DE60038244D1 - Methode zur dns sequenzierung - Google Patents

Methode zur dns sequenzierung

Info

Publication number
DE60038244D1
DE60038244D1 DE60038244T DE60038244T DE60038244D1 DE 60038244 D1 DE60038244 D1 DE 60038244D1 DE 60038244 T DE60038244 T DE 60038244T DE 60038244 T DE60038244 T DE 60038244T DE 60038244 D1 DE60038244 D1 DE 60038244D1
Authority
DE
Germany
Prior art keywords
dna sequencing
polynucleotide
enzyme
detection
conformational change
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60038244T
Other languages
English (en)
Other versions
DE60038244T2 (de
Inventor
Daniel Henry Densham
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Gen Probe Inc
Original Assignee
Medical Biosystems Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Medical Biosystems Ltd filed Critical Medical Biosystems Ltd
Application granted granted Critical
Publication of DE60038244D1 publication Critical patent/DE60038244D1/de
Publication of DE60038244T2 publication Critical patent/DE60038244T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6869—Methods for sequencing

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Analytical Chemistry (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Saccharide Compounds (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
DE60038244T 1999-10-06 2000-10-06 DNA-Sequenzierungsverfahren Expired - Lifetime DE60038244T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB9923644 1999-10-06
GBGB9923644.0A GB9923644D0 (en) 1999-10-06 1999-10-06 DNA sequencing
PCT/GB2000/003860 WO2001025480A2 (en) 1999-10-06 2000-10-06 Dna sequencing method

Publications (2)

Publication Number Publication Date
DE60038244D1 true DE60038244D1 (de) 2008-04-17
DE60038244T2 DE60038244T2 (de) 2009-04-23

Family

ID=10862234

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60038244T Expired - Lifetime DE60038244T2 (de) 1999-10-06 2000-10-06 DNA-Sequenzierungsverfahren

Country Status (21)

Country Link
US (4) US20050214849A1 (de)
EP (1) EP1226271B1 (de)
JP (2) JP5030249B2 (de)
KR (1) KR100809171B1 (de)
CN (1) CN1159457C (de)
AT (1) ATE388242T1 (de)
AU (1) AU769102B2 (de)
BR (1) BR0014468A (de)
CA (1) CA2386115C (de)
DE (1) DE60038244T2 (de)
DK (1) DK1226271T3 (de)
EA (1) EA006702B1 (de)
ES (1) ES2302497T3 (de)
GB (1) GB9923644D0 (de)
HK (1) HK1045857A1 (de)
IL (2) IL148678A0 (de)
IS (1) IS6333A (de)
MX (1) MXPA02003534A (de)
NZ (1) NZ517775A (de)
PT (1) PT1226271E (de)
WO (1) WO2001025480A2 (de)

