CN1391615A - Dna测序方法 - Google Patents
Dna测序方法 Download PDFInfo
- Publication number
- CN1391615A CN1391615A CN00813785A CN00813785A CN1391615A CN 1391615 A CN1391615 A CN 1391615A CN 00813785 A CN00813785 A CN 00813785A CN 00813785 A CN00813785 A CN 00813785A CN 1391615 A CN1391615 A CN 1391615A
- Authority
- CN
- China
- Prior art keywords
- enzyme
- polynucleotide
- mark
- along
- solid support
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6869—Methods for sequencing
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- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Molecular Biology (AREA)
- Physics & Mathematics (AREA)
- Biotechnology (AREA)
- Analytical Chemistry (AREA)
- Biophysics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Saccharide Compounds (AREA)
- Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
- Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
Abstract
Description
Claims (21)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB9923644.0A GB9923644D0 (en) | 1999-10-06 | 1999-10-06 | DNA sequencing |
GB9923644.0 | 1999-10-06 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN1391615A true CN1391615A (zh) | 2003-01-15 |
CN1159457C CN1159457C (zh) | 2004-07-28 |
Family
ID=10862234
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CNB008137854A Expired - Lifetime CN1159457C (zh) | 1999-10-06 | 2000-10-06 | Dna测序方法 |
Country Status (21)
Country | Link |
---|---|
US (4) | US20050214849A1 (zh) |
EP (1) | EP1226271B1 (zh) |
JP (2) | JP5030249B2 (zh) |
KR (1) | KR100809171B1 (zh) |
CN (1) | CN1159457C (zh) |
AT (1) | ATE388242T1 (zh) |
AU (1) | AU769102B2 (zh) |
BR (1) | BR0014468A (zh) |
CA (1) | CA2386115C (zh) |
DE (1) | DE60038244T2 (zh) |
DK (1) | DK1226271T3 (zh) |
EA (1) | EA006702B1 (zh) |
ES (1) | ES2302497T3 (zh) |
GB (1) | GB9923644D0 (zh) |
HK (1) | HK1045857A1 (zh) |
IL (2) | IL148678A0 (zh) |
IS (1) | IS6333A (zh) |
MX (1) | MXPA02003534A (zh) |
NZ (1) | NZ517775A (zh) |
PT (1) | PT1226271E (zh) |
WO (1) | WO2001025480A2 (zh) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102317471A (zh) * | 2008-12-11 | 2012-01-11 | 加利福尼亚大学董事会 | 用于单个dna分子的直接测序的方法和系统 |
CN101460953B (zh) * | 2006-03-31 | 2012-05-30 | 索雷克萨公司 | 用于合成分析的序列的系统和装置 |
Families Citing this family (44)
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ES2183394T5 (es) * | 1997-07-28 | 2012-05-03 | Gen-Probe Incorporated | Análisis de la secuencia de ácidos nucleicos |
US6780591B2 (en) | 1998-05-01 | 2004-08-24 | Arizona Board Of Regents | Method of determining the nucleotide sequence of oligonucleotides and DNA molecules |
US7875440B2 (en) | 1998-05-01 | 2011-01-25 | Arizona Board Of Regents | Method of determining the nucleotide sequence of oligonucleotides and DNA molecules |
GB9907812D0 (en) * | 1999-04-06 | 1999-06-02 | Medical Biosystems Ltd | Sequencing |
EP1681356B1 (en) | 1999-05-19 | 2011-10-19 | Cornell Research Foundation, Inc. | Method for sequencing nucleic acid molecules |
US7056661B2 (en) | 1999-05-19 | 2006-06-06 | Cornell Research Foundation, Inc. | Method for sequencing nucleic acid molecules |
GB9923644D0 (en) | 1999-10-06 | 1999-12-08 | Medical Biosystems Ltd | DNA sequencing |
US20030064366A1 (en) | 2000-07-07 | 2003-04-03 | Susan Hardin | Real-time sequence determination |
