CN103054043B - Composite capsule for delaying senescence - Google Patents
Composite capsule for delaying senescence Download PDFInfo
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- CN103054043B CN103054043B CN201310034852.8A CN201310034852A CN103054043B CN 103054043 B CN103054043 B CN 103054043B CN 201310034852 A CN201310034852 A CN 201310034852A CN 103054043 B CN103054043 B CN 103054043B
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Abstract
The invention relates to a composite capsule for delaying senescence, which aims at solving the technical problems of making up the blank of the prior art and providing a composite capsule for delaying senescence. The composite capsule for delaying senescence internally contains the following ingredients in parts by weight: 245-300 parts of soybean extractive, 45-55 parts of grape seed extractive, 1.35-1.65 parts of vitamin B1, 1.35-1.65 parts of vitamin B6 and 0.0027-0.0033 part of vitamin B12. According to the composite capsule, the soybean isoflavone, grape seed procyanidine and B-group vitamins are mutually prepared and acted cooperatively, various essential nutrients are provided and at the same time the conditioning of the soybean isoflavone to body functions of the middle-aged and the elderly is brought into play; if the product is taken for a long time, the health-care effects of delay senescence and improving climacteric syndrome are achieved, and therefore, the composite capsule is applicable to the vast middle-aged and the elderly.
Description
Technical field
The present invention relates to a kind of complex capsule of delaying sanility.
Background technology
In this formula, the Main Ingredients and Appearance of extract of soybean is isoflavones, research shows that isoflavones has unique biological nature and function, take 40～80mg isoflavones every day, the equal tool such as angiocardiopathy, osteoporosis and climacteric metancholia is had a better role, and the generation of anti-cancer in advance, thereby play the effect delaying senility.Not accommodating doubting, the absorption that increases soybean and bean product is of value to health.
Grape seed extract Main Ingredients and Appearance is OPC (PCO) and polyphenols, is a kind of effective free radical scavenger, and its antioxygenic property is remarkable, has anti-cardiovascular disease, anti-mutation, delaying senility function.The antioxidation activity of PCO is 20 times of VC, 50 times of VE.
B family vitamin B
1, B
6deng metabolism that in vivo can involved in sugar, promote energetic supersession, safeguard that neural and digestive system has important function.
But above-mentioned substance according to what proportioning is grouped together, just can reach the best effect delaying senility, prior art is without any enlightenment.
Summary of the invention
The technical problem to be solved in the present invention is the above-mentioned defect that how to overcome prior art, and a kind of complex capsule of delaying sanility is provided.
For solving the problems of the technologies described above, the grape seed extract of the extract of soybean that the capsule 's content of the complex capsule of this delaying sanility comprises 245-300 weight portion, 45-55 weight portion, the Cobastab of 1.35-16.5 weight portion
1, 1.35-1.65 weight portion Cobastab
6, 0.0027-0.0033 weight portion Cobastab
12.
As optimization, every contains: extract of soybean 245mg-300mg, grape seed extract 45mg-55mg, Cobastab
11.35mg-1.65mg, Cobastab
61.35mg-1.65mg, Cobastab
120.0027mg-0.0033mg.
The present invention is with the mutual compatibility synergy such as isoflavones, grape pip procyanidin, B family vitamin, when the various nutrients of needed by human are provided, give full play to again the adjusting of isoflavones to middle-aged and old functions, this product of long-term taking can play the health-care effect that delays senility, improves climacteric metancholia, is applicable to vast middle old people garment and uses.
The specific embodiment
Embodiment 1: get the extract of soybean of 270g, the Cobastab of the grape seed extract of 50g, 1.5g
1, 1.5g Cobastab
6, 0.003g Cobastab
12, fully mix, obtain mixture.
Said mixture is respectively charged in capsule, obtains the complex capsule A of delaying sanility, every 0.2 grammes per square metre.
Embodiment 2: get the extract of soybean of 245g, the Cobastab of the grape seed extract of 55g, 1.35g
1, 1.65g Cobastab
6, 0.0027g Cobastab
12, fully mix, obtain mixture.
Said mixture is respectively charged in capsule, obtains the complex capsule B of delaying sanility, every 0.2 grammes per square metre.
Embodiment 3: get the extract of soybean of 300g, the Cobastab of the grape seed extract of 45g, 1.65g
1, 1.35g Cobastab
6, 0.0033g Cobastab
12, fully mix, obtain mixture.
