CN1255155C

CN1255155C - Medicine for curing rheumatic and rheumatoid diseases and its preparing method

Info

Publication number: CN1255155C
Application number: CNB001032771A
Authority: CN
Inventors: 王春亭; 黄庆茁; 陈漠达; 韩振兴
Original assignee: 黄庆茁
Priority date: 2000-03-21
Filing date: 2000-03-21
Publication date: 2006-05-10
Anticipated expiration: 2020-03-21
Also published as: CN1314161A

Abstract

The present invention discloses new medicine treating rheumatic and rheumatoid diseases, which is pure Chinese medicine preparation proportionally prepared from raw materials, such as common monkshood mother roots, wild aconite roots, cassia twigs, acanthopanax barks, Chinese angelica, chuanxiong rhizomes, yam rhizomes, aconite roots, cyathula roots, safflower, pubescent angelica roots, pangolin (processed), tripterygium wilfordii, hemsleyadin, notopterygium roots, etc. The medicine is made into various medicament forms after treatment according to different properties of the medicine, such as a mixture, etc. The medicine has the advantages of unique formula and preparation method, treatment on both manifestation and root causes of diseases and conspicuous curative effect.

Description

Medicine for the treatment of rheumatic and rheumatoid diseases and preparation method thereof

The present invention relates to a kind of medicine for the treatment of rheumatism, rheumatism, the pure Chinese medicinal preparation of a kind for the treatment of rheumatism of making take natural Chinese medicinal herb as raw material, class wind disease specifically the invention still further relates to the preparation method of this medicine.

Rheumatic disease is a kind of class disease that affects BJM and annex and cartilaginous tissue such as synovial bursa, packing, cartilage, tendon, stndon sheath, manadesma etc. of making a general reference. This disease is a kind of common disease, and the physical and mental health that is seriously endangering the patient causes very big misery for patient's body and mind, causes in daily life great inconvenience. That the characteristics of incidence of this illness is that the course of disease is more is chronic, repeatedly outbreak, immunity is unusual or biochemical change, and thus or cause Other diseases such as renal failure etc. And atrophic diseases is from immunity disease take chronic polyarthritis as a kind of general firmly, this disease incidence of disease is high, adopt clinically at present steroids or the treatments of non-hormonal medicaments such as indoles, anti-inflammatory are painful, ibuprofen for this type of disease, if this two classes drug main synthesizes to reach result for the treatment of by what suppress prostaglandins in different links more. Although this disease is controlled, can inspire the pathology of sclerotin. GI bad reaction can occur in long-term this type of medicine that uses, and will cause that also the bone inner structure changes.

The object of the present invention is to provide a kind of medicine for the treatment of rheumatism, rheumatism, patient's whole body is played the effect of warming channel and expelling cold, dampness removing vein relaxing, promoting blood circulation and stopping pain, and can make erythrocyte sedimentation rate value, rheumatoid factor and non-fusibility streptostacin 0 etc. recover normal, and taking convenience, toxic and side effect is little.

Another object of the present invention is to provide the preparation method of this medicine.

Solution of the present invention is based on motherland's medical science to rheumatism, rheumatoid disease morbidity pathogenic mechanism understanding and principle of reatment, the Chinese drugs agentia of from Chinese medicine, choosing the natural drug of warming channel and expelling cold, the dampness removing vein relaxing of temperature, promoting blood circulation and stopping pain and making, each medicine synergy of distinguishing the flavor of is to reach curative effect.

Medicine of the present invention is by minute making (consumption is weight portion) the following composition:

Radix Aconiti cortex acanthopanacis Bi  safflower

90-120 90-120 90-120 40-60

Radix Aconiti Kusnezoffii Radix Angelicae Sinensis monkshood levisticum

90-120 90-120 40-60 40-60

The pangolin of cassia twig Ligusticum wallichii radix cyathulae through concocting

90-120 90-120 40-60 40-60

Thunder godvine

90-120

Saussurea involucrata

90-120

Notopterygium root

40-60。

Preparing the preferred weight of prescription of the present invention (part) ratio is:

Radix Aconiti cortex acanthopanacis Bi  safflower thunder godvine

100 100 100 50 100

Radix Aconiti Kusnezoffii Radix Angelicae Sinensis monkshood levisticum saussurea involucrata

100 100 50 50 100

The pangolin notopterygium root of cassia twig Ligusticum wallichii radix cyathulae through concocting

100 50 50 50 50。

Composition in the medicine of the present invention: monkshood, radix aconiti agrestis, monkshood have stronger warming channel and expelling cold effect, thunder godvine, saussurea involucrata, cortex acanthopanacis, Bi , notopterygium root have sharp water clearing damp, the effect of removing obstruction in channels to relieve pain, Radix Angelicae Sinensis, Ligusticum wallichii, safflower have function of promoting blood circulation to disperse blood clots, and pangolin (process of preparing Chinese medicine), cassia twig, to lead ruton good through the effect spy.

Medicine of the present invention can be made various formulations according to a conventional method, wherein preferred mixture.

Instructions of taking: 2 times on the one, each 20-30ml, one after each meal or follow the doctor's advice.

The rheumatic arthritis diagnostic criteria:

1) take the large arthralgia of four limbs as main, stretches the symptoms such as inconvenience, heating with miserable numbness, joint song.

