CN1360586A - 通过对四氢叶酸酯盐分级结晶来制备四氢叶酸酯盐和四氢叶酸的纯立体异构体的方法 - Google Patents
通过对四氢叶酸酯盐分级结晶来制备四氢叶酸酯盐和四氢叶酸的纯立体异构体的方法 Download PDFInfo
- Publication number
- CN1360586A CN1360586A CN00810243A CN00810243A CN1360586A CN 1360586 A CN1360586 A CN 1360586A CN 00810243 A CN00810243 A CN 00810243A CN 00810243 A CN00810243 A CN 00810243A CN 1360586 A CN1360586 A CN 1360586A
- Authority
- CN
- China
- Prior art keywords
- acid
- tetrahydrofolic acid
- thfa
- diastereomer
- represent
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D475/00—Heterocyclic compounds containing pteridine ring systems
- C07D475/02—Heterocyclic compounds containing pteridine ring systems with an oxygen atom directly attached in position 4
- C07D475/04—Heterocyclic compounds containing pteridine ring systems with an oxygen atom directly attached in position 4 with a nitrogen atom directly attached in position 2
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
Description
Claims (15)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CH1300/1999 | 1999-07-14 | ||
CH1300/99 | 1999-07-14 | ||
CH01300/99A CH695217A5 (de) | 1999-07-14 | 1999-07-14 | Verfahren zur Trennung optischer Isomeren von Tetrahydrofolsäureestersalzen und Tetrahydrofolsäure. |
Publications (2)
Publication Number | Publication Date |
---|---|
CN1360586A true CN1360586A (zh) | 2002-07-24 |
CN1206229C CN1206229C (zh) | 2005-06-15 |
Family
ID=4207222
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CNB008102430A Expired - Lifetime CN1206229C (zh) | 1999-07-14 | 2000-07-12 | 通过对四氢叶酸酯盐分级结晶来制备四氢叶酸酯盐和四氢叶酸的纯立体异构体的方法 |
Country Status (13)
Country | Link |
---|---|
US (1) | US6858731B1 (zh) |
EP (1) | EP1200436B1 (zh) |
JP (1) | JP4949581B2 (zh) |
CN (1) | CN1206229C (zh) |
AT (1) | ATE412654T1 (zh) |
AU (1) | AU6272700A (zh) |
CA (1) | CA2378869C (zh) |
CH (1) | CH695217A5 (zh) |
DE (1) | DE50015428D1 (zh) |
DK (1) | DK1200436T3 (zh) |
ES (1) | ES2316375T3 (zh) |
PT (1) | PT1200436E (zh) |
WO (1) | WO2001004121A1 (zh) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN112351818A (zh) * | 2018-07-06 | 2021-02-09 | 默克专利股份有限公司 | 5-甲基-(6s)-四氢叶酸和l-异亮氨酸乙酯的结晶盐 |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CH694251A5 (de) * | 1999-07-14 | 2004-10-15 | Eprova Ag | Herstellung von Tetrahydropterin und Derivaten. |
ITMI20020132A1 (it) * | 2002-01-25 | 2003-07-25 | Gmt Fine Chemicals Sa | Processo per l'ottenimento dell'acido (6s)-5,6,7,8-tetraidrofolico |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS497416A (zh) * | 1972-05-12 | 1974-01-23 | ||
DE3821875C1 (zh) * | 1988-06-29 | 1990-02-15 | Eprova Ag, Forschungsinstitut, Schaffhausen, Ch | |
CH681303A5 (zh) * | 1991-01-16 | 1993-02-26 | Eprova Ag | |
CH682664A5 (en) * | 1991-10-15 | 1993-10-29 | Eprova Ag | Stable salts of 5,10-methylene tetrahydrofolate. |
CH686369A5 (de) * | 1994-05-09 | 1996-03-15 | Eprova Ag | Stabile kristalline (6S)- und (6R)-Tetrahydrofolseure. |
JP3433301B2 (ja) * | 1993-11-25 | 2003-08-04 | アサヒビール株式会社 | 5,6,7,8−テトラヒドロ−d−ネオプテリンの有機酸塩の製造法 |
-
1999
- 1999-07-14 CH CH01300/99A patent/CH695217A5/de not_active IP Right Cessation
