CN1348451A - 治疗抑郁症的氮杂吲哚衍生物 - Google Patents

治疗抑郁症的氮杂吲哚衍生物 Download PDF

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Publication number
CN1348451A
CN1348451A CN00806589A CN00806589A CN1348451A CN 1348451 A CN1348451 A CN 1348451A CN 00806589 A CN00806589 A CN 00806589A CN 00806589 A CN00806589 A CN 00806589A CN 1348451 A CN1348451 A CN 1348451A
Authority
CN
China
Prior art keywords
compound
following formula
ring
halogen
heterocycle
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN00806589A
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English (en)
Chinese (zh)
Inventor
R·E·穆肖
K·L·梅赫尔
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wyeth LLC
Original Assignee
American Home Products Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by American Home Products Corp filed Critical American Home Products Corp
Publication of CN1348451A publication Critical patent/CN1348451A/zh
Pending legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
CN00806589A 1999-04-22 2000-04-20 治疗抑郁症的氮杂吲哚衍生物 Pending CN1348451A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US29673699A 1999-04-22 1999-04-22
US09/296,736 1999-04-22

Publications (1)

Publication Number Publication Date
CN1348451A true CN1348451A (zh) 2002-05-08

Family

ID=23143341

Family Applications (1)

Application Number Title Priority Date Filing Date
CN00806589A Pending CN1348451A (zh) 1999-04-22 2000-04-20 治疗抑郁症的氮杂吲哚衍生物

Country Status (8)

Country Link
EP (1) EP1171439A1 (fr)
JP (1) JP2002543079A (fr)
CN (1) CN1348451A (fr)
AR (1) AR028475A1 (fr)
AU (1) AU4364400A (fr)
BR (1) BR0010693A (fr)
CA (1) CA2367681A1 (fr)
WO (1) WO2000064898A1 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN100338062C (zh) * 2002-03-28 2007-09-19 卫材株式会社 作为c－Jun N－末端激酶抑制剂的氮杂吲哚类化合物

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101084225B (zh) 2004-11-26 2011-03-02 詹森药业有限公司 具有改良的抗精神病和抗焦虑活性的异噁唑啉-吲哚衍生物
WO2008063888A2 (fr) 2006-11-22 2008-05-29 Plexxikon, Inc. Composés modulant l'activité de c-fms et/ou de c-kit et utilisations associées
WO2009012283A1 (fr) 2007-07-17 2009-01-22 Plexxikon Inc. Composés et procédés pour la modulation des kinases et leurs indications
ES2552386T3 (es) 2009-04-03 2015-11-27 F. Hoffmann-La Roche Ag Composiciones de {3-[5-(4-cloro-fenil)-1H-pirrol[2,3-b]piridin-3-carbonil]-2,4-difluoro-fenil}-amida del ácido propano-1-sulfónico y usos de las mismas
HUE031048T2 (en) 2009-06-17 2017-06-28 Vertex Pharma Influenza virus replication inhibitors
JP2013510166A (ja) 2009-11-06 2013-03-21 プレキシコン インコーポレーテッド キナーゼ調節のための化合物、方法およびその適用
CN103492381A (zh) 2010-12-16 2014-01-01 沃泰克斯药物股份有限公司 流感病毒复制的抑制剂
AU2012214762B2 (en) 2011-02-07 2015-08-13 Plexxikon Inc. Compounds and methods for kinase modulation, and indications therefor
TWI558702B (zh) 2011-02-21 2016-11-21 普雷辛肯公司 醫藥活性物質的固態形式
UA118010C2 (uk) 2011-08-01 2018-11-12 Вертекс Фармасьютікалз Інкорпорейтед Інгібітори реплікації вірусів грипу
US9150570B2 (en) 2012-05-31 2015-10-06 Plexxikon Inc. Synthesis of heterocyclic compounds
RS57541B1 (sr) 2013-11-13 2018-10-31 Vertex Pharma Postupci za pripremu inhibitora replikacije virusa gripa
CN105849100B (zh) 2013-11-13 2019-07-16 沃泰克斯药物股份有限公司 流感病毒复制抑制剂
WO2016183120A1 (fr) 2015-05-13 2016-11-17 Vertex Pharmaceuticals Incorporated Inhibiteurs de la réplication des virus de la grippe
JP6704416B2 (ja) 2015-05-13 2020-06-03 バーテックス ファーマシューティカルズ インコーポレイテッドＶｅｒｔｅｘ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｉｎｃｏｒｐｏｒａｔｅｄ インフルエンザウイルスの複製の阻害剤を調製する方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5521197A (en) * 1994-12-01 1996-05-28 Eli Lilly And Company 3-<1-alkylenearyl>-4-<1,2,3,6-tetrahydropyridinyl>-and 3-<1-alkylenearyl>-4-piperidinyl-1h-indoles: new 5-HT1F agonists
US5576321A (en) * 1995-01-17 1996-11-19 Eli Lilly And Company Compounds having effects on serotonin-related systems
US5627196A (en) * 1995-01-17 1997-05-06 Eli Lilly And Company Compounds having effects on serotonin-related systems

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN100338062C (zh) * 2002-03-28 2007-09-19 卫材株式会社 作为c－Jun N－末端激酶抑制剂的氮杂吲哚类化合物

Also Published As

Publication number Publication date
AR028475A1 (es) 2003-05-14
CA2367681A1 (fr) 2000-11-02
BR0010693A (pt) 2002-02-05
WO2000064898A1 (fr) 2000-11-02
EP1171439A1 (fr) 2002-01-16
JP2002543079A (ja) 2002-12-17
AU4364400A (en) 2000-11-10

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C02 Deemed withdrawal of patent application after publication (patent law 2001)
WD01 Invention patent application deemed withdrawn after publication