WO2002044425A2 (en) | 2000-12-01 | 2002-06-06 | Visigen Biotechnologies, Inc. | Enzymatic nucleic acid synthesis: compositions and methods for altering monomer incorporation fidelity |
GB0112238D0 (en) * | 2001-05-18 | 2001-07-11 | Medical Biosystems Ltd | Sequencing method |
US6902921B2 (en) | 2001-10-30 | 2005-06-07 | 454 Corporation | Sulfurylase-luciferase fusion proteins and thermostable sulfurylase |
US6956114B2 (en) | 2001-10-30 | 2005-10-18 | '454 Corporation | Sulfurylase-luciferase fusion proteins and thermostable sulfurylase |
SE0201655D0 (sv) * | 2002-05-31 | 2002-05-31 | Amersham Biosciences Ab | A method of electrophoresis |
US20070122808A1 (en) * | 2003-07-15 | 2007-05-31 | Densham Daniel H | Measurement of a polynuleotide amplification reaction |
GB0317343D0 (en) * | 2003-07-24 | 2003-08-27 | Medical Biosystems Ltd | Polynucleotide sequencing |
US7169560B2 (en) | 2003-11-12 | 2007-01-30 | Helicos Biosciences Corporation | Short cycle methods for sequencing polynucleotides |
US7981604B2 (en) | 2004-02-19 | 2011-07-19 | California Institute Of Technology | Methods and kits for analyzing polynucleotide sequences |
US7170050B2 (en) | 2004-09-17 | 2007-01-30 | Pacific Biosciences Of California, Inc. | Apparatus and methods for optical analysis of molecules |
US7666593B2 (en) | 2005-08-26 | 2010-02-23 | Helicos Biosciences Corporation | Single molecule sequencing of captured nucleic acids |
GB0721340D0 (en) * | 2007-10-30 | 2007-12-12 | Isis Innovation | Polymerase-based single-molecule DNA sequencing |
CA2991818C (en) | 2008-03-28 | 2022-10-11 | Pacific Biosciences Of California, Inc. | Compositions and methods for nucleic acid sequencing |
US9182406B2 (en) | 2008-08-04 | 2015-11-10 | Biodesy, Inc. | Nonlinear optical detection of molecules comprising an unnatural amino acid possessing a hyperpolarizability |
US8911972B2 (en) | 2009-12-16 | 2014-12-16 | Pacific Biosciences Of California, Inc. | Sequencing methods using enzyme conformation |
WO2011159942A1 (en) * | 2010-06-18 | 2011-12-22 | Illumina, Inc. | Conformational probes and methods for sequencing nucleic acids |
WO2012129347A1 (en) | 2011-03-21 | 2012-09-27 | Biodesy, Llc | Classification of kinase inhibitors using nonlinear optical techniques |
DE102013202721A1 (de) * | 2013-02-20 | 2014-08-21 | Siemens Aktiengesellschaft | Sequenziervorrichtung zum Sequenzieren mindestens eines Nukleinsäureeinzelstrangs und Verfahren zum Sequenzieren mindestens eines Nukleinsäureeinzelstrangs |
GB201306444D0 (en) * | 2013-04-09 | 2013-05-22 | Base4 Innovation Ltd | Single nucleotide detection method |
EP3828279B1 (en) | 2014-07-15 | 2022-11-16 | Illumina, Inc. | Biochemically activated electronic device |
WO2016106286A1 (en) | 2014-12-23 | 2016-06-30 | Biodesy, Inc. | Attachment of proteins to interfaces for use in nonlinear optical detection |
US10077470B2 (en) | 2015-07-21 | 2018-09-18 | Omniome, Inc. | Nucleic acid sequencing methods and systems |
US10294514B2 (en) | 2016-04-29 | 2019-05-21 | Omniome, Inc. | Sequencing method employing ternary complex destabilization to identify cognate nucleotides |
CA3033741A1 (en) | 2016-08-15 | 2018-02-22 | Omniome, Inc. | Method and system for sequencing nucleic acids |
US10428378B2 (en) | 2016-08-15 | 2019-10-01 | Omniome, Inc. | Sequencing method for rapid identification and processing of cognate nucleotide pairs |
