸盐、盐酸精氨酸、天冬酰胺、天冬氨酸、瓜氨酸、半胱氨酸、胱氨酸、谷氨酰胺、谷氨酸及其盐类、甘氨酸、组氨酸及其盐类、羟基脯氨酸、异亮氨酸、亮氨酸、赖氨酸及其盐类、蛋氨酸、鸟氨酸乙酸盐及盐酸盐、苯基丙氨酸、脯氨酸、丝氨酸、苏氨酸、色氨酸、酪氨酸和缬氨酸等；DL型列举有，丙氨酸、半胱氨酸及其盐类、蛋氨酸、苯基丙氨酸、苏氨酸、色氨酸和缬氨酸等；D型列举有，丙氨酸、半胱氨酸盐酸盐水合物和苯基丙氨酸等。还有，L-精氨酸与L-天冬酰胺等L-氨基酸复合盐和混合物、天冬氨酸钾等氨基酸金属盐、盐酸L-乙基半胱氨酸等氨基酸酯、乙酰基半胱氨酸等乙酰基氨基酸、腺嘌呤、腺苷等核酸关联物质、β-丙氨酸等ω-氨基酸和组胺二盐酸盐等氨基酸代谢物、ν-氨基丁酸、牛磺酸、硫代牛磺酸、次牛磺酸等。作为维生素，列举有，例如，维生素A、维生素B1、维生素B2、维生素B6、维生素B12、维生素C、维生素D、维生素E、维生素K、叶酸、烟酸、硫辛酸、泛酸、维生素H、辅酶Q、前列腺素等，这些维生素的衍生物也包括在内，并不仅限于这些。作为其它食品中允许使用的原材料？原料，例如，列举有，独行菜属、猫爪猴耳环、三十碳烷、裂蹄木层孔菌、DHA、EPA、神经酰胺、乳酰肝褐质、pycnogenol、芦荟、蜂王胶、褪黑激素、胎盘、蜂窝蜡胶、异黄酮、大豆卵磷脂、蛋黄卵磷脂、蛋黄油、软骨素、可可块、胶原、醋、小球藻、螺旋藻、银杏叶、绿茶、杜仲茶、黄妃茶、乌龙茶、桑叶、甜茶、花薄荷茶、不饱和脂肪酸、低聚糖等糖类、减肥甜味料、食物纤维、大豆肽等功能性原材料、双岐杆菌、红麹等菌类、伞菌、姬松蘑、松蘑等蘑菇类、乌饭树紫黑浆果、洋李脯、葡萄、橄榄、梅、柑橘类等水果类、落花生、苦扁桃、芝麻、胡椒等干果类、青椒、辣椒、葱、南瓜、瓜、人参、牛蒡、黄麻叶、蒜、紫苏、辣根、西红柿、韭菜、姜、叶菜、芋、豆等蔬菜类、裙带菜等海草类、鱼类与贝类、食用肉和家禽及鲸肉类、谷类等物质或它们的提取物、干制品、粗制品、精制品、加工物、酿造品等。其中，以减肥甜味料、食物纤维、大豆肽等功能性原材料为优选。
还有，从适合于日常使用的观点说，本发明的组合物以食品组合物或医药组合物为优选。
作为本发明的食品组合物，不光是含有茶氨酸的食品，也包括了含有茶氨酸的食品添加物。
作为本发明中所包括的所述食品，可以列举的有，干燥食品、添加物等固体食品，还有冷饮和矿泉水、嗜好饮料、酒精饮料等液体食品等。对固体食品没有特别的限制，详细列举有，例如，糊状制品、大豆加工品、奶油冻、果子、酸乳酪、冻点心、饴糖、巧克力、口香糖、椒盐饼干、饼干、小甜饼干、糕点、面包等。还有，作为液体食品，没有特别的限制，详细可以列举的有，绿茶、乌龙茶、红茶、药草茶等茶类、浓缩果汁、浓缩还原果汁、榨制的果汁、水果混合果汁、含果肉的果汁、果汁饮料、水果-蔬菜混合果汁、蔬菜果汁、碳酸饮料、冷饮、牛乳、乳饮料、日本酒、啤酒、红酒、鸡尾酒、烧酒、威士忌等。
还有，作为本发明的药物组合物，只要是含有茶氨酸的就可以，没有特别的限制。例如，其形态是溶液、悬浮物、粉末、固体成型物等任何一种都行。作为剂型，列举有锭剂、胶囊、粉末制剂、颗粒制剂、饮剂等。还有，可以与其它的药物合并使用。
对所述的其它药物没有特别的限制，例如，治疗ADHD用的盐酸利他林、匹莫林、盐酸丙咪嗪、盐酸麦普替林、盐酸去甲替林、2-(4-甲基氨基丁氧基)二苯甲烷、去甲肾上腺素吸收阻隔剂的托模新定、降血压剂、抗精神病药、抗躁狂药、抗焦虑抗药、催眠药、精神振奋药、抗癫 药、镇静药、抗帕金森氏症的药物、选择性血清素再吸收抑制剂、选择性血清素去甲肾上腺素再吸收障碍药等抗忧郁剂等针对精神的药、加味逍遥散、当归芍药散等中药等。
本发明的组合物的制法没有特别的选择，例如，把茶氨酸与其它的原材料粉末混合的制法、把茶氨酸与其它原材料溶解于溶剂中制成混合溶液的制法、还有，把其混合溶液冷冻干燥的制法、喷雾干燥制法等一般的食品或药品的制法也可以适用。在制造本发明的组合物时可以使用的茶氨酸以外的成分，只要不妨害由茶氨酸体现出的希望效果，可适当地与所期望的用途一致地选择。
例如，用常规方法将茶氨酸配合到已有的食品中，并使制造后的本发明的食品组合物中的茶氨酸含量优选在前述组合物中的合适的茶氨酸含量范围内，就可以制造本发明的食品组合物。还有，把茶氨酸与，例如，大家知道的适合于口服的有机或无机载体、赋形剂、结合剂、稳定剂等，按照制造食品组合物时一样，优选在前面所讲的在组合物中合适的茶氨酸含量范围中，用通常方法配合进茶氨酸，就可以制造成药物组合物。因此，作为本发明的一个形态，提供了茶氨酸在制造用于改善注意力缺乏多动性障碍的药物中的用途。
进一步说，作为本发明的一个形态，提供了个体服用茶氨酸来改善注意力缺乏多动性障碍的方法。采用所述方法，不用担心副作用的发生，能够安全而有效地改善该个体的注意力缺乏多动性障碍。
