CN1341209A - 使用偏振光对组织成像 - Google Patents

使用偏振光对组织成像 Download PDF

Info

Publication number
CN1341209A
CN1341209A CN00804259A CN00804259A CN1341209A CN 1341209 A CN1341209 A CN 1341209A CN 00804259 A CN00804259 A CN 00804259A CN 00804259 A CN00804259 A CN 00804259A CN 1341209 A CN1341209 A CN 1341209A
Authority
CN
China
Prior art keywords
light
tissue
polarization
image
optical fiber
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN00804259A
Other languages
English (en)
Chinese (zh)
Inventor
斯蒂芬·F·富尔格休姆
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Newton Laboratories Inc
Original Assignee
Newton Laboratories Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Newton Laboratories Inc filed Critical Newton Laboratories Inc
Publication of CN1341209A publication Critical patent/CN1341209A/zh
Pending legal-status Critical Current

Links

Images

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B23/00—Telescopes, e.g. binoculars; Periscopes; Instruments for viewing the inside of hollow bodies; Viewfinders; Optical aiming or sighting devices
    • G02B23/24—Instruments or systems for viewing the inside of hollow bodies, e.g. fibrescopes
    • G02B23/2407—Optical details
    • G02B23/2461—Illumination
    • G02B23/2469—Illumination using optical fibres
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B1/00—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
    • A61B1/00064—Constructional details of the endoscope body
    • A61B1/00071—Insertion part of the endoscope body
    • A61B1/0008—Insertion part of the endoscope body characterised by distal tip features
    • A61B1/00096—Optical elements
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B1/00—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
    • A61B1/00064—Constructional details of the endoscope body
    • A61B1/00071—Insertion part of the endoscope body
    • A61B1/0008—Insertion part of the endoscope body characterised by distal tip features
    • A61B1/00097—Sensors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B1/00—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
    • A61B1/00163—Optical arrangements
    • A61B1/00172—Optical arrangements with means for scanning
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B1/00—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
    • A61B1/00163—Optical arrangements
    • A61B1/00186—Optical arrangements with imaging filters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0075—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence by spectroscopy, i.e. measuring spectra, e.g. Raman spectroscopy, infrared absorption spectroscopy
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B23/00—Telescopes, e.g. binoculars; Periscopes; Instruments for viewing the inside of hollow bodies; Viewfinders; Optical aiming or sighting devices
    • G02B23/24—Instruments or systems for viewing the inside of hollow bodies, e.g. fibrescopes
    • G02B23/2407—Optical details
    • G02B23/2423—Optical details of the distal end
    • G02B23/243—Objectives for endoscopes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/47—Scattering, i.e. diffuse reflection
    • G01N2021/4704—Angular selective
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/47—Scattering, i.e. diffuse reflection
    • G01N2021/4792—Polarisation of scatter light
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/47—Scattering, i.e. diffuse reflection
    • G01N21/49—Scattering, i.e. diffuse reflection within a body or fluid

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Surgery (AREA)
  • General Health & Medical Sciences (AREA)
  • Optics & Photonics (AREA)
  • Pathology (AREA)
  • Biophysics (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Radiology & Medical Imaging (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Physics & Mathematics (AREA)
  • Astronomy & Astrophysics (AREA)
  • Analytical Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
  • Endoscopes (AREA)
  • Eye Examination Apparatus (AREA)
  • Instruments For Viewing The Inside Of Hollow Bodies (AREA)
CN00804259A 1999-01-25 2000-01-25 使用偏振光对组织成像 Pending CN1341209A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US11722199P 1999-01-25 1999-01-25
US60/117,221 1999-01-25

Publications (1)

Publication Number Publication Date
CN1341209A true CN1341209A (zh) 2002-03-20

Family

ID=22371613

Family Applications (1)

Application Number Title Priority Date Filing Date
CN00804259A Pending CN1341209A (zh) 1999-01-25 2000-01-25 使用偏振光对组织成像

Country Status (9)

