CN1446225A - 5′－脱氧－n－(取代氧羰基)－5－氟胞嘧啶及其衍生物、制备方法,和包括该物质作为活性成分的抗癌组合物 - Google Patents

5′－脱氧－n－(取代氧羰基)－5－氟胞嘧啶及其衍生物、制备方法,和包括该物质作为活性成分的抗癌组合物 Download PDF

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Publication number
CN1446225A
CN1446225A CN01813741A CN01813741A CN1446225A CN 1446225 A CN1446225 A CN 1446225A CN 01813741 A CN01813741 A CN 01813741A CN 01813741 A CN01813741 A CN 01813741A CN 1446225 A CN1446225 A CN 1446225A
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CN
China
Prior art keywords
general formula
group
fluorocytosine
compound
derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN01813741A
Other languages
English (en)
Chinese (zh)
Inventor
金官熙
金润哲
金智英
李庆镐
卢文锺
朴永锡
曺成敏
朴镐珍
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Kolon Industries Inc
Original Assignee
Kolon Industries Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from KR1020000046179A external-priority patent/KR100730768B1/ko
Priority claimed from KR1020010044193A external-priority patent/KR20030009649A/ko
Application filed by Kolon Industries Inc filed Critical Kolon Industries Inc
Publication of CN1446225A publication Critical patent/CN1446225A/zh
Pending legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
CN01813741A 2000-08-09 2001-08-08 5′－脱氧－n－(取代氧羰基)－5－氟胞嘧啶及其衍生物、制备方法,和包括该物质作为活性成分的抗癌组合物 Pending CN1446225A (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
KR1020000046179A KR100730768B1 (ko) 2000-08-09 2000-08-09 5'-데옥시-ｎ-알킬옥시카르보닐-5-플루오로사이토신-5'-카르복실산 및 그 유도체와 이들의 제조방법
KR46179/2000 2000-08-09
KR1020010044193A KR20030009649A (ko) 2001-07-23 2001-07-23 Ν-알키닐옥시카르보닐-5-플루오로시토신 유도체, 그제조방법 및 이를 유효성분으로 포함하는 항암제
KR44193/2001 2001-07-23

Publications (1)

Publication Number Publication Date
CN1446225A true CN1446225A (zh) 2003-10-01

Family

ID=26638291

Family Applications (1)

Application Number Title Priority Date Filing Date
CN01813741A Pending CN1446225A (zh) 2000-08-09 2001-08-08 5′－脱氧－n－(取代氧羰基)－5－氟胞嘧啶及其衍生物、制备方法,和包括该物质作为活性成分的抗癌组合物

Country Status (5)

Country Link
EP (1) EP1311524A2 (enExample)
JP (1) JP2004505899A (enExample)
CN (1) CN1446225A (enExample)
AU (1) AU2001278804A1 (enExample)
WO (1) WO2002011668A2 (enExample)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103897004A (zh) * 2012-12-27 2014-07-02 鲁南制药集团股份有限公司 一种卡培他滨的合成方法
CN101993464B (zh) * 2009-08-19 2014-07-23 成都弘达药业有限公司 一种卡培他滨的制备方法
CN110831605A (zh) * 2017-04-26 2020-02-21 托马斯·I.·卡尔曼 多靶标的核苷衍生物

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2045256A4 (en) * 2006-07-21 2009-09-02 Taiho Pharmaceutical Co Ltd 2'-CYANOPYRIMIDINNUKLEOSIDVERBINDUNG
EP3452044A4 (en) * 2016-06-28 2020-04-22 Cellix Bio Private Limited COMPOSITIONS AND METHODS FOR THE TREATMENT OF CANCER
KR20210057025A (ko) * 2018-08-03 2021-05-20 셀릭스 바이오 프라이빗 리미티드 암의 치료를 위한 조성물 및 방법

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5968914A (en) * 1987-10-28 1999-10-19 Pro-Neuron, Inc. Treatment of chemotherapeutic agent and antiviral agent toxicity with acylated pyrimidine nucleosides
US5276151A (en) * 1990-02-01 1994-01-04 Emory University Method of synthesis of 1,3-dioxolane nucleosides
US5204466A (en) * 1990-02-01 1993-04-20 Emory University Method and compositions for the synthesis of bch-189 and related compounds
US5914331A (en) * 1990-02-01 1999-06-22 Emory University Antiviral activity and resolution of 2-hydroxymethyl-5-(5-fluorocytosin-1-yl)-1,3-oxathiolane

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101993464B (zh) * 2009-08-19 2014-07-23 成都弘达药业有限公司 一种卡培他滨的制备方法
CN103897004A (zh) * 2012-12-27 2014-07-02 鲁南制药集团股份有限公司 一种卡培他滨的合成方法
CN103897004B (zh) * 2012-12-27 2017-05-31 鲁南制药集团股份有限公司 一种卡培他滨的合成方法
CN110831605A (zh) * 2017-04-26 2020-02-21 托马斯·I.·卡尔曼 多靶标的核苷衍生物

Also Published As

Publication number Publication date
WO2002011668A2 (en) 2002-02-14
WO2002011668A3 (en) 2002-04-18
AU2001278804A1 (en) 2002-02-18
EP1311524A2 (en) 2003-05-21
JP2004505899A (ja) 2004-02-26

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