-
2000
- 2000-07-12 EP EP00949322A patent/EP1200436B1/de not_active Expired - Lifetime
- 2000-07-12 WO PCT/EP2000/006647 patent/WO2001004121A1/de active Application Filing
- 2000-07-12 US US10/030,693 patent/US6858731B1/en not_active Expired - Lifetime
- 2000-07-12 AU AU62727/00A patent/AU6272700A/en not_active Abandoned
- 2000-07-12 ES ES00949322T patent/ES2316375T3/es not_active Expired - Lifetime
- 2000-07-12 CA CA002378869A patent/CA2378869C/en not_active Expired - Lifetime
- 2000-07-12 JP JP2001509730A patent/JP4949581B2/ja not_active Expired - Lifetime
- 2000-07-12 DE DE50015428T patent/DE50015428D1/de not_active Expired - Lifetime
- 2000-07-12 CN CNB008102430A patent/CN1206229C/zh not_active Expired - Lifetime
- 2000-07-12 AT AT00949322T patent/ATE412654T1/de active
- 2000-07-12 PT PT00949322T patent/PT1200436E/pt unknown
- 2000-07-12 DK DK00949322T patent/DK1200436T3/da active
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN112351818A (zh) * | 2018-07-06 | 2021-02-09 | 默克专利股份有限公司 | 5-甲基-(6s)-四氢叶酸和l-异亮氨酸乙酯的结晶盐 |
Also Published As
Publication number | Publication date |
---|---|
ES2316375T3 (es) | 2009-04-16 |
CA2378869C (en) | 2006-12-12 |
CA2378869A1 (en) | 2001-01-18 |
PT1200436E (pt) | 2009-02-10 |
ATE412654T1 (de) | 2008-11-15 |
WO2001004121A1 (de) | 2001-01-18 |
EP1200436A1 (de) | 2002-05-02 |
JP2003504371A (ja) | 2003-02-04 |
CN1206229C (zh) | 2005-06-15 |
DK1200436T3 (da) | 2009-02-23 |
JP4949581B2 (ja) | 2012-06-13 |
EP1200436B1 (de) | 2008-10-29 |
CH695217A5 (de) | 2006-01-31 |
US6858731B1 (en) | 2005-02-22 |
AU6272700A (en) | 2001-01-30 |
DE50015428D1 (de) | 2008-12-11 |
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C14 | Grant of patent or utility model | ||
GR01 | Patent grant | ||
ASS | Succession or assignment of patent right |
Owner name: MERCK + CIE PARTNERSHIP CORPORATION Free format text: FORMER OWNER: EPROVA AG (CH) FORSCHUNGSINSTITUT IM LATERNENACKER 5 CH-8200 SCHAFFHAUSEN (SWITZ Effective date: 20110511 |
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C41 | Transfer of patent application or patent right or utility model | ||
C56 | Change in the name or address of the patentee |
Owner name: MERCK + CIE CORPORATION Free format text: FORMER NAME: MERCK + CIE PARTNERSHIP CORPORATION |
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CP01 | Change in the name or title of a patent holder |
Address after: Schaffhausen, Switzerland Patentee after: Eprova AG Address before: Schaffhausen, Switzerland Patentee before: Merck and Seay partnership |
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TR01 | Transfer of patent right |
Effective date of registration: 20110511 Address after: Schaffhausen, Switzerland Patentee after: Merck and Seay partnership Address before: Schaffhausen, Switzerland Patentee before: Eprova AG |
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CX01 | Expiry of patent term |
Granted publication date: 20050615 |
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CX01 | Expiry of patent term |