CN1259369A - Medicine for treating rigid spine inflammation and prepn. method thereof - Google Patents
Medicine for treating rigid spine inflammation and prepn. method thereof Download PDFInfo
- Publication number
- CN1259369A CN1259369A CN99117885A CN99117885A CN1259369A CN 1259369 A CN1259369 A CN 1259369A CN 99117885 A CN99117885 A CN 99117885A CN 99117885 A CN99117885 A CN 99117885A CN 1259369 A CN1259369 A CN 1259369A
- Authority
- CN
- China
- Prior art keywords
- radix
- eupolyphaga
- salviae miltiorrhizae
- treatment
- ginseng
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Medicines Containing Plant Substances (AREA)
Abstract
The present invention relates to a medicine for treating ankylosing spondylitis and its prepn. method. It is composed of rehmannia root, ginseng, radix aconiti praeparata, salvia root, wolfberry fruit, Chinese dodder seed, scrophalaria root etc. which are decocted into liquid extract and further made into honey pill. The invented medicine possesses anti inflammation action and can regulate the immune function of organism, it can be used to treat rheumatic arthritis.
Description
The present invention relates to a kind of medicament for the treatment of ankylosing spondylitis, is the Chinese medicine of feedstock production with the Chinese herbal medicine specifically, the invention still further relates to this medicaments preparation method.
Ankylosing spondylitis is a kind of chronic, general, be the vertebral arthropathy of feature with the autoimmune, primary disease is fallen ill about 1,500 ten thousand people in China every year approximately, show that according to another World Health Organization's investigation the whole world ten thousand person-times of 4000-4500 takes place approximately at every year, is a kind of commonly encountered diseases, frequently-occurring disease.
For the treatment of ankylosing spondylitis, also there is not special effective method at present.The on-steroidal antiinflammatory of using in treatment can only improve its symptom, can not disease controlling make progress; Though and the Radix Tripterygii Wilfordii preparation that adopts has certain curative effect morely, side effect is big, and is influential to liver and gonad, poison bigger, can not long-term prescription (referring to Chinese journal of orthopedics 1984,4 (3), 133 pages, work such as Guo Juling literary composition: Radix Tripterygii Wilfordii tincture treatment rheumatic arthritis and ankylosing spondylitis; Combination of Chinese and Western medicine magazine 1990,10 (11), 652 pages, work literary compositions such as tight jasper: Chinese medicine rheumatism sheet treatment ankylosing spondylitis observation of curative effect).Also adopt treatment ankylosing spondylitises such as some other medicaments such as D-penicillamine, golden salt both at home and abroad, but poor effect.
The purpose of this invention is to provide a kind of Chinese medicine preparation that can reach the control ankylosing spondylitis state of an illness by antiinflammatory and mediator's body immunity function, recover patient's allomeric function.
Another object of the present invention provides the manufacture method of above-mentioned medicament.
The present invention is realized by following technical scheme:
A kind of medicament for the treatment of ankylosing spondylitis, its main component comprises following Chinese medicinal ingredients:
(the component meter is together following by weight for the Radix Rehmanniae: 200-300.)；
Radix Ginseng: 6-12;
Radix Aconiti Lateralis Preparata: 20-75.
The medicament of above-mentioned treatment ankylosing spondylitis for strengthening curative effect, also can add following Chinese medicinal ingredients:
Radix Salviae Miltiorrhizae: 15-45;
Eupolyphaga: 20-60:
Fructus Lycii: 45-60;
Semen Cuscutae: 45-60
Radix Scrophulariae: 100-200.
The method of above-mentioned raw materials being made medicament is:
Earlier the each component raw material is weighed by the prescription requirement, is undertaken by following operation then:
1. earlier with Radix Ginseng, Radix Salviae Miltiorrhizae, eupolyphaga drying, be ground into 200 order fine powders;
2. Radix Aconiti Lateralis Preparata, the Radix Rehmanniae, Fructus Lycii, Semen Cuscutae, Radix Scrophulariae are boiled and decoct twice, each 1.5 hours, remove slag, filter, reheat is concentrated into flowing soaking paste;
3. Radix Ginseng, Radix Salviae Miltiorrhizae, eupolyphaga fine powder are mixed with condensed cream, add proper honey and make big honeyed pills.