Country Link
EP (1) EP1153280A2 (ko)
JP (1) JP2002535645A (ko)
KR (1) KR20010110346A (ko)
CN (1) CN1341209A (ko)
AU (1) AU2628200A (ko)
CA (1) CA2371782A1 (ko)
HK (1) HK1041727A1 (ko)
NZ (1) NZ513118A (ko)
WO (1) WO2000043750A2 (ko)

Cited By (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN100443041C (zh) * 2004-05-26 2008-12-17 吴冈 具有测量功能的内窥镜系统及其测量方法
CN100506150C (zh) * 2007-04-28 2009-07-01 马剑文 活体组织光学检测装置及其工作方法
CN101326428B (zh) * 2005-10-11 2011-05-18 杜克大学 用于内窥镜的角度分辨低相干干涉测量的系统和方法
CN102227625A (zh) * 2008-12-02 2011-10-26 皇家飞利浦电子股份有限公司 用于通过受抑全内反射来探测目标颗粒的传感器装置
CN101641043B (zh) * 2007-03-12 2012-01-11 皇家飞利浦电子股份有限公司 用于复合上皮早期癌症的诊断和分期的系统
CN102749287A (zh) * 2003-06-04 2012-10-24 突慧公司 利用光的传播模式测量物质中的光学不均匀性和其他属性
CN103596487A (zh) * 2011-07-15 2014-02-19 奥林巴斯医疗株式会社 探头
CN104219988A (zh) * 2012-05-25 2014-12-17 奥林巴斯医疗株式会社 测量探头
CN104280350A (zh) * 2013-07-03 2015-01-14 庞小峰 一种特殊锐化的癌症早期诊断和治疗效果检查的装置
CN104619235A (zh) * 2012-09-13 2015-05-13 奥林巴斯株式会社 测量探头以及生物体光学测量系统
WO2018126497A1 (zh) * 2017-01-09 2018-07-12 清华大学深圳研究生院 一种头端调制的内窥偏振成像系统及测量方法
CN113075097A (zh) * 2021-03-22 2021-07-06 厦门理工学院 一种基于散射光偏振检测的粒径测量方法、装置及设备

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002071026A2 (en) * 2001-03-02 2002-09-12 Spectrx, Inc. System and method for determining tissue characteristics
WO2002018658A1 (en) * 2000-08-14 2002-03-07 Oralscan Laboratories, Inc. Detection of epithelial dysplasia
JP2005515472A (ja) 2002-01-18 2005-05-26 ニユートン・ラボラトリーズ・インコーポレーテツド 分光診断方法とシステム
US7404929B2 (en) 2002-01-18 2008-07-29 Newton Laboratories, Inc. Spectroscopic diagnostic methods and system based on scattering of polarized light
AU2002337504A1 (en) * 2002-06-08 2003-12-22 Kwon Soo Ha Method for protein chip analysis by using surface plasmon resonance spectroscopic imaging technology
JP4535697B2 (ja) * 2003-07-23 2010-09-01 オリンパス株式会社 生体組織の光散乱観測内視鏡装置
CA2539184A1 (en) * 2003-09-19 2005-03-31 The General Hospital Corporation Fluorescence polarization imaging devices and methods
WO2007014213A2 (en) * 2005-07-25 2007-02-01 Massachusetts Institute Of Technology Tri modal spectroscopic imaging
WO2008102294A2 (en) * 2007-02-20 2008-08-28 Koninklijke Philips Electronics N.V. An optical device for assessing optical depth in a sample
DE202008009859U1 (de) * 2007-12-21 2009-03-05 Berthold Technologies Gmbh & Co. Kg Vorrichtung zur wahlweisen Messung von insbesondere Lumineszenz- und/oder Fluoreszenzstrahlung
JP4575474B2 (ja) * 2008-06-11 2010-11-04 国立大学法人東京工業大学 生体組織識別装置および方法
KR101109968B1 (ko) 2008-07-23 2012-02-17 올림푸스 메디칼 시스템즈 가부시키가이샤 피검체 관측 장치 및 피검체 관측 방법
JP2010025867A (ja) * 2008-07-23 2010-02-04 Olympus Medical Systems Corp 被検体観測装置及び被検体観測方法
JP5191831B2 (ja) * 2008-07-23 2013-05-08 オリンパスメディカルシステムズ株式会社 被検体観測装置及び被検体観測装置の作動方法
JP5532479B2 (ja) * 2010-03-31 2014-06-25 住友化学株式会社 金型検査方法、防眩製品ヘイズ予測方法および防眩製品反射像鮮明度予測方法
JPWO2012057150A1 (ja) * 2010-10-29 2014-05-12 オリンパス株式会社 光学測定装置およびプローブ
JP6028015B2 (ja) * 2012-03-07 2016-11-16 オリンパス株式会社 測定プローブ
CN104159500B (zh) 2012-03-08 2018-08-07 皇家飞利浦有限公司 用于确定组织的特性的装置
DE102012221527A1 (de) * 2012-11-26 2014-06-12 Heine Optotechnik Gmbh & Co Kg Optisches Diagnoseinstrument
EP2989441B1 (en) * 2013-04-21 2019-01-02 Mobileodt Ltd A polarized light imaging apparatus and associated method for separating light from a surface of a sample and its deeper layers
KR101503272B1 (ko) 2013-07-26 2015-03-18 연세대학교 원주산학협력단 관절염 진단을 위한 다중 모드 광 영상장치
CA3074566A1 (en) * 2017-08-31 2019-03-07 Metalenz, Inc. Transmissive metasurface lens integration
WO2021021671A1 (en) 2019-07-26 2021-02-04 Metalenz, Inc. Aperture-metasurface and hybrid refractive-metasurface imaging systems
US11927769B2 (en) 2022-03-31 2024-03-12 Metalenz, Inc. Polarization sorting metasurface microlens array device

