DE60234535D1 - Peptid aufreinigung - Google Patents
Peptid aufreinigungInfo
- Publication number
- DE60234535D1 DE60234535D1 DE60234535T DE60234535T DE60234535D1 DE 60234535 D1 DE60234535 D1 DE 60234535D1 DE 60234535 T DE60234535 T DE 60234535T DE 60234535 T DE60234535 T DE 60234535T DE 60234535 D1 DE60234535 D1 DE 60234535D1
- Authority
- DE
- Germany
- Prior art keywords
- sub
- solvent
- water
- mixture
- decapeptide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 108090000765 processed proteins & peptides Proteins 0.000 title 1
- 238000000746 purification Methods 0.000 title 1
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 abstract 3
- VLKZOEOYAKHREP-UHFFFAOYSA-N n-Hexane Chemical compound CCCCCC VLKZOEOYAKHREP-UHFFFAOYSA-N 0.000 abstract 3
- 239000002904 solvent Substances 0.000 abstract 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 2
- IMNFDUFMRHMDMM-UHFFFAOYSA-N N-Heptane Chemical compound CCCCCCC IMNFDUFMRHMDMM-UHFFFAOYSA-N 0.000 abstract 2
- XBDQKXXYIPTUBI-UHFFFAOYSA-N dimethylselenoniopropionate Natural products CCC(O)=O XBDQKXXYIPTUBI-UHFFFAOYSA-N 0.000 abstract 2
- 150000002148 esters Chemical class 0.000 abstract 2
- UAEPNZWRGJTJPN-UHFFFAOYSA-N methylcyclohexane Chemical compound CC1CCCCC1 UAEPNZWRGJTJPN-UHFFFAOYSA-N 0.000 abstract 2
- 238000001556 precipitation Methods 0.000 abstract 2
- 239000011877 solvent mixture Substances 0.000 abstract 2
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 abstract 1
- XDTMQSROBMDMFD-UHFFFAOYSA-N Cyclohexane Chemical compound C1CCCCC1 XDTMQSROBMDMFD-UHFFFAOYSA-N 0.000 abstract 1
- 125000005907 alkyl ester group Chemical group 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 150000001735 carboxylic acids Chemical class 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 238000004090 dissolution Methods 0.000 abstract 1
- 238000001035 drying Methods 0.000 abstract 1
- GYNNXHKOJHMOHS-UHFFFAOYSA-N methyl-cycloheptane Natural products CC1CCCCCC1 GYNNXHKOJHMOHS-UHFFFAOYSA-N 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- TVMXDCGIABBOFY-UHFFFAOYSA-N octane Chemical compound CCCCCCCC TVMXDCGIABBOFY-UHFFFAOYSA-N 0.000 abstract 1
- 239000003960 organic solvent Substances 0.000 abstract 1
- 235000019260 propionic acid Nutrition 0.000 abstract 1
- IUVKMZGDUIUOCP-BTNSXGMBSA-N quinbolone Chemical compound O([C@H]1CC[C@H]2[C@H]3[C@@H]([C@]4(C=CC(=O)C=C4CC3)C)CC[C@@]21C)C1=CCCC1 IUVKMZGDUIUOCP-BTNSXGMBSA-N 0.000 abstract 1
- 238000005406 washing Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/30—Extraction; Separation; Purification by precipitation
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Analytical Chemistry (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE0104462A SE0104462D0 (sv) | 2001-12-29 | 2001-12-29 | Peptide purifcation (Peptidrening) |
| PCT/IB2002/005581 WO2003055900A1 (en) | 2001-12-29 | 2002-12-23 | Peptide purification |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE60234535D1 true DE60234535D1 (de) | 2010-01-07 |
Family
ID=20286556
