CN1332029C - 突变的重组过敏原 - Google Patents

突变的重组过敏原 Download PDF

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Publication number
CN1332029C
CN1332029C CNB998040312A CN99804031A CN1332029C CN 1332029 C CN1332029 C CN 1332029C CN B998040312 A CNB998040312 A CN B998040312A CN 99804031 A CN99804031 A CN 99804031A CN 1332029 C CN1332029 C CN 1332029C
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CN
China
Prior art keywords
allergen
recombinant
derived
amino acid
segment
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Expired - Fee Related
Application number
CNB998040312A
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English (en)
Chinese (zh)
Other versions
CN1293710A (zh
Inventor
H·H·意普森
M·D·司庞弗特
J·N·拉森
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ALK Abello AS
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ALK Abello AS
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Application filed by ALK Abello AS filed Critical ALK Abello AS
Publication of CN1293710A publication Critical patent/CN1293710A/zh
Application granted granted Critical
Publication of CN1332029C publication Critical patent/CN1332029C/zh
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/415—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from plants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Botany (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Immunology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pulmonology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CNB998040312A 1998-03-16 1999-03-16 突变的重组过敏原 Expired - Fee Related CN1332029C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DK36498 1998-03-16
DK0364/98 1998-03-16

Publications (2)

Publication Number Publication Date
CN1293710A CN1293710A (zh) 2001-05-02
CN1332029C true CN1332029C (zh) 2007-08-15

Family

ID=8092687

Family Applications (1)

Application Number Title Priority Date Filing Date
CNB998040312A Expired - Fee Related CN1332029C (zh) 1998-03-16 1999-03-16 突变的重组过敏原

Country Status (19)

Country Link
US (1) US20040091500A1 (enExample)
EP (1) EP1062341B1 (enExample)
JP (1) JP2002506648A (enExample)
KR (1) KR20010041918A (enExample)
CN (1) CN1332029C (enExample)
AT (1) ATE408690T1 (enExample)
AU (1) AU749749B2 (enExample)
CA (1) CA2323687C (enExample)
DE (1) DE69939584D1 (enExample)
DK (1) DK1062341T3 (enExample)
ES (1) ES2313776T3 (enExample)
HU (1) HUP0101464A3 (enExample)
IL (2) IL138339A0 (enExample)
NO (1) NO328354B1 (enExample)
NZ (1) NZ506665A (enExample)
PL (1) PL194804B1 (enExample)
PT (1) PT1062341E (enExample)
WO (1) WO1999047680A1 (enExample)
ZA (1) ZA200004819B (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102690340A (zh) * 2012-03-30 2012-09-26 广州医学院第二附属医院 一种重组巴西坚果过敏原与突变体及其制备方法和应用

