CN1261045C - Anti-oxidation health-care food, and its prodn. method - Google Patents
Anti-oxidation health-care food, and its prodn. method Download PDFInfo
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Abstract
The present invention discloses an antioxidation health-care food with high safety, no toxic or side effect and systematic and comprehensive antioxidation and a manufacturing method thereof. The antioxidation health-care food is prepared from the effective ingredients of 95 to 190 parts by weight of procyanidin, 75 to 125 parts by weight of soybean isoflavone, 95 to 200 parts by weight of vitamin C and 35 to 65 parts by weight of vitamin E. The scientifically prepared antioxidation health-care food of the present invention has the advantages of reasonable formula, direct or indirect oxygen radical clearance by various antioxidation nutrients, comprehensive and systematic antioxidation, beauty treatment, face nourishment, immunity regulation and aging delay. The raw materials of the antioxidation health-care food of the present invention are all extracted from foods or nutritional supplements, or natural products are directly adopted; therefore, the antioxidation health-care food is a natural antioxidation health-care food which has high safety and no toxic or side effect and can be taken for a long time.
Description
(1) technical field:
The present invention relates to a kind of health food, particularly a kind of anti-oxidation health food the invention still further relates to the manufacture method of this anti-oxidation health food.
(2) background technology:
The generation of biological interior free yl isoreactivity oxygen and cause the harm that the biological cell oxidative damage is caused is one of major reason that causes the organism aging.These free radicals comprise oxygen radical, hydroperoxyl radical and hydrogen peroxide etc., and they extensively are present in the body tissue.Under the normal condition, the oxygen great majority that participate in metabolism combine generation water with hydrogen, yet have 4%～5% oxygen will form superoxide anion, and the latter can form hydrogen peroxide again.Unrighted acid in free radical attack cells film, the mitochondrial membrane causes lipid peroxidation to strengthen, and lipid peroxidation product can be decomposed into the more freedom base again, causes the chain reaction of free radical.Like this, the integrality of membrane structure is damaged, and causes the extensive injuries of brain cell, muscle cell, liver cell and subcellular structure.And the lipid peroxidation of anti-oxidant nutrient in can ameliorate body improves the activity of antioxidase in the body, and to strengthening antioxidant ability of organism, delaying senility plays an important role.
Human body can have much from the antioxidant of external world's picked-up, for example: vitamin C, vitamin E, carotenoid group, flavonoids, epiphysin, human body auxin etc.Usually the consumer all be with wherein one, two kind of antioxidant, as strengthen antioxidant ability of organism, anti-aging health food is directly used, or other food of arranging in pairs or groups is together taken.But owing to anti-oxidation efficacy, the effect of various antioxidants is not quite similar, only simple take wherein one, two kind of antioxidant, very limited of its antioxidant effect, can not play system and comprehensive antioxidation to body, also be difficult to the effect that reaches the desired beautifying face and moistering lotion of consumer, delays senility.Therefore, it is raw material or with other food collocation preparation of arranging in pairs or groups of several antioxidants that people attempt multiple antioxidant, can produce the health food that can play better antioxidation with expectation to body, as application number be: 00121388, name is called the Chinese invention patent of " a kind of strong anti-oxidative composite capsule of grape seed extract OPC and manufacture method thereof ", disclosing a kind of mainly is to be antioxidant with the high-quality grape seed extract OPC, be equipped with Gypenosides, lucidum spore powder, the health food that vitamin C is made, this product has the function of regulating body immunity, and can play certain antioxidation, but the comprehensive oxidation resistant effect of the system that can not reach to human body.And choose several antioxidants arbitrarily, or select several antioxidants and other food mixed preparing health food, its raw material is chosen, the proportioning between each raw material and consumption are all grasped than difficult, the validity that has also just caused human body to use lacks enough scientific basis, the anti-oxidation efficacy that it can be brought into play is lower, also may produce some side effects, problems such as its security, less stable occur because of some raw materials interaction wherein.So do not find as yet at present that a kind of consumer is badly in need of safely, have no side effect, and can system, comprehensively bring into play the natural health care of anti-oxidation function.