2) there is the painful history of pharynx or paddle to drench with rain before the disease and occupies for a long time the wetland history;

3) some patients were can have low-heat, four limbs erythema annulare or erythema nodosum, Cardiac Involvemant;

4) erythrocyte sedimentation rate value (ESR)＞20mm/h, antistreptolysin O＞500 μ.

The Diagnosis of Rheumatoid Arthritis standard:

1) deadlock at least 1 hour in morning (this symptom continued more than 6 weeks);

2) 3 or 3 above swollen joints (this symptom continued more than 6 weeks);

3) gastral cavity metacarpal joint or PIP swollen (this struggles and continues more than 6 weeks);

4) limb inferior thyroid tubercle;

5) hand X sheet changes (have at least osteoporosis and joint space narrow);

6) symmetry swollen joint (this symptom continued more than 6 weeks):

7) rheumatoid factor (RF) positive.

All patients possess 4 above persons of above-mentioned standard, just can be diagnosed as rheumatoid arthritis.

More than the SS of each symptom as follows:

1. cure: diagnostic criteria is all recovered normally, below the erythrocyte sedimentation rate value 15mm/h.

2. produce effects: clinical symptoms disappear substantially, and it is normal that the sign Index for examination still fails to recover.

3. effective: cardinal symptom alleviates.

4. invalid: the result is unchanged in treatment.

Its result for the treatment of can be added up referring to table 1 all ages and classes clinical data.

Table 1 all ages and classes clinical data statistics

Age	Case load (number)	Cure	Produce effects	Effectively	Invalid
Age	Case load (number)	Cure	Produce effects	Effectively	Invalid	16-30	40	28	8	4	0
31-40	58	32	20	6	0	16-30	40	28	8	4	0
31-40	58	32	20	6	0	41-55	72	39	10	20	3
Efficient		58％	22.4％	17.6％	2％	41-55	72	39	10	20	3

By above clinical data as seen, the advantage of medicine of the present invention is and can treats both principal and secondary aspect of disease, quickly link and cure rheumatism, rheumatism. And can make erythrocyte sedimentation rate value, rheumatoid factor and non-fusibility streptostacin 0 etc. recover normal, effectively improve patient's self immunity. And have alleviation and healing effect, be difficult for recurrence. Taking convenience, toxic and side effect are little.

Embodiment:

Medicine material prescription of the present invention (gram):

Radix Aconiti cortex acanthopanacis Bi  safflower thunder godvine

100 100 100 50 100

100 100 50 50 100

100 50 50 50 50。

The preparation method:

Take by weighing by prescription and to be ground into 40 purpose corase meal boiling secondaries after the crude drug of respectively distinguishing the flavor of mixes, add 10000 milliliters in water for the first time and decocted 2 hours, add 5000 milliliters in water for the second time and decocted 1.5 hours. Collecting decoction, filter, be concentrated into 4600 milliliters, add 3 times of amount 95% ethanol, left standstill 24 hours, filter, Recycled ethanol, add water and dilute in right amount, refrigerate 24 hours, filter, add 3000 milliliters of simple syrups, Sodium Benzoate is an amount of, add again 10000 milliliters in water, stir evenly, packing, 100 milliliters every bottle.

Model case:

1. Confucian Garden is vertical, the man, and 24 years old now, pipe people from city of Zhengzhou City suffered from the large arthralgia of four limbs, moving difficulty. In many large hospital treatments, poor effect. To our hospital, be rheumatic arthritis after diagnosing, oral medicine of the present invention, symptom obviously alleviates after two days, serve on 20 days, and illness all disappears, and every Index for examination is normal.

2. Liu Qiang, the man, 46 years old, the Erqi District people of Zhengzhou City suffered from the rheumatoid arthritis disease, check in that my institute is medical, oral medicine of the present invention 40 days, symptom all disappears, and recovers normal operation.

Claims

1, a kind of medicine for the treatment of rheumatism and atrophic diseases is characterized in that it is the medicament of being made by the raw material of following weight proportioning:

Radix Aconiti 100 Radix Aconiti Kusnezoffiis 100 cassia twig 100

Cortex acanthopanacis 100 Radix Angelicae Sinensis 100 Ligusticum wallichiis 50

Bi  100 monkshoods 50 radix cyathulaes 50

The pangolin 50 of safflower 50 levisticums 50 through concocting

Thunder godvine 100 saussurea involucrata 100 notopterygium roots 50.

2, the medicine for the treatment of rheumatism according to claim 1 and atrophic diseases is characterized in that said medicament is mixture.

3, the preparation method for the treatment of rheumatism according to claim 1 and 2 and atrophic diseases medicine, it is characterized in that: be ground into 40 purpose corase meal boiling secondaries after each flavor crude drug is mixed, adding for the first time 10000 milliliters in water decocted 2 hours, adding for the second time 5000 milliliters in water decocted 1.5 hours, collecting decoction, filter, be concentrated into 4600 milliliters, add 3 times of amount 95% ethanol, left standstill 24 hours, filtration, Recycled ethanol add water and dilute in right amount, refrigerate 24 hours, filter, add 3000 milliliters of simple syrups, Sodium Benzoate is an amount of, adds 10000 milliliters in water again, stir evenly, packing.

4, the preparation method of the medicine for the treatment of rheumatism according to claim 3 and atrophic diseases, the packing volume that it is characterized in that said mixture is 100 milliliters.