Theory of Chinese medical science thinks that the cause of disease of primary disease is an insufficiency of kidney-YANG, and the resistance of wind-cold damp pathogen numbness injures governor vessel.Through wasting QI-blood and pathogen heat-transformation and deficiency of both the liver and kidney.But most of patients is natural endowment deficiency (it is the oxidisability result that some cases has inherited genetic factors-70% patient HLA-B27).So the rule of treatment answers warming and recuperating the kidney-YANG, nourishing the liver and kidney, benefiting QI and nourishing blood and collateral dredging to invigorate blood circulation.Contain the Radix Rehmanniae, Radix Ginseng, Radix Aconiti Lateralis Preparata, Radix Salviae Miltiorrhizae, Radix Scrophulariae, Herba cuscutae in the present invention prescription, Chinese medicines such as Fructus Lycii, eupolyphaga, wherein, Radix Ginseng, Radix Salviae Miltiorrhizae benefiting qi and nourishing blood; Radix Aconiti Lateralis Preparata, Semen Cuscutae warming the kidney to invigorate YANG, invigorating the liver and kidney, beneficial vital essence; The Radix Rehmanniae, Radix Scrophulariae, Fructus Lycii nourishing the liver and kidney, replenishing YIN and removing heat; Radix Salviae Miltiorrhizae, eupolyphaga blood circulation promoting and blood stasis dispelling, hard masses softening and resolving.Full side has the effect of benefiting qi and nourishing blood, warming the kidney to invigorate YANG, nourishing the liver and kidney, blood circulation promoting and blood stasis dispelling.Learn that from modern medicine Radix Aconiti Lateralis Preparata, Radix Salviae Miltiorrhizae have antiinflammatory action; Radix Ginseng, Fructus Lycii tool immunoregulation effect; Radix Rehmanniae ginseng promotes lymphocyte transformation, and regulating immunological function improves body immunity.Show that through toxicologic study this medicine is nontoxic can be taken for a long time.The animal main pharmacodynamics studies show that this medical instrument has antiinflammatory action and regulates body's immunity.So reach disease controlling by above-mentioned pharmacological action clinically, remove symptom, recover the purpose of allomeric function, this medicine is except that being applied to treat the ankylosing spondylitis, still can treat diseases such as rheumatic, rheumatoid arthritis, be a kind of Chinese medicine preparation of safe, nontoxic, determined curative effect.
The clinical observation situation is as follows
(1) curative effect: 38 cases of this group are all followed up a case by regular visits to, wherein 35 examples with the anti-time more than 1 year, average 2 years 2 months, effective percentage 94.74% as a result, obvious effective rate reaches 71.06%.
(3) spinal motion and thorax mobility: to comparing before and after 26 routine patient's spinal motions and the 12 routine thorax mobility treatments, as long as X-ray film is not found " bamboo spine ", contrast before and after the treatment, spinal motion all is significantly improved (p＞0.05), and anteflexion motion improves very obviously (p＜0.01).Measure the 4th rib movement of thorax degree, improve (p＜0.01) of highly significant is also arranged before and after the treatment, the largest motion scope increases more than the 4cm.
(3) lab testing: 38 routine rheumatoid factor (RF) are all negative; 9 examples detect HLA-B27, and wherein 7 examples are positive; It is 27-125mm/h that 28 routine erythrocyte sedimentation rates are arranged before the treatment, and above person's 12 examples of 60mm/h all have the decline (p＜0.01) of highly significant after the treatment.Acute inflammation active stage before the detection of this group immune indexes is all selected to treat, the obviously fast person of erythrocyte sedimentation rate, with sb.'s illness took a favorable turn, the level of immune globulin Pseudobulbus Bletillae (Rhizoma Bletillae) complement C3 has remarkable decline (p＜0.05), but part patient's hemogram returns in normal range from too high or too low, illustrates that also this medicine does not have obvious harmful effect to hemogram.
(4) total joint functional evaluation: confirm with anti-result, after most of cases were taken this medicine, the total joint function had very significantly improvement (p＜0.01) before the treatment, and wherein 3 routine indexes are 3 grades patient, reach 1 grade or 2 grades after the treatment, recover respectively to go to school and housework.
(6) side effect: whole patient's period in a medicine, find no the clinical manifestation of tangible hepatorenal damage, removing 4 routine period in a medicine has inappetence, stomach discomfort, feels sick, and 1 example has outside the laxativeness treatment improvement, does not see other side effect and untoward reaction.Above-mentioned untoward reaction may be to due to the tolerance individual variation of Mel in this medicament.
