CN1279602A - 防晒浓缩物 - Google Patents
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Abstract
稳定均匀分散体防晒浓缩物,以重量计含有:(a)约30—65%超细二氧化钛或氧化锌,或其混合物,(b)约30—70%有机防晒剂,和(c)约0.25—25%分散助剂,所述分散助剂是用C4-C36α-烯烃烷基化处理过的聚乙烯吡咯烷酮。
Description
本发明背景
1.本发明领域
本发明是关于防晒组合物,更准确地说是关于超细二氧化钛或氧化锌在以α—烯烃进行过烷基化处理的聚乙烯吡咯烷酮作为分散助剂的有机防晒剂中的稳定均匀分散体。
2.现有技术说明
防晒组合物在现有技术中已经详细说明过。例如参见美国专利4,810,489;4,820,508;5,026,540;5,041,281;5,207,998;5,219,559;5,306,485;5,445,815;5,508,024;5,599,529;和5,603,863。所述组合物通常用预定量的几种组分混合配制。但是,不利的是所述混合经常需要在昂贵的混合设备中,各组分复杂按精心按排的顺序加入以保证形成均匀分散的组合物。
因此,本发明的目的是提供稳定均匀分散体形式的防晒浓缩物,以所述浓缩物通过载体简单稀释,可以容易地制备防晒组合物。
本发明的另一个目的是提供防晒浓缩物,其含有超细二氧化钛或氧化锌在以α—烯烃烷基化处理过的聚乙烯吡咯烷酮作为分散助剂的有机防晒剂中的稳定均匀分散体。
本发明再一个目的是提供防水防晒浓缩物,其含有亲水或疏水聚乙烯吡咯烷酮和α—烯共聚物中的无机阳光阻隔剂和吸收UV的有机防晒剂,其中所述浓缩物的颗粒度约0.01—0.2μ,优选约0.05—0.1μ,而Brookfield粘度约4,000—1,000,000cps,优选约5,000—400,000cps。
从下面本发明更详细的说明中会明白本发明的这些和其他目的和特征。
本发明概述
本文说明的是稳定均匀分散体形式的防水防晒浓缩物,其含有(重量):
(a)约30—65%超细二氧化钛或氧化锌,或其混合物,
(b)约30—70%有机防晒剂,和
(c)约0.25—25%分散助剂,为C4—C36α—烯烃烷基化处理过的聚乙烯吡咯烷酮。
所述浓缩物合适的粒度是约0.01—0.2μ,优选约0.05—0.1μ,而Brookfield粘度是约4,000—1,000,000cps,优选5,000—400,000cps。
商品防晒组合物,可以容易地将本发明的防晒浓缩物与水和所述组合物的其他常规组分混合而制备。
本发明详细说明
本发明的防水防晒浓缩物含有阻隔阳光组分(a),是超细二氧化钛或氧化锌,其量是所述浓缩物重量的约30—65%。优选超细二氧化钛。
本发明的防晒浓缩物还含有吸收UV—的防晒剂,即活性组合(b)。合适的有机防晒剂包括:桂醚酯(对甲氧基肉桂酸2—乙氧基乙酯)、二乙醇胺对甲氧基肉桂酸酯、二棓酰三油酸酯4—二(羟丙基)氨基苯甲酸乙酯、对甲氧基肉桂酸乙基己酯、水杨酸2—乙基己酯、氨基苯甲酸甘油酯、高水杨酸酯(水杨酸3,3,5—三甲基环己基酯)、三乙醇胺水杨酸酯、2—苯基苯并咪唑—5—磺酸、苯酰羟基甲氧基苯磺酸(2—羟基—4—甲氧基二苯甲酮—5—磺酸)、Padimate A(对二甲基氨基苯甲酸戊酯)、Padimate O(对氨基苯甲酸辛基二甲酯),和邻氨基苯甲酸基酯,和其混合物。
所述防晒剂也可以包括特别适合于防止紫外线A(320—400nm)的防晒物质。该化合物宜于选自2—羟基—4—甲氧基二苯甲酮、2,2′—4—甲氧基二羟基二苯甲酮、2—氰基—3,3—二苯基丙烯酸2—乙基己酯、甲基亚苄基樟脑、4—叔丁基—4′—甲氧基二苯甲酰甲烷和其混合物。
有机防晒剂总量占总浓缩物的约30%—70%,优选约35—55%(重量)。
本发明防晒浓缩物的组分(c)是使浓缩物成为稳定均匀分散体形式的分散助剂。本文分散助剂是用C4—C36α—烯烃烷基化处理过的聚乙烯吡咯烷酮(PVP),其合适量是所述浓缩物的约0.25—25%(重量)。组分c可以是亲水或疏水的聚合物。亲水共聚物通过将C4α—烯接枝在PVP上制备,其由International Specialty Products Inc.(ISP)以Ganex P—904LC和P—904销售。所述浓缩物中存在的亲水共聚物的合适量是所述浓缩物的约0.25—4%,优选约0.5—2%(重量)。疏水共聚物通过将C16—C36α—烯接枝在PVP上制备。这些疏水共聚物也可以从ISP以下述商标得到:Ganex V—216液体,或Ganex V—220和WP 660蜡状固体或薄片。所述浓缩物中GanexV—216的合适量是约O.25—25%,最佳5—20%,而Ganex V—220的合适量是约5—25%,优选10—20%。优选的疏水共聚物是GanexV—216。含有C20α—烯共聚物优选量是约5—25%。