(3) summary of the invention:
The present invention will disclose a kind of safe, without any side effects and can play system, the comprehensive anti-oxidation health food of antioxidation, and the present invention also will disclose the manufacture method of this anti-oxidation health food.
The inventor rest on a scientific basis theory, through repetition test, chosen from various antioxidants and can be used as food consumption, nontoxic, four kinds of antioxidants with different anti-oxidation efficacies of OPC, isoflavones, vitamin C, vitamin E of having no side effect are in order to prepare anti-oxidation health food of the present invention.When each raw material of choosing health food of the present invention carries out combination collocation, must consider effect that they can be brought into play separately and the trade-off effect that they are arranged in pairs or groups and can produce.At first, selecting OPC is to consider that OPC is as a kind of natural, have stronger oxidation resistance, its oxidation resistance is ascorbic 20 times, 50 times of vitamin E, and OPC contains two above vicinal hydroxyl groups, have very strong hydrogen supply capacity, after providing H, can become stable dimer with other combined with radical to active free radical, thereby the chain reaction of the free radical that is produced in the cut-out body, the performance antioxidation.And select for use isoflavones to be simultaneously because isoflavones can be induced activities of antioxidant enzymes, suppress the effect of the generation of active oxygen and hydrogen oxide, the oxidative damage that reduces DNA, inhibition lipid peroxidation; Also have the generation of prevention lipid peroxidation and the chain reaction of blocking-up lipid peroxidation simultaneously, to reach the purpose of removing active oxygen radical.Adding vitamin C again and vitamin E is used in combination in the prescription of anti-oxidation health food of the present invention, is because vitamin C and vitamin E belong to low molecule polyphenoils together, but equal scavenger interior free yls.Vitamin E can improve body endogenous antioxidase level, strengthens the anti-oxidative defense ability; And vitamin C can reduce the peroxidation of radical pair polyunsaturated fatty acid, improve the utilization rate of oxygen in the body, improve the body ability to work thereby reach, postpone or the generation that lessens fatigue, accelerate effects such as fatigue recovery, and coordinative role mutually between vitamin E and the vitamin C, vitamin C can shift by electronics and make the oxidized form vitamin E recover reducing activity, can also assist vitamin E and glutathione to remove free radical.And vitamin C and vitamin E all can be repaired the damage that the body inner cell is subjected to because of the destruction of free radical; vitamin C can be protected the integrality of cell biological film; vitamin E then is antioxidant and a membrane stabilizer in the cell biological film; both combinations can be from the inside to the outside the reparation damaged cell; and the protection cell is avoided the destruction of free radical; therefore The combined is got up to act on and can be influenced each other; mutually promote; the performance coordinative role; body is played bigger antioxidation; add isoflavones and induce activities of antioxidant enzymes; strengthen the oxidation resistance of body; reduce the oxidative damage of DNA; the generation and the lipid peroxidation that suppress active oxygen and hydrogen oxide; the effect of the generation of prevention lipid peroxidation; and the chain reaction performance antioxidation of OPC blocking-up lipid peroxidation; thereby the damage that can be subjected to because of the effect of free radical at repair cell; stable and the integrality of protection cell; when reaching the oxidation resistance that strengthens cell; cut-out causes the chain reaction of the free radical of body aging; and directly or indirectly remove free radical in the body; system and comprehensively eliminate and variously in the body cause old and feeble materials; strengthen the oxidation resistance of body, reach the purpose that delays senility.
Each material proportional quantity of anti-oxidation health food of the present invention is through repeatedly scientific experimentation of applicant, and tackling the intake of various nutritions and Chinese Soclety of Nutrition with human body, meals to be recommended every index such as quantity delivered serve as according to formulating, and its effective ingredient is: 95～190 weight portion OPCs, 30～50 weight portion isoflavones, 95～200 weight portion vitamin Cs, 35～65 weight portion vitamin Es; Each effective ingredient optimal components ratio that we choose is counted with weight portion: 120～160 parts of OPCs, 35～45 parts of isoflavones, 120～160 parts of vitamin Cs, 40～60 parts of vitamin Es; And the best proportioning of each effective ingredient is counted with weight portion: 142 parts of OPCs, 40 parts of isoflavones, 147 parts of vitamin Cs, 50 parts of vitamin Es.