在本形态中，为了得到本发明所预期的效果，茶氨酸的有效服用量，一般为，例如，对人而言，平均每天的服用优选为0.2～200mg/kg体重，更优选为0.5～50mg/kg体重。但是，对于各个体，由于有个体差异(年龄、性别、症状的种类和程度等)，所以本发明的茶氨酸的服用量并不仅限于所述的范围。为得到本发明所期望的效果，应该根据个体的具体情况来适当调节其服用量。
服用茶氨酸，无论服用含茶氨酸本身还是服用本发明的组合物都可以，以食品组合物或药物组合物为优选。还有，服用的方法、服用次数、服用时间都没有特别的限制，对前面所述个体，优选的是，对人，例如，分1次和数次，以口服为好，只要是在上述有效服用量范围服用茶氨酸就行。通过日常服用茶氨酸或本发明的组合物也能够得到预防效果。
本发明中所使用的茶氨酸的安全性高，例如，用鼠进行急性毒性试验，口服5g/kg没有死亡例，在一般状态和体重等方面没有发现异常。还有，特别是已知L-茶氨酸是茶的香味的主要成分，并用作呈现该味道的食品添加物，根据食品卫生法，其添加量没有限制。而且，与以往的药物不同，由于完全看不到茶氨酸的副作用，所以用本发明的组合物就可以谋求安全且有效地改善注意力缺乏多动性障碍。
下面用实施例来详细说明本发明，不过，本发明并不只限于该实施例。再者，在制造实施例1中所用的组合物时，使用了L-茶氨酸(太阳化学(株)制造，商品名：SUNTHEANINE)。
实施例1
给已由医生诊断为注意力缺乏多动性障碍的5名患者服用了含茶氨酸的组合物。再者，此组合物是按20重量％的L-茶氨酸含量，将L-茶氨酸与结晶纤维素、蔗糖脂肪酸酯、还原麦芽糖、二氧化硅、乳糖、天冬酰苯丙氨酸甲酯(aspartame)混合，压片，制成片剂。
(1)患者1
7岁11个月、智商IQ75的男孩(体重23.2kg)。在妊娠、生产时没有特别的异常。有学习中不能坐在座位上、不听别人的话等、多动、情绪不稳定、注意力分散等症状，符合前面所述的[诊断基准]，被诊断为ADHD。在以50mg/天服用L-茶氨酸8个星期结束后，虽然还留一点点症状，但前述症状基本上消失。主治医生判定此组合物的效果为“有效”。
(2)患者2
12岁10个月，智商IQ85的女孩(体重40.6kg)。在妊娠、生产时没有特别的异常。有不能镇静、行动前不加考虑、在人前兴奋、不听别人的话、骚扰朋友的游玩等不能入睡、集中困难、情绪不稳定、注意力分散等症状，符合前面所述的[诊断基准]，被诊断为ADHD。服用利他灵(利他林；methylphenidate)过程中虽然症状稳定，但副作用重，停止服用。在以200mg/天服用L-茶氨酸10个星期结束后，虽然还留一点点症状，但前述症状基本上消失。主治医生判定此组合物的效果为“有效”。
(3)患者3
4岁6个月、智商IQ80的男孩(体重18.2kg)。在妊娠、生产时没有特别的异常。有总是中断会话、入睡差、骚扰别人等的攻击性、注意力分散、不睡、暴力等症状，符合前面所述的[诊断基准]，被诊断为ADHD。将L-茶氨酸以100mg/天和利他灵一起服用了1星期。其结果，虽然还留一点点症状，但前述症状基本上消失。
(4)患者4
15岁、智商IQ95的男孩(体重60.2kg)。在妊娠、生产时没有特别的异常。有在人前兴奋、注意力分散、暴力等症状，符合前面所述的[诊断基准]，被诊断为ADHD。在去学校前仅服用1次L-茶氨酸200mg，就可以没有问题地上课。不过，次日就恢复原有的症状，不能确认经1次服用的持续性。
(5)患者5
22岁、智商IQ70的男性(体重60.6kg)。在妊娠、生产时没有特别的异常。有总是中断会话、多动、冲动、注意力分散等症状，符合前面所述的[诊断基准]，被诊断为ADHD。在以60mg/天服用L-茶氨酸共服用1星期结束后，其症状明显改善，虽然还留一点点症状，但前述症状基本上消失。
从上述例子可以知道，使用本发明的组合物，可以实现安全且有效的改善注意力缺乏多动性障碍。
产业化应用可能性
本发明提供用于改善注意力缺乏多动性障碍的组合物以及改善注意力缺乏多动性障碍的方法。由于用此组合物和方法可以安全且有效的改善注意力缺乏多动性障碍，对注意力缺乏多动性障碍的治疗、预防等是有用的。
Claims (4)
1.一种用于改善注意力缺乏多动性障碍的组合物，其特征在于，它合有茶氨酸。
2.权利要求项1所述的组合物，该组合物是食品组合物或药品组合物。
3.一种改善注意力缺乏多动性障碍的方法，该方法给个体服用茶氨酸。
4.茶氨酸在制造用于改善注意力缺乏多动性障碍的药物中的用途。
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102526347A (zh) * | 2012-03-14 | 2012-07-04 | 上海善力健保健食品有限公司 | 一种具有改善记忆及脑功能保健品及制作方法 |
| CN102755490A (zh) * | 2012-07-03 | 2012-10-31 | 杨振刚 | 九香散加味治疗帕金森病 |