本发明的防晒浓缩物可以通过用常规廉价搅拌设备将组分(a)、(b)和(c)简单混合制备。这样得到的防晒浓缩物是无机防晒剂、有机防晒剂和Ganex分散剂的稳定均匀分散体,其颗粒度约0.01—0.2μ,优选0.05—0.1μ,而Brookfield粘度4,000—1,000,000cps,优选约5,000—400,000cps。
此后,在需要时,用合适载体和其他添加剂简单稀释该防晒浓缩物即可容易地配制出最终使用的广谱防水防晒组合物,根据使用者的皮肤选择的SPF值下,所述组合物可以使活性阻隔阳光剂及防晒剂均匀分布。
本发明用下列实施例加以说明。
实施例1
用均化器将100g Ganex V—216溶于200g Escalo1 557中制备有机防晒溶液。然后将500g 2mm硅酸锆小珠加入砂研磨容器中,加入足量上述溶液以掩盖所述小珠。将200g Kemira UV—TitanM—262超细二氧化钛缓慢地加入到所述锆珠中。所述研磨处理进行4小时,过滤出所述锆球。得到白色分散体,其Brookfield粘度6040cps(Helipath,spindle TB @10rpm)。
实施例2—16
按照实施例1的方法,制备下列分散体系。
实施例2白色分散体:Ganex V—216——75gEscalol 557——225gUF TiO2,Kemira UV Titan M262——200gBrookfield粘度7800cps(spindle TB @10rpm)。
实施例3白色分散体:Ganex V—216——50gEscalol 557——250gUF TiO2,Kemira UV Titan M262——200gBrookfield粘度16,200cps(spindle TB @10rpm)
实施例4白色分散体:Ganex V—216——25gEscalol 557——275gUF TiO2, Kemira UV Titan M262——200gBrookfield粘度22,600cps(spindle TB @10rpm)。
实施例5白色分散体:Ganex V—216——10gEscalol 557——290gUF TiO2,Kemira UV Titan M262——200gBrookfield粘度21,900cps(spindle TB @10rpm)
实施例6白色分散体:Ganex V—216——5gEscalol 557——295gUF TiO2,Kemira UV Titan M262——200gBrookfield粘度25,200cps (spindle TB @10rpm)
实施例7
用119g Escalol 557中的6.28g Ganex V—216、314g 2mm硅酸锆小珠、二氧化钛和94.5g Finex 25超细氧化锌,重复实施例1的方法。得到白色分散体,其Brookfield粘度28,000cps(spindle TC@10rpm)。
实施例8白色分散体:Ganex V—216——5gEscalol 557——295gUF TiO2,Tayca SMT—100 SAS——200gBrookfield粘度83,000cps(spindle TC @10rpm) 。
实施例9白色分散体:Ganex V—216——6gEscalol 557——354gUF TiO2,Kemira UV—X161——240gBrookfield粘度256,000cps(spindle TE @10rpm)。
实施例10浅米黄色分散体:Ganex V—216——6gEscalol 557——380gUF TiO2,Tayca MT—100T——240gBrookfield粘度302,000cps(spindle TE @10rpm)
实施例11白色分散体:Ganex P—904——5gEscalol 557——295gUF TiO2,Kemria UV—Titan M—262——200gBrookfield粘度104,000cps(spindle TE @10rpm) 。
实施例12浅米黄色分散体:Ganex P—904——5gEscalol 557——295gUF TiO2,Tayca MT—100T——200gBrookfield粘度334,000cps(spindle TE @10rpm)
实施例13膏体:Ganex V—220——100gEscalol 557——250gUF TiO2, Kemria UV—Titan M—262——200g所述分散体是膏状。
实施例14白色分散体:Ganex P—904——12gEscalol 557——348gUF ZnO,Z—Cote HP—1——240gBrookfield粘度12,000cps(spindle TB @10rpm)
实施例15白色分散体:Ganex V—516——12gEscalol 557——348gUF TiO2, Kemria UV—Titan M—262——240gBrookfield粘度84,400cps(spindle TD @10rpm)。