EP3562962B1 (en) | 2016-12-30 | 2022-01-05 | Omniome, Inc. | Method and system employing distinguishable polymerases for detecting ternary complexes and identifying cognate nucleotides |
WO2018136487A1 (en) | 2017-01-20 | 2018-07-26 | Omniome, Inc. | Process for cognate nucleotide detection in a nucleic acid sequencing workflow |
US9951385B1 (en) | 2017-04-25 | 2018-04-24 | Omniome, Inc. | Methods and apparatus that increase sequencing-by-binding efficiency |
US10161003B2 (en) | 2017-04-25 | 2018-12-25 | Omniome, Inc. | Methods and apparatus that increase sequencing-by-binding efficiency |
NZ759548A (en) * | 2017-09-15 | 2024-05-31 | Illumina Inc | Sequence-detection system |
CA3079411C (en) | 2017-10-19 | 2023-12-05 | Omniome, Inc. | Simultaneous background reduction and complex stabilization in binding assay workflows |
US11499962B2 (en) | 2017-11-17 | 2022-11-15 | Ultima Genomics, Inc. | Methods and systems for analyte detection and analysis |
US10267790B1 (en) | 2017-11-17 | 2019-04-23 | Ultima Genomics, Inc. | Systems for biological sample processing and analysis |
US10512911B1 (en) * | 2018-12-07 | 2019-12-24 | Ultima Genomics, Inc. | Implementing barriers for controlled environments during sample processing and detection |
US11118223B2 (en) | 2019-03-14 | 2021-09-14 | Ultima Genomics, Inc. | Methods, devices, and systems for analyte detection and analysis |
US12060148B2 (en) | 2022-08-16 | 2024-08-13 | Honeywell International Inc. | Ground resonance detection and warning system and method |
Family Cites Families (33)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SE462454B (sv) | 1988-11-10 | 1990-06-25 | Pharmacia Ab | Maetyta foer anvaendning i biosensorer |
GB8910880D0 (en) * | 1989-05-11 | 1989-06-28 | Amersham Int Plc | Sequencing method |
CA2044616A1 (en) | 1989-10-26 | 1991-04-27 | Roger Y. Tsien | Dna sequencing |
US5583026A (en) * | 1994-08-31 | 1996-12-10 | Cornell Research Foundation, Inc. | Process for reconstituting the polymerase III* and other subassemblies of E. coli DNA polymerase III holoenzyme from peptide subunits |
GB9208733D0 (en) | 1992-04-22 | 1992-06-10 | Medical Res Council | Dna sequencing method |
US5360714A (en) * | 1992-08-28 | 1994-11-01 | Fox Chase Cancer Center | Hepadnavirus polymerase gene product having RNA-dependent DNA priming and reverse transcriptase activities and methods of measuring the activities thereof |
AU687801B2 (en) | 1993-03-19 | 1998-03-05 | Sequenom, Inc. | DNA sequencing by mass spectrometry via exonuclease degradation |
WO1995006138A1 (en) * | 1993-08-25 | 1995-03-02 | The Regents Of The University Of California | Microscopic method for detecting micromotions |
US5747247A (en) * | 1994-07-25 | 1998-05-05 | The Regents Of The University Of California | Spectroscopic helicase assay |
US5801042A (en) * | 1994-08-18 | 1998-09-01 | The Trustees Of Columbia University In The City Of New York | Unique associated Kaposi's sarcoma virus sequences and uses thereof |
US5753439A (en) * | 1995-05-19 | 1998-05-19 | Trustees Of Boston University | Nucleic acid detection methods |
EP1009802B1 (en) * | 1997-02-12 | 2004-08-11 | Eugene Y. Chan | Methods for analyzimg polymers |
WO1998039484A1 (en) * | 1997-03-05 | 1998-09-11 | Scriptgen Pharmaceuticals, Inc. | Screen employing fluorescence anisotropy to identify compounds with affinity for nucleic acids |
