CN1284527C - 一种口腔溃疡含片及其制备方法 - Google Patents
一种口腔溃疡含片及其制备方法 Download PDFInfo
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- CN1284527C CN1284527C CN 03142690 CN03142690A CN1284527C CN 1284527 C CN1284527 C CN 1284527C CN 03142690 CN03142690 CN 03142690 CN 03142690 A CN03142690 A CN 03142690A CN 1284527 C CN1284527 C CN 1284527C
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- ulcer
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- 208000007117 Oral Ulcer Diseases 0.000 title claims abstract description 56
- 238000002360 preparation method Methods 0.000 title claims description 24
- 208000002399 aphthous stomatitis Diseases 0.000 title description 15
- 239000006189 buccal tablet Substances 0.000 claims abstract description 38
- 229940046011 buccal tablet Drugs 0.000 claims abstract description 33
- DTGKSKDOIYIVQL-WEDXCCLWSA-N (+)-borneol Chemical compound C1C[C@@]2(C)[C@@H](O)C[C@@H]1C2(C)C DTGKSKDOIYIVQL-WEDXCCLWSA-N 0.000 claims abstract description 20
- 206010028034 Mouth ulceration Diseases 0.000 claims description 41
- 239000007937 lozenge Substances 0.000 claims description 38
- 238000002156 mixing Methods 0.000 claims description 35
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical group [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 claims description 32
- 239000005913 Maltodextrin Substances 0.000 claims description 25
- 229920002774 Maltodextrin Polymers 0.000 claims description 25
- 229940035034 maltodextrin Drugs 0.000 claims description 25
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 claims description 24
- 229930195725 Mannitol Natural products 0.000 claims description 24
- 239000000594 mannitol Substances 0.000 claims description 24
- 235000010355 mannitol Nutrition 0.000 claims description 24
- 239000000203 mixture Substances 0.000 claims description 20
- QQILFGKZUJYXGS-UHFFFAOYSA-N Indigo dye Chemical compound C1=CC=C2C(=O)C(C3=C(C4=CC=CC=C4N3)O)=NC2=C1 QQILFGKZUJYXGS-UHFFFAOYSA-N 0.000 claims description 19
- 239000011812 mixed powder Substances 0.000 claims description 19
- 235000019359 magnesium stearate Nutrition 0.000 claims description 16
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 14
- 229960000935 dehydrated alcohol Drugs 0.000 claims description 14
- 239000011230 binding agent Substances 0.000 claims description 12
- 239000003795 chemical substances by application Substances 0.000 claims description 11
- 239000008187 granular material Substances 0.000 claims description 8
- 239000007779 soft material Substances 0.000 claims description 7
- 239000000314 lubricant Substances 0.000 claims description 6
- 239000003085 diluting agent Substances 0.000 claims description 5
- 229920003081 Povidone K 30 Polymers 0.000 claims description 3
- 230000001476 alcoholic effect Effects 0.000 claims description 3
- -1 drying Substances 0.000 claims description 3
- 238000001035 drying Methods 0.000 claims 2
- 230000035876 healing Effects 0.000 abstract description 22
- 230000036407 pain Effects 0.000 abstract description 10
- 230000000694 effects Effects 0.000 abstract description 8
- 230000001737 promoting effect Effects 0.000 abstract description 6
- 238000000034 method Methods 0.000 abstract description 2
- 230000000638 stimulation Effects 0.000 abstract description 2
- REPVLJRCJUVQFA-UHFFFAOYSA-N (-)-isopinocampheol Natural products C1C(O)C(C)C2C(C)(C)C1C2 REPVLJRCJUVQFA-UHFFFAOYSA-N 0.000 abstract 1
- 235000000177 Indigofera tinctoria Nutrition 0.000 abstract 1
- 229940037003 alum Drugs 0.000 abstract 1
- 229940116229 borneol Drugs 0.000 abstract 1
