CA2323687C - Mutant recombinant allergens - Google Patents
Mutant recombinant allergens Download PDFInfo
- Publication number
- CA2323687C CA2323687C CA002323687A CA2323687A CA2323687C CA 2323687 C CA2323687 C CA 2323687C CA 002323687 A CA002323687 A CA 002323687A CA 2323687 A CA2323687 A CA 2323687A CA 2323687 C CA2323687 C CA 2323687C
- Authority
- CA
- Canada
- Prior art keywords
- allergen
- recombinant
- derived
- amino acid
- bet
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
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- 125000001500 prolyl group Chemical group [H]N1C([H])(C(=O)[*])C([H])([H])C([H])([H])C1([H])[H] 0.000 description 1
- 108010031719 prolyl-serine Proteins 0.000 description 1
- 108010070643 prolylglutamic acid Proteins 0.000 description 1
- 230000000069 prophylactic effect Effects 0.000 description 1
- 238000011321 prophylaxis Methods 0.000 description 1
- 235000009736 ragweed Nutrition 0.000 description 1
- 238000010188 recombinant method Methods 0.000 description 1
- 230000012121 regulation of immune response Effects 0.000 description 1
- 206010039083 rhinitis Diseases 0.000 description 1
- CVHZOJJKTDOEJC-UHFFFAOYSA-N saccharin Chemical compound C1=CC=C2C(=O)NS(=O)(=O)C2=C1 CVHZOJJKTDOEJC-UHFFFAOYSA-N 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- 230000011664 signaling Effects 0.000 description 1
- 239000004332 silver Substances 0.000 description 1
- 229910052709 silver Inorganic materials 0.000 description 1
- 238000004611 spectroscopical analysis Methods 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 238000012916 structural analysis Methods 0.000 description 1
- 238000010254 subcutaneous injection Methods 0.000 description 1
- 239000007929 subcutaneous injection Substances 0.000 description 1
- 235000000346 sugar Nutrition 0.000 description 1
- 150000008163 sugars Chemical class 0.000 description 1
- 230000008093 supporting effect Effects 0.000 description 1
- 239000000829 suppository Substances 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 238000013268 sustained release Methods 0.000 description 1
- 239000012730 sustained-release form Substances 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 229920001059 synthetic polymer Polymers 0.000 description 1
- 230000009885 systemic effect Effects 0.000 description 1
- 239000003826 tablet Substances 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- TXEYQDLBPFQVAA-UHFFFAOYSA-N tetrafluoromethane Chemical compound FC(F)(F)F TXEYQDLBPFQVAA-UHFFFAOYSA-N 0.000 description 1
- 125000000341 threoninyl group Chemical group [H]OC([H])(C([H])([H])[H])C([H])(N([H])[H])C(*)=O 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 235000013311 vegetables Nutrition 0.000 description 1
- 239000003981 vehicle Substances 0.000 description 1
- 239000000080 wetting agent Substances 0.000 description 1
- 210000005253 yeast cell Anatomy 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/415—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from plants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Botany (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Immunology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pulmonology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DK36498 | 1998-03-16 | ||
| DK0364/98 | 1998-03-16 | ||
| PCT/DK1999/000136 WO1999047680A1 (en) | 1998-03-16 | 1999-03-16 | Mutant recombinant allergens |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2323687A1 CA2323687A1 (en) | 1999-09-23 |
| CA2323687C true CA2323687C (en) | 2008-11-25 |
Family
ID=8092687
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002323687A Expired - Fee Related CA2323687C (en) | 1998-03-16 | 1999-03-16 | Mutant recombinant allergens |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US20040091500A1 (enExample) |