| CN110237062A (zh) * | 2019-07-10 | 2019-09-17 | 吉林农业大学 | 一种以葡萄糖胺为调节剂的能够增强注意力的制剂 |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5005879B2 (ja) * | 2004-02-18 | 2012-08-22 | 太陽化学株式会社 | 抗ストレス及びリラックス用組成物 |
| EP1819241B1 (en) * | 2004-12-08 | 2014-04-30 | Unilever PLC | Food or beverage product comprising theanine and caffeine for enhancing mental alertness |
| US8945655B2 (en) * | 2007-07-10 | 2015-02-03 | Conopco, Inc. | Stable and consumable compositions |
| US20090155420A1 (en) * | 2007-12-12 | 2009-06-18 | Conopco, Inc., D/B/A Unilever | Food product with stabilized non-protein amino acids |
| KR100945462B1 (ko) * | 2008-03-27 | 2010-03-05 | 주식회사 하이리빙 | 중금속의 체내 흡수 억제 및 체외 배출에 효과가 있는 식물성 식품조성물 및 이를 포함하는 건강식품 |
| PL2343987T3 (pl) * | 2008-11-11 | 2013-05-31 | Unilever Nv | Herbaciana kompozycja |
| JP7037161B2 (ja) * | 2016-07-07 | 2022-03-16 | 株式会社東洋新薬 | 経口組成物 |
| CN111034761A (zh) * | 2019-12-23 | 2020-04-21 | 江西普正制药股份有限公司 | 一种杜仲饼干及其制备方法 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0873350A (ja) * | 1994-09-06 | 1996-03-19 | Itouen:Kk | 脳機能改善剤、食品及び飲料 |
| JP4627813B2 (ja) * | 1995-06-27 | 2011-02-09 | 太陽化学株式会社 | テアニン含有組成物 |
| JPH0940568A (ja) * | 1995-07-31 | 1997-02-10 | Itouen:Kk | カフェイン興奮作用抑制剤 |
| US5869528A (en) * | 1997-07-22 | 1999-02-09 | Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. | Therapeutical method for the treatment of attention-deficit/hyperactive disorders |
| AU2548899A (en) * | 1998-02-23 | 1999-09-06 | Taiyo Kagaku Co. Ltd. | Composition comprising theanine |
| US6132724A (en) * | 1998-04-29 | 2000-10-17 | City Of Hope National Medical Center | Allelic polygene diagnosis of reward deficiency syndrome and treatment |
| JP4669095B2 (ja) * | 1999-07-19 | 2011-04-13 | 太陽化学株式会社 | ペットの問題行動抑制組成物 |
| US6520921B1 (en) * | 2000-06-20 | 2003-02-18 | Eastman Kodak Company | Method for determining attention deficit hyperactivity disorder (ADHD) medication dosage and for monitoring the effects of (ADHD) medication |
| JP5300167B2 (ja) * | 2001-08-24 | 2013-09-25 | 太陽化学株式会社 | 気分障害治療用組成物 |
| US7455002B2 (en) * | 2004-12-23 | 2008-11-25 | The Goodyear Tire & Rubber Company | Method for cutting elastomeric materials and the article made by the method |