- CKDOCTFBFTVPSN-UHFFFAOYSA-N borneol Natural products C1CC2(C)C(C)CC1C2(C)C CKDOCTFBFTVPSN-UHFFFAOYSA-N 0.000 abstract 1
- DTGKSKDOIYIVQL-UHFFFAOYSA-N dl-isoborneol Natural products C1CC2(C)C(O)CC1C2(C)C DTGKSKDOIYIVQL-UHFFFAOYSA-N 0.000 abstract 1
- 229940097275 indigo Drugs 0.000 abstract 1
- COHYTHOBJLSHDF-UHFFFAOYSA-N indigo powder Natural products N1C2=CC=CC=C2C(=O)C1=C1C(=O)C2=CC=CC=C2N1 COHYTHOBJLSHDF-UHFFFAOYSA-N 0.000 abstract 1
- 208000025865 Ulcer Diseases 0.000 description 63
- 231100000397 ulcer Toxicity 0.000 description 63
- 239000000843 powder Substances 0.000 description 39
- 210000000214 mouth Anatomy 0.000 description 33
- 238000000643 oven drying Methods 0.000 description 12
- NOOLISFMXDJSKH-UHFFFAOYSA-N p-menthan-3-ol Chemical compound CC(C)C1CCC(C)CC1O NOOLISFMXDJSKH-UHFFFAOYSA-N 0.000 description 12
- 239000003814 drug Substances 0.000 description 9
- 230000003203 everyday effect Effects 0.000 description 8
- WHNWPMSKXPGLAX-UHFFFAOYSA-N N-Vinyl-2-pyrrolidone Chemical compound C=CN1CCCC1=O WHNWPMSKXPGLAX-UHFFFAOYSA-N 0.000 description 7
- 239000002671 adjuvant Substances 0.000 description 7
- IDGUHHHQCWSQLU-UHFFFAOYSA-N ethanol;hydrate Chemical compound O.CCO IDGUHHHQCWSQLU-UHFFFAOYSA-N 0.000 description 7
- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 7
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 7
- 239000004677 Nylon Substances 0.000 description 6
- 229920001778 nylon Polymers 0.000 description 6
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 4
- 241000700159 Rattus Species 0.000 description 4
- 201000010099 disease Diseases 0.000 description 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 4
- 239000008101 lactose Substances 0.000 description 4
- 230000000306 recurrent effect Effects 0.000 description 4
- 230000001225 therapeutic effect Effects 0.000 description 4
- 230000000699 topical effect Effects 0.000 description 4
- 108010010803 Gelatin Proteins 0.000 description 3
- 230000036592 analgesia Effects 0.000 description 3
- 229940079593 drug Drugs 0.000 description 3
- 229920000159 gelatin Polymers 0.000 description 3
- 239000008273 gelatin Substances 0.000 description 3
- 235000019322 gelatine Nutrition 0.000 description 3
- 235000011852 gelatine desserts Nutrition 0.000 description 3
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 description 3
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 description 3
- 206010002091 Anaesthesia Diseases 0.000 description 2
- 229920000742 Cotton Polymers 0.000 description 2
- 206010039424 Salivary hypersecretion Diseases 0.000 description 2
- 230000037005 anaesthesia Effects 0.000 description 2
- 238000002512 chemotherapy Methods 0.000 description 2
- 235000009508 confectionery Nutrition 0.000 description 2
- 238000011010 flushing procedure Methods 0.000 description 2
- 210000002200 mouth mucosa Anatomy 0.000 description 2
- 235000020357 syrup Nutrition 0.000 description 2
- 239000006188 syrup Substances 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- NIXOWILDQLNWCW-UHFFFAOYSA-N Acrylic acid Chemical compound OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 description 1
- GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 description 1
- 208000035143 Bacterial infection Diseases 0.000 description 1
- 235000009161 Espostoa lanata Nutrition 0.000 description 1
- 240000001624 Espostoa lanata Species 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
- 206010067152 Oral herpes Diseases 0.000 description 1
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N Phenol Chemical compound OC1=CC=CC=C1 ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 description 1