US6159687A (en) * | 1997-03-18 | 2000-12-12 | Novo Nordisk A/S | Methods for generating recombined polynucleotides |
ES2183394T5 (es) | 1997-07-28 | 2012-05-03 | Gen-Probe Incorporated | Análisis de la secuencia de ácidos nucleicos |
US7875440B2 (en) * | 1998-05-01 | 2011-01-25 | Arizona Board Of Regents | Method of determining the nucleotide sequence of oligonucleotides and DNA molecules |
US6210896B1 (en) * | 1998-08-13 | 2001-04-03 | Us Genomics | Molecular motors |
WO2000009757A1 (en) | 1998-08-13 | 2000-02-24 | U.S. Genomics, Inc. | Optically characterizing polymers |
US6263286B1 (en) * | 1998-08-13 | 2001-07-17 | U.S. Genomics, Inc. | Methods of analyzing polymers using a spatial network of fluorophores and fluorescence resonance energy transfer |
JP2002537858A (ja) * | 1999-03-10 | 2002-11-12 | エーエスエム サイエンティフィック, インコーポレイテッド | 核酸の配列を直接決定するための方法 |
GB9907812D0 (en) * | 1999-04-06 | 1999-06-02 | Medical Biosystems Ltd | Sequencing |
US7056661B2 (en) * | 1999-05-19 | 2006-06-06 | Cornell Research Foundation, Inc. | Method for sequencing nucleic acid molecules |
US6335420B1 (en) | 1999-11-22 | 2002-01-01 | Ibc Advanced Technologies, Inc. | Polyamide ligand-containing polymeric resins and methods of using the same for removing, separating and/or concentrating desired metal ions from solutions |
GB9923644D0 (en) | 1999-10-06 | 1999-12-08 | Medical Biosystems Ltd | DNA sequencing |
US6908736B1 (en) * | 1999-10-06 | 2005-06-21 | Medical Biosystems, Ltd. | DNA sequencing method |
GB0112238D0 (en) | 2001-05-18 | 2001-07-11 | Medical Biosystems Ltd | Sequencing method |
GB0317343D0 (en) | 2003-07-24 | 2003-08-27 | Medical Biosystems Ltd | Polynucleotide sequencing |
GB0413082D0 (en) | 2004-06-11 | 2004-07-14 | Medical Biosystems Ltd | Method |
US8262900B2 (en) * | 2006-12-14 | 2012-09-11 | Life Technologies Corporation | Methods and apparatus for measuring analytes using large scale FET arrays |
US20100137143A1 (en) * | 2008-10-22 | 2010-06-03 | Ion Torrent Systems Incorporated | Methods and apparatus for measuring analytes |
US20100301398A1 (en) * | 2009-05-29 | 2010-12-02 | Ion Torrent Systems Incorporated | Methods and apparatus for measuring analytes |
US8673627B2 (en) * | 2009-05-29 | 2014-03-18 | Life Technologies Corporation | Apparatus and methods for performing electrochemical reactions |
US8574835B2 (en) * | 2009-05-29 | 2013-11-05 | Life Technologies Corporation | Scaffolded nucleic acid polymer particles and methods of making and using |
-
1999
- 1999-10-06 GB GBGB9923644.0A patent/GB9923644D0/en not_active Ceased
-
2000
- 2000-10-06 KR KR1020027004272A patent/KR100809171B1/ko not_active IP Right Cessation
- 2000-10-06 DK DK00964544T patent/DK1226271T3/da active
- 2000-10-06 WO PCT/GB2000/003860 patent/WO2001025480A2/en active IP Right Grant
- 2000-10-06 JP JP2001528630A patent/JP5030249B2/ja not_active Expired - Fee Related
- 2000-10-06 MX MXPA02003534A patent/MXPA02003534A/es unknown
- 2000-10-06 EP EP00964544A patent/EP1226271B1/en not_active Expired - Lifetime
- 2000-10-06 AT AT00964544T patent/ATE388242T1/de not_active IP Right Cessation
- 2000-10-06 PT PT00964544T patent/PT1226271E/pt unknown
- 2000-10-06 CA CA2386115A patent/CA2386115C/en not_active Expired - Lifetime
- 2000-10-06 EA EA200200428A patent/EA006702B1/ru not_active IP Right Cessation
- 2000-10-06 NZ NZ517775A patent/NZ517775A/en unknown