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE60234535T Expired - Lifetime DE60234535D1 (de) | 2001-12-29 | 2002-12-23 | Peptid aufreinigung |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US7057014B2 (de) |
| EP (1) | EP1468009B1 (de) |
| JP (1) | JP4378173B2 (de) |
| KR (1) | KR100880828B1 (de) |
| CN (1) | CN1272341C (de) |
| AT (1) | ATE449784T1 (de) |
| AU (1) | AU2002347550B2 (de) |
| CA (1) | CA2471717C (de) |
| DE (1) | DE60234535D1 (de) |
| DK (1) | DK1468009T3 (de) |
| ES (1) | ES2350880T3 (de) |
| HK (1) | HK1076112A1 (de) |
| IL (2) | IL162789A0 (de) |
| NO (1) | NO329024B1 (de) |
| NZ (1) | NZ534151A (de) |
| RU (1) | RU2303040C2 (de) |
| SE (1) | SE0104462D0 (de) |
| WO (1) | WO2003055900A1 (de) |
| ZA (1) | ZA200405135B (de) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1359722A1 (de) * | 2002-03-27 | 2003-11-05 | BRITISH TELECOMMUNICATIONS public limited company | System und Verfahren zur Übertragung von Datenströmen |
| US20090036435A1 (en) | 2005-01-21 | 2009-02-05 | Astex Therapeutics Limited | Pharmaceutical Compounds |
| JP5528806B2 (ja) | 2006-10-12 | 2014-06-25 | アステックス、セラピューティックス、リミテッド | 複合薬剤 |
| WO2008044045A1 (en) | 2006-10-12 | 2008-04-17 | Astex Therapeutics Limited | Pharmaceutical combinations |
| US9051349B2 (en) | 2007-11-21 | 2015-06-09 | Alba Therapeutics Corporation | Larazotide acetate compositions |
| EP2062909A1 (de) * | 2007-11-21 | 2009-05-27 | SOLVAY (Société Anonyme) | Herstellung von Peptiden und Reinigungsverfahren |
| EP2280993A1 (de) * | 2008-05-15 | 2011-02-09 | Novo Nordisk A/S | Reinigung von durch festphasensynthese hergestellten peptiden |
| CN102482326A (zh) * | 2009-04-10 | 2012-05-30 | 科登制药科罗拉多公司 | 分离治疗用肽的方法 |
| CA2884313C (en) | 2012-12-13 | 2023-01-03 | Immunomedics, Inc. | Dosages of immunoconjugates of antibodies and sn-38 for improved efficacy and decreased toxicity |
| US9931417B2 (en) | 2012-12-13 | 2018-04-03 | Immunomedics, Inc. | Antibody-SN-38 immunoconjugates with a CL2A linker |
| ES2819573T3 (es) | 2012-12-13 | 2021-04-16 | Immunomedics Inc | Método para producir inmunoconjugados de anticuerpo-SN-38 con un enlazador CL2A |
| AU2014293670B2 (en) * | 2013-07-23 | 2019-08-01 | Immunomedics, Inc. | Antibody-SN-38 immunoconjugates with a CL2A linker |
| CN109310385A (zh) | 2016-04-27 | 2019-02-05 | 免疫医疗公司 | 抗trop-2-sn-38抗体药物缀合物用于检查点抑制剂复发/难治的肿瘤的疗法的功效 |
| US10918734B2 (en) | 2017-03-27 | 2021-02-16 | Immunomedics, Inc. | Treatment of high Trop-2 expressing triple negative breast cancer (TNBC) with sacituzumab govitecan (IMMU-132) overcomes homologous recombination repair (HRR) rescue mediated by Rad51 |
| WO2018187074A1 (en) | 2017-04-03 | 2018-10-11 | Immunomedics, Inc. | Subcutaneous administration of antibody-drug conjugates for cancer therapy |
| CN113952944B (zh) * | 2021-12-23 | 2022-03-29 | 浙江湃肽生物有限公司深圳分公司 | 一种纯化九肽-1的方法 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8317697D0 (en) | 1983-06-29 | 1983-08-03 | Shell Int Research | Dissolution of peptides in non-aqueous and mixed non-aqueous/aqueous solvents |
| DE4001238A1 (de) * | 1990-01-18 | 1991-07-25 | Basf Ag | Verfahren zur anreicherung bzw. reinigung von biomolekuelen |
