JP2002510682A - うつ病治療用のインドール−３−イル−シクロヘキシルアミン誘導体（５−ｈｔ１受容体拮抗薬） - Google Patents

うつ病治療用のインドール−３−イル−シクロヘキシルアミン誘導体（５−ｈｔ１受容体拮抗薬）

Info

Publication number
JP2002510682A
JP2002510682A JP2000542313A JP2000542313A JP2002510682A JP 2002510682 A JP2002510682 A JP 2002510682A JP 2000542313 A JP2000542313 A JP 2000542313A JP 2000542313 A JP2000542313 A JP 2000542313A JP 2002510682 A JP2002510682 A JP 2002510682A
Authority
JP
Japan
Prior art keywords
hydrogen
lower alkyl
acid
indol
phenyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2000542313A
Other languages
English (en)
Japanese (ja)
Inventor
リチャード・エリック・ミューショー
ピン・チョウ
Original Assignee
アメリカン・ホーム・プロダクツ・コーポレイション
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by アメリカン・ホーム・プロダクツ・コーポレイション filed Critical アメリカン・ホーム・プロダクツ・コーポレイション
Publication of JP2002510682A publication Critical patent/JP2002510682A/ja
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Psychiatry (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pain & Pain Management (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
JP2000542313A 1998-04-08 1999-04-07 うつ病治療用のインドール−３−イル−シクロヘキシルアミン誘導体（５−ｈｔ１受容体拮抗薬） Pending JP2002510682A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US5724498A 1998-04-08 1998-04-08
US09/057,244 1998-04-08
PCT/US1999/007606 WO1999051592A1 (fr) 1998-04-08 1999-04-07 Derives d'amine indol-3-yl-cyclhexyle utilises dans le traitement de la depression (antagonistes du recepteur 5-ht1)

Publications (1)

Publication Number Publication Date
JP2002510682A true JP2002510682A (ja) 2002-04-09

Family

ID=22009404

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2000542313A Pending JP2002510682A (ja) 1998-04-08 1999-04-07 うつ病治療用のインドール−３−イル−シクロヘキシルアミン誘導体（５−ｈｔ１受容体拮抗薬）

Country Status (6)

Country Link
EP (1) EP1070063A1 (fr)
JP (1) JP2002510682A (fr)
CN (1) CN1304409A (fr)
AU (1) AU3476599A (fr)
CA (1) CA2327360A1 (fr)
WO (1) WO1999051592A1 (fr)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2006503037A (ja) * 2002-09-12 2006-01-26 ワイス 抗うつ作用を有する２，３−ジヒドロ−１，４−ベンゾジオキサンのシクロアルキルアミン誘導体
JP2006503040A (ja) * 2002-09-12 2006-01-26 ワイス 抗うつ剤としての複素環融合ベンゾジオキサンから成るシクロアルキルアミン誘導体

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6221863B1 (en) 1999-01-07 2001-04-24 American Home Products Corp. 3,4-dihydro-2H-benzo[1,4]oxazine derivatives
TW546299B (en) * 1999-01-07 2003-08-11 Wyeth Corp 3,4-dihydro-2H-benzo[1,4]oxazinyl-methyl-[3-(1H-indol-3-yl)-alkyl]-amines
AU2494300A (en) * 1999-01-07 2000-07-24 American Home Products Corporation 3,4-dihydro-2h-benzo(1,4)oxazine derivatives
GB0203804D0 (en) 2002-02-18 2002-04-03 Glaxo Group Ltd Compounds
US7276603B2 (en) * 2003-05-02 2007-10-02 Wyeth Benzofuranyl-and benzothienyl-piperazinyl quinolines and methods of their use

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3058980A (en) * 1962-10-16 Substitution products of benzo-
US4612312A (en) * 1984-07-30 1986-09-16 Merrell Dow Pharmaceuticals Inc. Glutarimide antianxiety and antihypertensive agents
GB8719167D0 (en) * 1987-08-13 1987-09-23 Glaxo Group Ltd Chemical compounds
DK37790A (da) * 1990-02-13 1991-08-14 Novo Nordisk As Indolderivater, deres fremstilling og anvendelse
US5189179A (en) * 1990-08-29 1993-02-23 Merrell Dow Pharmaceuticals Inc. Serotonin 5ht1a agonists
US5468768A (en) * 1994-01-06 1995-11-21 Bristol-Myers Squibb Company Antimigraine derivatives of indolylcycloalkanylamines
US5521197A (en) * 1994-12-01 1996-05-28 Eli Lilly And Company 3-<1-alkylenearyl>-4-<1,2,3,6-tetrahydropyridinyl>-and 3-<1-alkylenearyl>-4-piperidinyl-1h-indoles: new 5-HT1F agonists
MX9706969A (es) * 1995-03-20 1997-11-29 Lilly Co Eli 3-(1,2,3,6-tetrahidropiridin-4-il)-1h-indoles y 3-(piperidin-4-il)-1h-indoles sustituidos en la posicion 5: agonistas del 5-ht1f novedosos.

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2006503037A (ja) * 2002-09-12 2006-01-26 ワイス 抗うつ作用を有する２，３−ジヒドロ−１，４−ベンゾジオキサンのシクロアルキルアミン誘導体
JP2006503040A (ja) * 2002-09-12 2006-01-26 ワイス 抗うつ剤としての複素環融合ベンゾジオキサンから成るシクロアルキルアミン誘導体

Also Published As

Publication number Publication date
WO1999051592A1 (fr) 1999-10-14
AU3476599A (en) 1999-10-25
CA2327360A1 (fr) 1999-10-14
CN1304409A (zh) 2001-07-18
EP1070063A1 (fr) 2001-01-24

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