| EP (1) | EP1062341B1 (enExample) |
| JP (1) | JP2002506648A (enExample) |
| KR (1) | KR20010041918A (enExample) |
| CN (1) | CN1332029C (enExample) |
| AT (1) | ATE408690T1 (enExample) |
| AU (1) | AU749749B2 (enExample) |
| CA (1) | CA2323687C (enExample) |
| DE (1) | DE69939584D1 (enExample) |
| DK (1) | DK1062341T3 (enExample) |
| ES (1) | ES2313776T3 (enExample) |
| HU (1) | HUP0101464A3 (enExample) |
| IL (2) | IL138339A0 (enExample) |
| NO (1) | NO328354B1 (enExample) |
| NZ (1) | NZ506665A (enExample) |
| PL (1) | PL194804B1 (enExample) |
| PT (1) | PT1062341E (enExample) |
| WO (1) | WO1999047680A1 (enExample) |
| ZA (1) | ZA200004819B (enExample) |
Families Citing this family (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20020192792A1 (en) * | 2000-04-28 | 2002-12-19 | Palle Schneider | Laccase mutants |
| IT1318692B1 (it) * | 2000-09-12 | 2003-08-27 | Consiglio Nazionale Ricerche | Varianti di proteine allergeniche di phleum pratense. |
| IT1318690B1 (it) * | 2000-09-12 | 2003-08-27 | Consiglio Nazionale Ricerche | Varianti dell'allergene maggiore par j 2 di parietaria judaica. |
| EP1340085B1 (en) * | 2000-10-17 | 2008-07-30 | Besst-Test Aps | Assay for directly detecting a biological cell in a body fluid sample |
| DE60136653D1 (de) * | 2000-11-16 | 2009-01-02 | Alk Abello As | Mutante allergene |
| DK1219300T3 (da) * | 2000-12-28 | 2007-03-05 | Biomay Prod & Handel | Behandling af allergi |
| ATE448793T1 (de) * | 2001-03-02 | 2009-12-15 | Univ Rockefeller | Rekombinante hybrid-allergenkonstrukte mit verringerter allergenität unter beibehaltung der immunogenität des natürlichen allergens |
| EP1436627A2 (en) * | 2001-10-05 | 2004-07-14 | Novozymes A/S | Kit for predicting binding of a specific antibody to a potential immunogen and method of screening |
| WO2003072601A1 (de) * | 2002-02-27 | 2003-09-04 | Merck Patent Gmbh | VERFAHREN ZUR HERSTELLUNG VON HYPOALLERGENEM BIRKENPOLLENHAUPTALLERGEN rBet v 1 |
| EP1504089A2 (en) * | 2002-05-16 | 2005-02-09 | Alk Abell A/S | Allergen mutants |
| WO2004039834A2 (en) * | 2002-11-01 | 2004-05-13 | Alk-Abelló A/S | Recombinant protein variants |
| WO2004047793A1 (en) | 2002-11-26 | 2004-06-10 | Alk-Abelló A/S | Pharmaceutical allergen product |
| US8012505B2 (en) | 2003-02-28 | 2011-09-06 | Alk-Abello A/S | Dosage form having a saccharide matrix |
| CA2516291C (en) | 2003-02-28 | 2012-02-14 | Alk-Abello A/S | Dosage form having a saccharide matrix |
| WO2005058474A1 (en) | 2003-12-19 | 2005-06-30 | Alk-Abelló A/S | Cryogranulation and storage method for active pharmaceutical agents |
| AU2006299310A1 (en) | 2005-10-04 | 2007-04-12 | Alk-Abello A/S | Solid vaccine formulation |
| ITMI20052517A1 (it) * | 2005-12-29 | 2007-06-30 | Lofarma Spa | Varianbtio ipoallergeniche dell'allergene maggiore bet v 1 di polline di betula verrucosa |
| CN101473028B (zh) * | 2006-04-20 | 2012-11-07 | 新加坡国立大学 | 重组乳杆菌及其用途 |
| EP2481418A1 (en) * | 2007-02-15 | 2012-08-01 | MannKind Corporation | A method for enhancing T cell response |
| EP1974746B1 (en) | 2007-03-28 | 2012-01-11 | Alk-Abelló A/S | Use of an adjuvanted allergy vaccine formulation for parenteral administration |
| EP2028188A1 (en) * | 2007-08-21 | 2009-02-25 | Biomay AG | Hypoallergenic molecules |
| DE202008006598U1 (de) | 2008-04-11 | 2008-10-02 | Alk-Abelló A/S | Allergie-Impfstoff-Formulierung zur mucosalen Verabreichung |
| EP2442828B1 (en) | 2009-06-19 | 2016-08-03 | Alk-Abelló S.A. | Novel manner of administrating allergen in allergen specific immunotherapy |
| CN102584966A (zh) * | 2011-11-14 | 2012-07-18 | 广州医学院第二附属医院 | 一种重组花生过敏原与突变体及其制备方法和应用 |
| CN102690340A (zh) * | 2012-03-30 | 2012-09-26 | 广州医学院第二附属医院 | 一种重组巴西坚果过敏原与突变体及其制备方法和应用 |
