CA2327360A1 - Derives d'amine indol-3-yl-cyclhexyle utilises dans le traitement de la depression (antagonistes du recepteur 5-ht1) - Google Patents

Derives d'amine indol-3-yl-cyclhexyle utilises dans le traitement de la depression (antagonistes du recepteur 5-ht1) Download PDF

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Publication number
CA2327360A1
CA2327360A1 CA002327360A CA2327360A CA2327360A1 CA 2327360 A1 CA2327360 A1 CA 2327360A1 CA 002327360 A CA002327360 A CA 002327360A CA 2327360 A CA2327360 A CA 2327360A CA 2327360 A1 CA2327360 A1 CA 2327360A1
Authority
CA
Canada
Prior art keywords
hydrogen
lower alkyl
independently
indol
phenyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002327360A
Other languages
English (en)
Inventor
Richard Eric Mewshaw
Ping Zhou
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wyeth LLC
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2327360A1 publication Critical patent/CA2327360A1/fr
Abandoned legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants

Abstract

On décrit des composés qui sont efficaces dans le traitement des troubles des symptômes neurologiques affectés par la sérotonine (le récepteur 5-HT1A étant actif), ces composés étant représentés par la formule (I). Dans cette formule, R¿1? et R¿5? représentent chacun indépendamment, hydrogène, halogène, alcoxy inférieur, alkyle inférieur, cyano ou trifluorométhyle; R¿2? et R¿4? représentent chacun indépendamment hydrogène, alkyle inférieur, phényle ou phényle substitué; R¿3? représente hydrogène ou alkyle inférieur; et X et Y représentent chacun indépendamment O, NR¿6? ou Ch¿2?, R¿6? représentant hydrogène, alkyle inférieur, phényle ou phényle substitué. Cette invention concerne lesdits composés de formule (I) ainsi que leurs sels pharmaceutiquement acceptables. formule (I)
CA002327360A 1998-04-08 1999-04-07 Derives d'amine indol-3-yl-cyclhexyle utilises dans le traitement de la depression (antagonistes du recepteur 5-ht1) Abandoned CA2327360A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US5724498A 1998-04-08 1998-04-08
US09/057,244 1998-04-08
PCT/US1999/007606 WO1999051592A1 (fr) 1998-04-08 1999-04-07 Derives d'amine indol-3-yl-cyclhexyle utilises dans le traitement de la depression (antagonistes du recepteur 5-ht1)

Publications (1)

Publication Number Publication Date
CA2327360A1 true CA2327360A1 (fr) 1999-10-14

Family

ID=22009404

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002327360A Abandoned CA2327360A1 (fr) 1998-04-08 1999-04-07 Derives d'amine indol-3-yl-cyclhexyle utilises dans le traitement de la depression (antagonistes du recepteur 5-ht1)

Country Status (6)

Country Link
EP (1) EP1070063A1 (fr)
JP (1) JP2002510682A (fr)
CN (1) CN1304409A (fr)
AU (1) AU3476599A (fr)
CA (1) CA2327360A1 (fr)
WO (1) WO1999051592A1 (fr)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000040581A1 (fr) * 1999-01-07 2000-07-13 American Home Products Corporation Derives de la 3,4-dihydro-2h benzo[1,4]oxazine
US6221863B1 (en) 1999-01-07 2001-04-24 American Home Products Corp. 3,4-dihydro-2H-benzo[1,4]oxazine derivatives
TW546299B (en) * 1999-01-07 2003-08-11 Wyeth Corp 3,4-dihydro-2H-benzo[1,4]oxazinyl-methyl-[3-(1H-indol-3-yl)-alkyl]-amines
GB0203804D0 (en) * 2002-02-18 2002-04-03 Glaxo Group Ltd Compounds
US6911445B2 (en) * 2002-09-12 2005-06-28 Wyeth Antidepressant cycloalkylamine derivatives of heterocycle-fused benzodioxans
US7041697B2 (en) * 2002-09-12 2006-05-09 Wyeth Antidepressant cycloalkylamine derivatives of 2,3-dihydro-1,4-benzodioxan
US7276603B2 (en) 2003-05-02 2007-10-02 Wyeth Benzofuranyl-and benzothienyl-piperazinyl quinolines and methods of their use

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3058980A (en) * 1962-10-16 Substitution products of benzo-
US4612312A (en) * 1984-07-30 1986-09-16 Merrell Dow Pharmaceuticals Inc. Glutarimide antianxiety and antihypertensive agents
GB8719167D0 (en) * 1987-08-13 1987-09-23 Glaxo Group Ltd Chemical compounds
DK37790A (da) * 1990-02-13 1991-08-14 Novo Nordisk As Indolderivater, deres fremstilling og anvendelse
US5189179A (en) * 1990-08-29 1993-02-23 Merrell Dow Pharmaceuticals Inc. Serotonin 5ht1a agonists
US5468768A (en) * 1994-01-06 1995-11-21 Bristol-Myers Squibb Company Antimigraine derivatives of indolylcycloalkanylamines
US5521197A (en) * 1994-12-01 1996-05-28 Eli Lilly And Company 3-<1-alkylenearyl>-4-<1,2,3,6-tetrahydropyridinyl>-and 3-<1-alkylenearyl>-4-piperidinyl-1h-indoles: new 5-HT1F agonists
EA001113B1 (ru) * 1995-03-20 2000-10-30 Эли Лилли Энд Компани 5-замещенные-3-(1,2,3,6-тетрагидропиридин-4-ил)- и 3-(пиперидин-4-ил)-1н-индолы и их фармацевтически приемлемые соли и сольваты, фармацевтическая композиция на их основе, способ активации рецепторов 5-нт1 и способ ингибирования нейронной белковой транссудации

Also Published As

Publication number Publication date
AU3476599A (en) 1999-10-25
JP2002510682A (ja) 2002-04-09
CN1304409A (zh) 2001-07-18
EP1070063A1 (fr) 2001-01-24
WO1999051592A1 (fr) 1999-10-14

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Legal Events

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