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS61129554A (ja) * 1984-11-28 1986-06-17 Nippon Paint Co Ltd 散乱光測定装置
GB8701521D0 (en) * 1987-01-23 1993-12-01 British Aerospace Multi-parameter imaging polarimeter
US4953978A (en) * 1989-03-03 1990-09-04 Coulter Electronics Of New England, Inc. Particle size analysis utilizing polarization intensity differential scattering
AU1459392A (en) * 1991-02-22 1992-09-15 Coulter Corporation Method and apparatus for screening microscopic cells utilizing polarized light scatter techniques
JPH0611439A (ja) * 1992-06-29 1994-01-21 Olympus Optical Co Ltd 生体組織の酸素代謝測定装置
US5672875A (en) * 1992-07-15 1997-09-30 Optix Lp Methods of minimizing scattering and improving tissue sampling in non-invasive testing and imaging
US5421339A (en) * 1993-05-12 1995-06-06 Board Of Regents, The University Of Texas System Diagnosis of dysplasia using laser induced fluoroescence
JP3451515B2 (ja) * 1995-04-06 2003-09-29 オムロン株式会社 光学式センサ装置
US5788639A (en) * 1995-07-13 1998-08-04 Lucid Technologies, Inc. Confocal imaging through thick dermal tissue
US5719399A (en) * 1995-12-18 1998-02-17 The Research Foundation Of City College Of New York Imaging and characterization of tissue based upon the preservation of polarized light transmitted therethrough
JPH09297099A (ja) * 1996-05-07 1997-11-18 Hitachi Ltd カラー近接場光学顕微鏡
JPH10246697A (ja) * 1997-03-03 1998-09-14 Nikon Corp 光学的検査方法及び光学的検査装置