Anti-oxidation health food of the present invention can be made capsule, ointment, tablet, pulvis, liquid medicine and other acceptable formulation as required.
Selected OPC in the anti-oxidation health food of the present invention, the OPC that can adopt on the market to be sold also can adopt by the OPC that extracts in the pine bark; Or the OPC that obtains with other method; But preferably adopt by grape seed extract (grape seed extract, the anthocyanidin that GSE) provides.
Contain active very strong polyphenoils and multiple flavone compound in the grape seed extract, and adopt that contained anthocyanidin can reach 90～95% in the grape seed extract that following method produces, therefore be suitable for very much preparing anti-oxidation health food of the present invention, the manufacture method of grape seed extract can be as following step:
1) grape pip is placed 10 times be that 45～95% ethanol soaks to its weight, weight concentration, and refluxing extraction 1～3 time; The soak time of described grape pip was generally 2～4 hours, and each extraction time was generally 1～3 hour; For reaching best effect, the soak time of grape pip is preferably 3 hours; Extraction time is preferably 2 hours, and extraction time is preferably 2 times;
2) filter alcohol extract;
3) reclaim ethanol in the filtrate, and with its concentrate, centrifugation;
4) isolated clear liquid separates with macroreticular resin, and is that 25～75% ethanol carries out wash-out with weight concentration;
5), get finished product with the eluent drying.
Isoflavones in the anti-oxidation health food of the present invention, the various isoflavones that can select on the market to be sold, also the isoflavones that can be obtained by other method for example can adopt following method to prepare isoflavones, and its manufacture method step is as follows:
1) soybean is placed 10 times be that 45～95% ethanol soaks to its weight, weight concentration, and refluxing extraction 1～3 time; The soak time of described soybean was generally 2～4 hours, and each extraction time was generally 1～3 hour; For reaching better effect, the soak time of soybean is 3 hours; Extraction time is 2 hours, and extraction time is 2 times;
2) filter alcohol extract;
3) reclaim ethanol in the filtrate, and with its concentrate, centrifugation;
4) isolated clear liquid separates with macroreticular resin, and is 45～95% ethanol elution with weight concentration;
5), get finished product with the eluent drying.
The content of isoflavones reaches about 40% approximately in the isoflavones that the employing said method is produced.
And the vitamin C and the vitamin E that are adopted in the anti-oxidation health food of the present invention, can be natural, also can be artificial synthetic, as commercially available (as: DSM production) vitamin C, vitamin E, or natural VE powder, natural complex C powder, or adopt by the vitamin E that extracts in vitamin C that extracts in Kiwi berry, the citrus and the deep sea fish oil.
The manufacture method of anti-oxidation health food of the present invention, also can be as following step:
1) get the raw materials ready:
Take by weighing 100～200 weight portion grape seed extracts, 75～125 weight portion isoflavones, 95～200 weight portion vitamin Cs, 35～65 weight portion vitamin Es, 1～10 weight portion excipients; Contain OPC 95% in the wherein said grape seed extract;
2) each raw material with the said ratio amount mixes, and sieves, and packing gets product.
The manufacture method of anti-oxidation health food of the present invention, also can be as following step:
1) produce grape seed extract:
A) grape pip is placed 10 times be that 45～95% ethanol soaks refluxing extraction 1～3 time to its weight, weight concentration;
B) filter alcohol extract;
C) reclaim ethanol in the filtrate, and with its concentrate, centrifugation;
D) isolated clear liquid separates with macroreticular resin, and carries out wash-out with 25～75% ethanol;
E) with the eluent drying for standby;
2) produce isoflavones:
A) soybean is placed 10 times be that 45～95% ethanol soaks refluxing extraction 1～3 time to its weight, weight concentration;
B) filter alcohol extract;
C) reclaim ethanol in the filtrate, and with its concentrate, centrifugation;
D) isolated clear liquid separates with macroreticular resin, and with 45～95% ethanol elution;
E) with the eluent drying for standby;
3) take by weighing grape seed extract 100～200 weight portions, isoflavones 75～125 weight portions, vitamin C 95～200 weight portions, natural VE powder 75～125 weight portions of producing with said method;
4) each component with the said ratio amount mixes, and sieves, and packing gets product.
