WO2002011668A3 - 5'-deoxy-n-(substituted oxycarbonyl)-5-fluorocytosine and derivatives thereof, method of preparing same, and anticancer composition comprising same as active ingredients - Google Patents
5'-deoxy-n-(substituted oxycarbonyl)-5-fluorocytosine and derivatives thereof, method of preparing same, and anticancer composition comprising same as active ingredients Download PDFInfo
- Publication number
- WO2002011668A3 WO2002011668A3 PCT/KR2001/001351 KR0101351W WO0211668A3 WO 2002011668 A3 WO2002011668 A3 WO 2002011668A3 KR 0101351 W KR0101351 W KR 0101351W WO 0211668 A3 WO0211668 A3 WO 0211668A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- same
- fluorocytosine
- derivatives
- deoxy
- active ingredients
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Biotechnology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
Abstract
Priority Applications (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2002517006A JP2004505899A (en) | 2000-08-09 | 2001-08-08 | 5'-Deoxy-N- (substituted oxycarbonyl) -5-fluorocytosine and derivatives thereof, method for producing the same, and anticancer composition containing the same as an active ingredient |
US10/333,984 US20030166606A1 (en) | 2000-08-09 | 2001-08-08 | 5'-deoxy-n-(substituted oxycarbonyl)-5-fluorocytosine and derivatives thereof, method of preparing same, and anticancer composition comprising same as active ingredients |
EP01957021A EP1311524A2 (en) | 2000-08-09 | 2001-08-08 | 5'-deoxy-n-(substituted oxycarbonyl)-5-fluorocytosine and derivatives thereof, method of preparing same, and anticancer composition comprising same as active ingredients |
AU2001278804A AU2001278804A1 (en) | 2000-08-09 | 2001-08-08 | 5'-deoxy-n-(substituted oxycarbonyl)-5-fluorocytosine and derivatives thereof, method of preparing same, and anticancer composition comprising same as active ingredients |
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
KR2000/46179 | 2000-08-09 | ||
KR1020000046179A KR100730768B1 (en) | 2000-08-09 | 2000-08-09 | 5'-deoxy-N-alkyloxycarbonyl-5-fluorocytosine-5'-carboxylic acid and its derivatives, and process for preparing thereof |
KR2001/44193 | 2001-07-23 | ||
KR1020010044193A KR20030009649A (en) | 2001-07-23 | 2001-07-23 | N-alkynyloxycarbonyl-5-fluorocytosine derivatives, their preparation method, and anticancer agent comprising the same |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2002011668A2 WO2002011668A2 (en) | 2002-02-14 |
WO2002011668A3 true WO2002011668A3 (en) | 2002-04-18 |
Family
ID=26638291
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/KR2001/001351 WO2002011668A2 (en) | 2000-08-09 | 2001-08-08 | 5'-deoxy-n-(substituted oxycarbonyl)-5-fluorocytosine and derivatives thereof, method of preparing same, and anticancer composition comprising same as active ingredients |
Country Status (5)
Country | Link |
---|---|
EP (1) | EP1311524A2 (en) |
JP (1) | JP2004505899A (en) |
CN (1) | CN1446225A (en) |
AU (1) | AU2001278804A1 (en) |
WO (1) | WO2002011668A2 (en) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2045256A4 (en) * | 2006-07-21 | 2009-09-02 | Taiho Pharmaceutical Co Ltd | 2'-cyanopyrimidine nucleoside compound |
CN101993464B (en) * | 2009-08-19 | 2014-07-23 | 成都弘达药业有限公司 | Preparation method of capecitabine |
CN103897004B (en) * | 2012-12-27 | 2017-05-31 | 鲁南制药集团股份有限公司 | A kind of synthetic method of capecitabine |
WO2018002739A1 (en) * | 2016-06-28 | 2018-01-04 | Cellix Bio Private Limited | Compositions and methods for the treatment of cancer |
JP7173613B2 (en) * | 2017-04-26 | 2022-11-16 | カールマン,トーマス,アイ. | Multi-targeted nucleoside derivatives |
SG11202100411TA (en) * | 2018-08-03 | 2021-02-25 | Cellix Bio Private Ltd | Compositions and methods for the treatment of cancer |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5814639A (en) * | 1990-02-01 | 1998-09-29 | Emory University | Method for the synthesis, compositions and use of 2'-deoxy-5-fluoro-3'-thiacytidine and related compounds |
US5852027A (en) * | 1991-02-22 | 1998-12-22 | Emory University | Antiviral 1,3-dioxolane nucleoside analogues |
US5914331A (en) * | 1990-02-01 | 1999-06-22 | Emory University | Antiviral activity and resolution of 2-hydroxymethyl-5-(5-fluorocytosin-1-yl)-1,3-oxathiolane |
US5968914A (en) * | 1987-10-28 | 1999-10-19 | Pro-Neuron, Inc. | Treatment of chemotherapeutic agent and antiviral agent toxicity with acylated pyrimidine nucleosides |
-
2001
- 2001-08-08 EP EP01957021A patent/EP1311524A2/en not_active Withdrawn
- 2001-08-08 AU AU2001278804A patent/AU2001278804A1/en not_active Abandoned
- 2001-08-08 WO PCT/KR2001/001351 patent/WO2002011668A2/en not_active Application Discontinuation
- 2001-08-08 CN CN01813741A patent/CN1446225A/en active Pending
- 2001-08-08 JP JP2002517006A patent/JP2004505899A/en active Pending
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5968914A (en) * | 1987-10-28 | 1999-10-19 | Pro-Neuron, Inc. | Treatment of chemotherapeutic agent and antiviral agent toxicity with acylated pyrimidine nucleosides |
US5814639A (en) * | 1990-02-01 | 1998-09-29 | Emory University | Method for the synthesis, compositions and use of 2'-deoxy-5-fluoro-3'-thiacytidine and related compounds |
US5914331A (en) * | 1990-02-01 | 1999-06-22 | Emory University | Antiviral activity and resolution of 2-hydroxymethyl-5-(5-fluorocytosin-1-yl)-1,3-oxathiolane |
US5852027A (en) * | 1991-02-22 | 1998-12-22 | Emory University | Antiviral 1,3-dioxolane nucleoside analogues |
Also Published As
Publication number | Publication date |
---|---|
CN1446225A (en) | 2003-10-01 |
AU2001278804A1 (en) | 2002-02-18 |
JP2004505899A (en) | 2004-02-26 |
EP1311524A2 (en) | 2003-05-21 |
WO2002011668A2 (en) | 2002-02-14 |
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