CN1329890A - 磷酸苯丙哌林双层缓释片 - Google Patents
磷酸苯丙哌林双层缓释片 Download PDFInfo
- Publication number
- CN1329890A CN1329890A CN 01115128 CN01115128A CN1329890A CN 1329890 A CN1329890 A CN 1329890A CN 01115128 CN01115128 CN 01115128 CN 01115128 A CN01115128 A CN 01115128A CN 1329890 A CN1329890 A CN 1329890A
- Authority
- CN
- China
- Prior art keywords
- milligrams
- benproperine
- slow releasing
- benproperine phosphate
- phosphate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 229960001871 benproperine Drugs 0.000 title claims abstract description 51
- JTUQXGZRVLWBCR-UHFFFAOYSA-N 1-[1-[2-(phenylmethyl)phenoxy]propan-2-yl]piperidine Chemical compound C1CCCCN1C(C)COC1=CC=CC=C1CC1=CC=CC=C1 JTUQXGZRVLWBCR-UHFFFAOYSA-N 0.000 title claims abstract description 39
- 239000002355 dual-layer Substances 0.000 title claims abstract description 11
- 239000002994 raw material Substances 0.000 claims description 20
- 229920002472 Starch Polymers 0.000 claims description 17
- 239000008107 starch Substances 0.000 claims description 17
- 235000019698 starch Nutrition 0.000 claims description 17
- -1 benproperine phosphates Chemical class 0.000 claims description 16
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 claims description 16
- 229920000168 Microcrystalline cellulose Polymers 0.000 claims description 15
- 235000019813 microcrystalline cellulose Nutrition 0.000 claims description 15
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 claims description 14
- 239000008101 lactose Substances 0.000 claims description 14
- 229910019142 PO4 Inorganic materials 0.000 claims description 12
- 235000021317 phosphate Nutrition 0.000 claims description 12
- 239000008108 microcrystalline cellulose Substances 0.000 claims description 11
- 229940016286 microcrystalline cellulose Drugs 0.000 claims description 11
- 235000019325 ethyl cellulose Nutrition 0.000 claims description 8
- 229920001249 ethyl cellulose Polymers 0.000 claims description 8
- 235000019359 magnesium stearate Nutrition 0.000 claims description 8
- 239000011734 sodium Substances 0.000 claims description 8
- 229910052708 sodium Inorganic materials 0.000 claims description 8
- FPAFDBFIGPHWGO-UHFFFAOYSA-N dioxosilane;oxomagnesium;hydrate Chemical compound O.[Mg]=O.[Mg]=O.[Mg]=O.O=[Si]=O.O=[Si]=O.O=[Si]=O.O=[Si]=O FPAFDBFIGPHWGO-UHFFFAOYSA-N 0.000 claims description 7
- 239000010410 layer Substances 0.000 claims description 7
- 239000000463 material Substances 0.000 claims description 7
- 239000003795 chemical substances by application Substances 0.000 claims description 4
- 239000003814 drug Substances 0.000 abstract description 14
- 239000008280 blood Substances 0.000 abstract description 5
- 210000004369 blood Anatomy 0.000 abstract description 5
- 230000000694 effects Effects 0.000 abstract description 5
- 238000007723 die pressing method Methods 0.000 abstract 1
- 239000003826 tablet Substances 0.000 description 15
- 239000011248 coating agent Substances 0.000 description 8
- 238000000576 coating method Methods 0.000 description 8
- 238000002360 preparation method Methods 0.000 description 8
- 229940079593 drug Drugs 0.000 description 6
- 239000008187 granular material Substances 0.000 description 6
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 description 6
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 description 6
- RZVAJINKPMORJF-UHFFFAOYSA-N Acetaminophen Chemical compound CC(=O)NC1=CC=C(O)C=C1 RZVAJINKPMORJF-UHFFFAOYSA-N 0.000 description 4
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 4
- 239000004677 Nylon Substances 0.000 description 4
- 238000001035 drying Methods 0.000 description 4
- 229920001778 nylon Polymers 0.000 description 4
- 230000000954 anitussive effect Effects 0.000 description 3
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 description 3
- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 description 3
- 239000007921 spray Substances 0.000 description 3
- 206010011224 Cough Diseases 0.000 description 2
- 239000001856 Ethyl cellulose Substances 0.000 description 2
- ZZSNKZQZMQGXPY-UHFFFAOYSA-N Ethyl cellulose Chemical compound CCOCC1OC(OC)C(OCC)C(OCC)C1OC1C(O)C(O)C(OC)C(CO)O1 ZZSNKZQZMQGXPY-UHFFFAOYSA-N 0.000 description 2
- GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 description 2
- 238000010521 absorption reaction Methods 0.000 description 2
- 239000007888 film coating Substances 0.000 description 2
- 238000009501 film coating Methods 0.000 description 2
- 239000012729 immediate-release (IR) formulation Substances 0.000 description 2
- 238000001727 in vivo Methods 0.000 description 2
- 230000002045 lasting effect Effects 0.000 description 2