Anti-oxidation health food of the present invention is to adopt OPC, vitamin C, vitamin E, four kinds of anti-oxidant nutrient science of isoflavones formulated, its prescription rationally, various anti-oxidant nutrients all can play the effect of direct or indirect removing oxygen radical, play and bring into play antioxidation comprehensive, system, reach beautifying face and moistering lotion, regulate immunity, the effect that delays senility.And the raw material of anti-oxidation health food of the present invention is by extracting in food or the nutritional supplement or directly adopt natural prodcuts, so this anti-oxidation health food is a kind of safe, without any side effects fully, the natural anti-oxidation health food that can take for a long time.
(4) specific embodiment:
Embodiment 1:
1) grape pip is placed 10 times be that 70% ethanol soaked 2 hours to its weight, weight concentration, and refluxing extraction 2 times, each extraction time is 1 hour; Merge alcohol extract then twice, and filter; Reclaim the ethanol in the filtrate again, and with its concentrate, centrifugation; Isolated clear liquid separates with the D101 macroreticular resin, and carries out wash-out with 50% ethanol; Again the eluent drying is got dry extract, cross 80 mesh sieves, get grape seed extract fine powder (wherein containing OPC 90～95%).
2) soybean is placed 10 times be that 45% ethanol soaked 2 hours to its weight, weight concentration, and refluxing extraction 1 time, extraction time is 1 hour; Filter alcohol extract then; Reclaim the ethanol in the filtrate again, and with its concentrate, centrifugation; Isolated clear liquid separates with the D101 macroreticular resin, and with 70% ethanol elution; Again eluent is dried to dried cream, crosses 60 mesh sieves then, promptly get isoflavones fine powder (wherein containing isoflavones about 40%).
3) get the grape seed extract that obtains with the described method of step 1) 120 grams, step 2) described method isoflavones 75 grams, commercially available (as: DSM produces) natural VE powder (wherein containing vitamin E 50%) 80 grams, vitamin C 98 grams that obtain evenly mix with dolomol 1 gram as excipients, cross 60 mesh sieves, disinfection, packing promptly gets anti-oxidation health food capsule of the present invention.
Embodiment 2:
1) grape pip is placed 10 times be that 95% ethanol soaked 3 hours to its weight, weight concentration, and refluxing extraction 3 times, each extraction time is 2 hours; Merge alcohol extract then, and filter; Reclaim the ethanol in the filtrate again, and with its concentrate, centrifugation; Isolated clear liquid separates with the D101 macroreticular resin, and carries out wash-out with 75% ethanol; Again eluent is dried to dried cream, crosses 80 mesh sieves, get grape seed extract fine powder (wherein containing OPC 90～95%).
2) get with the described grape seed extract of step 1) 200 grams, isoflavones 50 grams, commercially available (as: DSM produces) vitamin E powder 62 grams, vitamin c powder 196 grams and evenly mix, cross 60 mesh sieves, disinfection, packing promptly gets anti-oxidation health food of the present invention.
Embodiment 3:
1) soybean is placed 10 times be that 70% ethanol soaks to its weight, weight concentration, and refluxing extraction 2 times, its soak time is 3 hours, each extraction time is 2 hours; Merge alcohol extract then, and filter; Reclaim the ethanol in the filtrate again, and with its concentrate, centrifugation; Isolated clear liquid separates with the D101 macroreticular resin, and with 95% ethanol elution; Again eluent is dried to dried cream, crosses 60 mesh sieves then, promptly get isoflavones fine powder (wherein containing isoflavones about 40%).
2) OPC 142 grams that get the isoflavones that obtains with the step 1) method 40 grams, from pine bark, extract, vitamin E 50 grams that from deep sea fish oil, extract, vitamin C 147 grams that from Chinese gooseberry, extract and evenly mix as dolomol 5 grams of excipients, cross 60 mesh sieves, disinfection, packing promptly gets anti-oxidation health food of the present invention.