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020192792A1 (en) * 2000-04-28 2002-12-19 Palle Schneider Laccase mutants
IT1318692B1 (it) * 2000-09-12 2003-08-27 Consiglio Nazionale Ricerche Varianti di proteine allergeniche di phleum pratense.
IT1318690B1 (it) * 2000-09-12 2003-08-27 Consiglio Nazionale Ricerche Varianti dell'allergene maggiore par j 2 di parietaria judaica.
EP1340085B1 (en) * 2000-10-17 2008-07-30 Besst-Test Aps Assay for directly detecting a biological cell in a body fluid sample
DE60136653D1 (de) * 2000-11-16 2009-01-02 Alk Abello As Mutante allergene
DK1219300T3 (da) * 2000-12-28 2007-03-05 Biomay Prod & Handel Behandling af allergi
ATE448793T1 (de) * 2001-03-02 2009-12-15 Univ Rockefeller Rekombinante hybrid-allergenkonstrukte mit verringerter allergenität unter beibehaltung der immunogenität des natürlichen allergens
EP1436627A2 (en) * 2001-10-05 2004-07-14 Novozymes A/S Kit for predicting binding of a specific antibody to a potential immunogen and method of screening
WO2003072601A1 (de) * 2002-02-27 2003-09-04 Merck Patent Gmbh VERFAHREN ZUR HERSTELLUNG VON HYPOALLERGENEM BIRKENPOLLENHAUPTALLERGEN rBet v 1
EP1504089A2 (en) * 2002-05-16 2005-02-09 Alk Abell A/S Allergen mutants
WO2004039834A2 (en) * 2002-11-01 2004-05-13 Alk-Abelló A/S Recombinant protein variants
WO2004047793A1 (en) 2002-11-26 2004-06-10 Alk-Abelló A/S Pharmaceutical allergen product
US8012505B2 (en) 2003-02-28 2011-09-06 Alk-Abello A/S Dosage form having a saccharide matrix
CA2516291C (en) 2003-02-28 2012-02-14 Alk-Abello A/S Dosage form having a saccharide matrix
WO2005058474A1 (en) 2003-12-19 2005-06-30 Alk-Abelló A/S Cryogranulation and storage method for active pharmaceutical agents
AU2006299310A1 (en) 2005-10-04 2007-04-12 Alk-Abello A/S Solid vaccine formulation
ITMI20052517A1 (it) * 2005-12-29 2007-06-30 Lofarma Spa Varianbtio ipoallergeniche dell'allergene maggiore bet v 1 di polline di betula verrucosa
CN101473028B (zh) * 2006-04-20 2012-11-07 新加坡国立大学 重组乳杆菌及其用途
EP2481418A1 (en) * 2007-02-15 2012-08-01 MannKind Corporation A method for enhancing T cell response
EP1974746B1 (en) 2007-03-28 2012-01-11 Alk-Abelló A/S Use of an adjuvanted allergy vaccine formulation for parenteral administration
EP2028188A1 (en) * 2007-08-21 2009-02-25 Biomay AG Hypoallergenic molecules
DE202008006598U1 (de) 2008-04-11 2008-10-02 Alk-Abelló A/S Allergie-Impfstoff-Formulierung zur mucosalen Verabreichung
EP2442828B1 (en) 2009-06-19 2016-08-03 Alk-Abelló S.A. Novel manner of administrating allergen in allergen specific immunotherapy
CN102584966A (zh) * 2011-11-14 2012-07-18 广州医学院第二附属医院 一种重组花生过敏原与突变体及其制备方法和应用
CN102603879A (zh) * 2012-03-30 2012-07-25 广州医学院第二附属医院 一种重组大豆过敏原与突变体及其制备方法和应用
CN102617715A (zh) * 2012-03-30 2012-08-01 广州医学院第二附属医院 一种重组真菌主要过敏原与突变体及其制备方法和应用
CN102617719A (zh) * 2012-03-30 2012-08-01 广州医学院第二附属医院 一种重组大米过敏原与突变体及其制备方法和应用
CN102675439A (zh) * 2012-03-31 2012-09-19 广州医学院第二附属医院 一种重组黑麦草花粉过敏原与突变体的制备方法和应用
EP2952200A1 (en) 2014-06-04 2015-12-09 Alk-Abelló A/S Allergen for prophylactic treatment of allergy
EP4058059B1 (en) * 2019-11-13 2024-10-09 The Regents Of The University Of Michigan Nanoemulsion compositions for treating aeroallergen associated allergy and inflammation
CN111187606B (zh) * 2020-02-25 2022-06-14 江苏海洋大学 一种用于海水基可循环清洁压裂液的表面活性剂及其制备方法

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997033910A1 (en) * 1996-03-11 1997-09-18 The Rockefeller University Immunomodulatory peptides of vespid antigen 5

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69940805D1 (de) * 1998-01-31 2009-06-10 Sinai School Medicine Verfahren und reagenzien zur verminderung der klinischen reaktion zur allergie
IT1318692B1 (it) * 2000-09-12 2003-08-27 Consiglio Nazionale Ricerche Varianti di proteine allergeniche di phleum pratense.

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997033910A1 (en) * 1996-03-11 1997-09-18 The Rockefeller University Immunomodulatory peptides of vespid antigen 5

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102690340A (zh) * 2012-03-30 2012-09-26 广州医学院第二附属医院 一种重组巴西坚果过敏原与突变体及其制备方法和应用

Also Published As

Publication number Publication date
NO328354B1 (no) 2010-02-01
NO20004614D0 (no) 2000-09-15
CA2323687C (en) 2008-11-25
AU749749B2 (en) 2002-07-04
NO20004614L (no) 2000-10-26
EP1062341B1 (en) 2008-09-17
WO1999047680A1 (en) 1999-09-23
ES2313776T3 (es) 2009-03-01
HUP0101464A3 (en) 2004-10-28
ATE408690T1 (de) 2008-10-15
DK1062341T3 (da) 2008-11-03
ZA200004819B (en) 2001-05-30
PL343029A1 (en) 2001-07-30
CA2323687A1 (en) 1999-09-23
AU2714799A (en) 1999-10-11
HUP0101464A2 (hu) 2001-08-28
NZ506665A (en) 2003-08-29
CN1293710A (zh) 2001-05-02
HK1033591A1 (en) 2001-09-07
EP1062341A1 (en) 2000-12-27
IL138339A0 (en) 2001-10-31
JP2002506648A (ja) 2002-03-05
PL194804B1 (pl) 2007-07-31
DE69939584D1 (de) 2008-10-30
KR20010041918A (ko) 2001-05-25
PT1062341E (pt) 2008-12-24
IL138339A (en) 2009-06-15
US20040091500A1 (en) 2004-05-13

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C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C14 Grant of patent or utility model
GR01 Patent grant
C56 Change in the name or address of the patentee

Owner name: ALK-ABELL A/S

Free format text: FORMER NAME: ALK-ABELLO A/S

CP01 Change in the name or title of a patent holder

Address after: Holm Hess, Denmark

Patentee after: Alk Abello AS

Address before: Holm Hess, Denmark

Patentee before: Alk Abello AS

C17 Cessation of patent right
CF01 Termination of patent right due to non-payment of annual fee

Granted publication date: 20070815

Termination date: 20140316