Zoopery shows, observe by acute toxicity test (dosage is equivalent to 720 times of people's consumption) and long term toxicity test (dosage is equivalent to 80 times of people's consumption) rat, the anatomical tissue of 11 internal organs such as Liver and kidney is learned and is detected and the function no abnormality seen, shows that this medicine safety is nontoxic substantially.
The invention will be further described below in conjunction with embodiment:
Embodiment 1:
Take by weighing raw material (kilogram) by following proportioning
The Radix Rehmanniae 285 Radix Ginsengs 7 Radix Aconiti Lateralis Preparatas 68 Radix Scrophulariae 125
Radix Salviae Miltiorrhizae 43 eupolyphaga 27 Fructus Lyciis 56 Semen Cuscutae 56
Production technology is as follows:
With Radix Ginseng, Radix Salviae Miltiorrhizae, eupolyphaga drying, to be ground into 200 order fine powders standby; Radix Aconiti Lateralis Preparata, the Radix Rehmanniae, Fructus Lycii, Semen Cuscutae, unit are participated in jacketed pan, add entry 2.5cm to the powder, boil and decoct secondary.Each 1.5 hours, remove slag, filter, be concentrated into flowing soaking paste through heating again; Radix Ginseng, Radix Salviae Miltiorrhizae, eupolyphaga fine powder are mixed with condensed cream, add proper honey and make big honeyed pills, every ball 9 grams.
Embodiment 2:
Take by weighing raw material (kilogram) by following proportioning
The Radix Rehmanniae 216 Radix Ginsengs 9 Radix Aconiti Lateralis Preparatas 38 Radix Scrophulariae 142
Radix Salviae Miltiorrhizae 16 eupolyphaga 35 Fructus Lyciis 47 Semen Cuscutae 46
Production technology is the same.
Embodiment 3:
Take by weighing raw material (kilogram) by following proportioning
The Radix Rehmanniae 238 Radix Ginsengs 11 Radix Aconiti Lateralis Preparatas 23 Radix Scrophulariae 178
Radix Salviae Miltiorrhizae 32 eupolyphaga 56 Fructus Lyciis 51 Semen Cuscutae 49
Production technology is the same.
Embodiment 4:
Take by weighing raw material (kilogram) by following proportioning
The Radix Rehmanniae 207 Radix Ginsengs 11 Radix Aconiti Lateralis Preparatas 71.
Production technology is the same.
Claims (3)
1. medicament for the treatment of ankylosing spondylitis, it is characterized in that: its main component comprises following Chinese medicinal ingredients:
The Radix Rehmanniae: 200-300;
Radix Ginseng: 6-12;
Radix Aconiti Lateralis Preparata: 20-75.
2. the medicament of treatment ankylosing spondylitis according to claim 1 is characterized in that: also can add following Chinese medicinal ingredients:
Radix Salviae Miltiorrhizae: 15-45;
Eupolyphaga: 20-60;
Fructus Lycii: 45-60;
Semen Cuscutae: 45-60
Radix Scrophulariae: 100-200.
3. medicaments preparation method for the treatment of ankylosing spondylitis is characterized in that: earlier the each component raw material is weighed by the prescription requirement, undertaken by following operation then:
A. earlier with Radix Ginseng, Radix Salviae Miltiorrhizae, eupolyphaga drying, be ground into 200 order fine powders;
B. Radix Aconiti Lateralis Preparata, the Radix Rehmanniae, Fructus Lycii, Semen Cuscutae, Radix Scrophulariae are boiled and decoct twice, each 1.5 hours, remove slag, filter, reheat is concentrated into flowing soaking paste;
C. Radix Ginseng, Radix Salviae Miltiorrhizae, eupolyphaga fine powder are mixed with condensed cream, add proper honey and make big honeyed pills.With Radix Ginseng, Radix Salviae Miltiorrhizae, eupolyphaga drying, be ground into 200 order fine powders earlier; Radix Aconiti Lateralis Preparata, the Radix Rehmanniae, Fructus Lycii, Semen Cuscutae, Radix Scrophulariae are boiled twice, each 1.5 hours, remove slag, filter, reheat is concentrated into flowing soaking paste;
D. Radix Ginseng, Radix Salviae Miltiorrhizae, eupolyphaga fine powder are mixed with condensed cream, add proper honey, make big honeyed pills.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN99117885A CN1087949C (en) | 1999-10-14 | 1999-10-14 | Medicine for treating rigid spine inflammation and prepn. method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN99117885A CN1087949C (en) | 1999-10-14 | 1999-10-14 | Medicine for treating rigid spine inflammation and prepn. method thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1259369A true CN1259369A (en) | 2000-07-12 |
| CN1087949C CN1087949C (en) | 2002-07-24 |
Family
