CN1261428C - 用于生产海绵内酯和海绵内酯类似物的中间体的制备方法 - Google Patents

用于生产海绵内酯和海绵内酯类似物的中间体的制备方法 Download PDF

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Publication number
CN1261428C
CN1261428C CNB028039920A CN02803992A CN1261428C CN 1261428 C CN1261428 C CN 1261428C CN B028039920 A CNB028039920 A CN B028039920A CN 02803992 A CN02803992 A CN 02803992A CN 1261428 C CN1261428 C CN 1261428C
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CN
China
Prior art keywords
formula
alkyl
unsubstituted
mmol
compound
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
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CNB028039920A
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English (en)
Chinese (zh)
Other versions
CN1487929A (zh
Inventor
G·科克
O·卢瓦瑟勒尔
G·塞德尔迈耶
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Novartis AG
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Novartis AG
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Publication of CN1487929A publication Critical patent/CN1487929A/zh
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Publication of CN1261428C publication Critical patent/CN1261428C/zh
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D263/18—Oxygen atoms
    • C07D263/20—Oxygen atoms attached in position 2
    • C07D263/26—Oxygen atoms attached in position 2 with hetero atoms or acyl radicals directly attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/16—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D309/28—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/30—Oxygen atoms, e.g. delta-lactones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D319/04—1,3-Dioxanes; Hydrogenated 1,3-dioxanes
    • C07D319/06—1,3-Dioxanes; Hydrogenated 1,3-dioxanes not condensed with other rings
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Steroid Compounds (AREA)
  • Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Pyrane Compounds (AREA)
  • Polyoxymethylene Polymers And Polymers With Carbon-To-Carbon Bonds (AREA)
  • Treatments For Attaching Organic Compounds To Fibrous Goods (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
CNB028039920A 2001-01-22 2002-01-21 用于生产海绵内酯和海绵内酯类似物的中间体的制备方法 Expired - Fee Related CN1261428C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0101599.9A GB0101599D0 (en) 2001-01-22 2001-01-22 Organic compounds
GB0101599.9 2001-01-22

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CNA2005101126328A Division CN1775774A (zh) 2001-01-22 2002-01-21 用于生产海绵内酯和海绵内酯类似物的中间体的制备方法

Publications (2)

Publication Number Publication Date
CN1487929A CN1487929A (zh) 2004-04-07
CN1261428C true CN1261428C (zh) 2006-06-28

Family

ID=9907244

Family Applications (2)

Application Number Title Priority Date Filing Date
CNA2005101126328A Pending CN1775774A (zh) 2001-01-22 2002-01-21 用于生产海绵内酯和海绵内酯类似物的中间体的制备方法
CNB028039920A Expired - Fee Related CN1261428C (zh) 2001-01-22 2002-01-21 用于生产海绵内酯和海绵内酯类似物的中间体的制备方法

Family Applications Before (1)

Application Number Title Priority Date Filing Date
CNA2005101126328A Pending CN1775774A (zh) 2001-01-22 2002-01-21 用于生产海绵内酯和海绵内酯类似物的中间体的制备方法

Country Status (12)

Country Link
US (1) US6974875B2 (enExample)
EP (1) EP1368334B1 (enExample)
JP (1) JP4301810B2 (enExample)
CN (2) CN1775774A (enExample)
AT (1) ATE372332T1 (enExample)
AU (1) AU2002228057A1 (enExample)
BR (1) BR0206585A (enExample)
CA (1) CA2435371A1 (enExample)
DE (1) DE60222244T2 (enExample)
ES (1) ES2292726T3 (enExample)
GB (1) GB0101599D0 (enExample)
WO (1) WO2002057251A2 (enExample)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MY127609A (en) * 2000-08-07 2006-12-29 Novartis Ag Process for preparing discodermolide and analogues thereof
AU2003251431A1 (en) * 2002-07-22 2004-02-09 Cambridge University Technical Services Ltd. Synthesis of discodermolide
US7122686B2 (en) 2002-09-06 2006-10-17 University Of Pittsburgh Analogs of discodermolide and dictyostatin-1, intermediates therefor and methods of synthesis thereof
US7321046B2 (en) 2002-09-06 2008-01-22 University Of Pittsburgh Analogs of dictyostatin, intermediates therefor and methods of synthesis thereof
GB0226434D0 (en) * 2002-11-13 2002-12-18 Astrazeneca Ab Combination product
US7348436B2 (en) * 2004-03-02 2008-03-25 Kosan Biosciences Incorporated Compounds useful for the synthesis of (+)-discodermolide and methods thereof
US7214708B2 (en) * 2004-11-18 2007-05-08 Kosan Biosciences Incorporated Synthetic discodermolide analogs
US7816405B2 (en) 2005-04-19 2010-10-19 Eisai R&D Management Co., Ltd. Calcium bis [(2S)-3-[3-[(2S)-3-(4-chloro-2-cyanophenoxy)-2-fluoropropoxy]phenyl ]-2-isopropoxypropionate] and intermediate thereof
EP1873141A4 (en) * 2005-04-19 2010-09-22 Eisai R&D Man Co Ltd CALCIUM-BIS [2S] -3- [3- (2S) -3- (4-CHLORO-2-CYANOPHENOXY) -2-FLUORO-PROPOXYPHENYL] -2-ISOPROPOXYPROPIONATE] AND INTERMEDIATE PRODUCTS THEREOF
US7297807B1 (en) 2006-05-31 2007-11-20 The Research Foundation Of State University Of New York Intermediates for the synthesis of polypropionate antibiotics

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9315802D0 (en) 1993-07-30 1993-09-15 Roussel Lab Ltd Chemical compounds
US5789605A (en) * 1996-12-03 1998-08-04 Trustees Of The University Of Pennsylvania Synthetic techniques and intermediates for polyhydroxy, dienyl lactones and mimics thereof
US6096904A (en) 1996-12-03 2000-08-01 The Trustees Of The University Of Pennsylvania Synthetic techniques and intermediates for polyhydroxy, dienyl lactone derivatives
AU7267298A (en) * 1997-04-30 1998-11-24 Regents Of The University Of California, The Synthesis of discodermolide and analogs

Also Published As

Publication number Publication date
CN1487929A (zh) 2004-04-07
CN1775774A (zh) 2006-05-24
DE60222244D1 (de) 2007-10-18
HK1060882A1 (en) 2004-08-27
EP1368334A2 (en) 2003-12-10
CA2435371A1 (en) 2002-07-25
JP2004517891A (ja) 2004-06-17
ATE372332T1 (de) 2007-09-15
EP1368334B1 (en) 2007-09-05
GB0101599D0 (en) 2001-03-07
US20040073049A1 (en) 2004-04-15
AU2002228057A1 (en) 2002-07-30
WO2002057251A2 (en) 2002-07-25
US6974875B2 (en) 2005-12-13
WO2002057251A3 (en) 2002-10-10
JP4301810B2 (ja) 2009-07-22
BR0206585A (pt) 2003-12-16
ES2292726T3 (es) 2008-03-16
DE60222244T2 (de) 2008-05-29

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Granted publication date: 20060628

Termination date: 20110121