- 208000008630 Sialorrhea Diseases 0.000 description 1
- 229920002125 Sokalan® Polymers 0.000 description 1
- 208000036142 Viral infection Diseases 0.000 description 1
- 208000022362 bacterial infectious disease Diseases 0.000 description 1
- 230000037396 body weight Effects 0.000 description 1
- 238000001354 calcination Methods 0.000 description 1
- 229960001631 carbomer Drugs 0.000 description 1
- RNFNDJAIBTYOQL-UHFFFAOYSA-N chloral hydrate Chemical compound OC(O)C(Cl)(Cl)Cl RNFNDJAIBTYOQL-UHFFFAOYSA-N 0.000 description 1
- 229960002327 chloral hydrate Drugs 0.000 description 1
- 230000000052 comparative effect Effects 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 206010012601 diabetes mellitus Diseases 0.000 description 1
- 230000002124 endocrine Effects 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 239000000835 fiber Substances 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 description 1
- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 description 1
- 208000026278 immune system disease Diseases 0.000 description 1
- 238000007689 inspection Methods 0.000 description 1
- 238000011835 investigation Methods 0.000 description 1
- 230000000622 irritating effect Effects 0.000 description 1
- 230000007794 irritation Effects 0.000 description 1
- 229920003023 plastic Polymers 0.000 description 1
- 239000004033 plastic Substances 0.000 description 1
- 230000005180 public health Effects 0.000 description 1
- 210000003296 saliva Anatomy 0.000 description 1
- 208000026451 salivation Diseases 0.000 description 1
- 235000020374 simple syrup Nutrition 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 229960001957 stomatological preparations Drugs 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 241001529453 unidentified herpesvirus Species 0.000 description 1
- 230000009385 viral infection Effects 0.000 description 1
- 239000003643 water by type Substances 0.000 description 1
Landscapes
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Description
薄荷脑的用量 | 口感 |
0.25% | 无清凉效果 |
0.5% | 口感清凉 |
0.75% | 口感清凉,略麻 |
组别 | 给药剂量(mg) | 溃疡面积(以直径计:mm) | |||||
0天 | 1天 | 2天 | 3天 | 4天 | 5天 | ||
模型组 | 0 | 3.0±0.4 | 3.1±0.3 | 2.8±0.6 | 2.8±0.6 | 2.2±0.8 | 2.0±0.6 |
辅料组 | 0 | 3.0±0.4 | 2.9±0.4 | 2.7±0.5 | 2.3±0.6 | 1.75±0.5 | 1.6±0.7 |
含片高剂量组 | 9.4 | 3.0±0.8 | 2.4±0.8* | 1.5±1.2** | 0.9±1.4** | 0.3±0.6** | 0.1±0.2** |
含片中剂量组 | 4.7 | 3.0±0.6 | 3.0±0.5 | 2.5±0.6 | 2.3±0.7 | 1.0±0.8** | 0.4±0.5** |
含片低剂量组 | 2.4 | 3.0±0.3 | 2.7±0.6 | 2.7±0.5 | 2.6±0.6 | 1.5±0.8* | 1.3±0.8* |
口腔溃疡散组 | 80 | 2.9±0.4 | 2.6±0.4** | 2.0±0.5** | 1.2±0.4** | 0.8±0.6** | 0.4±0.5** |
组别 | 给药剂量(mg) | 溃疡愈合率(%) | |||||
0天 | 1天 | 2天 | 3天 | 4天 | 5天 | ||
模型组 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
辅料组 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
含片高剂量组 | 9.4 | 0 | 0 | 20* | 50* | 90* | 90* |
含片中剂量组 | 4.7 | 0 | 0 | 0 | 0 | 20* | 50* |
含片低剂量组 | 2.4 | 0 | 0 | 0 | 0 | 0 | 0 |
口腔溃疡散组 | 80 | 0 | 0 | 0 | 10* | 30* | 70* |
组别 | 例数 | 给药次数 | 溃疡愈合例数 | |||||
0天 | 1天 | 2天 | 3天 | 4天 | 5天 | |||
口腔溃疡含片组口腔溃疡散组 | 1010 | 33 | 00 | 00 | 31 | 42 | 32 | 5 |
Claims (3)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN 03142690 CN1284527C (zh) | 2002-06-18 | 2003-06-12 | 一种口腔溃疡含片及其制备方法 |
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN02121379.8 | 2002-06-18 | ||
CN02121379 | 2002-06-18 | ||
CN 03142690 CN1284527C (zh) | 2002-06-18 | 2003-06-12 | 一种口腔溃疡含片及其制备方法 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN1500521A CN1500521A (zh) | 2004-06-02 |
CN1284527C true CN1284527C (zh) | 2006-11-15 |