Said mixture is respectively charged in capsule, obtains the complex capsule C of delaying sanility, every 0.2 grammes per square metre.
Deferring senility test
1. materials and methods
1.1 material
1.1.1 sample: the complex capsule A of delaying sanility, the heavy 0.2g of every capsules content, adult's recommended intake is 2 of every days, by adult 60Kg batheroom scale, recommended intake can be converted as 6.7mg/Kg.bw..
1.1.2 animal used as test:
Mouse: Kunming kind, female, clean level, totally 50, wherein aged mouse (15 monthly age) is 40, body weight 48 ± 6g, 10 of few mouse in age (2 monthly age), body weight 29 ± 3g(Tongji Medical College, Huazhong Science and Technology Univ. Experimental Animal Center provides, No. 19-052, the moving word of doctor).
Fruit bat: Oregon K wild type Drosophila melanogaster (Drosophila melanogaster, nutrition and health care Food Research Inst. of Shanghai medical college of the ministry of railways provides).
1.1.3 key instrument and reagent:
SOD, MDA kit: Bioengineering Research Institute's (lot number is respectively 20010815 and 20010716) is built up in Nanjing.
722 spectrophotometers: Shanghai San analytical instrument factory
Biochemical constant incubator: Guangdong Medical Apparatus and Instruments Factory
Trace refrigerated centrifuge: Beijing medical centrifuge is long
1.2 method
1.2.1 drosophila survival experiment: by human body recommended intake experiment with computing concentration, be 13mg/100g culture medium, in this concentration by 3 times of groups apart from establishing 3 concentration groups, 360,120,40, four dosage groups of 13mg/100g culture medium, separately establish 1 control group.Collect the new fruit bat adult sprouting wings in 8 hours, under etherization, distinguish male and female, weigh and be divided at random 5 groups, every group 400, male and female half and half, are sub-packed in 3 * 10cm and cultivate (20/pipe) in vial, be placed in 25 ± 1 ℃, the biochemical cultivation case of relative humidity 45 ~ 75%, within every 4 days, change once freshly prepared culture medium, after fruit bat hatches 2 weeks, start to add tested material, observe drosophila survival, active situation every day 3 times, every 2 days time recording fruit bat death toll, until fruit bat is all dead.
1.2.2 anti-oxidant test: 40 aged mouses are divided into 4 groups at random by body weight, 10 few age mouse as control group in few age, three dosage groups and aged control group, one few age control group.Three dosage groups give tested material by 10,20,30 times of human body recommended intake (6.7mg/Kg.bw.) (67,133,200mg/Kg.bw.) per os gavages, and two control groups are filled with distilled water (respectively organize gavage capacity and be 0.2ml/10g.bw.).Duration of test is raised with complete granular material, and ad lib and drinking-water claim weekly body weight one time.During off-test, (30 days) are got eye socket blood and are surveyed Content of MDA and erythrocyte sod vigor.
1.2.3 statistical method: variance analysis (SAS software)
2. result
The impact of the complex capsule of 2.1 delaying sanilities on drosophila survival experiment: the results are shown in Table 1
The complex capsule of table 1 delaying sanility is on the impact of drosophila survival experiment (M ± SD)
Note: in table
*utmost point significant difference (a=0.01) has been compared in expression with control group
Between variance analysis and group, relatively (Q check) result shows, the average life span of male 120,40mg/100g culture medium two dosage groups and Mean longest life all the utmost point significantly higher than other control group of the same sex, the Mean longest life of 13mg/100g culture medium dosage group is significantly higher than other control group of the same sex (average life span: F=13.44, P<0.0001; Mean longest life: F=90.81, P<0.0001).Therefore tested material has the effect that extends significantly life span of drosophila melanogaster.
2.2 anti-oxidant tests
2.2.1 the impact of the complex capsule of delaying sanility on Mouse Weight: during giving tested material, Mouse Weight situation of change is as table 2
The variation (M ± SD) of table 2 duration of test Mouse Weight
From table 2, duration of test, each dosage group and aged control group mice body weight have no significant change, and few age control group mice because of in growth period, body weight constantly rises.