| DE19813849A1 (de) * | 1998-03-27 | 1999-09-30 | Degussa | Verfahren zur einstufigen Umsalzung und Aufreinigung von Oligopeptiden |
| EP0998940A1 (de) | 1998-09-30 | 2000-05-10 | Laboratoire Theramex | Pharmazeutische zusammensetzung basierend auf alpha-cyclodextrin für die orale verabreichung von LH-RH analogen |
| DE19911771B4 (de) * | 1999-03-17 | 2006-03-30 | Zentaris Gmbh | LHRH-Antagonist, Verfahren zu seiner Herstellung und seiner Verwendung |
-
2001
- 2001-12-29 SE SE0104462A patent/SE0104462D0/xx unknown
-
2002
- 2002-12-23 US US10/500,302 patent/US7057014B2/en not_active Expired - Fee Related
- 2002-12-23 DK DK02783479.5T patent/DK1468009T3/da active
- 2002-12-23 DE DE60234535T patent/DE60234535D1/de not_active Expired - Lifetime
- 2002-12-23 IL IL16278902A patent/IL162789A0/xx unknown
- 2002-12-23 CN CNB028283481A patent/CN1272341C/zh not_active Expired - Fee Related
- 2002-12-23 KR KR1020047010363A patent/KR100880828B1/ko not_active IP Right Cessation
- 2002-12-23 ES ES02783479T patent/ES2350880T3/es not_active Expired - Lifetime
- 2002-12-23 EP EP02783479A patent/EP1468009B1/de not_active Expired - Lifetime
- 2002-12-23 WO PCT/IB2002/005581 patent/WO2003055900A1/en active Search and Examination
- 2002-12-23 RU RU2004119965/04A patent/RU2303040C2/ru not_active IP Right Cessation
- 2002-12-23 CA CA2471717A patent/CA2471717C/en not_active Expired - Fee Related
- 2002-12-23 AT AT02783479T patent/ATE449784T1/de not_active IP Right Cessation
- 2002-12-23 NZ NZ534151A patent/NZ534151A/en not_active IP Right Cessation
- 2002-12-23 AU AU2002347550A patent/AU2002347550B2/en not_active Ceased
- 2002-12-23 JP JP2003556430A patent/JP4378173B2/ja not_active Expired - Fee Related
-
2004
- 2004-06-28 ZA ZA2004/05135A patent/ZA200405135B/en unknown
- 2004-06-29 IL IL162789A patent/IL162789A/en not_active IP Right Cessation
- 2004-07-16 NO NO20043046A patent/NO329024B1/no not_active IP Right Cessation
-
2005
- 2005-09-15 HK HK05108061A patent/HK1076112A1/xx not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| JP2005515217A (ja) | 2005-05-26 |
| DK1468009T3 (da) | 2010-04-06 |
| EP1468009B1 (de) | 2009-11-25 |
| NO20043046L (no) | 2004-08-30 |
| CN1272341C (zh) | 2006-08-30 |
| ES2350880T3 (es) | 2011-01-27 |
| NZ534151A (en) | 2007-05-31 |
| ZA200405135B (en) | 2005-08-31 |
| CA2471717A1 (en) | 2003-07-10 |
| US7057014B2 (en) | 2006-06-06 |
| AU2002347550A1 (en) | 2003-07-15 |
| US20060014694A1 (en) | 2006-01-19 |
| KR100880828B1 (ko) | 2009-01-30 |
| EP1468009A1 (de) | 2004-10-20 |
| JP4378173B2 (ja) | 2009-12-02 |
| RU2303040C2 (ru) | 2007-07-20 |
| SE0104462D0 (sv) | 2001-12-29 |
| KR20040090966A (ko) | 2004-10-27 |
| NO329024B1 (no) | 2010-08-02 |
| IL162789A0 (en) | 2005-11-20 |
| IL162789A (en) | 2010-04-29 |
| CA2471717C (en) | 2013-06-18 |
| AU2002347550B2 (en) | 2008-01-03 |
| RU2004119965A (ru) | 2006-01-10 |
| HK1076112A1 (en) | 2006-01-06 |
| CN1625561A (zh) | 2005-06-08 |
| ATE449784T1 (de) | 2009-12-15 |
| WO2003055900A1 (en) | 2003-07-10 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition |