CN1304409A - 用于治疗抑郁症的吲哚－3－基－环己胺衍生物(5－ht1受体拮抗剂) - Google Patents

用于治疗抑郁症的吲哚－3－基－环己胺衍生物(5－ht1受体拮抗剂) Download PDF

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Publication number
CN1304409A
CN1304409A CN99807010A CN99807010A CN1304409A CN 1304409 A CN1304409 A CN 1304409A CN 99807010 A CN99807010 A CN 99807010A CN 99807010 A CN99807010 A CN 99807010A CN 1304409 A CN1304409 A CN 1304409A
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CN
China
Prior art keywords
hydrogen
phenyl
compound
alkyl group
low alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN99807010A
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English (en)
Chinese (zh)
Inventor
R·E·穆肖
P·周
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wyeth LLC
Original Assignee
American Home Products Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by American Home Products Corp filed Critical American Home Products Corp
Publication of CN1304409A publication Critical patent/CN1304409A/zh
Pending legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Psychiatry (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pain & Pain Management (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
CN99807010A 1998-04-08 1999-04-07 用于治疗抑郁症的吲哚－3－基－环己胺衍生物(5－ht1受体拮抗剂) Pending CN1304409A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US5724498A 1998-04-08 1998-04-08
US09/057,244 1998-04-08

Publications (1)

Publication Number Publication Date
CN1304409A true CN1304409A (zh) 2001-07-18

Family

ID=22009404

Family Applications (1)

Application Number Title Priority Date Filing Date
CN99807010A Pending CN1304409A (zh) 1998-04-08 1999-04-07 用于治疗抑郁症的吲哚－3－基－环己胺衍生物(5－ht1受体拮抗剂)

Country Status (6)

Country Link
EP (1) EP1070063A1 (fr)
JP (1) JP2002510682A (fr)
CN (1) CN1304409A (fr)
AU (1) AU3476599A (fr)
CA (1) CA2327360A1 (fr)
WO (1) WO1999051592A1 (fr)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6221863B1 (en) 1999-01-07 2001-04-24 American Home Products Corp. 3,4-dihydro-2H-benzo[1,4]oxazine derivatives
TW546299B (en) * 1999-01-07 2003-08-11 Wyeth Corp 3,4-dihydro-2H-benzo[1,4]oxazinyl-methyl-[3-(1H-indol-3-yl)-alkyl]-amines
AU2494300A (en) * 1999-01-07 2000-07-24 American Home Products Corporation 3,4-dihydro-2h-benzo(1,4)oxazine derivatives
GB0203804D0 (en) 2002-02-18 2002-04-03 Glaxo Group Ltd Compounds
US7041697B2 (en) 2002-09-12 2006-05-09 Wyeth Antidepressant cycloalkylamine derivatives of 2,3-dihydro-1,4-benzodioxan
US6911445B2 (en) * 2002-09-12 2005-06-28 Wyeth Antidepressant cycloalkylamine derivatives of heterocycle-fused benzodioxans
US7276603B2 (en) * 2003-05-02 2007-10-02 Wyeth Benzofuranyl-and benzothienyl-piperazinyl quinolines and methods of their use

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3058980A (en) * 1962-10-16 Substitution products of benzo-
US4612312A (en) * 1984-07-30 1986-09-16 Merrell Dow Pharmaceuticals Inc. Glutarimide antianxiety and antihypertensive agents
GB8719167D0 (en) * 1987-08-13 1987-09-23 Glaxo Group Ltd Chemical compounds
DK37790A (da) * 1990-02-13 1991-08-14 Novo Nordisk As Indolderivater, deres fremstilling og anvendelse
US5189179A (en) * 1990-08-29 1993-02-23 Merrell Dow Pharmaceuticals Inc. Serotonin 5ht1a agonists
US5468768A (en) * 1994-01-06 1995-11-21 Bristol-Myers Squibb Company Antimigraine derivatives of indolylcycloalkanylamines
US5521197A (en) * 1994-12-01 1996-05-28 Eli Lilly And Company 3-<1-alkylenearyl>-4-<1,2,3,6-tetrahydropyridinyl>-and 3-<1-alkylenearyl>-4-piperidinyl-1h-indoles: new 5-HT1F agonists
MX9706969A (es) * 1995-03-20 1997-11-29 Lilly Co Eli 3-(1,2,3,6-tetrahidropiridin-4-il)-1h-indoles y 3-(piperidin-4-il)-1h-indoles sustituidos en la posicion 5: agonistas del 5-ht1f novedosos.

Also Published As

Publication number Publication date
WO1999051592A1 (fr) 1999-10-14
AU3476599A (en) 1999-10-25
CA2327360A1 (fr) 1999-10-14
JP2002510682A (ja) 2002-04-09
EP1070063A1 (fr) 2001-01-24

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WD01 Invention patent application deemed withdrawn after publication