实施例16白色分散体:Ganex WP—660——18gEscalol 557——402gUF TiO2, Tayca MT—100T——180gBrookfield粘度142,000cps (spindle TE @10rpm)
实施例1—16的分散体组合物
表
组分 | %重量 | Brookfield粘度 |
实施例1 | ||
Ganex V—216 | 20 | |
Escalol 557 | 40 | |
Kemira M262 | 40 | 6040cps |
实施例2 | ||
Ganex V—216 | 15 | |
Escalol 557 | 45 | |
Kemira M262 | 40 | 7800cps |
实施例3 | ||
Ganex V—216 | 10 | |
Escalol 557 | 50 | |
Kemira M262 | 40 | 16,200cps |
实施例4 | ||
Ganex V—216 | 5 | |
Escalol 557 | 55 | |
Kemira M262 | 40 | 22,600cps |
实施例5 | ||
Ganex V—216 | 2 | |
Escalol 557 | 58 | |
Kemira M262 | 40 | 21,900cps |
实施例6 | ||
Ganex V—216 | 1 | |
Escalol 557 | 59 | |
Kemira M262 | 40 | 25,200cps |
实施例7 | ||
Ganex V—216 | 2 | |
Escalol 557 | 38 | |
Kemira M262(TiO2) | 30 | |
Finex 25(ZnO) | 30 | 28,000cps |
实施例8 | ||
Ganex V—216 | 1 | |
Escalol 557 | 59 | |
Tayca SMT—100SAS | 40 | 83,000cps |
实施例9 | ||
Ganex V—216 | 1 | |
Escalol 557 | 59 | |
Kemira X—161 | 40 | 256,000cps |
实施例10 | ||
Ganex V—216 | 1 | |
Escalol 557 | 60.7 | |
Tayca MT 100T | 38.3 | 302,000cps |
实施例11 | ||
Ganex P—904 | 1 | |
Escalol 557 | 59 | |
Kemira M262 | 40 | 104,000cps |
实施例12 | ||
Ganex P—904 | 1 | |
Escalol 557 | 59 | |
Tayca MT 100T | 40 | 334,000cps |
实施例13 | ||
Ganex V—220 | 18.1 | |
Escalol 557 | 45.5 | |
Kemira M262 | 36.4 | Paste |
实施例14 | ||
Ganex P—904 | 2 | |
Escalol 557 | 58 | |
Z—Cote HP—1(ZnO) | 40 | 12,000cps |
实施例15 | ||
Ganex V—516 | 2 | |
Escalol 557 | 58 | |
Kemira M262 | 40 | 84,400cps |
实施例16 | ||
Ganex WP—660 | 3 | |
Escalol 557 | 67 | |
Tayca MT 100T | 30 | 142,000cps |
本发明的防晒浓缩物的制备
实施例17
将超细二氧化钛(kemira UV Titan M262,Tayca MT—100T或Tayca SMT—100 SAS),(240g,40%(重量)),GanexP—904(6g,1%(重量))和Escalol 557(357g,59%(重量))混合制备本发明的防晒浓缩物的稳定均匀分散体,过程如下:
在由安装在Premier分散器上的Cowles叶片提供的激烈搅拌下,将Ganex P—904和Escalol 557组分加热至50℃。在混合物达到50℃时将超细二氧化钛粉缓慢地加入所述混合物的涡流中,同时保持其温度于50℃。得到的混合物开始增稠,然后在3,000—5,000rpm下搅拌,物料再继续搅拌15分钟,然后冷却至室温,得到的分散体用3辊研磨机研磨两次。用Brookfield粘度计(Spindle TC,10rpm)测定的所述浓缩物粘度是149,000cps。
防水防晒组合物的制备
实施例18组分 %重量A相 12A 12B**去离子水 69.80 69.80V Gum Ultra 1.00 1.00(硅酸镁铝;二氧化钛;方英石;专卖物质)甘油,USP 1.00 1.00CMC(7H3SF) 0.50 0.50B相ProLipidTM131 3.00 3.00
(硬脂酸(和)山萮醇(和)
硬脂酸甘油酯(和)马来酸
化的豆油(和)卵磷脂(和)