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EP1354064A2 (de) 2000-12-01 2003-10-22 Visigen Biotechnologies, Inc. Enzymatische nukleinsäuresynthese: zusammensetzungen und verfahren, um die zuverlässigkeit des monomereinbaus zu erhöhen
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US6956114B2 (en) 2001-10-30 2005-10-18 '454 Corporation Sulfurylase-luciferase fusion proteins and thermostable sulfurylase
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US20070122808A1 (en) * 2003-07-15 2007-05-31 Densham Daniel H Measurement of a polynuleotide amplification reaction
GB0317343D0 (en) * 2003-07-24 2003-08-27 Medical Biosystems Ltd Polynucleotide sequencing
US7169560B2 (en) 2003-11-12 2007-01-30 Helicos Biosciences Corporation Short cycle methods for sequencing polynucleotides
CA2557177A1 (en) 2004-02-19 2005-09-01 Stephen Quake Methods and kits for analyzing polynucleotide sequences
US7170050B2 (en) 2004-09-17 2007-01-30 Pacific Biosciences Of California, Inc. Apparatus and methods for optical analysis of molecules
US7666593B2 (en) 2005-08-26 2010-02-23 Helicos Biosciences Corporation Single molecule sequencing of captured nucleic acids
US8241573B2 (en) * 2006-03-31 2012-08-14 Illumina, Inc. Systems and devices for sequence by synthesis analysis
GB0721340D0 (en) * 2007-10-30 2007-12-12 Isis Innovation Polymerase-based single-molecule DNA sequencing
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US9182406B2 (en) 2008-08-04 2015-11-10 Biodesy, Inc. Nonlinear optical detection of molecules comprising an unnatural amino acid possessing a hyperpolarizability
US20110294116A1 (en) * 2008-12-11 2011-12-01 The Regents of the Unicersity of California Methods and systems for direct sequencing of single dna molecules
US8911972B2 (en) 2009-12-16 2014-12-16 Pacific Biosciences Of California, Inc. Sequencing methods using enzyme conformation
WO2011159942A1 (en) 2010-06-18 2011-12-22 Illumina, Inc. Conformational probes and methods for sequencing nucleic acids
US9428789B2 (en) 2011-03-21 2016-08-30 Biodesy, Inc. Classification of kinase inhibitors using nonlinear optical techniques
DE102013202721A1 (de) * 2013-02-20 2014-08-21 Siemens Aktiengesellschaft Sequenziervorrichtung zum Sequenzieren mindestens eines Nukleinsäureeinzelstrangs und Verfahren zum Sequenzieren mindestens eines Nukleinsäureeinzelstrangs
GB201306444D0 (en) * 2013-04-09 2013-05-22 Base4 Innovation Ltd Single nucleotide detection method
SG11201700348VA (en) 2014-07-15 2017-02-27 Illumina Inc Biochemically activated electronic device
WO2016106286A1 (en) 2014-12-23 2016-06-30 Biodesy, Inc. Attachment of proteins to interfaces for use in nonlinear optical detection
US10077470B2 (en) 2015-07-21 2018-09-18 Omniome, Inc. Nucleic acid sequencing methods and systems
AU2017258619B2 (en) 2016-04-29 2020-05-14 Pacific Biosciences Of California, Inc. Sequencing method employing ternary complex destabilization to identify cognate nucleotides
WO2018034780A1 (en) 2016-08-15 2018-02-22 Omniome, Inc. Sequencing method for rapid identification and processing of cognate nucleotide pairs
JP6828140B2 (ja) 2016-08-15 2021-02-10 オムニオム インコーポレイテッドＯｍｎｉｏｍｅ， Ｉｎｃ． 核酸をシーケンシングするための方法及びシステム
AU2017386515B2 (en) 2016-12-30 2021-08-19 Pacific Biosciences Of California, Inc. Method and system employing distinguishable polymerases for detecting ternary complexes and identifying cognate nucleotides
US10975427B2 (en) 2017-01-20 2021-04-13 Omniome, Inc. Process for cognate nucleotide detection in a nucleic acid sequencing workflow
US9951385B1 (en) 2017-04-25 2018-04-24 Omniome, Inc. Methods and apparatus that increase sequencing-by-binding efficiency
US10161003B2 (en) 2017-04-25 2018-12-25 Omniome, Inc. Methods and apparatus that increase sequencing-by-binding efficiency
AU2018331533B2 (en) * 2017-09-15 2021-10-28 Illumina, Inc. Sequence-detection system
CA3079411C (en) 2017-10-19 2023-12-05 Omniome, Inc. Simultaneous background reduction and complex stabilization in binding assay workflows
US10267790B1 (en) 2017-11-17 2019-04-23 Ultima Genomics, Inc. Systems for biological sample processing and analysis
US11499962B2 (en) 2017-11-17 2022-11-15 Ultima Genomics, Inc. Methods and systems for analyte detection and analysis
US10512911B1 (en) * 2018-12-07 2019-12-24 Ultima Genomics, Inc. Implementing barriers for controlled environments during sample processing and detection