-
2001
- 2001-06-06 JP JP2001171342A patent/JP4812968B2/ja not_active Expired - Lifetime
- 2001-09-07 AU AU2001284470A patent/AU2001284470B2/en not_active Ceased
- 2001-09-07 KR KR10-2003-7001719A patent/KR100519574B1/ko active IP Right Grant
- 2001-09-07 US US10/343,931 patent/US20060004026A1/en not_active Abandoned
- 2001-09-07 DE DE60141918T patent/DE60141918D1/de not_active Expired - Lifetime
- 2001-09-07 CN CNB018148204A patent/CN1212836C/zh not_active Expired - Lifetime
- 2001-09-07 AT AT01963497T patent/ATE464894T1/de not_active IP Right Cessation
- 2001-09-07 CA CA002417837A patent/CA2417837C/en not_active Expired - Lifetime
- 2001-09-07 MX MXPA03001060A patent/MXPA03001060A/es not_active Application Discontinuation
- 2001-09-07 WO PCT/JP2001/007763 patent/WO2002100393A1/ja active IP Right Grant
- 2001-09-07 EP EP01963497A patent/EP1393725B1/en not_active Expired - Lifetime
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102526347A (zh) * | 2012-03-14 | 2012-07-04 | 上海善力健保健食品有限公司 | 一种具有改善记忆及脑功能保健品及制作方法 |
| CN102526347B (zh) * | 2012-03-14 | 2014-12-17 | 上海善力健保健食品有限公司 | 一种具有改善记忆及脑功能保健品及制作方法 |
| CN102755490A (zh) * | 2012-07-03 | 2012-10-31 | 杨振刚 | 九香散加味治疗帕金森病 |
| CN102755490B (zh) * | 2012-07-03 | 2013-10-23 | 杨振刚 | 九香散加味治疗帕金森病 |
| CN110237062A (zh) * | 2019-07-10 | 2019-09-17 | 吉林农业大学 | 一种以葡萄糖胺为调节剂的能够增强注意力的制剂 |
Also Published As
| Publication number | Publication date |
|---|---|
| ATE464894T1 (de) | 2010-05-15 |
| CA2417837C (en) | 2009-08-04 |
| EP1393725B1 (en) | 2010-04-21 |
| CA2417837A1 (en) | 2003-01-29 |
| CN1212836C (zh) | 2005-08-03 |
| KR100519574B1 (ko) | 2005-10-07 |
| JP2002363074A (ja) | 2002-12-18 |
| EP1393725A1 (en) | 2004-03-03 |
| AU2001284470B2 (en) | 2004-06-03 |
| MXPA03001060A (es) | 2003-05-27 |
| JP4812968B2 (ja) | 2011-11-09 |
| KR20030022366A (ko) | 2003-03-15 |
| DE60141918D1 (de) | 2010-06-02 |
| EP1393725A4 (en) | 2006-03-08 |
| US20060004026A1 (en) | 2006-01-05 |
| WO2002100393A1 (en) | 2002-12-19 |
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