C12—16醇(和)棕榈酸)
Ceraphyl 791 13.50 13.50
(硬脂酰硬脂酸异鲸蜡酯)
Ceraphyl 847 1.00 1.00
(硬脂酰硬脂酸
辛基十二烷基酯)
*本发明的浓缩物 10.00 10.00
C相
Germall Plus 0.20 0.20
(二偶氮烷基脲(和)
丁基氨基甲酸碘代丙炔酯)
100.00 100.00
*Escalol T
{kemira UV Titan
M262@40%+Ganex
V—220@20%+Escalol
557@20%}
**Escalol T中的Tayca MT100T
程序:
A阶段
1.根据物料多少将所述水加入合适大小的容器中。研磨同时开始混入V—Gum Ultra。混合时不加热。继续混合直到无可见树胶痕迹(形成细粒)。
2.这时可以预混合CMC和甘油。(应注意在此之前甘油和CMC不应预混合,因为该混合物很快稠化)。加进所述预混合物中时,可以开始加热该相直到其温度达到75℃。
B阶段
1.除了二氧化钛分散体(Escalol T)以后加入外,将所有油相组分加入合适大小的烧杯中。将所述烧杯放入水浴中,加热直到完全熔化。
2.将二氧化钛分散体(Escalol T)加入所述烧杯中并混合直到完全分散到油相中。
3.水相温度达到75℃时加入B相中,继续混合约30分钟。30分钟后用均化型Arde Barineo二元型混合器均化该乳状液。
4.一旦所述乳状液均化,可继续混合直到该批物料温度达到35℃—40℃,这时加入C相。继续混合直到所述物料温度达到25℃。
5.一开始和24小时后检测pH。测定初始粘度和24小时后粘度。
物理特性:
12A:
初始粘度(Brookfield RV TDV Ⅱ型,Spindle#4@20rpm)7,680cps
72小时后粘度(TC Spindle@10rpm)15,580
初始pH值6.18;72小时后6.24
用力擦抹:在擦净时不大会发白,但是Ganex V—220的“蜡质”感产生摩擦。
12B:
初始粘度(Brookfield RV TDV Ⅱ型,Spindle #4 @ 20rpm)11,300 cps
72小时后粘度(TC Spindle @ 20rpm)22,900cps
初始pH值6.0;72小时后5.94
用力擦抹:擦掉时不大会发白,但是Ganex V—220的“蜡质”感产生摩擦。
实施例19
组分 %重量
A相 13A 13B**
去离子水 69.80 69.80V Gum Ultra 1.00 1.00(硅酸镁铝;二氧化钛;方英石;专卖物质)甘油,USP 1.00 1.00CMC(7H3SF) 0.50 0.50B相ProLipidTM 131 3.00 3.00(硬脂酸(和)山萮醇(和)硬脂酸甘油酯(和)马来酸化的豆油(和)卵磷脂(和)C12—16醇(和)棕榈酸)Ceraphyl 791 13.50 13.50(硬脂酰硬脂酸异鲸蜡酯)Ceraphyl 847 1.00 1.00(硬脂酰硬脂酸辛基十二烷基酯)*本发明的浓缩物 10.00 10.00C相Germall Plus 0.20 0.20(二偶氮烷基脲(和)丁基氨基甲酸碘代丙炔酯)
100.00 100.00*Escalol T{Tayca MT100T@40%+Ganex V—216@ 20%+Escalol557 @ 20%}**使用Escalol T中的Kemira UV Titan M262
程序:
A阶段
1.根据物料多少将所述水加入合适大小的容器中。研碎同时开始混入V—Gum Ultra。混合时不加热。继续混合直到看不见树脂痕迹(形成细粒)。
2.这时可以预混合CMC和甘油。(应注意在此之前甘油和CMC不应预混合,因为该混合物很快稠化)。加入所述预混合物中时可以开始加热该相直到其温度达到75℃。
B阶段
1.除了二氧化钛分散体(Escalol T)以后加入外,将所有油相组分加入合适大小的烧杯中。将烧杯放入水浴中并加热直到完全熔化。
2.将二氧化钛分散体(Escalol T)加入油相中并混合直到完全分散到油相中。
3.在水相温度达到75℃时,将其加入B相中,继续混合约30分钟。30分钟后用均化型Arde Barinco二元型混合器均化乳状液。
4.一旦所述乳状液均化,可继续混合直到物料温度达到35℃—40℃,这时加入C相。继续混合直到物料温度达到25℃。
5.一开始和24小时后检测pH值。测定初始粘度和24小时后粘度。
物理特性:
13A:
初始粘度(Brookfield RV TDV Ⅱ型,TC Spindle @10rpm)16,300cps
72小时后粘度(TC Spindle @ 10rpm)14,750
初始pH 5.82;72小时后5.97
用力擦抹:在擦净时不大会发白。感觉很好且有平滑光泽外观。
13B:
初始粘度(Brookfield RV TDV Ⅱ型,TC Spindle @10rpm)14,800 cps
72小时后粘度(TC Spindle @ 10rpm)15,000cps