ID=5280324
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN99117885A Expired - Fee Related CN1087949C (en) | 1999-10-14 | 1999-10-14 | Medicine for treating rigid spine inflammation and prepn. method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1087949C (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102764393A (en) * | 2011-05-01 | 2012-11-07 | 闫凤宝 | Medicine for treating ankylosing spondylitis |
| CN105168910A (en) * | 2015-09-07 | 2015-12-23 | 王玉海 | Traditional Chinese medicinal preparation for treating ankylosing spondyloarthritis and preparation method of traditional Chinese medicinal preparation |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1088801A (en) * | 1993-01-01 | 1994-07-06 | 中国人民解放军第一军医大学 | Chinese patent medicine Jinguanpian tablets and the method for making thereof of treatment insensitive impediment, particularly RA and AS |
| CN1062180C (en) * | 1997-11-02 | 2001-02-21 | 王伊斌 | Medicine for tonifying the kidney and health-care contg. air bladder of fish |
-
1999
- 1999-10-14 CN CN99117885A patent/CN1087949C/en not_active Expired - Fee Related
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102764393A (en) * | 2011-05-01 | 2012-11-07 | 闫凤宝 | Medicine for treating ankylosing spondylitis |
| CN102764393B (en) * | 2011-05-01 | 2016-03-09 | 闫凤宝 | A kind of medicine for the treatment of ankylosing spondylitis |
| CN105168910A (en) * | 2015-09-07 | 2015-12-23 | 王玉海 | Traditional Chinese medicinal preparation for treating ankylosing spondyloarthritis and preparation method of traditional Chinese medicinal preparation |
Also Published As
| Publication number | Publication date |
|---|---|
| CN1087949C (en) | 2002-07-24 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN101411802B (en) | Black plaster for treating hyperosteogeny and preparation method thereof | |
| CN1161147C (en) | Oral Chinese medicine for curing osteoarthropathy | |
| CN1966018A (en) | Chinese medicinal formulation for treating rheumatic and rheumatoid disease | |
| CN1476849A (en) | Medicine composition for promoting blood circulation and removing stasis | |
| CN101703662B (en) | Oral Chinese medicament for treating hyperosteogeny | |
| CN1124156C (en) | Chinese-medicinal pills for treating rheumatism and preparing process thereof | |
| CN101912536B (en) | Medicinal composition for treating rheumatism and rheumatoid disease | |
| CN1087949C (en) | Medicine for treating rigid spine inflammation and prepn. method thereof | |
| CN1682811A (en) | Strengthening spine and bone pill ofr treating rigid spondylitis | |
| CN102872336B (en) | Traditional Chinese medicine for treating multiple myeloma | |
| CN1079029C (en) | Medical capsule for treating bone rheumatism and preparing process | |
| CN101167919B (en) | Medicine composition capable of promoting the growth of bone tissue and preparation technology and application thereof | |
| CN1309406C (en) | Medicinal preparation for treating rheumatism and rheumatoid diseases | |
| CN103316133B (en) | Medicine for treating lame impediment | |
| CN1103792A (en) | Proprietary Chinese medicine for curing stomach disease and the prepn. method | |
| CN1255155C (en) | Medicine for curing rheumatic and rheumatoid diseases and its preparing method | |
| CN1190215C (en) | Chinese medicine for treating rheumatism | |
| CN1088370C (en) | Tongguanshugan ointment and preparation process thereof | |
| CN106692873A (en) | Formula and preparation method of traditional Chinese medicine for treatimg hyperlipemia | |
| CN1294984C (en) | Combination of Chinese traditional medicine for treating rheumatoid arthritis and artjritis pauperum | |
| CN1269494C (en) | Medicine for treating numbness and preparing method thereof | |
| CN104383211A (en) | Traditional Chinese medicine clysis fluid for treating chronic renal insufficiency and yang deficiency-induced cold of diabetic nephropathy | |
| CN101049451A (en) | Application of compound preparation in medication for treating generalized bone fracture, weight reduction, and fighting against senium | |
| CN104042977A (en) | Traditional Chinese medicine for treating rheumatoid arthritis | |
| CN108310272A (en) | A kind of Chinese medicine composition and preparation method thereof for treating gout |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20020724 Termination date: 20141014 |
|
| EXPY | Termination of patent right or utility model |