CA2460693C - Alkyl urea retinoid agonists i - Google Patents

Alkyl urea retinoid agonists i Download PDF

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Publication number
CA2460693C
CA2460693C CA2460693A CA2460693A CA2460693C CA 2460693 C CA2460693 C CA 2460693C CA 2460693 A CA2460693 A CA 2460693A CA 2460693 A CA2460693 A CA 2460693A CA 2460693 C CA2460693 C CA 2460693C
Authority
CA
Canada
Prior art keywords
compound
alkyl
acid
emphysema
compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CA2460693A
Other languages
English (en)
French (fr)
Other versions
CA2460693A1 (en
Inventor
Paula Nanette Belloni
Denis John Kertesz
Michael Klaus
Jean-Marc Lapierre
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of CA2460693A1 publication Critical patent/CA2460693A1/en
Application granted granted Critical
Publication of CA2460693C publication Critical patent/CA2460693C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C275/28—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C275/42—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by carboxyl groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/04—One of the condensed rings being a six-membered aromatic ring
    • C07C2602/10—One of the condensed rings being a six-membered aromatic ring the other ring being six-membered, e.g. tetraline

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Dermatology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
CA2460693A 2001-09-18 2002-09-11 Alkyl urea retinoid agonists i Expired - Fee Related CA2460693C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US32296301P 2001-09-18 2001-09-18
US60/332,963 2001-09-18
PCT/EP2002/010179 WO2003024921A1 (en) 2001-09-18 2002-09-11 Alkyl urea retinoid agonists i

Publications (2)

Publication Number Publication Date
CA2460693A1 CA2460693A1 (en) 2003-03-27
CA2460693C true CA2460693C (en) 2010-12-07

Family

ID=33130243

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2460693A Expired - Fee Related CA2460693C (en) 2001-09-18 2002-09-11 Alkyl urea retinoid agonists i

Country Status (13)

Country Link
US (1) US6844466B2 (enExample)
EP (1) EP1430024A1 (enExample)
JP (1) JP4421293B2 (enExample)
KR (1) KR100896550B1 (enExample)
CN (1) CN1283621C (enExample)
AR (1) AR036533A1 (enExample)
AU (1) AU2002329276B2 (enExample)
BR (1) BR0212583A (enExample)
CA (1) CA2460693C (enExample)
MX (1) MXPA04002590A (enExample)
PL (1) PL370361A1 (enExample)
RU (1) RU2299877C2 (enExample)
WO (1) WO2003024921A1 (enExample)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2004251712A1 (en) * 2003-06-23 2005-01-06 Auspex Pharmaceuticals, Inc. Novel therapeautic agents for the treatment of cancer, metabolic diseases and skin disorders
WO2005108338A1 (en) * 2004-05-03 2005-11-17 Auspex Pharmaceuticals Novel therapeutic agents for the treatment of cancer, metabolic diseases and skin disorders
CN101146763A (zh) * 2005-03-30 2008-03-19 默克公司 胰高血糖素受体拮抗剂化合物、含有这种化合物的组合物以及使用方法
TW200821284A (en) * 2006-10-03 2008-05-16 Merck & Co Inc Glucagon receptor antagonist compounds, compositions containing such compounds and methods of use
CN111773213B (zh) 2010-09-01 2023-02-24 托马斯杰弗逊大学 用于肌肉修复和再生的组合物和方法
WO2014073209A1 (ja) 2012-11-08 2014-05-15 国立大学法人山口大学 角結膜障害の治療剤
KR101426197B1 (ko) * 2013-02-20 2014-08-01 여윤영 주먹밥틀
US10702502B2 (en) 2013-05-22 2020-07-07 Yamaguchi University Inhibitor for retinochoroidal disorders
CN105294567B (zh) * 2015-10-29 2018-10-09 湖北新烯王生物科技有限公司 取代的3-氟苯基甲醇类化合物、药物组合物及用途
ES2963348T3 (es) 2016-06-08 2024-03-26 Clementia Pharmaceuticals Inc Métodos para tratar la osificación heterotópica
JP7018957B2 (ja) 2016-11-16 2022-02-14 クレメンティア ファーマシューティカルズ インコーポレイテッド 多発性骨軟骨腫（ｍｏ）を処置するための方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
LU87821A1 (fr) 1990-10-12 1992-05-25 Cird Galderma Composes bi-aromatiques,et leur utilisation en medecine humaine et veterinaire et en cosmetique
DE69333894D1 (de) * 1992-04-22 2005-12-01 Ligand Pharm Inc Verbindungen mit Retinoid x rezeptorselektivität
US6093742A (en) 1997-06-27 2000-07-25 Vertex Pharmaceuticals, Inc. Inhibitors of p38
JO2178B1 (en) * 1999-10-19 2003-04-23 اف . هوفمان لاروش ايه جي Treatment of emphysema using rar selective retinoid antagonists

Also Published As

Publication number Publication date
AU2002329276B2 (en) 2008-04-24
BR0212583A (pt) 2004-10-13
CN1555359A (zh) 2004-12-15
MXPA04002590A (es) 2004-06-18
JP4421293B2 (ja) 2010-02-24
RU2299877C2 (ru) 2007-05-27
PL370361A1 (en) 2005-05-16
US20030158226A1 (en) 2003-08-21
RU2004111787A (ru) 2005-10-20
AR036533A1 (es) 2004-09-15
WO2003024921A1 (en) 2003-03-27
CN1283621C (zh) 2006-11-08
JP2005505571A (ja) 2005-02-24
CA2460693A1 (en) 2003-03-27
US6844466B2 (en) 2005-01-18
EP1430024A1 (en) 2004-06-23
KR20040035809A (ko) 2004-04-29
KR100896550B1 (ko) 2009-05-07

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JP2008534593A (ja) グルカゴン受容体アンタゴニスト化合物、そのような化合物を含む組成物、及びその使用方法
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Legal Events

Date Code Title Description
EEER Examination request
MKLA Lapsed

Effective date: 20130911