2.2.2 the impact of the complex capsule of delaying sanility on mice serum MDA content and erythrocyte sod vigor: measurement result is in Table 3
Table 3 mice serum MDA content and erythrocyte sod vigor (M ± SD)
Note: in table
*,
*represent respectively to have compared with aged control group significantly (a=0.05) and utmost point significant difference (a=0.01);
△ △expression with few age control group compared utmost point significant difference (a=0.01)
The results of analysis of variance shows: between dosage group and control group, on MDA content and SOD vigor, all have significant difference.Between group, relatively (Q check) result shows: 200mg/Kg.bw. dosage group Content of MDA is significantly lower than aged control group, the erythrocyte sod vigor utmost point is significantly higher than aged control group, demonstrates the effect that this tested material has raise significantly aged mouse SOD vigor and reduction MDA content.The SOD of three dosage group MDA content and 67,133mg/Kg.bw. two dosage groups active and with few age control group compare, all there is utmost point significant difference.
With the complex capsule B of delaying sanility and the complex capsule A of complex capsule C replacement delaying sanility, repeat above-mentioned animal experiment, result is without substantive difference.
2. conclusion
The complex capsule drosophila survival experiment result of delaying sanility demonstrates has the effect that extends drosphila metanogaster and Mean longest life; The anti-oxidant result of the test of mouse shows that tested material has the effect of remarkable rising aged mouse SOD vigor and reduction MDA content.According to < < function of health food, learn assessment process and method of inspection > >, judge that the complex capsule of delaying sanility has delaying senility function.
Above-mentioned experiment demonstration, the complex capsule of delaying sanility of the present invention can obviously delay senility, and long-term taking, without digestive discomfort.
The present invention includes but be not limited to above-mentioned embodiment, any product that meets the description of these claims, within all falling into protection scope of the present invention.
Claims (2)
1. a complex capsule for delaying sanility, is characterized in that: the grape seed extract of the extract of soybean that its capsule 's content comprises 245-300 weight portion, 45-55 weight portion, the Cobastab of 1.35-1.65 weight portion
1, 1.35-1.65 weight portion Cobastab
6, 0.0027-0.0033 weight portion Cobastab
12.
2. the complex capsule delaying senility according to claim 1, is characterized in that: every contains:
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN103211927A (en) * | 2013-04-26 | 2013-07-24 | 甘肃凯源生物技术开发中心 | Anti-aging composite tablet and preparation method thereof |
| CN104940241B (en) * | 2015-05-29 | 2018-09-21 | 湖北圣峰药业有限公司 | A kind of selenium worm grass compound preparation of prevention climacteric metancholia of women |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1618333A (en) * | 2004-12-09 | 2005-05-25 | 桂林莱茵生物制品有限公司 | Anti-oxidation health-care food, and its prodn. method |
| CN101361970A (en) * | 2008-09-28 | 2009-02-11 | 成都自豪药业有限公司 | Composition with beauty effect and health care efficacy and use thereof |
| CN101449818A (en) * | 2007-11-30 | 2009-06-10 | 北京因科瑞斯医药科技有限公司 | Medicine composition capable of delaying female aging and preparation method thereof |
| CN101697805A (en) * | 2009-09-14 | 2010-04-28 | 蔡晓东 | Grape pip soft capsules |
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2013
- 2013-01-29 CN CN201310034852.8A patent/CN103054043B/en active Active
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1618333A (en) * | 2004-12-09 | 2005-05-25 | 桂林莱茵生物制品有限公司 | Anti-oxidation health-care food, and its prodn. method |
| CN101449818A (en) * | 2007-11-30 | 2009-06-10 | 北京因科瑞斯医药科技有限公司 | Medicine composition capable of delaying female aging and preparation method thereof |
| CN101361970A (en) * | 2008-09-28 | 2009-02-11 | 成都自豪药业有限公司 | Composition with beauty effect and health care efficacy and use thereof |
| CN101697805A (en) * | 2009-09-14 | 2010-04-28 | 蔡晓东 | Grape pip soft capsules |
Non-Patent Citations (3)
| Title |
|---|
| 一种延缓衰老胶囊的安全性研究;吴大伟等;《卫生毒理学杂志》;20030330;第17卷(第3期);第191页第1段 * |
| 吴大伟等.一种延缓衰老胶囊的安全性研究.《卫生毒理学杂志》.2003,第17卷(第3期),第191-192页. |
| 王其先等.22.维生素B是如何延缓衰老的？.《天天健康 中老年养生300问》.中国轻工业出版社,2004,第33-34页. * |
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