Embodiment 4:
Take by weighing vitamin E 50 grams, vitamin C 145 grams of isoflavones 46 grams that Guilin Laiyin Biological Product Co., Ltd produces, OPC 115 grams, commercially available (as: DSM produces) respectively and evenly mix as dolomol 6 grams of excipients, cross 60 mesh sieves, disinfection, packing promptly gets anti-oxidation health food of the present invention.
Embodiment 5:
Be the effect of regulating and delay senility etc. of the beautifying face and moistering lotion of verifying this anti-oxidation health food, antioxidation, immunity, on probation in 168 routine women, its effect is obvious.The participant is 30～55 years old women, and being face has color spot, or acne, pachylosis, the patient of symptom such as immunity is low.Contrast trial state with explanation of tables below.
Anti-oxidation health food trial effect of the present invention and control case table
| Group on probation | Control group 1 | Control group 2 | ||||
| Take the number course of treatment | 5 | Take for a long time | 5 | 5 | ||
| Number | 126 | 42 | 10 | 20 | ||
| Effect | Effect is fine | Number | 32 | 16 | 0 | 0 |
| ％ | 25.40 | 38.10 | 0 | 0 | ||
| Effect is obvious | Number | 60 | 23 | 0 | 0 | |
| ％ | 47.62 | 54.76 | 0 | 0 | ||
| Effect as seen | Number | 19 | 3 | 2 | 1 | |
| ％ | 15.08 | 7.14 | 20 | 5 | ||
| Invalid | Number | 15 | 0 | 8 | 19 | |
| ％ | 11.90 | 0 | 80 | 95 | ||
Each group situation of taking medicine is described as follows in the form:
Group on probation: sooner or later respectively obey this anti-oxidation health food once, each 0.5 gram is taken 2 every day, and 15 days is a course of treatment.
Control group 1:80 example has 30～55 years old women of above-mentioned symptom to take vitamin E, sooner or later services once, each gram, and 15 days is a course of treatment.
Control group 2: do not take medicine.
Take being described as follows of effect in the table:
Effect is fine: immunity strengthens, and delays senility, and facial colour spot disappears, and the skin exquisiteness is fair.
Effect is obvious: skin is delicate than before, and facial colour spot is thin out, and face is more ruddy light.
Effect is as seen: improve pachylosis and acne, skin is flexible than before.
Invalid: as not see that any change is arranged.
Claims (10)
1, a kind of anti-oxidation health food is characterized in that its effective ingredient is: 95～190 weight portion OPCs, 30～50 weight portion isoflavones, 95～200 weight portion vitamin Cs, 35～65 weight portion vitamin Es.
2, anti-oxidation health food according to claim 1 is characterized in that its effective ingredient is as follows in weight portion: 120～160 parts of OPCs, 35～45 parts of isoflavones, 120～160 parts of vitamin Cs, 40～60 parts of vitamin Es.
3, anti-oxidation health food according to claim 2 is characterized in that its effective ingredient is as follows in weight portion: 142 parts of OPCs, 40 parts of isoflavones, 147 parts of vitamin Cs, 50 parts of vitamin Es.
4, according to any one described anti-oxidation health food in the claim 1～3, it is characterized in that: described OPC is provided by grape seed extract.
5, anti-oxidation health food according to claim 4 is characterized in that: the manufacture method step of grape seed extract is as follows:
1) grape pip is placed 10 times be that 45～95% ethanol soaks refluxing extraction 1～3 time to its weight, weight concentration;
2) filter alcohol extract;
3) reclaim ethanol in the filtrate, and with its concentrate, centrifugation;
4) isolated clear liquid separates with macroreticular resin, and carries out wash-out with 25～75% ethanol;
5), get finished product with the eluent drying.
6, according to any one described anti-oxidation health food in the claim 1～3, it is characterized in that: the manufacture method of described isoflavones, its step is as follows:
1) soybean is placed 10 times be that 45～95% ethanol soaks refluxing extraction 1～3 time to its weight, weight concentration;
2) filter alcohol extract;
3) reclaim ethanol in the filtrate, and with its concentrate, centrifugation;
4) isolated clear liquid separates with macroreticular resin, and with 45～95% ethanol elution;
5), get finished product with the eluent drying.