一开始pH 5.97;72小时后6.20
用力擦抹:擦掉时不大会发白。感觉很好并有平滑光泽外观。
具体参考本发明的一些实施方案时,应明确对于本领域技术人员来说完全可以做出某些变化和改进。因此,本发明只受下面权利要求书限制。
Claims (15)
1.稳定均匀分散体型防水防晒浓缩物,按重量计含有:
(a)约30—65%超细二氧化钛或氧化锌,或其混合物,
(b)约30—70%有机防晒剂,和
(c)约0.25—25%分散助剂,所述分散助剂是用C4—C36α—烯烃烷基化处理过的聚乙烯吡咯烷酮。
2.根据权利要求1的防晒浓缩物,其颗粒度约为0.01—0.2μ
3.根据权利要求1的防晒浓缩物,其颗粒度约为0.05—0.1μ。
4.根据权利要求1的防晒浓缩物,其Brookfield粘度约为4,000—1,000,000cps。
5.根据权利要求1的防晒浓缩物,其Brookfield粘度约5,000—400,000cps。
6.根据权利要求1的防晒浓缩物,其中(c)是亲水聚合物,其含量约为0.25—4%。
7.根据权利要求6的防晒浓缩物,其中(c)是用C4α—烯烃接枝的聚乙烯吡咯烷酮,其含量约为0.5—2%。
8.根据权利要求1的防晒浓缩物,其中(c)是疏水共聚物,其含量约1—25%。
9.根据权利要求1的防晒浓缩物,其中(c)含有C16—C19α—烯烃,其含量约1—25%。
10.根据权利要求1的防晒浓缩物,其中(c)含有C20—C30α—烯烃,其含量5—25%。
11.根据权利要求1的防晒浓缩物,其中(a)含量是35—60%,(b)是35—55%,而(c)是5—25%。
12.根据权利要求1的防晒浓缩物,其中(a)是超细二氧化钛,其含量约40%,(b)是约59%,和(c)是亲水共聚物,其含量约1%。
13.根据权利要求1的防晒浓缩物,于其中加入水和任选添加剂便形成防晒组合物,所述组合物在使用者的皮肤上不同的SPF值下提供组分(a)的均匀分布。
14.根据权利要求1的防晒浓缩物,其中组分(b)是下列化合物中的一种或多种:羟苯酮(2—羟基—4—甲氧基二苯甲酮)、二羟苯酮(2,2’—二羟基—4—甲氧基二苯甲酮)、桂醚酯(对甲氧基肉桂酸2—乙氧基乙酯)、二乙醇胺对甲氧基肉桂酸酯、二棓酰三油酸酯4—二(羟丙基)氨基苯甲酸乙酯、2—氰基—3,3—二苯基丙烯酸2—乙基己酯、对甲氧基肉桂酸乙基己酯、水杨酸2—乙基己酯、氨基苯甲酸甘油酯、高水杨酸酯(水杨酸3,3,5—三甲基环己基酯)、三乙醇胺水杨酸酯、2—苯基苯并咪唑—5—磺酸、苯酰羟基甲氧基苯磺酸(2—羟基—4—甲氧基二苯甲酮—5—磺酸)、Padimate A(对二甲基氨基苯甲酸戊酯)、Padimate O(二甲基对氨基苯甲酸辛酯)、4—叔丁基—4′—甲氧基—二苯酰甲烷、和2—羟基—1,4—萘醌与二羟基丙酮的混合物、和邻氨基苯甲酸基酯、或其混合物、和甲氧基肉桂酸辛酯、奥克阿克里恩(octacrylene)、辛基二甲基对氨基苯甲酸、二苯甲酮和水杨酸辛酯,以及其混合物。
15.防晒混合物,含有权利要求1的防晒浓缩物、水和视需要加入的助剂。
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
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US08/968,171 US5916544A (en) | 1997-11-12 | 1997-11-12 | Sunscreen concentrate |
US08/968,171 | 1997-11-12 |
Publications (2)
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CN1279602A true CN1279602A (zh) | 2001-01-10 |
CN1154473C CN1154473C (zh) | 2004-06-23 |
Family
ID=25513851
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CNB988110504A Expired - Fee Related CN1154473C (zh) | 1997-11-12 | 1998-11-02 | 防晒浓缩物 |
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US (1) | US5916544A (zh) |
EP (1) | EP1037595A4 (zh) |
JP (1) | JP2001522790A (zh) |
CN (1) | CN1154473C (zh) |
AU (1) | AU752145B2 (zh) |
BR (1) | BR9815276A (zh) |
NZ (1) | NZ503821A (zh) |
WO (1) | WO1999024007A1 (zh) |
Cited By (1)