- 2000-10-06 BR BR0014468-1A patent/BR0014468A/pt not_active Application Discontinuation
- 2000-10-06 DE DE60038244T patent/DE60038244T2/de not_active Expired - Lifetime
- 2000-10-06 ES ES00964544T patent/ES2302497T3/es not_active Expired - Lifetime
- 2000-10-06 AU AU75467/00A patent/AU769102B2/en not_active Expired
- 2000-10-06 IL IL14867800A patent/IL148678A0/xx unknown
- 2000-10-06 CN CNB008137854A patent/CN1159457C/zh not_active Expired - Lifetime
-
2002
- 2002-03-13 IL IL148678A patent/IL148678A/en not_active IP Right Cessation
- 2002-04-05 IS IS6333A patent/IS6333A/is unknown
- 2002-08-23 HK HK02106240A patent/HK1045857A1/xx not_active IP Right Cessation
-
2005
- 2005-05-11 US US11/126,481 patent/US20050214849A1/en not_active Abandoned
-
2010
- 2010-02-22 US US12/710,059 patent/US7939264B1/en not_active Expired - Fee Related
-
2011
- 2011-03-29 US US13/074,949 patent/US20110177520A1/en not_active Abandoned
- 2011-12-01 JP JP2011264043A patent/JP2012196201A/ja active Pending
-
2012
- 2012-05-04 US US13/464,285 patent/US20120214164A1/en not_active Abandoned
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101460953B (zh) * | 2006-03-31 | 2012-05-30 | 索雷克萨公司 | 用于合成分析的序列的系统和装置 |
CN102317471A (zh) * | 2008-12-11 | 2012-01-11 | 加利福尼亚大学董事会 | 用于单个dna分子的直接测序的方法和系统 |
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Legal Events
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C06 | Publication | ||
PB01 | Publication | ||
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
C14 | Grant of patent or utility model | ||
GR01 | Patent grant | ||
ASS | Succession or assignment of patent right |
Owner name: RUIZHUWEIZHEN CO., LTD. Free format text: FORMER OWNER: MEDICAL BIOSYSTEMS LTD. Effective date: 20110614 Owner name: GEN-PROBE COMPANY Free format text: FORMER OWNER: MOBIUS BIOLOGICAL SYSTEMS INC. Effective date: 20110614 |
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C41 | Transfer of patent application or patent right or utility model | ||
C56 | Change in the name or address of the patentee |
Owner name: MOBIUS BIOLOGICAL SYSTEMS INC. Free format text: FORMER NAME: RUIZHUWEIZHEN CO., LTD. |
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COR | Change of bibliographic data |
Free format text: CORRECT: ADDRESS; FROM: DEVON, THE UNITED KINGDOM TO: KENT, THE UNITED KINGDOM Free format text: CORRECT: ADDRESS; FROM: KENT, THE UNITED KINGDOM TO: CALIFORNIA, THE USA |
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CP01 | Change in the name or title of a patent holder |
Address after: Kent England Patentee after: Mobius Biological Systems Co.,Ltd. Address before: Kent England Patentee before: Virgin Ruizhu Co.,Ltd. |
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TR01 | Transfer of patent right |
Effective date of registration: 20110614 Address after: American California Patentee after: Gen Probe Inc. Address before: Kent England Patentee before: Mobius Biological Systems Co.,Ltd. Effective date of registration: 20110614 Address after: Kent England Patentee after: Virgin Ruizhu Co.,Ltd. Address before: Devon Patentee before: Medical Biosystems Ltd. |
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CX01 | Expiry of patent term |
Granted publication date: 20040728 |
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CX01 | Expiry of patent term |