- 239000002075 main ingredient Substances 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 230000000144 pharmacologic effect Effects 0.000 description 2
- 239000011122 softwood Substances 0.000 description 2
- 235000020985 whole grains Nutrition 0.000 description 2
- DKSZLDSPXIWGFO-BLOJGBSASA-N (4r,4ar,7s,7ar,12bs)-9-methoxy-3-methyl-2,4,4a,7,7a,13-hexahydro-1h-4,12-methanobenzofuro[3,2-e]isoquinoline-7-ol;phosphoric acid;hydrate Chemical compound O.OP(O)(O)=O.OP(O)(O)=O.C([C@H]1[C@H](N(CC[C@@]112)C)C3)=C[C@H](O)[C@@H]1OC1=C2C3=CC=C1OC.C([C@H]1[C@H](N(CC[C@@]112)C)C3)=C[C@H](O)[C@@H]1OC1=C2C3=CC=C1OC DKSZLDSPXIWGFO-BLOJGBSASA-N 0.000 description 1
- GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 description 1
- 230000001154 acute effect Effects 0.000 description 1
- 229940124584 antitussives Drugs 0.000 description 1
- 229960004415 codeine phosphate Drugs 0.000 description 1
- ZZVUWRFHKOJYTH-UHFFFAOYSA-N diphenhydramine Chemical compound C=1C=CC=CC=1C(OCCN(C)C)C1=CC=CC=C1 ZZVUWRFHKOJYTH-UHFFFAOYSA-N 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 229940084936 gonak Drugs 0.000 description 1
- 229960001375 lactose Drugs 0.000 description 1
- 239000000314 lubricant Substances 0.000 description 1
- 238000005461 lubrication Methods 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 230000003533 narcotic effect Effects 0.000 description 1
- 238000012856 packing Methods 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 235000015424 sodium Nutrition 0.000 description 1
- 229940032147 starch Drugs 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 239000007939 sustained release tablet Substances 0.000 description 1
- 239000004408 titanium dioxide Substances 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Landscapes
- Medicinal Preparation (AREA)
Abstract
Description
Claims (4)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN 01115128 CN1218691C (zh) | 2001-07-11 | 2001-07-11 | 磷酸苯丙哌林双层缓释片 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN 01115128 CN1218691C (zh) | 2001-07-11 | 2001-07-11 | 磷酸苯丙哌林双层缓释片 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN1329890A true CN1329890A (zh) | 2002-01-09 |
CN1218691C CN1218691C (zh) | 2005-09-14 |
Family
ID=4661711
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN 01115128 Expired - Lifetime CN1218691C (zh) | 2001-07-11 | 2001-07-11 | 磷酸苯丙哌林双层缓释片 |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN1218691C (zh) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1301716C (zh) * | 2002-10-09 | 2007-02-28 | 重庆太极医药研究院 | 磷酸苯丙哌啉缓释滴丸及制备工艺 |
CN101543481B (zh) * | 2008-03-28 | 2011-03-23 | 北京四环科宝制药有限公司 | 一种双层灯盏花素缓释片及制备方法 |
-
2001
- 2001-07-11 CN CN 01115128 patent/CN1218691C/zh not_active Expired - Lifetime
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1301716C (zh) * | 2002-10-09 | 2007-02-28 | 重庆太极医药研究院 | 磷酸苯丙哌啉缓释滴丸及制备工艺 |
CN101543481B (zh) * | 2008-03-28 | 2011-03-23 | 北京四环科宝制药有限公司 | 一种双层灯盏花素缓释片及制备方法 |
Also Published As
Publication number | Publication date |
---|---|
CN1218691C (zh) | 2005-09-14 |
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Legal Events
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SE01 | Entry into force of request for substantive examination | ||
C06 | Publication | ||
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ASS | Succession or assignment of patent right |
Owner name: XI'AN DONGSHENG GROUP CO.,LTD. Free format text: FORMER OWNER: HUANG ZHENHUA Effective date: 20040806 |
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C41 | Transfer of patent application or patent right or utility model | ||
TA01 | Transfer of patent application right |
Effective date of registration: 20040806 Address after: 710075 Shaanxi city of Xi'an Province Tang Yan Road No. 23 Dongsheng Building Applicant after: Dongsheng Group Co., Ltd., Xi-an Address before: 250013 No. 161, Jiefang Road, Shandong, Ji'nan Applicant before: Huang Zhenhua |
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C14 | Grant of patent or utility model | ||
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REG | Reference to a national code |
Ref country code: HK Ref legal event code: GR Ref document number: 1084490 Country of ref document: HK |
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Effective date of registration: 20160203 Address after: 721400, Xiguan County, Fengxiang County, Shaanxi, Baoji Patentee after: Shaanxi Heng Cheng Pharmaceutical Co., Ltd. Address before: 710075 Shaanxi city of Xi'an Province Tang Yan Road No. 23 Dongsheng Building Patentee before: Dongsheng Group Co., Ltd., Xi-an |
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CX01 | Expiry of patent term |
Granted publication date: 20050914 |
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CX01 | Expiry of patent term |