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CN106333867A (zh) * | 2016-10-27 | 2017-01-18 | 广州市玮弘祺生物科技有限责任公司 | 一种防晒组合物及其制备方法和应用 |
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US7683098B2 (en) * | 1996-09-03 | 2010-03-23 | Ppg Industries Ohio, Inc. | Manufacturing methods for nanomaterial dispersions and products thereof |
DE19826840A1 (de) * | 1998-06-16 | 1999-12-23 | Merck Patent Gmbh | Dispersion anorganischer UV-Filter |
AU5002501A (en) * | 2000-03-03 | 2001-09-17 | Australian Imp Ers Ltd | Micronized zinc oxide skin protector formulation |
EP1595527A3 (en) * | 2000-03-03 | 2006-04-26 | Australian Importers, Ltd. | Micronized zinc oxide skin protector formulation |
US6436376B1 (en) * | 2001-02-26 | 2002-08-20 | Societe L'oreal S.A. | Enhanced SPF UV-sunscreen/tricontanyl PVP photoprotecting (sprayable) formulations |
CA2390952C (en) * | 2001-07-02 | 2006-07-11 | Rohm And Haas Company | Compositions and process for retaining active ingredients comprising networked structured polymers |
US6830746B2 (en) * | 2001-09-21 | 2004-12-14 | Playtex Products, Inc. | Sunscreen compositions |
BR0200007A (pt) * | 2002-01-04 | 2003-10-28 | Natura Cosmeticos Sa | Dispersão oleosa de pigmentos protetores contra radiação uv, processo para sua preparaçao e composiçao cosmética |
US20030219391A1 (en) * | 2002-02-28 | 2003-11-27 | L'oreal | Dispersed powders providing ultraviolet light protection, suitable for use in cosmetic compositions |
FR2918269B1 (fr) * | 2007-07-06 | 2016-11-25 | Oreal | Composition de protection solaire contenant l'association d'un polymere semi-cristallin et de particules de latex creuses. |
GB0817598D0 (en) * | 2008-09-25 | 2008-11-05 | Croda Int Plc | Sunscreen composition |
WO2011100278A1 (en) * | 2010-02-09 | 2011-08-18 | Md Solarsciences Corp. | Sunscreen composition with improved aesthetic properties |
JP6122614B2 (ja) * | 2012-11-05 | 2017-04-26 | 株式会社コーセー | 液状二層型化粧料 |
EP2982363A1 (en) | 2014-08-04 | 2016-02-10 | Omya International AG | Two component system for cosmetic formulations |
CN104840372B (zh) * | 2015-02-01 | 2018-04-24 | 中国人民解放军第四军医大学 | 一种含天然产物松果菊苷的高原防晒霜 |