| CN102603879A (zh) * | 2012-03-30 | 2012-07-25 | 广州医学院第二附属医院 | 一种重组大豆过敏原与突变体及其制备方法和应用 |
| CN102617715A (zh) * | 2012-03-30 | 2012-08-01 | 广州医学院第二附属医院 | 一种重组真菌主要过敏原与突变体及其制备方法和应用 |
| CN102617719A (zh) * | 2012-03-30 | 2012-08-01 | 广州医学院第二附属医院 | 一种重组大米过敏原与突变体及其制备方法和应用 |
| CN102675439A (zh) * | 2012-03-31 | 2012-09-19 | 广州医学院第二附属医院 | 一种重组黑麦草花粉过敏原与突变体的制备方法和应用 |
| EP2952200A1 (en) | 2014-06-04 | 2015-12-09 | Alk-Abelló A/S | Allergen for prophylactic treatment of allergy |
| EP4058059B1 (en) * | 2019-11-13 | 2024-10-09 | The Regents Of The University Of Michigan | Nanoemulsion compositions for treating aeroallergen associated allergy and inflammation |
| CN111187606B (zh) * | 2020-02-25 | 2022-06-14 | 江苏海洋大学 | 一种用于海水基可循环清洁压裂液的表面活性剂及其制备方法 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5804201A (en) * | 1996-03-11 | 1998-09-08 | The Rockefeller University | Immunomodulatory peptides of vespid antigen 5 |
| DE69940805D1 (de) * | 1998-01-31 | 2009-06-10 | Sinai School Medicine | Verfahren und reagenzien zur verminderung der klinischen reaktion zur allergie |
| IT1318692B1 (it) * | 2000-09-12 | 2003-08-27 | Consiglio Nazionale Ricerche | Varianti di proteine allergeniche di phleum pratense. |
-
1999
- 1999-03-16 DK DK99907345T patent/DK1062341T3/da active
- 1999-03-16 EP EP99907345A patent/EP1062341B1/en not_active Revoked
- 1999-03-16 HU HU0101464A patent/HUP0101464A3/hu unknown
- 1999-03-16 CN CNB998040312A patent/CN1332029C/zh not_active Expired - Fee Related
- 1999-03-16 AU AU27147/99A patent/AU749749B2/en not_active Ceased
- 1999-03-16 PL PL343029A patent/PL194804B1/pl not_active IP Right Cessation
- 1999-03-16 PT PT99907345T patent/PT1062341E/pt unknown
- 1999-03-16 JP JP2000536863A patent/JP2002506648A/ja active Pending
- 1999-03-16 DE DE69939584T patent/DE69939584D1/de not_active Expired - Lifetime
- 1999-03-16 IL IL13833999A patent/IL138339A0/xx unknown
- 1999-03-16 CA CA002323687A patent/CA2323687C/en not_active Expired - Fee Related
- 1999-03-16 KR KR1020007010225A patent/KR20010041918A/ko not_active Ceased
- 1999-03-16 ES ES99907345T patent/ES2313776T3/es not_active Expired - Lifetime
- 1999-03-16 WO PCT/DK1999/000136 patent/WO1999047680A1/en not_active Ceased
- 1999-03-16 AT AT99907345T patent/ATE408690T1/de active
- 1999-03-16 NZ NZ506665A patent/NZ506665A/en not_active IP Right Cessation
-
2000
- 2000-09-07 IL IL138339A patent/IL138339A/en not_active IP Right Cessation
- 2000-09-12 ZA ZA200004819A patent/ZA200004819B/xx unknown
- 2000-09-15 NO NO20004614A patent/NO328354B1/no not_active IP Right Cessation
-
2003
- 2003-11-20 US US10/719,553 patent/US20040091500A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| NO328354B1 (no) | 2010-02-01 |
| NO20004614D0 (no) | 2000-09-15 |
| AU749749B2 (en) | 2002-07-04 |
| NO20004614L (no) | 2000-10-26 |
| EP1062341B1 (en) | 2008-09-17 |
| WO1999047680A1 (en) | 1999-09-23 |
| ES2313776T3 (es) | 2009-03-01 |
| HUP0101464A3 (en) | 2004-10-28 |
| CN1332029C (zh) | 2007-08-15 |
| ATE408690T1 (de) | 2008-10-15 |
| DK1062341T3 (da) | 2008-11-03 |
| ZA200004819B (en) | 2001-05-30 |
| PL343029A1 (en) | 2001-07-30 |
| CA2323687A1 (en) | 1999-09-23 |
| AU2714799A (en) | 1999-10-11 |
| HUP0101464A2 (hu) | 2001-08-28 |
| NZ506665A (en) | 2003-08-29 |
| CN1293710A (zh) | 2001-05-02 |
| HK1033591A1 (en) | 2001-09-07 |
| EP1062341A1 (en) | 2000-12-27 |
| IL138339A0 (en) | 2001-10-31 |
| JP2002506648A (ja) | 2002-03-05 |
| PL194804B1 (pl) | 2007-07-31 |
| DE69939584D1 (de) | 2008-10-30 |
| KR20010041918A (ko) | 2001-05-25 |
| PT1062341E (pt) | 2008-12-24 |
| IL138339A (en) | 2009-06-15 |
| US20040091500A1 (en) | 2004-05-13 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| MKLA | Lapsed |
Effective date: 20150316 |