CN1272325C - 坎地沙坦酯中间体1-((2′-氰基联苯-4-基)甲基)-2-乙氧基苯并咪唑-7-甲酸乙酯的制备方法 - Google Patents
坎地沙坦酯中间体1-((2′-氰基联苯-4-基)甲基)-2-乙氧基苯并咪唑-7-甲酸乙酯的制备方法 Download PDFInfo
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- CN1272325C CN1272325C CN 03129766 CN03129766A CN1272325C CN 1272325 C CN1272325 C CN 1272325C CN 03129766 CN03129766 CN 03129766 CN 03129766 A CN03129766 A CN 03129766A CN 1272325 C CN1272325 C CN 1272325C
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- acid
- methyl
- cyanobiphenyl
- candesartan cilexetil
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Abstract
Description
化合物(I)g | 氯化亚锡g | 酸-溶剂W/W | 得量g | HPLC% | 收率% |
80 | 216 | 氢溴酸-甲醇15% | 89 | 85.4 | 98.6 |
55 | 154 | 盐酸-异丙醇20% | 51.5 | 79.8 | 92.1 |
49 | 245 | 盐酸-乙酸-乙醇溶液35% | 44 | 96.8 | 88.3 |
化合物(II)g | 原碳酸四乙酯ml | 化合物(III)得量g | HPLC% | 收率% |
89 | 185 | 53 | 96.8 | 63.3 |
51.5 | 126 | 40 | 87.2 | 73.9 |
44 | 110 | 33 | 94 | 72.7 |
Claims (7)
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CN 03129766 CN1272325C (zh) | 2003-05-16 | 2003-05-16 | 坎地沙坦酯中间体1-((2′-氰基联苯-4-基)甲基)-2-乙氧基苯并咪唑-7-甲酸乙酯的制备方法 |
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CN 03129766 CN1272325C (zh) | 2003-05-16 | 2003-05-16 | 坎地沙坦酯中间体1-((2′-氰基联苯-4-基)甲基)-2-乙氧基苯并咪唑-7-甲酸乙酯的制备方法 |
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CN1548424A CN1548424A (zh) | 2004-11-24 |
CN1272325C true CN1272325C (zh) | 2006-08-30 |
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CN 03129766 Expired - Fee Related CN1272325C (zh) | 2003-05-16 | 2003-05-16 | 坎地沙坦酯中间体1-((2′-氰基联苯-4-基)甲基)-2-乙氧基苯并咪唑-7-甲酸乙酯的制备方法 |
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Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
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US8530506B2 (en) * | 2009-11-17 | 2013-09-10 | Mitsubishi Tanabe Pharma Corporation | Process for production of biphenyl derivative |
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EE01 | Entry into force of recordation of patent licensing contract |
Assignee: Tianjin Medicine Research Institute of Pharmaceutical Co., Ltd. Assignor: Tianjin Institute of Pharmaceutical Research Contract fulfillment period: 2006.10.31 to 2023.5.15 contract change Contract record no.: 2009120000002 Denomination of invention: Candesartan ester intermediate 1- ((2 '- cyano biphenyl -4- group) methyl) -2- ethoxy benzimidazole -7- ethyl formate preparation method Granted publication date: 20060830 License type: Exclusive license Record date: 2009.2.24 |
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Free format text: EXCLUSIVE LICENSE; TIME LIMIT OF IMPLEMENTING CONTACT: 2006.10.31 TO 2023.5.15; CHANGE OF CONTRACT Name of requester: TIANJIN MEDICINE RESEARCH ACADEMY PHARMACEUTICAL C Effective date: 20090224 |
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