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Application Number | Title | Priority Date | Filing Date |
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CN 03142690 Expired - Lifetime CN1284527C (zh) | 2002-06-18 | 2003-06-12 | 一种口腔溃疡含片及其制备方法 |
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Country | Link |
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CN (1) | CN1284527C (zh) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102485216A (zh) * | 2010-12-03 | 2012-06-06 | 中山市中健药物研究所有限公司 | 一种药品爽口片 |
CN102178748B (zh) * | 2011-04-13 | 2012-09-26 | 姜殿玺 | 一种治疗溃疡的外用药剂 |
CN105079043A (zh) * | 2015-09-25 | 2015-11-25 | 钱保法 | 一种治疗顽固性口疮病的药物及其制备方法 |
CN106620081A (zh) * | 2017-03-14 | 2017-05-10 | 四川香龙丹医药科技有限公司 | 一种治疗口腔溃疡的含片 |
CN107334800A (zh) * | 2017-07-07 | 2017-11-10 | 姜荣成 | 治疗口腔溃疡的药物 |
-
2003
- 2003-06-12 CN CN 03142690 patent/CN1284527C/zh not_active Expired - Lifetime
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Publication number | Publication date |
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CN1500521A (zh) | 2004-06-02 |
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Owner name: LUYE NATURAL MEDICINAL RESEARCH DEVELOPING CO., L Free format text: FORMER OWNER: SHANDONG GREEN LEAF PHARMACEUTICAL CO., LTD. Effective date: 20060908 |
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Effective date of registration: 20060908 Address after: 264003, No. 9, Po Yuen Road, Laishan District, Shandong, Yantai Patentee after: SHANDONG LUYE NATURAL DRUG RESEARCH AND DEVELOPMENT CO.,LTD. Address before: 264003, No. 9, Po Yuen Road, Laishan District, Shandong, Yantai Patentee before: Shandong Luye Pharmaceutical Co.,Ltd. |
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C14 | Grant of patent or utility model | ||
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EE01 | Entry into force of recordation of patent licensing contract |
Assignee: Xi'an Haixin Pharmaceutical Co.,Ltd. Assignor: SHANDONG LUYE NATURAL DRUG RESEARCH AND DEVELOPMENT CO.,LTD. Contract fulfillment period: 2006.12.10 to 2016.12.10 Contract record no.: 2009610000130 Denomination of invention: Keep-in-mouth tablet for oral ulcer and preparation method Granted publication date: 20061115 License type: Exclusive license Record date: 20091207 |
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LIC | Patent licence contract for exploitation submitted for record |
Free format text: EXCLUSIVE LICENSE; TIME LIMIT OF IMPLEMENTING CONTACT: 2006.12.10 TO 2016.12.10; CHANGE OF CONTRACT Name of requester: XI'AN HAIXIN PHARMACEUTICAL CO., LTD. Effective date: 20091207 |
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Owner name: XI'AN HAIXIN PHARMACEUTICAL CO., LTD. Free format text: FORMER OWNER: LUYE NATURAL MEDICINAL RESEARCH DEVELOPING CO., LTD., SHANDONG PROV. Effective date: 20100827 |
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Free format text: CORRECT: ADDRESS; FROM: 264003 NO.9, BAOYUAN ROAD, LAISHAN DISTRICT, YANTAI CITY, SHANDONG PROVINCE TO: 710075 NO.20, TUANJIE SOUTH ROAD, HIGH-TECH. DEVELOPMENT ZONE, XI'AN CITY |
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Effective date of registration: 20100827 Address after: 710075, Xi'an hi tech Development Zone, unity South Road, No. 20 Patentee after: Xi'an Haixin Pharmaceutical Co.,Ltd. Address before: 264003 Laishan, Shandong Province Bao Road, No. 9 District, No. Patentee before: SHANDONG LUYE NATURAL DRUG RESEARCH AND DEVELOPMENT CO.,LTD. |
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Granted publication date: 20061115 |