Cited By (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102749287B (zh) * 2003-06-04 2015-08-19 广东永士达医疗科技有限公司 利用光的传播模式测量物质中的光学不均匀性和其他属性
CN102749287A (zh) * 2003-06-04 2012-10-24 突慧公司 利用光的传播模式测量物质中的光学不均匀性和其他属性
CN100443041C (zh) * 2004-05-26 2008-12-17 吴冈 具有测量功能的内窥镜系统及其测量方法
CN101326428B (zh) * 2005-10-11 2011-05-18 杜克大学 用于内窥镜的角度分辨低相干干涉测量的系统和方法
CN101641043B (zh) * 2007-03-12 2012-01-11 皇家飞利浦电子股份有限公司 用于复合上皮早期癌症的诊断和分期的系统
CN100506150C (zh) * 2007-04-28 2009-07-01 马剑文 活体组织光学检测装置及其工作方法
CN102227625A (zh) * 2008-12-02 2011-10-26 皇家飞利浦电子股份有限公司 用于通过受抑全内反射来探测目标颗粒的传感器装置
CN103596487A (zh) * 2011-07-15 2014-02-19 奥林巴斯医疗株式会社 探头
CN103596487B (zh) * 2011-07-15 2015-11-25 奥林巴斯株式会社 探头
CN104219988A (zh) * 2012-05-25 2014-12-17 奥林巴斯医疗株式会社 测量探头
CN104619235A (zh) * 2012-09-13 2015-05-13 奥林巴斯株式会社 测量探头以及生物体光学测量系统
US10149619B2 (en) 2012-09-13 2018-12-11 Olympus Corporation Measurement probe and biological optical measurement system
CN104280350A (zh) * 2013-07-03 2015-01-14 庞小峰 一种特殊锐化的癌症早期诊断和治疗效果检查的装置
WO2018126497A1 (zh) * 2017-01-09 2018-07-12 清华大学深圳研究生院 一种头端调制的内窥偏振成像系统及测量方法
CN113075097A (zh) * 2021-03-22 2021-07-06 厦门理工学院 一种基于散射光偏振检测的粒径测量方法、装置及设备

Also Published As

Publication number Publication date
JP2002535645A (ja) 2002-10-22
KR20010110346A (ko) 2001-12-13
CA2371782A1 (en) 2000-07-27
AU2628200A (en) 2000-08-07
EP1153280A2 (en) 2001-11-14
HK1041727A1 (zh) 2002-07-19
NZ513118A (en) 2004-02-27
WO2000043750A2 (en) 2000-07-27
WO2000043750A3 (en) 2000-11-23
WO2000043750A9 (en) 2001-08-30

Similar Documents

Publication Publication Date Title
CN1341209A (zh) 使用偏振光对组织成像
CN1211046C (zh) 一种在体外检测组织中发育异常的方法和光纤探头
CN100381095C (zh) 非侵入地探测组织中氧代谢量的装置
CN103635131B (zh) 对相关组织样本进行光学分析的设备
Gebhart et al. Liquid-crystal tunable filter spectral imaging for brain tumor demarcation
EP1372469B1 (en) Method for the determination of the optical properties of a multi-layered tissue
US7440659B2 (en) Depth-resolved reflectance instrument and method for its use
US20110059016A1 (en) Optical assay system with a multi-probe imaging array
JPH11506202A (ja) 非侵入的検査及びイメージングにおける散乱を最小化し且つ組織サンプリングを改善する方法
CN1169665A (zh) 用于生物组织体内测量的光耦合器
CA2175348A1 (en) Object imaging using diffuse light
CN101612034B (zh) 重构混浊介质光学参数的时间分辨测量系统及方法
WO2013185087A1 (en) Methods and systems for intraoperative tumor margin assessment in surgical cavities and resected tissue specimens
JPH11510254A (ja) 光学的微細プローベ及び材料のスペクトル分析方法
CN104873175A (zh) 扩散光学层析和光声层析联合测量系统及方法
Qu et al. Excitation-and-collection geometry insensitive fluorescence imaging of tissue-simulating turbid media
US20190041328A1 (en) Portable optical apparatus for diffuse reflectance spectroscopy
Baria et al. Label-free spectroscopic diagnosis of urothelial carcinoma
Wood et al. Infrared imaging of normal and diseased cervical tissue sections
Baria et al. Tumour detection and staging through multimodal fibre-probe spectroscopy
AU2002251598B2 (en) Method and an arrangement for the determination of the optical properties of a multi-layered tissue
Nathel Diagnostic Scattering Properties of Particles and Tissues
AU2004205093A1 (en) Polarized light scattering spectroscopy of tissue
Backman Light scattering spectroscopic imaging of tissues
AU2004222851A1 (en) Imaging of tissue using polarized light

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C02 Deemed withdrawal of patent application after publication (patent law 2001)
WD01 Invention patent application deemed withdrawn after publication