CA2367681A1 - Derives d'azaindole destines au traitement de la depression - Google Patents

Derives d'azaindole destines au traitement de la depression Download PDF

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Publication number
CA2367681A1
CA2367681A1 CA002367681A CA2367681A CA2367681A1 CA 2367681 A1 CA2367681 A1 CA 2367681A1 CA 002367681 A CA002367681 A CA 002367681A CA 2367681 A CA2367681 A CA 2367681A CA 2367681 A1 CA2367681 A1 CA 2367681A1
Authority
CA
Canada
Prior art keywords
compound
formula
pharmaceutically acceptable
ring
halogen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002367681A
Other languages
English (en)
Inventor
Kristin Lynne Meagher
Richard Eric Mewshaw
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wyeth LLC
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2367681A1 publication Critical patent/CA2367681A1/fr
Abandoned legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

L'invention concerne des composés utilisés dans le traitement de maladies en rapport avec les troubles des systèmes neurologiques liés à la sérotonine, tel que la dépression et l'anxiété. Ces composés sont représentés par la formule (I), dans laquelle R¿1? et R¿2? forment un noyau carbocyclique ou hétérocyclique de 5 à 7 atomes, ledit noyau pouvant être saturé ou non saturé ; X est indépendamment hydrogène, cyano, carbamoyl, halogène ou alcoxy, ou des sels pharmaceutiquement acceptables desdits composés.
CA002367681A 1999-04-22 2000-04-20 Derives d'azaindole destines au traitement de la depression Abandoned CA2367681A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US29673699A 1999-04-22 1999-04-22
US09/296,736 1999-04-22
PCT/US2000/010628 WO2000064898A1 (fr) 1999-04-22 2000-04-20 Derives d'azaindole destines au traitement de la depression

Publications (1)

Publication Number Publication Date
CA2367681A1 true CA2367681A1 (fr) 2000-11-02

Family

ID=23143341

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002367681A Abandoned CA2367681A1 (fr) 1999-04-22 2000-04-20 Derives d'azaindole destines au traitement de la depression

Country Status (8)

Country Link
EP (1) EP1171439A1 (fr)
JP (1) JP2002543079A (fr)
CN (1) CN1348451A (fr)
AR (1) AR028475A1 (fr)
AU (1) AU4364400A (fr)
BR (1) BR0010693A (fr)
CA (1) CA2367681A1 (fr)
WO (1) WO2000064898A1 (fr)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2005534619A (ja) * 2002-03-28 2005-11-17 エーザイ株式会社 Ｃ−ｊｕｎｎ−末端キナーゼ阻害剤としてのアザインドール
DE602005016836D1 (de) 2004-11-26 2009-11-05 Janssen Pharmaceutica Nv Chotischer und anxiolytischer aktivität
WO2008063888A2 (fr) 2006-11-22 2008-05-29 Plexxikon, Inc. Composés modulant l'activité de c-fms et/ou de c-kit et utilisations associées
BRPI0814423B1 (pt) 2007-07-17 2022-04-19 Plexxikon, Inc Compostos que modulam quinase e composição farmacêutica compreendendo os mesmos
AR078033A1 (es) 2009-04-03 2011-10-12 Plexxikon Inc Una dispersion solida, que contiene al compuesto {3-[5-(4-(cloro-fenil)-1h-pirrolo[2,3-b]piridina-3-carbonil]-2,4-difluor-fenil}-amida del acido propano-1-sulfonico, composiciones y formulaciones que comprenden a dicha dispersion solida; metodos para fabricar dicha dispersion solida, formas 1 y 2 de
GEP20156325B (en) 2009-06-17 2015-07-10 Vertex Pharma Inhibitors of influenza viruses replication
ES2633317T3 (es) 2009-11-06 2017-09-20 Plexxikon, Inc. Compuestos y métodos para la modulación de quinasas, e indicaciones para ello
MX2013006836A (es) 2010-12-16 2013-09-26 Vertex Pharma Inhibidores de la replicacion de los virus de la influenza.
MA34948B1 (fr) 2011-02-07 2014-03-01 Plexxikon Inc Composes et procedes de modulation de kinase, et leurs indications
TWI558702B (zh) 2011-02-21 2016-11-21 普雷辛肯公司 醫藥活性物質的固態形式
UA118010C2 (uk) 2011-08-01 2018-11-12 Вертекс Фармасьютікалз Інкорпорейтед Інгібітори реплікації вірусів грипу
US9150570B2 (en) 2012-05-31 2015-10-06 Plexxikon Inc. Synthesis of heterocyclic compounds
EP3421468B1 (fr) 2013-11-13 2020-11-04 Vertex Pharmaceuticals Incorporated Procédés de préparation d'inhibiteurs de réplication de virus de la grippe
RS59144B1 (sr) 2013-11-13 2019-09-30 Vertex Pharma Inhibitori replikacije virusa influence
WO2016183116A1 (fr) 2015-05-13 2016-11-17 Vertex Pharmaceuticals Incorporated Procédés de préparation d'inhibiteurs de réplication des virus de la grippe
WO2016183120A1 (fr) 2015-05-13 2016-11-17 Vertex Pharmaceuticals Incorporated Inhibiteurs de la réplication des virus de la grippe

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5521197A (en) * 1994-12-01 1996-05-28 Eli Lilly And Company 3-<1-alkylenearyl>-4-<1,2,3,6-tetrahydropyridinyl>-and 3-<1-alkylenearyl>-4-piperidinyl-1h-indoles: new 5-HT1F agonists
US5576321A (en) * 1995-01-17 1996-11-19 Eli Lilly And Company Compounds having effects on serotonin-related systems
US5627196A (en) * 1995-01-17 1997-05-06 Eli Lilly And Company Compounds having effects on serotonin-related systems

Also Published As

Publication number Publication date
WO2000064898A1 (fr) 2000-11-02
AR028475A1 (es) 2003-05-14
JP2002543079A (ja) 2002-12-17
BR0010693A (pt) 2002-02-05
CN1348451A (zh) 2002-05-08
AU4364400A (en) 2000-11-10
EP1171439A1 (fr) 2002-01-16

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