CN1307157C - 化合物 - Google Patents

化合物 Download PDF

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Publication number
CN1307157C
CN1307157C CNB018142141A CN01814214A CN1307157C CN 1307157 C CN1307157 C CN 1307157C CN B018142141 A CNB018142141 A CN B018142141A CN 01814214 A CN01814214 A CN 01814214A CN 1307157 C CN1307157 C CN 1307157C
Authority
CN
China
Prior art keywords
phenyl
acetamide
amino
piperidinyl
hydroxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CNB018142141A
Other languages
English (en)
Chinese (zh)
Other versions
CN1476434A (zh
Inventor
T·埃里克森
T·克林格斯特德特
T·马斯西
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
AstraZeneca AB
Original Assignee
AstraZeneca AB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from SE0002331A external-priority patent/SE0002331D0/xx
Priority claimed from SE0004480A external-priority patent/SE0004480D0/xx
Application filed by AstraZeneca AB filed Critical AstraZeneca AB
Publication of CN1476434A publication Critical patent/CN1476434A/zh
Application granted granted Critical
Publication of CN1307157C publication Critical patent/CN1307157C/zh
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/56—Nitrogen atoms
    • C07D211/58—Nitrogen atoms attached in position 4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/06—Anti-spasmodics, e.g. drugs for colics, esophagic dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Rheumatology (AREA)
  • Neurology (AREA)
  • Pain & Pain Management (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
CNB018142141A 2000-06-20 2001-06-14 化合物 Expired - Fee Related CN1307157C (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
SE0002331A SE0002331D0 (sv) 2000-06-20 2000-06-20 Novel compounds
SE00023317 2000-06-20
SE00044800 2000-12-05
SE0004480A SE0004480D0 (sv) 2000-12-05 2000-12-05 Novel compounds
PCT/SE2001/001377 WO2001098273A1 (en) 2000-06-20 2001-06-14 Novel compounds

Publications (2)

Publication Number Publication Date
CN1476434A CN1476434A (zh) 2004-02-18
CN1307157C true CN1307157C (zh) 2007-03-28

Family

ID=26655154

Family Applications (1)

Application Number Title Priority Date Filing Date
CNB018142141A Expired - Fee Related CN1307157C (zh) 2000-06-20 2001-06-14 化合物

Country Status (22)

Country Link
US (3) US6911458B2 (enExample)
EP (1) EP1299357A1 (enExample)
JP (1) JP4022142B2 (enExample)
KR (1) KR100799061B1 (enExample)
CN (1) CN1307157C (enExample)
AR (1) AR028948A1 (enExample)
AU (2) AU2001274763B2 (enExample)
BR (1) BR0111667A (enExample)
CA (1) CA2414095C (enExample)
CZ (1) CZ20024146A3 (enExample)
EE (1) EE05157B1 (enExample)
HU (1) HUP0301187A3 (enExample)
IL (2) IL153167A0 (enExample)
IS (1) IS6658A (enExample)
MX (1) MXPA02012425A (enExample)
MY (1) MY136520A (enExample)
NO (1) NO324698B1 (enExample)
NZ (1) NZ523047A (enExample)
PL (1) PL203936B1 (enExample)
RU (2) RU2298550C2 (enExample)
SK (1) SK17932002A3 (enExample)
WO (1) WO2001098273A1 (enExample)

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US7723509B2 (en) 2003-04-17 2010-05-25 Alnylam Pharmaceuticals IRNA agents with biocleavable tethers
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US8017762B2 (en) 2003-04-17 2011-09-13 Alnylam Pharmaceuticals, Inc. Modified iRNA agents
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SE0303541D0 (sv) 2003-12-22 2003-12-22 Astrazeneca Ab New compounds
CN101233107A (zh) * 2005-08-01 2008-07-30 阿斯利康(瑞典)有限公司 作为趋化因子受体调节剂用于治疗呼吸系统疾病的新哌啶衍生物
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TW200734305A (en) * 2005-08-02 2007-09-16 Astrazeneca Ab New salt III
TW200738635A (en) * 2005-08-02 2007-10-16 Astrazeneca Ab New salt
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US20080064884A1 (en) * 2006-05-10 2008-03-13 Astrazeneca Ab Novel Process 1
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JO2849B1 (en) 2007-02-13 2015-03-15 جانسين فارماسوتيكا ان. في Dopamine 2 receptor antagonists are rapidly hydrolyzed
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HRP20170570T1 (hr) 2008-07-31 2017-06-16 Janssen Pharmaceutica Nv Piperazin-1-il-trifluormetil-supstituirani-piridini kao brzo disocirajući antagonisti receptora dopamina 2
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CN113767095A (zh) 2019-05-01 2021-12-07 勃林格殷格翰国际有限公司 (r)-4-溴苯磺酸(2-甲基环氧乙烷-2-基)甲酯
EP4115885A1 (en) 2021-07-05 2023-01-11 Charité - Universitätsmedizin Berlin A pharmaceutical composition comprising bay 86-5277 and salts thereof for use in the treatment of viral infections and hyperinflammation
US12263157B2 (en) 2021-12-14 2025-04-01 Boehringer Ingelheim International Gmbh Aldosterone synthase inhibitors for treating chronic kidney disease

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