WO2002011668A3 - 5'-deoxy-n-(substituted oxycarbonyl)-5-fluorocytosine and derivatives thereof, method of preparing same, and anticancer composition comprising same as active ingredients - Google Patents

5'-deoxy-n-(substituted oxycarbonyl)-5-fluorocytosine and derivatives thereof, method of preparing same, and anticancer composition comprising same as active ingredients Download PDF

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Publication number
WO2002011668A3
WO2002011668A3 PCT/KR2001/001351 KR0101351W WO0211668A3 WO 2002011668 A3 WO2002011668 A3 WO 2002011668A3 KR 0101351 W KR0101351 W KR 0101351W WO 0211668 A3 WO0211668 A3 WO 0211668A3
Authority
WO
WIPO (PCT)
Prior art keywords
same
fluorocytosine
derivatives
deoxy
active ingredients
Prior art date
Application number
PCT/KR2001/001351
Other languages
French (fr)
Other versions
WO2002011668A2 (en
Inventor
Kwan-Hee Kim
Youn-Chul Kim
Ji-Young Kim
Kyeong-Ho Lee
Moon-Jong Noh
Young-Seok Park
Sung-Min Cho
Ho-Jin Park
Original Assignee
Kolon Inc
Kim Kwan Hee
Kim Youn Chul
Kim Ji Young
Lee Kyeong Ho
Noh Moon Jong
Park Young Seok
Cho Sung Min
Park Ho Jin
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from KR1020000046179A external-priority patent/KR100730768B1/en
Priority claimed from KR1020010044193A external-priority patent/KR20030009649A/en
Application filed by Kolon Inc, Kim Kwan Hee, Kim Youn Chul, Kim Ji Young, Lee Kyeong Ho, Noh Moon Jong, Park Young Seok, Cho Sung Min, Park Ho Jin filed Critical Kolon Inc
Priority to JP2002517006A priority Critical patent/JP2004505899A/en
Priority to US10/333,984 priority patent/US20030166606A1/en
Priority to EP01957021A priority patent/EP1311524A2/en
Priority to AU2001278804A priority patent/AU2001278804A1/en
Publication of WO2002011668A2 publication Critical patent/WO2002011668A2/en
Publication of WO2002011668A3 publication Critical patent/WO2002011668A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)

Abstract

Disclosed is a new fluorocytosine and derivatives thereof. The fluorocytosine and derivatives thereof provide a pharmaceutical composition exhibiting better anti-cancer characteristics than the conventional composition.
PCT/KR2001/001351 2000-08-09 2001-08-08 5'-deoxy-n-(substituted oxycarbonyl)-5-fluorocytosine and derivatives thereof, method of preparing same, and anticancer composition comprising same as active ingredients WO2002011668A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
JP2002517006A JP2004505899A (en) 2000-08-09 2001-08-08 5'-Deoxy-N- (substituted oxycarbonyl) -5-fluorocytosine and derivatives thereof, method for producing the same, and anticancer composition containing the same as an active ingredient
US10/333,984 US20030166606A1 (en) 2000-08-09 2001-08-08 5'-deoxy-n-(substituted oxycarbonyl)-5-fluorocytosine and derivatives thereof, method of preparing same, and anticancer composition comprising same as active ingredients
EP01957021A EP1311524A2 (en) 2000-08-09 2001-08-08 5'-deoxy-n-(substituted oxycarbonyl)-5-fluorocytosine and derivatives thereof, method of preparing same, and anticancer composition comprising same as active ingredients
AU2001278804A AU2001278804A1 (en) 2000-08-09 2001-08-08 5'-deoxy-n-(substituted oxycarbonyl)-5-fluorocytosine and derivatives thereof, method of preparing same, and anticancer composition comprising same as active ingredients

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
KR2000/46179 2000-08-09
KR1020000046179A KR100730768B1 (en) 2000-08-09 2000-08-09 5'-deoxy-N-alkyloxycarbonyl-5-fluorocytosine-5'-carboxylic acid and its derivatives, and process for preparing thereof
KR2001/44193 2001-07-23
KR1020010044193A KR20030009649A (en) 2001-07-23 2001-07-23 N-alkynyloxycarbonyl-5-fluorocytosine derivatives, their preparation method, and anticancer agent comprising the same

Publications (2)

Publication Number Publication Date
WO2002011668A2 WO2002011668A2 (en) 2002-02-14
WO2002011668A3 true WO2002011668A3 (en) 2002-04-18

Family

ID=26638291

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/KR2001/001351 WO2002011668A2 (en) 2000-08-09 2001-08-08 5'-deoxy-n-(substituted oxycarbonyl)-5-fluorocytosine and derivatives thereof, method of preparing same, and anticancer composition comprising same as active ingredients

Country Status (5)

Country Link
EP (1) EP1311524A2 (en)
JP (1) JP2004505899A (en)
CN (1) CN1446225A (en)
AU (1) AU2001278804A1 (en)
WO (1) WO2002011668A2 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2045256A4 (en) * 2006-07-21 2009-09-02 Taiho Pharmaceutical Co Ltd 2'-cyanopyrimidine nucleoside compound
CN101993464B (en) * 2009-08-19 2014-07-23 成都弘达药业有限公司 Preparation method of capecitabine
CN103897004B (en) * 2012-12-27 2017-05-31 鲁南制药集团股份有限公司 A kind of synthetic method of capecitabine
WO2018002739A1 (en) * 2016-06-28 2018-01-04 Cellix Bio Private Limited Compositions and methods for the treatment of cancer
JP7173613B2 (en) * 2017-04-26 2022-11-16 カールマン，トーマス，アイ． Multi-targeted nucleoside derivatives
SG11202100411TA (en) * 2018-08-03 2021-02-25 Cellix Bio Private Ltd Compositions and methods for the treatment of cancer

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5814639A (en) * 1990-02-01 1998-09-29 Emory University Method for the synthesis, compositions and use of 2'-deoxy-5-fluoro-3'-thiacytidine and related compounds
US5852027A (en) * 1991-02-22 1998-12-22 Emory University Antiviral 1,3-dioxolane nucleoside analogues
US5914331A (en) * 1990-02-01 1999-06-22 Emory University Antiviral activity and resolution of 2-hydroxymethyl-5-(5-fluorocytosin-1-yl)-1,3-oxathiolane
US5968914A (en) * 1987-10-28 1999-10-19 Pro-Neuron, Inc. Treatment of chemotherapeutic agent and antiviral agent toxicity with acylated pyrimidine nucleosides

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5968914A (en) * 1987-10-28 1999-10-19 Pro-Neuron, Inc. Treatment of chemotherapeutic agent and antiviral agent toxicity with acylated pyrimidine nucleosides
US5814639A (en) * 1990-02-01 1998-09-29 Emory University Method for the synthesis, compositions and use of 2'-deoxy-5-fluoro-3'-thiacytidine and related compounds
US5914331A (en) * 1990-02-01 1999-06-22 Emory University Antiviral activity and resolution of 2-hydroxymethyl-5-(5-fluorocytosin-1-yl)-1,3-oxathiolane
US5852027A (en) * 1991-02-22 1998-12-22 Emory University Antiviral 1,3-dioxolane nucleoside analogues

Also Published As

Publication number Publication date
CN1446225A (en) 2003-10-01
AU2001278804A1 (en) 2002-02-18
JP2004505899A (en) 2004-02-26
EP1311524A2 (en) 2003-05-21
WO2002011668A2 (en) 2002-02-14

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