CN1283621C - 烷基脲的类维生素a激动剂ⅰ - Google Patents

烷基脲的类维生素a激动剂ⅰ Download PDF

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Publication number
CN1283621C
CN1283621C CNB028181522A CN02818152A CN1283621C CN 1283621 C CN1283621 C CN 1283621C CN B028181522 A CNB028181522 A CN B028181522A CN 02818152 A CN02818152 A CN 02818152A CN 1283621 C CN1283621 C CN 1283621C
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CN
China
Prior art keywords
compounds
alkyl
acid
compound
emphysema
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
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CNB028181522A
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English (en)
Chinese (zh)
Other versions
CN1555359A (zh
Inventor
保拉·南妮特·贝洛尼
丹尼斯·约翰·凯尔泰斯
米夏埃尔·克劳斯
让－马克·拉皮埃尔
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F Hoffmann La Roche AG
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F Hoffmann La Roche AG
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Publication of CN1555359A publication Critical patent/CN1555359A/zh
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Publication of CN1283621C publication Critical patent/CN1283621C/zh
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C275/28—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C275/42—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by carboxyl groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/04—One of the condensed rings being a six-membered aromatic ring
    • C07C2602/10—One of the condensed rings being a six-membered aromatic ring the other ring being six-membered, e.g. tetraline

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Dermatology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
CNB028181522A 2001-09-18 2002-09-11 烷基脲的类维生素a激动剂ⅰ Expired - Fee Related CN1283621C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US32296301P 2001-09-18 2001-09-18
US60/332,963 2001-09-18

Publications (2)

Publication Number Publication Date
CN1555359A CN1555359A (zh) 2004-12-15
CN1283621C true CN1283621C (zh) 2006-11-08

Family

ID=33130243

Family Applications (1)

Application Number Title Priority Date Filing Date
CNB028181522A Expired - Fee Related CN1283621C (zh) 2001-09-18 2002-09-11 烷基脲的类维生素a激动剂ⅰ

Country Status (13)

Country Link
US (1) US6844466B2 (enExample)
EP (1) EP1430024A1 (enExample)
JP (1) JP4421293B2 (enExample)
KR (1) KR100896550B1 (enExample)
CN (1) CN1283621C (enExample)
AR (1) AR036533A1 (enExample)
AU (1) AU2002329276B2 (enExample)
BR (1) BR0212583A (enExample)
CA (1) CA2460693C (enExample)
MX (1) MXPA04002590A (enExample)
PL (1) PL370361A1 (enExample)
RU (1) RU2299877C2 (enExample)
WO (1) WO2003024921A1 (enExample)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005000233A2 (en) * 2003-06-23 2005-01-06 Auspex Pharmaceuticals Novel therapeautic agents for the treatment of cancer, metabolic diseases and skin disorders
WO2005108338A1 (en) * 2004-05-03 2005-11-17 Auspex Pharmaceuticals Novel therapeutic agents for the treatment of cancer, metabolic diseases and skin disorders
WO2006104826A2 (en) * 2005-03-30 2006-10-05 Merck & Co., Inc. Glucagon receptor antagonist compounds, compositions containing such compounds and methods of use
TW200821284A (en) * 2006-10-03 2008-05-16 Merck & Co Inc Glucagon receptor antagonist compounds, compositions containing such compounds and methods of use
PL2613776T3 (pl) 2010-09-01 2021-01-11 Thomas Jefferson University Kompozycja oraz sposób naprawy i regeneracji mięśni
CN109589324B (zh) 2012-11-08 2022-06-14 国立大学法人山口大学 角结膜病症的治疗剂
KR101426197B1 (ko) * 2013-02-20 2014-08-01 여윤영 주먹밥틀
CN105377258B (zh) 2013-05-22 2020-08-28 国立大学法人山口大学 视网膜脉络膜病症的抑制剂
CN105294567B (zh) * 2015-10-29 2018-10-09 湖北新烯王生物科技有限公司 取代的3-氟苯基甲醇类化合物、药物组合物及用途
ES2963348T3 (es) 2016-06-08 2024-03-26 Clementia Pharmaceuticals Inc Métodos para tratar la osificación heterotópica
BR112019009929A2 (pt) 2016-11-16 2019-08-20 Clementia Pharmaceuticals Inc métodos para inibir a formação de um osteocondroma, para reduzir o tamanho de um osteocondroma, para desacelerar o crescimento de um osteocondroma e para reduzir hiperplasia de cartilagem

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
LU87821A1 (fr) 1990-10-12 1992-05-25 Cird Galderma Composes bi-aromatiques,et leur utilisation en medecine humaine et veterinaire et en cosmetique
BR9306284A (pt) * 1992-04-22 1998-01-13 Ligand Pharm Inc Compostos tendo seletividade pra receptores de retinóides x
US6093742A (en) 1997-06-27 2000-07-25 Vertex Pharmaceuticals, Inc. Inhibitors of p38
JO2178B1 (en) * 1999-10-19 2003-04-23 اف . هوفمان لاروش ايه جي Treatment of emphysema using rar selective retinoid antagonists

Also Published As

Publication number Publication date
JP4421293B2 (ja) 2010-02-24
CA2460693A1 (en) 2003-03-27
AR036533A1 (es) 2004-09-15
MXPA04002590A (es) 2004-06-18
RU2004111787A (ru) 2005-10-20
CN1555359A (zh) 2004-12-15
KR100896550B1 (ko) 2009-05-07
KR20040035809A (ko) 2004-04-29
US6844466B2 (en) 2005-01-18
CA2460693C (en) 2010-12-07
EP1430024A1 (en) 2004-06-23
AU2002329276B2 (en) 2008-04-24
JP2005505571A (ja) 2005-02-24
US20030158226A1 (en) 2003-08-21
RU2299877C2 (ru) 2007-05-27
WO2003024921A1 (en) 2003-03-27
BR0212583A (pt) 2004-10-13
PL370361A1 (en) 2005-05-16

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CF01 Termination of patent right due to non-payment of annual fee

Granted publication date: 20061108

Termination date: 20120911