CA2435371A1 - Process for preparing intermediates for the manufacture of discodermolide and discodermolide analogues - Google Patents

Process for preparing intermediates for the manufacture of discodermolide and discodermolide analogues Download PDF

Info

Publication number
CA2435371A1
CA2435371A1 CA002435371A CA2435371A CA2435371A1 CA 2435371 A1 CA2435371 A1 CA 2435371A1 CA 002435371 A CA002435371 A CA 002435371A CA 2435371 A CA2435371 A CA 2435371A CA 2435371 A1 CA2435371 A1 CA 2435371A1
Authority
CA
Canada
Prior art keywords
formula
alkyl
phenyl
protecting groups
unsubstituted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002435371A
Other languages
English (en)
French (fr)
Inventor
Guido Koch
Olivier Loiseleur
Gottfried Sedelmeier
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2435371A1 publication Critical patent/CA2435371A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D263/18—Oxygen atoms
    • C07D263/20—Oxygen atoms attached in position 2
    • C07D263/26—Oxygen atoms attached in position 2 with hetero atoms or acyl radicals directly attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/16—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D309/28—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/30—Oxygen atoms, e.g. delta-lactones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D319/04—1,3-Dioxanes; Hydrogenated 1,3-dioxanes
    • C07D319/06—1,3-Dioxanes; Hydrogenated 1,3-dioxanes not condensed with other rings
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Steroid Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Pyrane Compounds (AREA)
  • Polyoxymethylene Polymers And Polymers With Carbon-To-Carbon Bonds (AREA)
  • Treatments For Attaching Organic Compounds To Fibrous Goods (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
CA002435371A 2001-01-22 2002-01-21 Process for preparing intermediates for the manufacture of discodermolide and discodermolide analogues Abandoned CA2435371A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB0101599.9A GB0101599D0 (en) 2001-01-22 2001-01-22 Organic compounds
GB0101599.9 2001-01-22
PCT/EP2002/000570 WO2002057251A2 (en) 2001-01-22 2002-01-21 Process for preparing intermediates for the manufacture of discodermolide and discodermolide analogues

Publications (1)

Publication Number Publication Date
CA2435371A1 true CA2435371A1 (en) 2002-07-25

Family

ID=9907244

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002435371A Abandoned CA2435371A1 (en) 2001-01-22 2002-01-21 Process for preparing intermediates for the manufacture of discodermolide and discodermolide analogues

Country Status (12)

Country Link
US (1) US6974875B2 (enExample)
EP (1) EP1368334B1 (enExample)
JP (1) JP4301810B2 (enExample)
CN (2) CN1775774A (enExample)
AT (1) ATE372332T1 (enExample)
AU (1) AU2002228057A1 (enExample)
BR (1) BR0206585A (enExample)
CA (1) CA2435371A1 (enExample)
DE (1) DE60222244T2 (enExample)
ES (1) ES2292726T3 (enExample)
GB (1) GB0101599D0 (enExample)
WO (1) WO2002057251A2 (enExample)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MY127609A (en) * 2000-08-07 2006-12-29 Novartis Ag Process for preparing discodermolide and analogues thereof
WO2004009574A1 (en) * 2002-07-22 2004-01-29 Novartis Ag Synthesis of discodermolide
US7321046B2 (en) 2002-09-06 2008-01-22 University Of Pittsburgh Analogs of dictyostatin, intermediates therefor and methods of synthesis thereof
WO2004022552A1 (en) * 2002-09-06 2004-03-18 University Of Pittsburgh Analogs of discodermolide and dictyostatin-1, intermediates therefor and methods of synthesis thereof
GB0226434D0 (en) * 2002-11-13 2002-12-18 Astrazeneca Ab Combination product
WO2005084349A2 (en) * 2004-03-02 2005-09-15 Kosan Biosciences, Inc. Compounds useful for the synthesis of (+)-discodermolide and methods therefor
US7214708B2 (en) * 2004-11-18 2007-05-08 Kosan Biosciences Incorporated Synthetic discodermolide analogs
US7816405B2 (en) 2005-04-19 2010-10-19 Eisai R&D Management Co., Ltd. Calcium bis [(2S)-3-[3-[(2S)-3-(4-chloro-2-cyanophenoxy)-2-fluoropropoxy]phenyl ]-2-isopropoxypropionate] and intermediate thereof
WO2006115130A1 (ja) * 2005-04-19 2006-11-02 Eisai R & D Management Co., Ltd. ビス［（２ｓ）－３－［３－［（２ｓ）－３－（４－クロロ－２－シアノフェノキシ）－２－フルオロプロポキシ］フェニル］－２－イソプロポキシプロピオン酸］カルシウム及びその中間体
US7297807B1 (en) 2006-05-31 2007-11-20 The Research Foundation Of State University Of New York Intermediates for the synthesis of polypropionate antibiotics

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9315802D0 (en) 1993-07-30 1993-09-15 Roussel Lab Ltd Chemical compounds
US6096904A (en) * 1996-12-03 2000-08-01 The Trustees Of The University Of Pennsylvania Synthetic techniques and intermediates for polyhydroxy, dienyl lactone derivatives
US5789605A (en) * 1996-12-03 1998-08-04 Trustees Of The University Of Pennsylvania Synthetic techniques and intermediates for polyhydroxy, dienyl lactones and mimics thereof
WO1998048791A1 (en) * 1997-04-30 1998-11-05 The Regents Of The University Of California Synthesis of discodermolide and analogs

Also Published As

Publication number Publication date
GB0101599D0 (en) 2001-03-07
ES2292726T3 (es) 2008-03-16
EP1368334B1 (en) 2007-09-05
WO2002057251A3 (en) 2002-10-10
CN1261428C (zh) 2006-06-28
WO2002057251A2 (en) 2002-07-25
EP1368334A2 (en) 2003-12-10
CN1775774A (zh) 2006-05-24
JP4301810B2 (ja) 2009-07-22
US20040073049A1 (en) 2004-04-15
BR0206585A (pt) 2003-12-16
US6974875B2 (en) 2005-12-13
JP2004517891A (ja) 2004-06-17
AU2002228057A1 (en) 2002-07-30
DE60222244D1 (de) 2007-10-18
ATE372332T1 (de) 2007-09-15
DE60222244T2 (de) 2008-05-29
HK1060882A1 (en) 2004-08-27
CN1487929A (zh) 2004-04-07

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Legal Events

Date Code Title Description
EEER Examination request
FZDE Discontinued