CN1367778A - 新型的具有5,6取代嘧啶环的羧酸衍生物、其制备方法和作为内皮素受体拮抗药的用途 - Google Patents
新型的具有5,6取代嘧啶环的羧酸衍生物、其制备方法和作为内皮素受体拮抗药的用途 Download PDFInfo
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- CN1367778A CN1367778A CN00810533A CN00810533A CN1367778A CN 1367778 A CN1367778 A CN 1367778A CN 00810533 A CN00810533 A CN 00810533A CN 00810533 A CN00810533 A CN 00810533A CN 1367778 A CN1367778 A CN 1367778A
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- A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
- A61P5/16—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4 for decreasing, blocking or antagonising the activity of the thyroid hormones
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/34—One oxygen atom
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/52—Two oxygen atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
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- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Urology & Nephrology (AREA)
- Pulmonology (AREA)
- Vascular Medicine (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Hydrogenated Pyridines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19933164.2 | 1999-07-20 | ||
| DE19933164A DE19933164A1 (de) | 1999-07-20 | 1999-07-20 | Neue Carbonsäurederivate mit 5,6 substituiertem Pyrimidinring, ihre Herstellung und Verwendung als Endothelin Rezeptorantagonisten |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1367778A true CN1367778A (zh) | 2002-09-04 |
Family
ID=7914884
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN00810533A Pending CN1367778A (zh) | 1999-07-20 | 2000-07-05 | 新型的具有5,6取代嘧啶环的羧酸衍生物、其制备方法和作为内皮素受体拮抗药的用途 |
Country Status (21)
| Country | Link |
|---|---|
| EP (1) | EP1196394A1 (hu) |
| JP (1) | JP2003505377A (hu) |
| KR (1) | KR20020019550A (hu) |
| CN (1) | CN1367778A (hu) |
| AR (1) | AR030026A1 (hu) |
| AU (1) | AU6561500A (hu) |
| BG (1) | BG106321A (hu) |
| BR (1) | BR0012592A (hu) |
| CA (1) | CA2379545A1 (hu) |
| CZ (1) | CZ2002190A3 (hu) |
| DE (1) | DE19933164A1 (hu) |
| HU (1) | HUP0202646A3 (hu) |
| IL (1) | IL147666A0 (hu) |
| MX (1) | MXPA02000616A (hu) |
| NO (1) | NO20020254L (hu) |
| PL (1) | PL353165A1 (hu) |
| SK (1) | SK772002A3 (hu) |
| TR (1) | TR200200622T2 (hu) |
| TW (1) | TW555749B (hu) |
| WO (1) | WO2001005771A1 (hu) |
| ZA (1) | ZA200200333B (hu) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2712865B1 (en) * | 2009-07-10 | 2016-03-16 | Cadila Healthcare Limited | Improved process for the preparation of ambrisentan |
| CA2792473A1 (en) | 2010-03-15 | 2011-09-22 | Natco Pharma Limited | A process for the preparation of highly pure ambrisentan |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19636046A1 (de) * | 1996-09-05 | 1998-03-12 | Basf Ag | Neue Carbonsäurederivate, ihre Herstellung und Verwendung als gemischte ET¶A¶/ET¶B¶-Rezeptorantagonisten |
| EP1027338A2 (de) * | 1997-10-31 | 2000-08-16 | Basf Aktiengesellschaft | Neue carbonsäurederivate, die amidseitenketten tragen, ihre herstellung und verwendung als endothelin-rezeptorantagonisten |
-
1999
- 1999-07-20 DE DE19933164A patent/DE19933164A1/de not_active Withdrawn
-
2000
- 2000-07-05 CZ CZ2002190A patent/CZ2002190A3/cs unknown
- 2000-07-05 MX MXPA02000616A patent/MXPA02000616A/es unknown
- 2000-07-05 SK SK77-2002A patent/SK772002A3/sk unknown
- 2000-07-05 BR BR0012592-0A patent/BR0012592A/pt not_active IP Right Cessation
- 2000-07-05 HU HU0202646A patent/HUP0202646A3/hu unknown
- 2000-07-05 KR KR1020027000815A patent/KR20020019550A/ko not_active Application Discontinuation
- 2000-07-05 CA CA002379545A patent/CA2379545A1/en not_active Abandoned
- 2000-07-05 AU AU65615/00A patent/AU6561500A/en not_active Abandoned
- 2000-07-05 JP JP2001511432A patent/JP2003505377A/ja not_active Abandoned
- 2000-07-05 CN CN00810533A patent/CN1367778A/zh active Pending
- 2000-07-05 WO PCT/EP2000/006293 patent/WO2001005771A1/de not_active Application Discontinuation
- 2000-07-05 TR TR2002/00622T patent/TR200200622T2/xx unknown
- 2000-07-05 IL IL14766600A patent/IL147666A0/xx unknown
- 2000-07-05 EP EP00953009A patent/EP1196394A1/de not_active Withdrawn
- 2000-07-05 PL PL00353165A patent/PL353165A1/xx not_active Application Discontinuation
- 2000-07-13 TW TW089113992A patent/TW555749B/zh active
- 2000-07-17 AR ARP000103661A patent/AR030026A1/es unknown
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2002
- 2002-01-15 ZA ZA200200333A patent/ZA200200333B/en unknown
- 2002-01-17 NO NO20020254A patent/NO20020254L/no not_active Application Discontinuation
- 2002-01-18 BG BG106321A patent/BG106321A/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CA2379545A1 (en) | 2001-01-25 |
| JP2003505377A (ja) | 2003-02-12 |
| SK772002A3 (en) | 2003-01-09 |
| KR20020019550A (ko) | 2002-03-12 |
| NO20020254D0 (no) | 2002-01-17 |
| EP1196394A1 (de) | 2002-04-17 |
| WO2001005771A1 (de) | 2001-01-25 |
| IL147666A0 (en) | 2002-08-14 |
| MXPA02000616A (es) | 2002-08-30 |
| NO20020254L (no) | 2002-02-20 |
| AR030026A1 (es) | 2003-08-13 |
| AU6561500A (en) | 2001-02-05 |
| DE19933164A1 (de) | 2001-01-25 |
| TW555749B (en) | 2003-10-01 |
| BG106321A (en) | 2002-08-30 |
| CZ2002190A3 (cs) | 2003-08-13 |
| ZA200200333B (en) | 2003-04-30 |
| TR200200622T2 (hu) | 2002-06-21 |
| HUP0202646A3 (en) | 2003-03-28 |
| HUP0202646A2 (hu) | 2003-02-28 |
| PL353165A1 (en) | 2003-10-20 |
| BR0012592A (pt) | 2002-05-28 |
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