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CA2044616A1 (en) 1989-10-26 1991-04-27 Roger Y. Tsien Dna sequencing
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US5360714A (en) * 1992-08-28 1994-11-01 Fox Chase Cancer Center Hepadnavirus polymerase gene product having RNA-dependent DNA priming and reverse transcriptase activities and methods of measuring the activities thereof
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WO1995006138A1 (en) * 1993-08-25 1995-03-02 The Regents Of The University Of California Microscopic method for detecting micromotions
US5747247A (en) * 1994-07-25 1998-05-05 The Regents Of The University Of California Spectroscopic helicase assay
US5801042A (en) * 1994-08-18 1998-09-01 The Trustees Of Columbia University In The City Of New York Unique associated Kaposi's sarcoma virus sequences and uses thereof
US5753439A (en) * 1995-05-19 1998-05-19 Trustees Of Boston University Nucleic acid detection methods
EP1009802B1 (de) * 1997-02-12 2004-08-11 Eugene Y. Chan Verfahren zur analyse von polymeren
CA2282418A1 (en) * 1997-03-05 1998-09-11 Scriptgen Pharmaceuticals, Inc. Screen employing fluorescence anisotropy to identify compounds with affinity for nucleic acids
US6159687A (en) * 1997-03-18 2000-12-12 Novo Nordisk A/S Methods for generating recombined polynucleotides
RU2198221C2 (ru) * 1997-07-28 2003-02-10 Медикал Биосистемз Лтд. Способ секвенирования полинуклеотида и устройство для его осуществления
US7875440B2 (en) * 1998-05-01 2011-01-25 Arizona Board Of Regents Method of determining the nucleotide sequence of oligonucleotides and DNA molecules
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US6263286B1 (en) * 1998-08-13 2001-07-17 U.S. Genomics, Inc. Methods of analyzing polymers using a spatial network of fluorophores and fluorescence resonance energy transfer
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ES2310514T3 (es) * 1999-03-10 2009-01-16 Asm Scientific, Inc. Un metodo para la secuenciacion directa de acido nucleico.
GB9907812D0 (en) * 1999-04-06 1999-06-02 Medical Biosystems Ltd Sequencing
US7056661B2 (en) * 1999-05-19 2006-06-06 Cornell Research Foundation, Inc. Method for sequencing nucleic acid molecules
US6335420B1 (en) 1999-11-22 2002-01-01 Ibc Advanced Technologies, Inc. Polyamide ligand-containing polymeric resins and methods of using the same for removing, separating and/or concentrating desired metal ions from solutions
US6908736B1 (en) * 1999-10-06 2005-06-21 Medical Biosystems, Ltd. DNA sequencing method
GB9923644D0 (en) 1999-10-06 1999-12-08 Medical Biosystems Ltd DNA sequencing
GB0112238D0 (en) 2001-05-18 2001-07-11 Medical Biosystems Ltd Sequencing method
GB0317343D0 (en) 2003-07-24 2003-08-27 Medical Biosystems Ltd Polynucleotide sequencing
GB0413082D0 (en) 2004-06-11 2004-07-14 Medical Biosystems Ltd Method
US8262900B2 (en) * 2006-12-14 2012-09-11 Life Technologies Corporation Methods and apparatus for measuring analytes using large scale FET arrays
US20100301398A1 (en) * 2009-05-29 2010-12-02 Ion Torrent Systems Incorporated Methods and apparatus for measuring analytes
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US8673627B2 (en) * 2009-05-29 2014-03-18 Life Technologies Corporation Apparatus and methods for performing electrochemical reactions

Also Published As

Publication number Publication date
WO2001025480A2 (en) 2001-04-12
IL148678A0 (en) 2002-09-12
CN1159457C (zh) 2004-07-28
IS6333A (is) 2002-04-05
EP1226271B1 (de) 2008-03-05
PT1226271E (pt) 2008-05-23
ES2302497T3 (es) 2008-07-16
EA200200428A1 (ru) 2002-10-31
CA2386115C (en) 2010-06-15
AU7546700A (en) 2001-05-10
CA2386115A1 (en) 2001-04-12
IL148678A (en) 2008-12-29
ATE388242T1 (de) 2008-03-15
GB9923644D0 (en) 1999-12-08
US20110177520A1 (en) 2011-07-21
DE60038244T2 (de) 2009-04-23
EP1226271A2 (de) 2002-07-31
CN1391615A (zh) 2003-01-15
AU769102B2 (en) 2004-01-15
BR0014468A (pt) 2002-08-20
WO2001025480A3 (en) 2002-05-16
US20120214164A1 (en) 2012-08-23
NZ517775A (en) 2004-01-30
JP2003511043A (ja) 2003-03-25
KR100809171B1 (ko) 2008-02-29
JP2012196201A (ja) 2012-10-18
US7939264B1 (en) 2011-05-10
MXPA02003534A (es) 2004-09-10
US20050214849A1 (en) 2005-09-29
HK1045857A1 (en) 2002-12-13
EA006702B1 (ru) 2006-02-24
KR20020059444A (ko) 2002-07-12
DK1226271T3 (da) 2008-07-07
JP5030249B2 (ja) 2012-09-19

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Legal Events

Date Code Title Description
8381 Inventor (new situation)

Inventor name: DENSHAM, DANIEL HENRY, TOTNES, DEVON, GB

8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: GEN-PROBE INCORPORATED, SAN DIEGO, CALIF., US