CN1272341C - 肽的纯化 - Google Patents

肽的纯化 Download PDF

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Publication number
CN1272341C
CN1272341C CNB028283481A CN02828348A CN1272341C CN 1272341 C CN1272341 C CN 1272341C CN B028283481 A CNB028283481 A CN B028283481A CN 02828348 A CN02828348 A CN 02828348A CN 1272341 C CN1272341 C CN 1272341C
Authority
CN
China
Prior art keywords
solvent mixture
decapeptide
nonapeptide
precipitation
alcohol
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CNB028283481A
Other languages
English (en)
Chinese (zh)
Other versions
CN1625561A (zh
Inventor
J·H·拉斯姆森
P·H·拉斯姆森
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
CARLBIOTECH Ltd AS
Original Assignee
CARLBIOTECH Ltd AS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by CARLBIOTECH Ltd AS filed Critical CARLBIOTECH Ltd AS
Publication of CN1625561A publication Critical patent/CN1625561A/zh
Application granted granted Critical
Publication of CN1272341C publication Critical patent/CN1272341C/zh
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/30—Extraction; Separation; Purification by precipitation

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
CNB028283481A 2001-12-29 2002-12-23 肽的纯化 Expired - Fee Related CN1272341C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE0104462A SE0104462D0 (sv) 2001-12-29 2001-12-29 Peptide purifcation (Peptidrening)
SE01044627 2001-12-29

Publications (2)

Publication Number Publication Date
CN1625561A CN1625561A (zh) 2005-06-08
CN1272341C true CN1272341C (zh) 2006-08-30

Family

ID=20286556

Family Applications (1)

Application Number Title Priority Date Filing Date
CNB028283481A Expired - Fee Related CN1272341C (zh) 2001-12-29 2002-12-23 肽的纯化

Country Status (18)

Country Link
US (1) US7057014B2 (OSRAM)
EP (1) EP1468009B1 (OSRAM)
JP (1) JP4378173B2 (OSRAM)
KR (1) KR100880828B1 (OSRAM)
CN (1) CN1272341C (OSRAM)
AT (1) ATE449784T1 (OSRAM)
AU (1) AU2002347550B2 (OSRAM)
CA (1) CA2471717C (OSRAM)
DE (1) DE60234535D1 (OSRAM)
DK (1) DK1468009T3 (OSRAM)
ES (1) ES2350880T3 (OSRAM)
IL (2) IL162789A0 (OSRAM)
NO (1) NO329024B1 (OSRAM)
NZ (1) NZ534151A (OSRAM)
RU (1) RU2303040C2 (OSRAM)
SE (1) SE0104462D0 (OSRAM)
WO (1) WO2003055900A1 (OSRAM)
ZA (1) ZA200405135B (OSRAM)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1359722A1 (en) * 2002-03-27 2003-11-05 BRITISH TELECOMMUNICATIONS public limited company Data streaming system and method
US20090036435A1 (en) 2005-01-21 2009-02-05 Astex Therapeutics Limited Pharmaceutical Compounds
EP2073807A1 (en) 2006-10-12 2009-07-01 Astex Therapeutics Limited Pharmaceutical combinations
WO2008044041A1 (en) 2006-10-12 2008-04-17 Astex Therapeutics Limited Pharmaceutical combinations
US9051349B2 (en) 2007-11-21 2015-06-09 Alba Therapeutics Corporation Larazotide acetate compositions
EP2062909A1 (en) * 2007-11-21 2009-05-27 SOLVAY (Société Anonyme) Peptide production and purification process
JP2011520844A (ja) * 2008-05-15 2011-07-21 ノボ・ノルデイスク・エー／エス 固相合成法により調製されたペプチドの精製
US9028833B2 (en) 2012-12-13 2015-05-12 Immunomedics, Inc. Dosages of immunoconjugates of antibodies and SN-38 for improved efficacy and decreased toxicity
DK2417152T3 (da) * 2009-04-10 2013-12-16 Corden Pharma Colorado Inc Fremgangsmåde til isolering af linaclotid
WO2015012904A2 (en) * 2012-12-13 2015-01-29 Immunomedics, Inc. Antibody-sn-38 immunoconjugates with a cl2a linker
US9931417B2 (en) 2012-12-13 2018-04-03 Immunomedics, Inc. Antibody-SN-38 immunoconjugates with a CL2A linker
CN105407891A (zh) * 2013-07-23 2016-03-16 免疫医疗公司 具有cl2a接头的抗体-sn-38免疫缀合物
CN109310385A (zh) 2016-04-27 2019-02-05 免疫医疗公司 抗trop-2-sn-38抗体药物缀合物用于检查点抑制剂复发/难治的肿瘤的疗法的功效
CA3050332A1 (en) 2017-03-27 2018-10-04 Immunomedics, Inc. Treatment of trop-2 expressing triple negative breast cancer with sacituzumab govitecan and a rad51 inhibitor
EP3606964A4 (en) 2017-04-03 2020-12-09 Immunomedics, Inc. SUBCUTANE ADMINISTRATION OF ANTIBODY DRUG CONJUGATES FOR CANCER THERAPY
CN113952944B (zh) * 2021-12-23 2022-03-29 浙江湃肽生物有限公司深圳分公司 一种纯化九肽-1的方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8317697D0 (en) * 1983-06-29 1983-08-03 Shell Int Research Dissolution of peptides in non-aqueous and mixed non-aqueous/aqueous solvents
DE4001238A1 (de) * 1990-01-18 1991-07-25 Basf Ag Verfahren zur anreicherung bzw. reinigung von biomolekuelen
DE19544212A1 (de) * 1995-11-28 1997-06-05 Asta Medica Ag Neue LH-RH-Antagonisten mit verbesserter Wirkung
DE19813849A1 (de) * 1998-03-27 1999-09-30 Degussa Verfahren zur einstufigen Umsalzung und Aufreinigung von Oligopeptiden
EP0998940A1 (en) * 1998-09-30 2000-05-10 Laboratoire Theramex Pharmaceutical compositions based on alpha-cyclodextrin for the oral administration of LH-RH analogues
DE19911771B4 (de) * 1999-03-17 2006-03-30 Zentaris Gmbh LHRH-Antagonist, Verfahren zu seiner Herstellung und seiner Verwendung

Also Published As

Publication number Publication date
ES2350880T3 (es) 2011-01-27
EP1468009A1 (en) 2004-10-20
DE60234535D1 (de) 2010-01-07
DK1468009T3 (da) 2010-04-06
RU2004119965A (ru) 2006-01-10
CA2471717A1 (en) 2003-07-10
JP4378173B2 (ja) 2009-12-02
IL162789A (en) 2010-04-29
HK1076112A1 (en) 2006-01-06
RU2303040C2 (ru) 2007-07-20
NO329024B1 (no) 2010-08-02
WO2003055900A1 (en) 2003-07-10
US7057014B2 (en) 2006-06-06
JP2005515217A (ja) 2005-05-26
NZ534151A (en) 2007-05-31
ZA200405135B (en) 2005-08-31
AU2002347550B2 (en) 2008-01-03
US20060014694A1 (en) 2006-01-19
SE0104462D0 (sv) 2001-12-29
AU2002347550A1 (en) 2003-07-15
CA2471717C (en) 2013-06-18
NO20043046L (no) 2004-08-30
IL162789A0 (en) 2005-11-20
EP1468009B1 (en) 2009-11-25
ATE449784T1 (de) 2009-12-15
KR100880828B1 (ko) 2009-01-30
KR20040090966A (ko) 2004-10-27
CN1625561A (zh) 2005-06-08

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