EP3434103B1 (en) * | 2017-07-25 | 2020-02-12 | Certis Europe BV | Daminozide composition |
AU2018100349B4 (en) * | 2017-08-22 | 2019-01-03 | Iris Id Pty Limited | Dispensing System |
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US4893729A (en) * | 1988-07-08 | 1990-01-16 | Jerry R. Iggulden | Selectable mixing bottle |
GB8827968D0 (en) * | 1988-11-30 | 1989-01-05 | Boots Co Plc | Sunscreen compositions |
PH31287A (en) * | 1991-05-07 | 1998-07-06 | Rihardson Vicks Inc | Photoprotection compositions. |
US5597574A (en) * | 1992-11-13 | 1997-01-28 | Isp Investments Inc. | UV protective aqueous emulsion and emulsifiable solids for cosmetic and agrichemical formulations |
US5417961A (en) * | 1993-04-30 | 1995-05-23 | Colgate-Palmolive Company | Sunscreen compositions |
US5445815A (en) * | 1993-11-22 | 1995-08-29 | Siegfried; Robert W. | Dry sunscreen composition |
-
1997
- 1997-11-12 US US08/968,171 patent/US5916544A/en not_active Expired - Lifetime
-
1998
- 1998-11-02 JP JP2000520102A patent/JP2001522790A/ja not_active Withdrawn
- 1998-11-02 WO PCT/US1998/023317 patent/WO1999024007A1/en not_active Application Discontinuation
- 1998-11-02 NZ NZ503821A patent/NZ503821A/xx not_active IP Right Cessation
- 1998-11-02 AU AU12991/99A patent/AU752145B2/en not_active Ceased
- 1998-11-02 CN CNB988110504A patent/CN1154473C/zh not_active Expired - Fee Related
- 1998-11-02 EP EP98956472A patent/EP1037595A4/en not_active Withdrawn
- 1998-11-02 BR BR9815276-9A patent/BR9815276A/pt not_active Application Discontinuation
Cited By (1)
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CN106333867A (zh) * | 2016-10-27 | 2017-01-18 | 广州市玮弘祺生物科技有限责任公司 | 一种防晒组合物及其制备方法和应用 |
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US5916544A (en) | 1999-06-29 |
BR9815276A (pt) | 2000-10-31 |
WO1999024007A1 (en) | 1999-05-20 |
NZ503821A (en) | 2003-01-31 |
EP1037595A1 (en) | 2000-09-27 |
EP1037595A4 (en) | 2001-02-14 |
CN1154473C (zh) | 2004-06-23 |
JP2001522790A (ja) | 2001-11-20 |
AU752145B2 (en) | 2002-09-05 |
AU1299199A (en) | 1999-05-31 |
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