7, anti-oxidation health food according to claim 5 is characterized in that: in the manufacture method step 1) of grape seed extract, the soak time of grape pip is 2～4 hours; Extraction time is 1～3 hour.
8, anti-oxidation health food according to claim 6 is characterized in that: in the manufacture method step 1) of isoflavones, the soak time of soybean is 2～4 hours; Extraction time is 1～3 hour.
9, anti-oxidation health food according to claim 8 is characterized in that: in the manufacture method step 1) of isoflavones, the soak time of soybean is 3 hours; Extraction time is 2 hours, and extraction time is 2 times.
10, a kind of manufacture method of anti-oxidation health food, its step is as follows:
1) produce grape seed extract:
A) grape pip is placed 10 times be that 45～95% ethanol soaks refluxing extraction 1～3 time to its weight, weight concentration;
B) filter alcohol extract;
C) reclaim ethanol in the filtrate, and with its concentrate, centrifugation;
D) isolated clear liquid separates with macroreticular resin, and carries out wash-out with 25～75% ethanol;
E) with the eluent drying for standby;
2) produce isoflavones:
A) soybean is placed 10 times be that 45～95% ethanol soaks refluxing extraction 1～3 time to its weight, weight concentration;
B) filter alcohol extract;
C) reclaim ethanol in the filtrate, and with its concentrate, centrifugation;
D) isolated clear liquid separates with macroreticular resin, and with 45～95% ethanol elution;
E) with the eluent drying for standby;
3) take by weighing grape seed extract 100～200 weight portions, isoflavones 75～125 weight portions, vitamin C 95～200 weight portions, natural VE powder 75～125 weight portions of producing with said method;
4) each component with the said ratio amount mixes, and sieves, and packing gets product.
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| Application Number | Priority Date | Filing Date | Title |
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| CNB2004100814472A CN1261045C (en) | 2004-12-09 | 2004-12-09 | Anti-oxidation health-care food, and its prodn. method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
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| CNB2004100814472A CN1261045C (en) | 2004-12-09 | 2004-12-09 | Anti-oxidation health-care food, and its prodn. method |
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| CN1261045C true CN1261045C (en) | 2006-06-28 |
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Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100443115C (en) * | 2006-04-27 | 2008-12-17 | 北京东方兴企食品工业技术有限公司 | Granule with beauty and health function |
| CN101653256B (en) * | 2009-06-09 | 2012-06-13 | 厦门市丝浓食品有限公司 | Producing method of health product capsule for beautifying face and moistering lotion |
| CN102657334B (en) * | 2012-05-14 | 2013-09-04 | 青岛海隆达生物科技有限公司 | Hard capsules taking grape seed extracts as raw materials and preparation method for hard capsules |
| CN103054043B (en) * | 2013-01-29 | 2014-03-26 | 汤臣倍健股份有限公司 | Composite capsule for delaying senescence |
| CN103598586A (en) * | 2013-11-20 | 2014-02-26 | 山西振东五和健康食品股份有限公司 | Anti-oxidation health-care food and preparation method thereof |
| CN103704720A (en) * | 2013-12-20 | 2014-04-09 | 林元藻 | Anti-aging healthcare food for middle aged and elderly people |
| CN104606392B (en) * | 2014-12-29 | 2018-11-16 | 上海交大昂立股份有限公司 | A kind of composition for the antioxidant activity increasing antioxidant |
| CN106138478A (en) * | 2015-03-25 | 2016-11-23 | 烟台宝备生物技术有限公司 | The medicine of a kind of enhancing immunity or health food |
| CN109497120A (en) * | 2018-05-22 | 2019-03-22 | 金华墨香食品连锁有限公司 | A kind of anti-oxidant crisp short cakes with sesame formula and preparation method |
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Address after: No. 19 Renmin South Road, Lingui District, Guilin City, Guangxi Zhuang Autonomous Region, 541100 Patentee after: Guilin Laiyin Biotechnology Co., Ltd. Address before: 541100 Yangtang Industrial Park, Lingui Town, Lingui County, Guilin City, Guangxi Zhuang Autonomous Region Patentee before: Guilin Laiyin Biotechnology Co., Ltd. |
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| CP02 | Change in the address of a patent holder |